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Items: 78

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
KIF1B
(E1006G)
Single nucleotide variant
(missense variant +1 more)
not specified
+1 more
GBenign/Likely benign
KIF1B
(T827I +1 more)
Single nucleotide variant
(missense variant)
not specified
+4 more
GConflicting classifications of pathogenicity
SDHB
(S163P)
Single nucleotide variant
(missense variant)
Paragangliomas 4
+7 more
GConflicting classifications of pathogenicity
MUTYH
(H305N +7 more)
Single nucleotide variant
(missense variant +1 more)
Malignant tumor of breast
GUncertain significance
SDHC
(M164L +10 more)
Single nucleotide variant
(missense variant)
Paragangliomas 3
+6 more
GConflicting classifications of pathogenicity
FH
(N415D)
Single nucleotide variant
(missense variant)
Malignant tumor of breast
GUncertain significance
MSH2
(P259S +1 more)
Single nucleotide variant
(missense variant)
MSH2-related disorder
+6 more
GConflicting classifications of pathogenicity
MSH6
(V878A +2 more)
Single nucleotide variant
(missense variant)
Lynch syndrome
GBenign
BARD1
(Q11H)
Single nucleotide variant
(missense variant +1 more)
Familial cancer of breast
+4 more
GConflicting classifications of pathogenicity
FANCD2, LOC107303338
(P593S +1 more)
Single nucleotide variant
(missense variant)
Fanconi anemia complementation group D2
+4 more
GConflicting classifications of pathogenicity
MLH1
(I219V +2 more)
Single nucleotide variant
(missense variant +1 more)
Lynch syndrome
GBenign
MLH1
(V618M +7 more)
Single nucleotide variant
(missense variant)
Lynch syndrome
GBenign
CASR
(A986S +1 more)
Single nucleotide variant
(missense variant)
not specified
+7 more
GBenign
ATR
(E471Q)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GConflicting classifications of pathogenicity
TERT
(A279T)
Single nucleotide variant
(missense variant +1 more)
Pulmonary fibrosis and/or bone marrow failure, Telomere-related, 1
+6 more
GBenign
FANCE
(P85S)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
POLH
(G209V +1 more)
Single nucleotide variant
(missense variant)
not specified
+3 more
GBenign/Likely benign
WRN
(T324A)
Single nucleotide variant
(missense variant)
Werner syndrome
+3 more
GBenign/Likely benign
PRKDC
(G3149D)
Single nucleotide variant
(missense variant)
Severe combined immunodeficiency due to DNA-PKcs deficiency
+2 more
GBenign/Likely benign
EXT1
(R605Q)
Single nucleotide variant
(missense variant)
Multiple congenital exostosis
GUncertain significance
RECQL4
(R902W)
Single nucleotide variant
(missense variant)
not provided
+3 more
GConflicting classifications of pathogenicity
RECQL4
(S862L)
Single nucleotide variant
(missense variant)
Baller-Gerold syndrome
+1 more
GUncertain significance
TSC1
(S530T +3 more)
Single nucleotide variant
(missense variant)
not provided
+4 more
GConflicting classifications of pathogenicity
TSC1
(M322T +2 more)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+5 more
GBenign
LOC106736614, RET
(G7D)
Single nucleotide variant
(missense variant)
not provided
+7 more
GUncertain significance
RET
(V262A +3 more)
Single nucleotide variant
(missense variant)
Multiple endocrine neoplasia, type 2
+8 more
GConflicting classifications of pathogenicity
RET
(R982C +17 more)
Single nucleotide variant
(missense variant)
not provided
+11 more
GConflicting classifications of pathogenicity
FANCF
(A186V)
Single nucleotide variant
(missense variant)
Ovarian cancer
+4 more
GBenign/Likely benign
TYR
(R402Q)
Single nucleotide variant
(missense variant)
not provided
+5 more
GConflicting classifications of pathogenicity; other
ATM
(Q414K)
Single nucleotide variant
(missense variant)
Ataxia-telangiectasia syndrome
GUncertain significance
ATM
(S474N)
Single nucleotide variant
(missense variant)
Ataxia-telangiectasia syndrome
+1 more
GUncertain significance
ATM
(F582L)
Single nucleotide variant
(missense variant)
Ataxia-telangiectasia syndrome
+5 more
GConflicting classifications of pathogenicity
ATM, C11orf65
(K1964E)
Single nucleotide variant
(missense variant +1 more)
Hereditary breast ovarian cancer syndrome
+7 more
GConflicting classifications of pathogenicity
POLE
(A1885T)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
BRCA2
(A938fs)
Deletion
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
(R2787C)
Single nucleotide variant
(missense variant)
not provided
+4 more
GConflicting classifications of pathogenicity
BRCA2
(D2900V)
Single nucleotide variant
(missense variant)
not specified
+3 more
GConflicting classifications of pathogenicity
BRCA2
(A2951T)
Single nucleotide variant
(missense variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GBenign
BRCA2
(T3033fs)
Duplication
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
(K3196E)
Single nucleotide variant
(missense variant)
Hereditary breast ovarian cancer syndrome
+3 more
