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Items: 1 to 100 of 173

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
LDLR, LDLR-AS1
Single nucleotide variant
(non-coding transcript variant)
Hypercholesterolemia, familial, 1
GBenign
LDLR, LDLR-AS1
Single nucleotide variant
(non-coding transcript variant)
Hypercholesterolemia, familial, 1
GUncertain significance
LDLR, LDLR-AS1
Single nucleotide variant
(non-coding transcript variant)
Hypercholesterolemia, familial, 1
GUncertain significance
LDLR, LDLR-AS1
Single nucleotide variant
(non-coding transcript variant +1 more)
Hypercholesterolemia, familial, 1
+1 more
GUncertain significance
LDLR, LDLR-AS1
(M1fs)
Deletion
(non-coding transcript variant +2 more)
not provided
GPathogenic
LDLR, LDLR-AS1
(W4fs)
Deletion
(non-coding transcript variant +2 more)
Hypercholesterolemia, familial, 1
+3 more
GPathogenic
LDLR, LDLR-AS1
(W4*)
Single nucleotide variant
(non-coding transcript variant +1 more)
Cardiovascular phenotype
+3 more
GPathogenic
LDLR, LDLR-AS1
(G20R)
Single nucleotide variant
(non-coding transcript variant +1 more)
Hypercholesterolemia, familial, 1
GBenign
LDLR, LDLR-AS1
Single nucleotide variant
(non-coding transcript variant +1 more)
not provided
+4 more
GBenign/Likely benign
LDLR
(C27W)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
Single nucleotide variant
(synonymous variant)
Familial hypercholesterolemia
+4 more
GConflicting classifications of pathogenicity
LDLR
(V45G)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
LDLR
(C132W +1 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
LDLR
(A50T)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+4 more
GConflicting classifications of pathogenicity
LDLR
(A50S)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+5 more
GConflicting classifications of pathogenicity
LDLR
Single nucleotide variant
(synonymous variant)
not provided
+4 more
GBenign/Likely benign
LDLR
(E58*)
Single nucleotide variant
(nonsense)
Familial hypercholesterolemia
+2 more
GPathogenic/Likely pathogenic
LDLR
Single nucleotide variant
(synonymous variant +1 more)
Cardiovascular phenotype
+4 more
GLikely benign
LDLR
(E101K)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(R191H)
Single nucleotide variant
(missense variant +2 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(C109Y +1 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
+3 more
GPathogenic/Likely pathogenic
LDLR
(E113K +1 more)
Single nucleotide variant
(missense variant +1 more)
Cardiovascular phenotype
+4 more
GConflicting classifications of pathogenicity
LDLR
(C116Y +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
LDLR
(D118N +1 more)
Single nucleotide variant
(missense variant +1 more)
Cardiovascular phenotype
+3 more
GUncertain significance
LDLR
(E140D +1 more)
Single nucleotide variant
(missense variant +1 more)
Familial hypercholesterolemia
+2 more
GPathogenic/Likely pathogenic
LDLR
(C143* +1 more)
Single nucleotide variant
(nonsense +1 more)
Familial hypercholesterolemia
+3 more
GPathogenic
LDLR
Single nucleotide variant
(synonymous variant +1 more)
not provided
+1 more
GConflicting classifications of pathogenicity
LDLR
(W165* +1 more)
Single nucleotide variant
(nonsense +1 more)
not provided
+1 more
GPathogenic
LDLR
Single nucleotide variant
(synonymous variant +1 more)
Hypercholesterolemia, familial, 1
GLikely benign
LDLR
(C167S +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GUncertain significance
LDLR
(C173R +1 more)
Single nucleotide variant
(missense variant +1 more)
Cardiovascular phenotype
+3 more
GPathogenic/Likely pathogenic
LDLR
(C173W +1 more)
Single nucleotide variant
(missense variant +1 more)
Familial hypercholesterolemia
+3 more
GPathogenic/Likely pathogenic
LDLR
(S177L +1 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(E179K +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GConflicting classifications of pathogenicity
LDLR
(P181R +1 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GLikely pathogenic
LDLR
(C184Y +1 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
Single nucleotide variant
(synonymous variant +1 more)
Hypercholesterolemia, familial, 1
GLikely benign
LDLR
(C197G +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+4 more
GPathogenic/Likely pathogenic
LDLR
(C197Y +1 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
+4 more
GPathogenic/Likely pathogenic
LDLR
(W214* +1 more)
Single nucleotide variant
(nonsense +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(C216F +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GConflicting classifications of pathogenicity
LDLR
(G219del +1 more)
Microsatellite
(inframe_deletion +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(G218fs +1 more)
Deletion
(frameshift variant +1 more)
Hypercholesterolemia, familial, 1
+3 more
GPathogenic/Likely pathogenic
LDLR
(D221N +1 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
+3 more
GPathogenic/Likely pathogenic
LDLR
(D221G +1 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(C222R +1 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GLikely pathogenic
LDLR
(D186fs +1 more)
Indel
(frameshift variant +1 more)
Cardiovascular phenotype
+2 more
GPathogenic
LDLR
(D186fs +1 more)
Deletion
(frameshift variant +1 more)
Cardiovascular phenotype
+4 more
GPathogenic/Likely pathogenic
