"Mayo Clinic Laboratories, Mayo Clinic"[submitter] AND "APC"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 2683781	NM_000038.6(APC):c.-30467_-30466delinsC	APC, LOC129994371	Indel	not provided	GUncertain significance
Select item 3380994	NM_001127511.3(APC):c.-38_165+37del	APC	Deletion (splice donor variant +3 more)	not provided	GPathogenic
Select item 218010	NM_000038.6(APC):c.95A>G (p.Asn32Ser)	APC (N32S)	Single nucleotide variant (missense variant +2 more)	Familial adenomatous polyposis 1 +4 more	GConflicting classifications of pathogenicity
Select item 135683	NM_000038.6(APC):c.120G>A (p.Glu40=)	APC	Single nucleotide variant (synonymous variant +2 more)	not provided +4 more	GBenign/Likely benign
Select item 490194	NM_000038.6(APC):c.135+2T>C	APC	Single nucleotide variant (splice donor variant +1 more)	Familial adenomatous polyposis 1 +2 more	GLikely pathogenic
Select item 82873	NM_000038.6(APC):c.136-53T>C	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +1 more	GBenign
Select item 492652	NM_000038.6(APC):c.136-18T>C	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +1 more	GLikely benign
Select item 217938	NM_000038.6(APC):c.193C>A (p.Gln65Lys)	APC (Q65K +3 more)	Single nucleotide variant (missense variant +1 more)	Familial adenomatous polyposis 1 +2 more	GUncertain significance
Select item 217943	NM_000038.6(APC):c.207del (p.Glu70fs)	APC (E11fs +3 more)	Deletion (frameshift variant +1 more)	not provided	GLikely pathogenic
Select item 141515	NM_000038.6(APC):c.220+2T>A	APC	Single nucleotide variant (splice donor variant)	Familial adenomatous polyposis 1 +2 more	GPathogenic/Likely pathogenic
Select item 217946	NM_000038.6(APC):c.220+28A>G	APC	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 217945	NM_000038.6(APC):c.220+124C>G	APC	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 217948	NM_000038.6(APC):c.221-29G>C	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +2 more	GLikely benign
Select item 217947	NM_000038.6(APC):c.221-1G>A	APC	Single nucleotide variant (splice acceptor variant)	Familial adenomatous polyposis 1 +1 more	GPathogenic/Likely pathogenic
Select item 217950	NM_000038.6(APC):c.244T>A (p.Phe82Ile)	APC (F82I +3 more)	Single nucleotide variant (missense variant +1 more)	Familial adenomatous polyposis 1 +1 more	GUncertain significance
Select item 217952	NM_000038.6(APC):c.268A>G (p.Lys90Glu)	APC (K100E +3 more)	Single nucleotide variant (missense variant +1 more)	not provided +4 more	GUncertain significance
Select item 217957	NM_000038.6(APC):c.288T>G (p.Tyr96Ter)	APC (Y106* +3 more)	Single nucleotide variant (nonsense +1 more)	Familial multiple polyposis syndrome +2 more	GPathogenic
Select item 135695	NM_000038.6(APC):c.295C>T (p.Arg99Trp)	APC (R99W +3 more)	Single nucleotide variant (missense variant +1 more)	Familial adenomatous polyposis 1	GBenign FDA Recognized database
Select item 217958	NM_000038.6(APC):c.301G>T (p.Gly101Ter)	APC (G101* +3 more)	Single nucleotide variant (nonsense +1 more)	Familial adenomatous polyposis 1 +1 more	GPathogenic
Select item 482406	NM_000038.6(APC):c.313A>G (p.Ser105Gly)	APC (S105G +3 more)	Single nucleotide variant (missense variant +1 more)	Classic or attenuated familial adenomatous polyposis +3 more	GUncertain significance
