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Items: 20

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
POLE
(R1630W)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+4 more
GUncertain significance
POLE
(R1508H)
Single nucleotide variant
(missense variant)
Colorectal cancer, susceptibility to, 12
+4 more
GConflicting classifications of pathogenicity
POLE
(V1426I)
Single nucleotide variant
(missense variant)
Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency
+3 more
GUncertain significance
POLE
(D1354E)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
POLE
(R1324H)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
POLE
(R1284Q)
Single nucleotide variant
(missense variant)
not specified
+2 more
GConflicting classifications of pathogenicity
POLE
(E1253Q)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
POLE
(R1077C)
Single nucleotide variant
(missense variant)
Colorectal cancer, susceptibility to, 12
+2 more
GUncertain significance
POLE
(R712C)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+1 more
GUncertain significance
POLE
(P697R)
Single nucleotide variant
(missense variant)
not provided
+3 more
GConflicting classifications of pathogenicity
POLE
(L690V)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
POLE
(R446Q)
Single nucleotide variant
(missense variant)
not provided
+4 more
GConflicting classifications of pathogenicity
POLE
(K425R)
Single nucleotide variant
(missense variant)
not specified
+3 more
GUncertain significance
POLE
(H144R)
Single nucleotide variant
(missense variant)
not provided
+5 more
GUncertain significance
POLE
Single nucleotide variant
(synonymous variant)
not provided
+1 more
GConflicting classifications of pathogenicity
POLE
(R77H)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
POLE
(D73G)
Single nucleotide variant
(missense variant)
Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency
+4 more
GUncertain significance
POLE
(R52W)
Single nucleotide variant
(missense variant)
not specified
+5 more
GConflicting classifications of pathogenicity
LOC130009266, POLE
Single nucleotide variant
(splice donor variant)
not provided
+1 more
GConflicting classifications of pathogenicity
LOC130009266, POLE
(M1L)
Single nucleotide variant
(missense variant +1 more)
Colorectal cancer, susceptibility to, 12
+3 more
GConflicting classifications of pathogenicity
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