"Mayo Clinic Laboratories, Mayo Clinic"[submitter] AND "MSH6"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 89164	NM_000179.3(MSH6):c.-8C>T	MSH6	Single nucleotide variant (5 prime UTR variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 183723	NM_000179.3(MSH6):c.10C>T (p.Gln4Ter)	MSH6 (Q4*)	Single nucleotide variant (nonsense +1 more)	Lynch syndrome 5 +7 more	GPathogenic/Likely pathogenic
Select item 89540	NM_000179.3(MSH6):c.59C>T (p.Ala20Val)	MSH6 (A20V)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome 1	GLikely benign
Select item 36581	NM_000179.3(MSH6):c.116G>A (p.Gly39Glu)	MSH6 (G39E)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome	GBenign
Select item 455121	NM_000179.3(MSH6):c.118G>A (p.Ala40Thr)	MSH6 (A40T)	Single nucleotide variant (missense variant +1 more)	not provided +4 more	GUncertain significance
Select item 184901	NM_000179.3(MSH6):c.166_171dup (p.54GP[3])	MSH6	Duplication (inframe_insertion +1 more)	not provided +5 more	GUncertain significance
Select item 36584	NM_000179.3(MSH6):c.186C>A (p.Arg62=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Lynch syndrome	GBenign
Select item 492704	NM_000179.3(MSH6):c.260+2T>A	LOC129933707, MSH6	Single nucleotide variant (splice donor variant +1 more)	Lynch syndrome	GLikely pathogenic
Select item 492705	NM_000179.3(MSH6):c.260+3A>G	LOC129933707, MSH6	Single nucleotide variant (intron variant)	Hereditary nonpolyposis colorectal neoplasms	GUncertain significance
Select item 89295	NM_000179.3(MSH6):c.260+22C>G	LOC129933707, MSH6	Single nucleotide variant (intron variant)	Lynch syndrome	GBenign
Select item 218055	NM_000179.3(MSH6):c.261-1G>C	MSH6	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +4 more	GPathogenic/Likely pathogenic
Select item 36587	NM_000179.3(MSH6):c.276A>G (p.Pro92=)	MSH6	Single nucleotide variant (synonymous variant +2 more)	Lynch syndrome	GBenign
Select item 141913	NM_000179.3(MSH6):c.369A>T (p.Lys123Asn)	MSH6 (K123N)	Single nucleotide variant (missense variant +2 more)	not provided +3 more	GUncertain significance
Select item 41596	NM_000179.3(MSH6):c.431G>T (p.Ser144Ile)	MSH6 (S144I)	Single nucleotide variant (missense variant +2 more)	Lynch syndrome	GBenign
Select item 89522	NM_000179.3(MSH6):c.457+13A>G	MSH6	Single nucleotide variant (intron variant)	Lynch syndrome	GLikely benign
Select item 89534	NM_000179.3(MSH6):c.467C>G (p.Ser156Ter)	MSH6 (S156*)	Single nucleotide variant (nonsense +2 more)	Lynch syndrome	GPathogenic
Select item 185008	NM_000179.3(MSH6):c.503C>G (p.Ala168Gly)	MSH6 (A168G)	Single nucleotide variant (missense variant +2 more)	Hereditary nonpolyposis colorectal neoplasms +5 more	GConflicting classifications of pathogenicity
Select item 36597	NM_000179.3(MSH6):c.540T>C (p.Asp180=)	MSH6	Single nucleotide variant (synonymous variant +2 more)	Lynch syndrome	GBenign
Select item 89543	NM_000179.3(MSH6):c.628-56C>T	MSH6	Single nucleotide variant (intron variant)	Lynch syndrome	GBenign
Select item 36599	NM_000179.3(MSH6):c.642C>T (p.Tyr214=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Lynch syndrome	GBenign
