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Items: 73

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
LOC130005193, SMPD1
(R3fs)
Deletion
(frameshift variant +2 more)
Niemann-Pick disease, type B
+1 more
GPathogenic
LOC130005193, SMPD1
(R3H)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type B
+3 more
GConflicting classifications of pathogenicity
LOC130005193, SMPD1
(Q10*)
Single nucleotide variant
(nonsense +2 more)
Niemann-Pick disease, type B
+1 more
GPathogenic/Likely pathogenic
SMPD1, LOC130005193
(E18*)
Single nucleotide variant
(nonsense +2 more)
Niemann-Pick disease, type B
+1 more
GPathogenic/Likely pathogenic
LOC130005193, SMPD1
(Q19fs)
Deletion
(frameshift variant +2 more)
Niemann-Pick disease, type A
+1 more
GConflicting classifications of pathogenicity
LOC130005193, SMPD1
(Q21*)
Single nucleotide variant
(nonsense +2 more)
Niemann-Pick disease, type B
+1 more
GPathogenic/Likely pathogenic
LOC130005193, SMPD1
(G29fs)
Deletion
(frameshift variant +2 more)
Niemann-Pick disease, type B
+2 more
GPathogenic
SMPD1
(W32*)
Single nucleotide variant
(nonsense +2 more)
Niemann-Pick disease, type B
+1 more
GPathogenic/Likely pathogenic
SMPD1
(W32*)
Single nucleotide variant
(nonsense +2 more)
Niemann-Pick disease, type A
+1 more
GPathogenic/Likely pathogenic
SMPD1
(D51fs)
Deletion
(frameshift variant +2 more)
Niemann-Pick disease, type A
+1 more
GPathogenic/Likely pathogenic
SMPD1
(S65fs)
Deletion
(frameshift variant +2 more)
Niemann-Pick disease, type A
+2 more
GPathogenic/Likely pathogenic
SMPD1
(R81*)
Single nucleotide variant
(nonsense +2 more)
Niemann-Pick disease, type A
+1 more
GPathogenic/Likely pathogenic
SMPD1
(L105P)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+1 more
GPathogenic/Likely pathogenic
SMPD1
Single nucleotide variant
(splice donor variant)
Niemann-Pick disease, type B
+1 more
GLikely pathogenic
SMPD1
(I118fs +1 more)
Deletion
(frameshift variant +2 more)
Niemann-Pick disease, type B
+2 more
GPathogenic/Likely pathogenic
SMPD1
(C159R +1 more)
Single nucleotide variant
(missense variant +2 more)
Sphingomyelin/cholesterol lipidosis
+3 more
GPathogenic/Likely pathogenic
SMPD1
(L163P +1 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type B
+1 more
GConflicting classifications of pathogenicity
SMPD1
(S173fs +1 more)
Duplication
(frameshift variant +2 more)
Niemann-Pick disease, type A
+2 more
GPathogenic/Likely pathogenic
SMPD1
(W176* +1 more)
Single nucleotide variant
(nonsense +2 more)
Niemann-Pick disease, type B
+1 more
GPathogenic/Likely pathogenic
SMPD1
(I178N +1 more)
Single nucleotide variant
(missense variant +2 more)
not provided
+3 more
GConflicting classifications of pathogenicity
SMPD1
(L179fs +1 more)
Deletion
(frameshift variant +2 more)
Niemann-Pick disease, type A
+2 more
GPathogenic/Likely pathogenic
SMPD1
(P186L +1 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+3 more
GPathogenic
SMPD1
(S191fs +1 more)
Deletion
(frameshift variant +2 more)
Sphingomyelin/cholesterol lipidosis
+3 more
GPathogenic
SMPD1
(A194fs +1 more)
Duplication
(frameshift variant +2 more)
not provided
+2 more
GPathogenic/Likely pathogenic
SMPD1
(P193fs +1 more)
Deletion
(frameshift variant +2 more)
Niemann-Pick disease, type A
+1 more
GPathogenic/Likely pathogenic
SMPD1
(L227P +1 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type B
+2 more
GConflicting classifications of pathogenicity
SMPD1
(R230C +1 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+3 more
GPathogenic/Likely pathogenic
SMPD1
(R240Q +1 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type B
+3 more
GBenign/Likely benign
SMPD1
(G247S +1 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+3 more
GPathogenic/Likely pathogenic
SMPD1
(S250R +1 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+3 more
GPathogenic/Likely pathogenic
SMPD1
(D253H +1 more)
Single nucleotide variant
(missense variant +2 more)
Sphingomyelin/cholesterol lipidosis
+3 more
GPathogenic/Likely pathogenic
SMPD1
(L262fs +1 more)
Deletion
(frameshift variant +2 more)
Niemann-Pick disease, type A
+3 more
GPathogenic
SMPD1
(H283fs +1 more)
Duplication
(frameshift variant +2 more)
Niemann-Pick disease, type B
+2 more
GPathogenic
SMPD1
(Q294K +1 more)
Single nucleotide variant
(missense variant +2 more)
not specified
+5 more
GPathogenic
SMPD1
(L304P +1 more)
Single nucleotide variant
Niemann-Pick disease, type A
+3 more
GPathogenic/Likely pathogenic
SMPD1
(V314M +1 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+2 more
GConflicting classifications of pathogenicity
SMPD1
(G319R +1 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+1 more