LDLR
(E228Q +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+3 more
GPathogenic/Likely pathogenic
LDLR
(E228* +1 more)
Single nucleotide variant
(nonsense +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(R237H +2 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
+2 more
GConflicting classifications of pathogenicity
LDLR
(E240K +2 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(R253W +2 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GUncertain significance
LDLR
(R257W +2 more)
Single nucleotide variant
(missense variant +1 more)
not specified
+4 more
GConflicting classifications of pathogenicity
LDLR
(R216Q +2 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GUncertain significance
LDLR
(E131fs +2 more)
Deletion
(frameshift variant +1 more)
not provided
GLikely pathogenic
LDLR
(D266E +2 more)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(N272T +2 more)
Single nucleotide variant
(missense variant +1 more)
Familial hypercholesterolemia
+2 more
GUncertain significance
LDLR
Single nucleotide variant
(intron variant)
not provided
GUncertain significance
LDLR
(T106fs +3 more)
Deletion
(frameshift variant)
not provided
+3 more
GPathogenic/Likely pathogenic
LDLR
(E277K +3 more)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+4 more
GConflicting classifications of pathogenicity
LDLR
(C116* +3 more)
Single nucleotide variant
(nonsense)
not provided
GLikely pathogenic
LDLR
(S286R +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GLikely pathogenic
LDLR
(E288K +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(C128G +3 more)
Single nucleotide variant
(missense variant)
not provided
GLikely pathogenic
LDLR
(R132T +3 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
LDLR
(D304N +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(S306L +3 more)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+3 more
GPathogenic/Likely pathogenic
LDLR
Single nucleotide variant
(intron variant)
Hypercholesterolemia, familial, 1
GBenign
LDLR
Single nucleotide variant
(intron variant)
Hypercholesterolemia, familial, 1
GBenign
LDLR
Single nucleotide variant
(splice acceptor variant)
Familial hypercholesterolemia
+2 more
GPathogenic/Likely pathogenic
LDLR
(G323S +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GUncertain significance
LDLR
(G324S +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GBenign
LDLR
(C198S +3 more)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+1 more
GLikely pathogenic
LDLR
Single nucleotide variant
(synonymous variant)
Hypercholesterolemia, familial, 1
+4 more
GBenign/Likely benign
LDLR
(E337K +3 more)
Single nucleotide variant
(missense variant)
not provided
+3 more
GConflicting classifications of pathogenicity
LDLR
(L339P +3 more)
Single nucleotide variant
(missense variant)
not provided
+3 more
GConflicting classifications of pathogenicity
LDLR
(D342E +3 more)
Single nucleotide variant
(missense variant)
not specified
+4 more
GConflicting classifications of pathogenicity
LDLR
(G343S +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(R350* +3 more)
Single nucleotide variant
(nonsense)
Hypercholesterolemia, familial, 1
GPathogenic
LDLR
(R350P +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GLikely pathogenic
LDLR
Deletion
(splice donor variant)
Familial hypercholesterolemia
+4 more
GPathogenic/Likely pathogenic
LDLR
(C352F +3 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic/Likely pathogenic
LDLR
Single nucleotide variant
(synonymous variant)
Cardiovascular phenotype
+4 more
GConflicting classifications of pathogenicity
LDLR
Single nucleotide variant
(intron variant)
Familial hypercholesterolemia
+4 more
GConflicting classifications of pathogenicity
LDLR
Single nucleotide variant
(intron variant)
Hypercholesterolemia, familial, 1
GBenign
LDLR
Single nucleotide variant
(splice acceptor variant)
not provided
+3 more
GPathogenic/Likely pathogenic
LDLR
(D354G +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+4 more
GPathogenic/Likely pathogenic
LDLR
(C368Y +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+3 more
GPathogenic/Likely pathogenic
LDLR
Single nucleotide variant
(synonymous variant)
not specified
+4 more
GLikely benign
LDLR
(Y207fs +3 more)
Duplication
(frameshift variant)
Hypercholesterolemia, familial, 1
+4 more
GPathogenic/Likely pathogenic
LDLR
(C250fs +3 more)
Deletion
(frameshift variant)
Familial hypercholesterolemia
+2 more
GPathogenic
LDLR
Single nucleotide variant
(synonymous variant)
Hypercholesterolemia, familial, 1
GLikely benign
LDLR
Single nucleotide variant
(intron variant)
Hypercholesterolemia, familial, 1
+4 more
GPathogenic/Likely pathogenic
LDLR
(A399T +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+4 more
GConflicting classifications of pathogenicity
LDLR
(L401V +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+3 more
GPathogenic/Likely pathogenic
LDLR
(E408K +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GLikely pathogenic
LDLR
(L414R +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GUncertain significance
LDLR
(R416W +3 more)
Single nucleotide variant
(missense variant)
Homozygous familial hypercholesterolemia
+4 more
GPathogenic/Likely pathogenic
LDLR
(V429M +3 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
GPathogenic
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