Select item 216321	NM_000179.3(MSH6):c.643G>A (p.Val215Ile)	MSH6 (V215I +1 more)	Single nucleotide variant (5 prime UTR variant +1 more)	not provided +5 more	GConflicting classifications of pathogenicity
Select item 8932	NM_000179.3(MSH6):c.651dup (p.Lys218Ter)	MSH6 (K88* +1 more)	Duplication (nonsense +1 more)	Lynch syndrome	GPathogenic
Select item 455338	NM_000179.3(MSH6):c.661_672del (p.Glu221_Glu224del)	MSH6	Deletion (inframe_deletion +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 89551	NM_000179.3(MSH6):c.660A>C (p.Glu220Asp)	MSH6 (E220D +1 more)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome	GLikely benign
Select item 89552	NM_000179.3(MSH6):c.663A>C (p.Glu221Asp)	MSH6 (E221D +1 more)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +6 more	GConflicting classifications of pathogenicity
Select item 89563	NM_000179.3(MSH6):c.742C>T (p.Arg248Ter)	MSH6 (R248* +1 more)	Single nucleotide variant (nonsense +1 more)	Lynch syndrome	GPathogenic
Select item 140780	NM_000179.3(MSH6):c.749T>C (p.Val250Ala)	MSH6 (V250A +1 more)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome +7 more	GConflicting classifications of pathogenicity
Select item 237215	NM_000179.3(MSH6):c.818G>T (p.Gly273Val)	MSH6 (G273V +1 more)	Single nucleotide variant (missense variant +1 more)	Endometrial carcinoma +5 more	GConflicting classifications of pathogenicity
Select item 89572	NM_000179.3(MSH6):c.866_867delinsAA (p.Gly289Glu)	MSH6 (G159E +1 more)	Indel (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +7 more	GConflicting classifications of pathogenicity
Select item 89574	NM_000179.3(MSH6):c.892C>T (p.Arg298Ter)	MSH6 (R298* +1 more)	Single nucleotide variant (nonsense +1 more)	Lynch syndrome	GPathogenic
Select item 218080	NM_000179.3(MSH6):c.900dup (p.Lys301fs)	MSH6 (K301fs +1 more)	Duplication (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome +4 more	GPathogenic
Select item 230518	NM_000179.3(MSH6):c.972A>C (p.Lys324Asn)	MSH6 (K324N +2 more)	Single nucleotide variant (missense variant)	not provided +6 more	GConflicting classifications of pathogenicity
Select item 141908	NM_000179.3(MSH6):c.1007C>G (p.Thr336Ser)	MSH6 (T336S +2 more)	Single nucleotide variant (missense variant)	Hereditary nonpolyposis colorectal neoplasms +3 more	GConflicting classifications of pathogenicity
Select item 187718	NM_000179.3(MSH6):c.1037C>T (p.Ser346Phe)	MSH6 (S346F +2 more)	Single nucleotide variant (missense variant)	Hereditary nonpolyposis colorectal neoplasms +5 more	GConflicting classifications of pathogenicity
Select item 89172	NM_000179.3(MSH6):c.1109T>C (p.Leu370Ser)	MSH6 (L370S +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome 5 +6 more	GPathogenic/Likely pathogenic
Select item 89174	NM_000179.3(MSH6):c.1135_1139del (p.Arg378_Arg379insTer)	MSH6	Microsatellite (nonsense)	Lynch syndrome	GPathogenic
Select item 492706	NM_000179.3(MSH6):c.1135A>T (p.Arg379Ter)	MSH6 (R379* +2 more)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +2 more	GPathogenic
Select item 42467	NM_000179.3(MSH6):c.1164C>T (p.His388=)	MSH6	Single nucleotide variant (synonymous variant)	Lynch syndrome	GBenign
Select item 218051	NM_000179.3(MSH6):c.1168_1170delinsAA (p.Asp390fs)	MSH6 (D88fs +2 more)	Indel (frameshift variant)	not provided +5 more	GPathogenic