GConflicting classifications of pathogenicity
SMPD1
(N320D +1 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+2 more
GConflicting classifications of pathogenicity
SMPD1
(F332fs +2 more)
Deletion
(frameshift variant +1 more)
Niemann-Pick disease, type A
+3 more
GPathogenic
SMPD1
(W342C +2 more)
Single nucleotide variant
(missense variant +1 more)
not specified
+2 more
GConflicting classifications of pathogenicity
SMPD1
Single nucleotide variant
(splice acceptor variant +1 more)
Niemann-Pick disease, type A
+2 more
GPathogenic/Likely pathogenic
SMPD1
(F368fs +2 more)
Duplication
(frameshift variant +2 more)
Niemann-Pick disease, type B
+1 more
GPathogenic/Likely pathogenic
SMPD1
(L371fs +2 more)
Microsatellite
(frameshift variant +2 more)
Niemann-Pick disease, type A
+1 more
GPathogenic/Likely pathogenic
SMPD1
(R378H +2 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type B
+3 more
GConflicting classifications of pathogenicity
SMPD1
(L382fs +2 more)
Microsatellite
(frameshift variant +2 more)
Niemann-Pick disease, type A
+2 more
GPathogenic/Likely pathogenic
SMPD1
(R389H +2 more)
Single nucleotide variant
(missense variant +2 more)
not provided
+2 more
GUncertain significance
SMPD1
(W393G +2 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+3 more
GPathogenic
SMPD1
Single nucleotide variant
(splice acceptor variant)
Niemann-Pick disease, type A
+2 more
GLikely pathogenic
SMPD1
(H423Y +3 more)
Single nucleotide variant
(missense variant +1 more)
Niemann-Pick disease, type A
+3 more
GPathogenic
SMPD1
(G426S +3 more)
Single nucleotide variant
(missense variant +1 more)
Sphingomyelin/cholesterol lipidosis
+3 more
GPathogenic/Likely pathogenic
SMPD1
(P429L +3 more)
Single nucleotide variant
(missense variant +1 more)
Niemann-Pick disease, type B
+1 more
GConflicting classifications of pathogenicity
SMPD1
(C433W +3 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GLikely pathogenic
SMPD1
(R443* +3 more)
Single nucleotide variant
(nonsense +1 more)
Sphingomyelin/cholesterol lipidosis
+4 more
GPathogenic
SMPD1
Single nucleotide variant
(splice acceptor variant)
Niemann-Pick disease, type A
+2 more
GPathogenic/Likely pathogenic
SMPD1
(A454V +3 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+2 more
GConflicting classifications of pathogenicity
SMPD1
(R476W +3 more)
Single nucleotide variant
(missense variant +1 more)
Sphingomyelin/cholesterol lipidosis
+4 more
GPathogenic/Likely pathogenic
SMPD1
(P477L +3 more)
Single nucleotide variant
(missense variant +1 more)
Niemann-Pick disease, type A
+3 more
GPathogenic/Likely pathogenic
SMPD1
(A487V +3 more)
Single nucleotide variant
(missense variant +1 more)
not specified
+3 more
GConflicting classifications of pathogenicity
SMPD1
(R498C +3 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+3 more
GPathogenic/Likely pathogenic
APBB1, SMPD1
(R498L +4 more)
Single nucleotide variant
(missense variant +1 more)
Niemann-Pick disease, type A
+4 more
GPathogenic/Likely pathogenic
SMPD1
(C506Y)
Single nucleotide variant
(synonymous variant +2 more)
Niemann-Pick disease, type A
+1 more
GLikely benign
SMPD1
(Y500H +3 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+1 more
GConflicting classifications of pathogenicity
SMPD1
(Y506* +3 more)
Single nucleotide variant
(nonsense +2 more)
Niemann-Pick disease, type A
+2 more
GPathogenic/Likely pathogenic
SMPD1
(S510F +3 more)
Single nucleotide variant
(missense variant +2 more)
not specified
+3 more
GConflicting classifications of pathogenicity
SMPD1
(Y519C +3 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+2 more
GConflicting classifications of pathogenicity
SMPD1
(R542* +3 more)
Single nucleotide variant
(nonsense +2 more)
not provided
+4 more
GConflicting classifications of pathogenicity
SMPD1
(H577R +3 more)
Single nucleotide variant
(missense variant +2 more)
not provided
+3 more
GConflicting classifications of pathogenicity
SMPD1
(R591C +3 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type B
+2 more
GUncertain significance
SMPD1
(A596fs +3 more)
Microsatellite
(frameshift variant +2 more)
Niemann-Pick disease, type A
+1 more
GPathogenic/Likely pathogenic
SMPD1
(A290fs +3 more)
Deletion
(frameshift variant +2 more)
Niemann-Pick disease, type A
+2 more
GPathogenic/Likely pathogenic
SMPD1
(A601T +3 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+1 more
GConflicting classifications of pathogenicity
SMPD1
(R602H +3 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+3 more
GPathogenic/Likely pathogenic
APBB1, SMPD1
(R610del +3 more)
Microsatellite
(inframe_deletion +2 more)
not specified
+3 more
GPathogenic
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