"Mayo Clinic Laboratories, Mayo Clinic"[submitter] AND "MLH3"[gene] - ClinVar

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Items: 35

	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 5562	NM_001040108.2(MLH3):c.4351G>A (p.Glu1451Lys)	MLH3 (E1451K +1 more)	Single nucleotide variant (missense variant)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 257253	NM_001040108.2(MLH3):c.4335A>G (p.Gln1445=)	MLH3	Single nucleotide variant (synonymous variant)	not specified +2 more	GBenign
Select item 492689	NM_001040108.2(MLH3):c.4242+28G>C	MLH3	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 314370	NM_001040108.2(MLH3):c.4242+13C>G	MLH3	Single nucleotide variant (intron variant)	not specified +2 more	GBenign/Likely benign
Select item 314371	NM_001040108.2(MLH3):c.3987+15C>T	MLH3	Single nucleotide variant (intron variant)	not specified +2 more	GLikely benign
Select item 492690	NM_001040108.2(MLH3):c.3828-15A>C	MLH3	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 492691	NM_001040108.2(MLH3):c.3828-24del	MLH3	Deletion (intron variant)	not specified	GLikely benign
Select item 492692	NM_001040108.2(MLH3):c.3716-10C>T	MLH3	Single nucleotide variant (intron variant)	not specified +1 more	GLikely benign
Select item 545612	NM_001040108.2(MLH3):c.3643+2T>C	MLH3	Single nucleotide variant (splice donor variant)	Colorectal cancer, hereditary nonpolyposis, type 7	GUncertain significance
Select item 492693	NM_001040108.2(MLH3):c.3571-26G>T	MLH3	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 492694	NM_001040108.2(MLH3):c.3570+28A>T	MLH3	Single nucleotide variant (intron variant)	not specified	GBenign
Select item 416458	NM_001040108.2(MLH3):c.3488G>A (p.Gly1163Asp)	MLH3 (G1163D)	Single nucleotide variant (missense variant)	not specified +2 more	GConflicting classifications of pathogenicity
Select item 314375	NM_001040108.2(MLH3):c.3440A>T (p.Asn1147Ile)	MLH3 (N1147I)	Single nucleotide variant (missense variant)	Colorectal cancer, hereditary nonpolyposis, type 7 +4 more	GConflicting classifications of pathogenicity
Select item 1469302	NM_001040108.2(MLH3):c.3325C>T (p.Pro1109Ser)	MLH3 (P1109S)	Single nucleotide variant (missense variant)	not provided +2 more	GUncertain significance
Select item 492695	NM_001040108.2(MLH3):c.3154del (p.Leu1052fs)	MLH3 (L1052fs)	Deletion (frameshift variant)	Colorectal cancer, hereditary nonpolyposis, type 7 +1 more	GUncertain significance
Select item 492696	NM_001040108.2(MLH3):c.2962A>T (p.Ile988Phe)	MLH3 (I988F)	Single nucleotide variant (missense variant)	not specified	GUncertain significance
Select item 314382	NM_001040108.2(MLH3):c.2825C>T (p.Thr942Ile)	MLH3 (T942I)	Single nucleotide variant (missense variant)	not specified +2 more	GBenign/Likely benign
Select item 257252	NM_001040108.2(MLH3):c.2531C>T (p.Pro844Leu)	MLH3 (P844L)	Single nucleotide variant (missense variant)	not specified +2 more	GBenign
Select item 492697	NM_001040108.2(MLH3):c.2490T>G (p.Phe830Leu)	MLH3 (F830L)	Single nucleotide variant (missense variant)	Colorectal cancer, hereditary nonpolyposis, type 7 +1 more	GBenign/Likely benign
Select item 257251	NM_001040108.2(MLH3):c.2476A>G (p.Asn826Asp)	MLH3 (N826D)	Single nucleotide variant (missense variant)	not provided +2 more	GBenign
Select item 314383	NM_001040108.2(MLH3):c.2390G>A (p.Arg797His)	MLH3 (R797H)	Single nucleotide variant (missense variant)	Colorectal cancer, hereditary nonpolyposis, type 7 +2 more	GBenign
Select item 2563570	NM_001040108.2(MLH3):c.2257T>G (p.Ser753Ala)	MLH3 (S753A)	Single nucleotide variant (missense variant)	not provided +1 more	GUncertain significance
Select item 314386	NM_001040108.2(MLH3):c.2159A>G (p.Tyr720Cys)	MLH3 (Y720C)	Single nucleotide variant (missense variant)	Colorectal cancer, hereditary nonpolyposis, type 7 +2 more	GBenign/Likely benign
Select item 238246	NM_001040108.2(MLH3):c.1939C>T (p.Arg647Cys)	MLH3 (R647C)	Single nucleotide variant (missense variant)	Colorectal cancer, hereditary nonpolyposis, type 7 +2 more	GConflicting classifications of pathogenicity
Select item 849935	NM_001040108.2(MLH3):c.1619A>G (p.Asn540Ser)	MLH3 (N540S)	Single nucleotide variant (missense variant)	not provided +1 more	GUncertain significance
Select item 1163960	NM_001040108.2(MLH3):c.1384G>A (p.Asp462Asn)	MLH3 (D462N)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 544288	NM_001040108.2(MLH3):c.1234A>G (p.Lys412Glu)	MLH3 (K412E)	Single nucleotide variant (missense variant)	not specified +2 more	GConflicting classifications of pathogenicity
Select item 492698	NM_001040108.2(MLH3):c.911G>T (p.Gly304Val)	MLH3 (G304V)	Single nucleotide variant (missense variant)	not specified	GLikely benign
Select item 220781	NM_001040108.2(MLH3):c.691A>C (p.Lys231Gln)	MLH3 (K231Q)	Single nucleotide variant (missense variant)	not provided +2 more	GBenign/Likely benign
Select item 314391	NM_001040108.2(MLH3):c.666G>A (p.Lys222=)	MLH3	Single nucleotide variant (synonymous variant)	not specified +2 more	GBenign/Likely benign
Select item 1163961	NM_001040108.2(MLH3):c.536C>T (p.Ser179Leu)	MLH3 (S179L)	Single nucleotide variant (missense variant)	not provided +1 more	GUncertain significance
Select item 221151	NM_001040108.2(MLH3):c.444G>C (p.Val148=)	MLH3	Single nucleotide variant (synonymous variant)	not specified +2 more	GBenign
Select item 221150	NM_001040108.2(MLH3):c.408T>C (p.Asp136=)	MLH3	Single nucleotide variant (synonymous variant)	not provided +2 more	GBenign/Likely benign
Select item 314393	NM_001040108.2(MLH3):c.149T>A (p.Phe50Tyr)	MLH3 (F50Y)	Single nucleotide variant (missense variant)	Colorectal cancer, hereditary nonpolyposis, type 7 +4 more	GConflicting classifications of pathogenicity
Select item 238254	NM_001040108.2(MLH3):c.8A>G (p.Lys3Arg)	MLH3 (K3R)	Single nucleotide variant (missense variant)	Colorectal cancer, hereditary nonpolyposis, type 7 +2 more	GBenign/Likely benign

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Items: 35