Select item 36582	NM_000179.3(MSH6):c.1186C>G (p.Leu396Val)	MSH6 (L396V +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GBenign
Select item 89178	NM_000179.3(MSH6):c.1190_1191del (p.Tyr397fs)	MSH6 (Y267fs +1 more)	Deletion (frameshift variant)	Lynch syndrome	GPathogenic
Select item 183760	NM_000179.3(MSH6):c.1295T>C (p.Phe432Ser)	MSH6 (F432S +2 more)	Single nucleotide variant (missense variant)	Hereditary nonpolyposis colon cancer +6 more	GPathogenic/Likely pathogenic
Select item 218052	NM_000179.3(MSH6):c.1312dup (p.Met438fs)	MSH6 (M308fs +2 more)	Duplication (frameshift variant)	Lynch syndrome 5	GPathogenic
Select item 36583	NM_000179.3(MSH6):c.1345C>T (p.Leu449=)	MSH6	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +6 more	GBenign
Select item 224534	NM_000179.3(MSH6):c.1352del (p.Phe451fs)	MSH6 (F149fs +1 more)	Deletion (frameshift variant)	Endometrial carcinoma +5 more	GPathogenic/Likely pathogenic
Select item 135829	NM_000179.3(MSH6):c.1449G>T (p.Val483=)	MSH6	Single nucleotide variant (synonymous variant)	not specified +6 more	GConflicting classifications of pathogenicity
Select item 89197	NM_000179.3(MSH6):c.1483C>T (p.Arg495Ter)	MSH6 (R495* +2 more)	Single nucleotide variant (nonsense)	Lynch syndrome	GPathogenic
Select item 218053	NM_000179.3(MSH6):c.1490_1491del (p.Arg497fs)	MSH6 (R195fs +2 more)	Deletion (frameshift variant)	Hereditary nonpolyposis colorectal neoplasms	GPathogenic
Select item 89198	NM_000179.3(MSH6):c.1508C>G (p.Ser503Cys)	MSH6 (S201C +1 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GLikely benign
Select item 41588	NM_000179.3(MSH6):c.1526T>C (p.Val509Ala)	MSH6 (V509A +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GLikely benign
Select item 135830	NM_000179.3(MSH6):c.1599G>C (p.Glu533Asp)	MSH6 (E533D +2 more)	Single nucleotide variant (missense variant)	Breast and/or ovarian cancer +7 more	GConflicting classifications of pathogenicity
Select item 140961	NM_000179.3(MSH6):c.1634_1635del (p.Lys545fs)	MSH6 (K243fs +2 more)	Deletion (frameshift variant)	not provided +6 more	GPathogenic/Likely pathogenic
Select item 134852	NM_000179.3(MSH6):c.1730G>A (p.Arg577His)	MSH6 (R577H +2 more)	Single nucleotide variant (missense variant)	not provided +6 more	GConflicting classifications of pathogenicity
Select item 127563	NM_000179.3(MSH6):c.1746T>G (p.Phe582Leu)	MSH6 (F582L +2 more)	Single nucleotide variant (missense variant)	Endometrial carcinoma +5 more	GConflicting classifications of pathogenicity
Select item 410412	NM_000179.3(MSH6):c.1815_1816del (p.Lys606fs)	MSH6 (K476fs +2 more)	Deletion (frameshift variant)	Hereditary nonpolyposis colon cancer +5 more	GPathogenic
Select item 182626	NM_000179.3(MSH6):c.1822A>G (p.Ile608Val)	MSH6 (I608V +2 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 218054	NM_000179.3(MSH6):c.1883G>A (p.Trp628Ter)	MSH6 (W628* +2 more)	Single nucleotide variant (nonsense)	Lynch syndrome 5 +1 more	GPathogenic
Select item 237148	NM_000179.3(MSH6):c.1937A>G (p.Lys646Arg)	MSH6 (K646R +2 more)	Single nucleotide variant (missense variant)	not provided +6 more	GConflicting classifications of pathogenicity