Select item 217979	NM_000038.6(APC):c.422+75T>C	APC	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 217981	NM_000038.6(APC):c.423-17T>A	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +3 more	GBenign/Likely benign
Select item 181781	NM_000038.6(APC):c.423-4del	APC	Deletion (intron variant)	Familial adenomatous polyposis 1	GBenign FDA Recognized database
Select item 82911	NM_000038.6(APC):c.423-16A>T	APC	Single nucleotide variant (intron variant)	not specified +2 more	GBenign/Likely benign
Select item 217982	NM_000038.6(APC):c.423-3_423-2del	APC	Deletion (splice acceptor variant)	Familial adenomatous polyposis 1	GUncertain significance FDA Recognized database
Select item 142189	NM_000038.6(APC):c.423-3T>A	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +2 more	GPathogenic/Likely pathogenic
Select item 181833	NM_000038.6(APC):c.423-1G>C	APC	Single nucleotide variant (splice acceptor variant)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic
Select item 142574	NM_000038.6(APC):c.426_427del (p.Leu143fs)	APC (L143fs +3 more)	Deletion (frameshift variant +1 more)	not provided +5 more	GPathogenic
Select item 217984	NM_000038.6(APC):c.450_453del (p.Glu151fs)	APC (E92fs +3 more)	Deletion (frameshift variant +1 more)	Familial adenomatous polyposis 1 +2 more	GPathogenic
Select item 216848	NM_000038.6(APC):c.453del (p.Glu152fs)	APC (E127fs +3 more)	Deletion (frameshift variant +1 more)	Familial adenomatous polyposis 1 +2 more	GPathogenic
Select item 411479	NM_000038.6(APC):c.471G>A (p.Trp157Ter)	APC (W157* +3 more)	Single nucleotide variant (nonsense +1 more)	Familial adenomatous polyposis 1 +2 more	GPathogenic
Select item 217990	NM_000038.6(APC):c.475dup (p.Tyr159fs)	APC (Y100fs +3 more)	Duplication (frameshift variant +1 more)	Familial adenomatous polyposis 1 +2 more	GPathogenic
Select item 236607	NM_000038.6(APC):c.476dup (p.Tyr159Ter)	APC (Y159* +3 more)	Duplication (nonsense +1 more)	Hereditary cancer-predisposing syndrome +2 more	GPathogenic/Likely pathogenic
Select item 246084	NM_000038.6(APC):c.477C>G (p.Tyr159Ter)	APC (Y159* +3 more)	Single nucleotide variant (nonsense +1 more)	Familial adenomatous polyposis 1 +3 more	GPathogenic
Select item 215564	NM_000038.6(APC):c.477C>T (p.Tyr159=)	APC	Single nucleotide variant (synonymous variant +1 more)	Familial adenomatous polyposis 1 +3 more	GBenign/Likely benign
Select item 217991	NM_000038.6(APC):c.487C>T (p.Gln163Ter)	APC (Q163* +3 more)	Single nucleotide variant (nonsense +1 more)	Familial adenomatous polyposis 1 +3 more	GPathogenic
Select item 804	NM_000038.6(APC):c.509_512del (p.Asp170fs)	APC (D170fs +3 more)	Microsatellite (frameshift variant +1 more)	Familial adenomatous polyposis 1	GPathogenic FDA Recognized database
Select item 217993	NM_000038.6(APC):c.524_531+4del	APC	Deletion (splice donor variant)	Familial adenomatous polyposis 1 +1 more	GPathogenic/Likely pathogenic
Select item 232758	NM_000038.6(APC):c.531+1G>C	APC	Single nucleotide variant (splice donor variant)	Familial adenomatous polyposis 1 +2 more	GPathogenic/Likely pathogenic
Select item 217995	NM_000038.6(APC):c.531+2T>C	APC	Single nucleotide variant (splice donor variant)	Familial adenomatous polyposis 1 +1 more	GPathogenic