GConflicting classifications of pathogenicity
BRCA2
(K3326*)
Single nucleotide variant
(nonsense)
BRCA2-related cancer predisposition
GBenign
TINF2
(S245Y +1 more)
Single nucleotide variant
(missense variant)
Dyskeratosis congenita
+5 more
GBenign/Likely benign
MLH3
(M809V)
Single nucleotide variant
(missense variant)
Lynch syndrome 1
+2 more
GConflicting classifications of pathogenicity
TSHR
(P68S)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+4 more
GConflicting classifications of pathogenicity
DICER1
(I461V)
Single nucleotide variant
(missense variant)
DICER1-related tumor predisposition
GBenign
FANCI
(S1211F +2 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
SLX4
(T1475A)
Single nucleotide variant
(missense variant)
Malignant tumor of breast
GUncertain significance
SLX4
(P975L)
Single nucleotide variant
(missense variant)
Fanconi anemia complementation group P
+3 more
GBenign/Likely benign
SLX4
(G141W)
Single nucleotide variant
(missense variant)
not provided
+4 more
GConflicting classifications of pathogenicity
PALB2
(P864S)
Single nucleotide variant
(missense variant)
not specified
+7 more
GBenign/Likely benign
PALB2
(E672Q)
Single nucleotide variant
(missense variant)
Familial cancer of breast
GBenign
PALB2
(L278H)
Indel
(missense variant)
not provided
+7 more
GConflicting classifications of pathogenicity
FANCA
(T266A +1 more)
Single nucleotide variant
(missense variant)
not specified
+4 more
GBenign
MC1R
(V60L)
Single nucleotide variant
(missense variant)
Melanoma, cutaneous malignant, susceptibility to, 5
+5 more
GBenign/Likely benign
MC1R
(R160W)
Single nucleotide variant
(missense variant)
Melanoma, cutaneous malignant, susceptibility to, 5
+2 more
GConflicting classifications of pathogenicity
WRAP53
(A280T)
Single nucleotide variant
(missense variant)
Malignant tumor of breast
GUncertain significance
BRCA1
(W1815* +80 more)
Single nucleotide variant
(nonsense +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
BRCA1
(C1740Y +79 more)
Single nucleotide variant
(missense variant +2 more)
Hereditary cancer-predisposing syndrome
+2 more
GLikely pathogenic
BRCA1
(M1652I +76 more)
Single nucleotide variant
(missense variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GBenign
BRCA1
(S1613G +77 more)
Single nucleotide variant
(missense variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GBenign
BRCA1, LOC126862571
(C1146fs +21 more)
Deletion
(frameshift variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
BRCA1
(E1038G +20 more)
Single nucleotide variant
(missense variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GBenign
BRCA1
(L455fs +20 more)
Deletion
(frameshift variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
BRCA1
(Q356R +20 more)
Single nucleotide variant
(missense variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GBenign
BRCA1
Single nucleotide variant
(splice acceptor variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
+2 more
GPathogenic/Likely pathogenic
BRCA1, LOC111589215
Single nucleotide variant
(5 prime UTR variant +1 more)
not specified
+3 more
GConflicting classifications of pathogenicity
BRIP1
(R264W)
Single nucleotide variant
(missense variant)
not specified
+6 more
GConflicting classifications of pathogenicity
AXIN2
(S762N +1 more)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+3 more
GConflicting classifications of pathogenicity
AXIN2
(A695S +1 more)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+3 more
GConflicting classifications of pathogenicity
STK11
(S404F)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+5 more
GConflicting classifications of pathogenicity
SMARCA4
Single nucleotide variant
(intron variant)
Intellectual disability, autosomal dominant 16
+4 more
GBenign/Likely benign
POLD1
(V759I +1 more)
Single nucleotide variant
(missense variant +1 more)
Colorectal cancer, susceptibility to, 10
+3 more
GConflicting classifications of pathogenicity
CHEK2
(D438Y +4 more)
Single nucleotide variant
(missense variant)
CHEK2-related cancer predisposition
+10 more
GConflicting classifications of pathogenicity
CHEK2
(G167R +1 more)
Single nucleotide variant
(missense variant +2 more)
Hereditary breast ovarian cancer syndrome
+7 more
GPathogenic/Likely pathogenic
CHEK2
(I157T +1 more)
Single nucleotide variant
(missense variant +2 more)
not specified
+14 more
GConflicting classifications of pathogenicity; risk factor
NF2
(F592L +1 more)
Single nucleotide variant
(missense variant +2 more)
Neurofibromatosis, type 2
+2 more
GConflicting classifications of pathogenicity
FANCB
(F590S)
Single nucleotide variant
(missense variant)
VACTERL association, X-linked, with or without hydrocephalus
+6 more
GConflicting classifications of pathogenicity
FANCB
(T494A)
Single nucleotide variant
(missense variant)
Fanconi anemia
GUncertain significance
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