Select item 89245	NM_000179.3(MSH6):c.2057G>A (p.Gly686Asp)	MSH6 (G686D +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GLikely pathogenic
Select item 89246	NM_000179.3(MSH6):c.2061T>A (p.Cys687Ter)	MSH6 (C687* +2 more)	Single nucleotide variant (nonsense)	Lynch syndrome	GPathogenic
Select item 492707	NM_000179.3(MSH6):c.2095G>T (p.Glu699Ter)	MSH6 (E699* +2 more)	Single nucleotide variant (nonsense)	Lynch syndrome 5	GPathogenic
Select item 89256	NM_000179.3(MSH6):c.2150_2153del (p.Val717fs)	MSH6 (V415fs +1 more)	Deletion (frameshift variant)	Lynch syndrome	GPathogenic
Select item 182664	NM_000179.3(MSH6):c.2187C>A (p.Ala729=)	MSH6	Single nucleotide variant (synonymous variant)	not specified +4 more	GBenign/Likely benign
Select item 183739	NM_000179.3(MSH6):c.2230dup (p.Glu744fs)	MSH6 (E442fs +2 more)	Duplication (frameshift variant)	not provided +6 more	GPathogenic/Likely pathogenic
Select item 89263	NM_000179.3(MSH6):c.2239C>T (p.Leu747=)	MSH6	Single nucleotide variant (synonymous variant)	not provided +4 more	GBenign/Likely benign
Select item 36585	NM_000179.3(MSH6):c.2253T>C (p.Asn751=)	MSH6	Single nucleotide variant (synonymous variant)	Lynch syndrome	GBenign
Select item 42468	NM_000179.3(MSH6):c.2272C>T (p.Leu758=)	MSH6	Single nucleotide variant (synonymous variant)	Lynch syndrome	GBenign
Select item 89267	NM_000179.3(MSH6):c.2314C>T (p.Arg772Trp)	MSH6 (R772W +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GPathogenic
Select item 219956	NM_000179.3(MSH6):c.2320C>G (p.Leu774Val)	MSH6 (L774V +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome 5 +6 more	GUncertain significance
Select item 89279	NM_000179.3(MSH6):c.2398G>C (p.Val800Leu)	MSH6 (V800L +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome 1	GLikely benign
Select item 142970	NM_000179.3(MSH6):c.2555AGA[2] (p.Lys854del)	MSH6 (K854del +2 more)	Microsatellite (inframe_deletion)	Endometrial carcinoma +4 more	GUncertain significance
Select item 8931	NM_000179.3(MSH6):c.2633T>C (p.Val878Ala)	MSH6 (V878A +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GBenign
Select item 89312	NM_000179.3(MSH6):c.2731C>T (p.Arg911Ter)	MSH6 (R911* +2 more)	Single nucleotide variant (nonsense)	Lynch syndrome	GPathogenic
Select item 231018	NM_000179.3(MSH6):c.2745C>G (p.Ala915=)	MSH6	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 218056	NM_000179.3(MSH6):c.2805_2806del (p.Asp936fs)	MSH6 (D936fs +2 more)	Deletion (frameshift variant)	Lynch syndrome 5 +1 more	GPathogenic
Select item 1796595	NM_000179.3(MSH6):c.2831_2835del (p.Ile944fs)	MSH6 (I944fs +2 more)	Deletion (frameshift variant)	Lynch syndrome 5 +2 more	GPathogenic/Likely pathogenic
Select item 237168	NM_000179.3(MSH6):c.2830A>G (p.Ile944Val)	MSH6 (I944V +2 more)	Single nucleotide variant (missense variant)	Endometrial carcinoma +5 more	GConflicting classifications of pathogenicity
Select item 492708	NM_000179.3(MSH6):c.2872C>G (p.Gln958Glu)	MSH6 (Q958E +2 more)	Single nucleotide variant (missense variant)	Hereditary nonpolyposis colorectal neoplasms	GUncertain significance
Select item 186181	NM_000179.3(MSH6):c.2876G>A (p.Arg959His)	MSH6 (R959H +2 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +6 more	GUncertain significance