Select item 217994	NM_000038.6(APC):c.531+2T>A	APC	Single nucleotide variant (splice donor variant)	Familial adenomatous polyposis 1 +2 more	GPathogenic/Likely pathogenic
Select item 217996	NM_000038.6(APC):c.541C>T (p.Gln181Ter)	APC (Q181* +3 more)	Single nucleotide variant (nonsense +1 more)	not provided +2 more	GPathogenic
Select item 1690367	NM_000038.6(APC):c.635_636dup (p.Arg213fs)	APC (R154fs +3 more)	Duplication (frameshift variant +1 more)	Familial adenomatous polyposis 1 +1 more	GPathogenic/Likely pathogenic
Select item 140952	NM_000038.6(APC):c.637C>T (p.Arg213Ter)	APC (R213* +3 more)	Single nucleotide variant (nonsense +1 more)	Familial adenomatous polyposis 1 +8 more	GPathogenic OOncogenic
Select item 814	NM_000038.6(APC):c.643C>T (p.Gln215Ter)	APC (Q215* +3 more)	Single nucleotide variant (nonsense +1 more)	not specified +8 more	GPathogenic
Select item 218000	NM_000038.6(APC):c.645+1G>A	APC	Single nucleotide variant (splice donor variant)	Familial adenomatous polyposis 1	GLikely pathogenic FDA Recognized database
Select item 218001	NM_000038.6(APC):c.645+32C>T	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +2 more	GBenign
Select item 218002	NM_000038.6(APC):c.645+61C>T	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1	GBenign
Select item 218003	NM_000038.6(APC):c.677del (p.Lys226fs)	APC (K167fs +3 more)	Deletion (frameshift variant +2 more)	Familial adenomatous polyposis 1 +2 more	GPathogenic/Likely pathogenic
Select item 42248	NM_000038.6(APC):c.694C>T (p.Arg232Ter)	APC (R232* +3 more)	Single nucleotide variant (nonsense +2 more)	Hereditary cancer-predisposing syndrome +8 more	GPathogenic OLikely oncogenic
Select item 92349	NM_000038.6(APC):c.705A>G (p.Leu235=)	APC	Single nucleotide variant (synonymous variant +2 more)	Familial adenomatous polyposis 1	GBenign FDA Recognized database
Select item 492653	NM_000038.6(APC):c.729+23T>C	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +2 more	GBenign/Likely benign
Select item 218004	NM_000038.6(APC):c.729+31A>G	APC	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 218006	NM_000038.6(APC):c.730-29A>T	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +2 more	GBenign
Select item 218005	NM_000038.6(APC):c.730-22G>C	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +1 more	GLikely benign
Select item 492654	NM_000038.6(APC):c.734C>A (p.Ser245Ter)	APC (S227* +5 more)	Single nucleotide variant (nonsense +1 more)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic
Select item 135720	NM_000038.6(APC):c.777G>T (p.Arg259=)	APC	Single nucleotide variant (synonymous variant +1 more)	Classic or attenuated familial adenomatous polyposis +5 more	GConflicting classifications of pathogenicity
Select item 218008	NM_000038.6(APC):c.800del (p.Gly267fs)	APC (G208fs +5 more)	Deletion (frameshift variant +1 more)	Familial adenomatous polyposis 1	GPathogenic
Select item 470138	NM_000038.6(APC):c.832C>T (p.Gln278Ter)	APC (Q278* +5 more)	Single nucleotide variant (nonsense +1 more)	Familial adenomatous polyposis 1	GPathogenic
Select item 218009	NM_000038.6(APC):c.835-24A>T	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +1 more	GLikely benign
Select item 184999	NM_000038.6(APC):c.847C>T (p.Arg283Ter)	APC (R265* +5 more)	Single nucleotide variant (nonsense +1 more)	Familial adenomatous polyposis 1	GPathogenic FDA Recognized database
Select item 798	NM_000038.6(APC):c.904C>T (p.Arg302Ter)	APC (R302* +6 more)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +5 more	GPathogenic/Likely pathogenic
Select item 254733	NM_000038.6(APC):c.933+30A>G	APC	Single nucleotide variant (intron variant)	not provided +2 more	GBenign/Likely benign
Select item 411396	NM_000038.6(APC):c.934G>A (p.Val312Met)	APC (V294M +6 more)	Single nucleotide variant (missense variant +1 more)	Familial adenomatous polyposis 1 +2 more	GUncertain significance
Select item 141040	NM_000038.6(APC):c.935dup (p.Glu313fs)	APC (E288fs +6 more)	Duplication (frameshift variant +1 more)	Familial adenomatous polyposis 1 +4 more	GPathogenic/Likely pathogenic
Select item 184937	NM_000038.6(APC):c.994C>T (p.Arg332Ter)	APC (R314* +6 more)	Single nucleotide variant (nonsense +1 more)	Hereditary cancer-predisposing syndrome +9 more	GPathogenic
Select item 217918	NM_000038.6(APC):c.1045C>T (p.Gln349Ter)	APC (Q331* +6 more)	Single nucleotide variant (nonsense +1 more)	Familial adenomatous polyposis 1 +1 more	GPathogenic
Select item 127275	NM_000038.6(APC):c.1213C>T (p.Arg405Ter)	APC (R405* +6 more)	Single nucleotide variant (nonsense +1 more)	Familial multiple polyposis syndrome +3 more	GPathogenic
Select item 217919	NM_000038.6(APC):c.1229dup (p.Leu410fs)	APC (L392fs +6 more)	Duplication (frameshift variant +1 more)	Familial adenomatous polyposis 1 +2 more	GPathogenic/Likely pathogenic
Select item 797	NM_000038.6(APC):c.1240C>T (p.Arg414Cys)	APC (R414C +10 more)	Single nucleotide variant (missense variant)	Familial adenomatous polyposis 1	GBenign FDA Recognized database
Select item 217920	NM_000038.6(APC):c.1243G>A (p.Ala415Thr)	APC (A397T +10 more)	Single nucleotide variant (missense variant)	Familial adenomatous polyposis 1 +4 more	GUncertain significance
Select item 217921	NM_000038.6(APC):c.1297C>T (p.Gln433Ter)	APC (Q415* +10 more)	Single nucleotide variant (nonsense)	Familial adenomatous polyposis 1 +1 more	GPathogenic
Select item 217922	NM_000038.6(APC):c.1310C>G (p.Pro437Arg)	APC (P419R +10 more)	Single nucleotide variant (missense variant)	Familial adenomatous polyposis 1 +1 more	GUncertain significance
Select item 217923	NM_000038.6(APC):c.1312+1G>A	APC	Single nucleotide variant (splice donor variant)	Familial adenomatous polyposis 1 +1 more	GPathogenic/Likely pathogenic
Select item 217924	NM_000038.6(APC):c.1312+3A>G	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1 +9 more	GPathogenic/Likely pathogenic
Select item 439407	NM_000038.6(APC):c.1312+27G>A	APC	Single nucleotide variant (intron variant)	not provided +1 more	GBenign
Select item 217925	NM_000038.6(APC):c.1408+27A>G	APC	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 217927	NM_000038.6(APC):c.1409-1G>T	APC	Single nucleotide variant (splice acceptor variant)	Familial adenomatous polyposis 1 +2 more	GPathogenic/Likely pathogenic
Select item 136405	NM_000038.6(APC):c.1419G>A (p.Gln473=)	APC	Single nucleotide variant (synonymous variant)	not provided +4 more	GBenign/Likely benign
Select item 217928	NM_000038.6(APC):c.1433T>G (p.Leu478Ter)	APC (L460* +12 more)	Single nucleotide variant (nonsense)	Familial adenomatous polyposis 1	GPathogenic