Select item 184156	NM_000179.3(MSH6):c.2877C>T (p.Arg959=)	MSH6	Single nucleotide variant (synonymous variant)	not specified +2 more	GLikely benign
Select item 184311	NM_000179.3(MSH6):c.2904C>G (p.Val968=)	MSH6	Single nucleotide variant (synonymous variant)	Breast and/or ovarian cancer +6 more	GBenign/Likely benign
Select item 140922	NM_000179.3(MSH6):c.2932C>T (p.Gln978Ter)	MSH6 (Q978* +2 more)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +3 more	GPathogenic
Select item 89330	NM_000179.3(MSH6):c.3013C>T (p.Arg1005Ter)	MSH6 (R1005* +2 more)	Single nucleotide variant (nonsense)	Lynch syndrome	GPathogenic
Select item 142781	NM_000179.3(MSH6):c.3037_3041del (p.Lys1013fs)	MSH6 (K711fs +1 more)	Deletion (frameshift variant)	Endometrial carcinoma +6 more	GPathogenic
Select item 492709	NM_000179.3(MSH6):c.3097A>G (p.Met1033Val)	MSH6 (M1033V +2 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 89338	NM_000179.3(MSH6):c.3103C>T (p.Arg1035Ter)	MSH6 (R1035* +2 more)	Single nucleotide variant (nonsense)	Lynch syndrome	GPathogenic
Select item 525755	NM_000179.3(MSH6):c.3108_3109del (p.Phe1037fs)	MSH6 (F735fs +1 more)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome +5 more	GPathogenic/Likely pathogenic
Select item 127580	NM_000179.3(MSH6):c.3142C>T (p.Gln1048Ter)	MSH6 (Q1048* +2 more)	Single nucleotide variant (nonsense)	not provided +3 more	GPathogenic
Select item 89340	NM_000179.3(MSH6):c.3155_3156del (p.Glu1052fs)	MSH6 (E750fs +2 more)	Microsatellite (frameshift variant)	Lynch syndrome	GPathogenic
Select item 89341	NM_000179.3(MSH6):c.3160A>T (p.Ile1054Phe)	MSH6 (I1054F +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GLikely benign
Select item 218057	NM_000179.3(MSH6):c.3172G>C (p.Asp1058His)	MSH6 (D1058H +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GLikely pathogenic
Select item 89343	NM_000179.3(MSH6):c.3172+171C>T	MSH6	Single nucleotide variant (intron variant)	Lynch syndrome	GBenign
Select item 89345	NM_000179.3(MSH6):c.3173-101G>C	MSH6	Single nucleotide variant (intron variant)	Lynch syndrome	GBenign
Select item 218059	NM_000179.3(MSH6):c.3173-97T>C	MSH6	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 218058	NM_000179.3(MSH6):c.3173-94A>G	MSH6	Single nucleotide variant (intron variant)	not specified	GBenign
Select item 42469	NM_000179.3(MSH6):c.3173-1G>C	MSH6	Single nucleotide variant (splice acceptor variant +1 more)	Hereditary cancer-predisposing syndrome +5 more	GPathogenic/Likely pathogenic
Select item 2673623	NM_000179.3(MSH6):c.3190_3192delinsCC (p.Ala1064fs)	MSH6 (A1008fs +12 more)	Indel (frameshift variant +3 more)	Lynch syndrome 5 +1 more	GPathogenic/Likely pathogenic
Select item 89352	NM_000179.3(MSH6):c.3202C>T (p.Arg1068Ter)	MSH6 (R1068* +2 more)	Single nucleotide variant (nonsense)	Lynch syndrome	GPathogenic
Select item 92576	NM_000179.3(MSH6):c.3203G>A (p.Arg1068Gln)	MSH6 (R766Q +1 more)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 41593	NM_000179.3(MSH6):c.3217C>T (p.Pro1073Ser)	MSH6 (P1073S +2 more)	Single nucleotide variant (missense variant)	Lynch syndrome	GLikely benign

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