Select item 42238	NM_000038.6(APC):c.1458T>C (p.Tyr486=)	APC	Single nucleotide variant (synonymous variant)	Familial adenomatous polyposis 1	GBenign FDA Recognized database
Select item 492655	NM_000038.6(APC):c.1494del (p.Arg498fs)	APC (R215fs +12 more)	Deletion (frameshift variant)	not provided	GLikely pathogenic
Select item 217929	NM_000038.6(APC):c.1500T>A (p.Tyr500Ter)	APC (Y482* +12 more)	Single nucleotide variant (nonsense)	Familial adenomatous polyposis 1 +1 more	GPathogenic
Select item 217930	NM_000038.6(APC):c.1525_1527del (p.Thr509del)	APC (T491del +12 more)	Deletion (inframe_deletion)	not provided	GLikely pathogenic
Select item 217931	NM_000038.6(APC):c.1549-1G>A	APC	Single nucleotide variant (splice acceptor variant)	Familial adenomatous polyposis 1	GLikely pathogenic
Select item 217932	NM_000038.6(APC):c.1609del (p.Ser537fs)	APC (S254fs +12 more)	Deletion (frameshift variant)	Familial adenomatous polyposis 1 +1 more	GPathogenic
Select item 3379596	NM_000038.6(APC):c.1625A>G (p.Gln542Arg)	APC (Q158R +18 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 492656	NM_000038.6(APC):c.1626+1G>A	APC	Single nucleotide variant (splice donor variant)	Hereditary cancer-predisposing syndrome +2 more	GPathogenic/Likely pathogenic
Select item 217933	NM_000038.6(APC):c.1627-93A>C	APC	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 216152	NM_000038.6(APC):c.1627-10T>G	APC	Single nucleotide variant (intron variant)	Familial adenomatous polyposis 1	GLikely benign
Select item 217934	NM_000038.6(APC):c.1629T>C (p.Val543=)	APC	Single nucleotide variant (synonymous variant)	Familial adenomatous polyposis 1 +2 more	GBenign/Likely benign
Select item 41520	NM_000038.6(APC):c.1631T>C (p.Ile544Thr)	APC (I544T +12 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GConflicting classifications of pathogenicity
Select item 42239	NM_000038.6(APC):c.1635G>A (p.Ala545=)	APC	Single nucleotide variant (synonymous variant)	Familial adenomatous polyposis 1	GBenign FDA Recognized database
Select item 217935	NM_000038.6(APC):c.1658G>A (p.Trp553Ter)	APC (W535* +12 more)	Single nucleotide variant (nonsense)	Familial adenomatous polyposis 1 +2 more	GPathogenic
Select item 808	NM_000038.6(APC):c.1690C>T (p.Arg564Ter)	APC (R564* +12 more)	Single nucleotide variant (nonsense)	Familial adenomatous polyposis 1 +4 more	GPathogenic
Select item 183766	NM_000038.6(APC):c.1695A>G (p.Glu565=)	APC	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GBenign
Select item 233973	NM_000038.6(APC):c.1866C>A (p.Tyr622Ter)	APC (Y604* +12 more)	Single nucleotide variant (nonsense)	Familial adenomatous polyposis 1 +2 more	GPathogenic
Select item 181790	NM_000038.6(APC):c.1867C>T (p.Arg623Trp)	APC (R605W +12 more)	Single nucleotide variant (missense variant)	Familial adenomatous polyposis 1 +3 more	GUncertain significance
Select item 236565	NM_000038.6(APC):c.1875_1878del (p.Asn627fs)	APC (N536fs +12 more)	Deletion (frameshift variant)	Familial adenomatous polyposis 1 +1 more	GPathogenic
Select item 411536	NM_000038.6(APC):c.1879_1882del (p.Asn627fs)	APC (N501fs +12 more)	Deletion (frameshift variant)	Familial adenomatous polyposis 1 +1 more	GPathogenic

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