"Genome-Nilou Lab"[submitter] AND "SOS2"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 859843	NM_006939.4(SOS2):c.3997T>C (p.Ter1333Arg)	SOS2	Single nucleotide variant (stop lost)	Noonan syndrome 9 +1 more	GUncertain significance
Select item 1605815	NM_006939.4(SOS2):c.3984A>G (p.Ala1328=)	SOS2	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +1 more	GLikely benign
Select item 766308	NM_006939.4(SOS2):c.3981T>C (p.Asn1327=)	SOS2	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +1 more	GLikely benign
Select item 280784	NM_006939.4(SOS2):c.3968C>T (p.Pro1323Leu)	SOS2 (P1323L)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +2 more	GUncertain significance
Select item 1107037	NM_006939.4(SOS2):c.3954A>G (p.Pro1318=)	SOS2	Single nucleotide variant (synonymous variant)	not specified +2 more	GLikely benign
Select item 475758	NM_006939.4(SOS2):c.3952C>T (p.Pro1318Ser)	SOS2 (P1318S)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +3 more	GBenign/Likely benign
Select item 1022197	NM_006939.4(SOS2):c.3944C>T (p.Ser1315Leu)	SOS2 (S1315L)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GConflicting classifications of pathogenicity
Select item 1022639	NM_006939.4(SOS2):c.3902A>G (p.His1301Arg)	SOS2 (H1301R)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GConflicting classifications of pathogenicity
Select item 475757	NM_006939.4(SOS2):c.3830T>C (p.Leu1277Pro)	SOS2 (L1277P)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +3 more	GBenign/Likely benign
Select item 968756	NM_006939.4(SOS2):c.3818G>A (p.Arg1273Gln)	SOS2 (R1273Q)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GConflicting classifications of pathogenicity
Select item 1525148	NM_006939.4(SOS2):c.3815G>A (p.Arg1272His)	SOS2 (R1272H)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GConflicting classifications of pathogenicity
Select item 384711	NM_006939.4(SOS2):c.3813G>A (p.Pro1271=)	SOS2	Single nucleotide variant (synonymous variant)	not provided +3 more	GBenign
Select item 984502	NM_006939.4(SOS2):c.3788C>G (p.Pro1263Arg)	SOS2 (P1263R)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +2 more	GConflicting classifications of pathogenicity
Select item 1471150	NM_006939.4(SOS2):c.3782C>G (p.Thr1261Ser)	SOS2 (T1261S)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GConflicting classifications of pathogenicity
Select item 717994	NM_006939.4(SOS2):c.3774G>A (p.Ser1258=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +3 more	GLikely benign
Select item 1362777	NM_006939.4(SOS2):c.3772T>G (p.Ser1258Ala)	SOS2 (S1258A)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GConflicting classifications of pathogenicity
Select item 542399	NM_006939.4(SOS2):c.3769A>G (p.Asn1257Asp)	SOS2 (N1257D)	Single nucleotide variant (missense variant)	not provided +2 more	GLikely benign
Select item 718837	NM_006939.4(SOS2):c.3762G>A (p.Thr1254=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +1 more	GLikely benign
Select item 475755	NM_006939.4(SOS2):c.3744G>T (p.Trp1248Cys)	SOS2 (W1248C)	Single nucleotide variant (missense variant)	Noonan syndrome and Noonan-related syndrome +4 more	GBenign/Likely benign
Select item 1367776	NM_006939.4(SOS2):c.3735T>G (p.Asp1245Glu)	SOS2 (D1245E)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +2 more	GConflicting classifications of pathogenicity
Select item 703832	NM_006939.4(SOS2):c.3729C>T (p.His1243=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +1 more	GLikely benign
Select item 1504724	NM_006939.4(SOS2):c.3698A>C (p.Asn1233Thr)	SOS2 (N1233T)	Single nucleotide variant (missense variant)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 706612	NM_006939.4(SOS2):c.3614C>T (p.Pro1205Leu)	SOS2 (P1205L)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +2 more	GBenign/Likely benign
Select item 761286	NM_006939.4(SOS2):c.3606T>C (p.Ser1202=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +1 more	GLikely benign
Select item 1166294	NM_006939.4(SOS2):c.3602A>G (p.His1201Arg)	SOS2 (H1201R)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +4 more	GBenign/Likely benign
Select item 987814	NM_006939.4(SOS2):c.3573T>G (p.Val1191=)	SOS2	Single nucleotide variant (synonymous variant)	not specified +2 more	GLikely benign
Select item 475754	NM_006939.4(SOS2):c.3540TCC[4] (p.Pro1183dup)	SOS2	Microsatellite (inframe_insertion)	Noonan syndrome and Noonan-related syndrome +4 more	GBenign/Likely benign
Select item 1404777	NM_006939.4(SOS2):c.3547C>T (p.Pro1183Ser)	SOS2 (P1183S)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +1 more	GConflicting classifications of pathogenicity
Select item 1607778	NM_006939.4(SOS2):c.3531G>A (p.Pro1177=)	SOS2	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +1 more	GLikely benign
Select item 943573	NM_006939.4(SOS2):c.3520G>A (p.Ala1174Thr)	SOS2 (A1174T)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GConflicting classifications of pathogenicity
Select item 475753	NM_006939.4(SOS2):c.3503C>A (p.Ser1168Tyr)	SOS2 (S1168Y)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +1 more	GLikely benign
Select item 1488342	NM_006939.4(SOS2):c.3497T>C (p.Met1166Thr)	SOS2 (M1166T)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +1 more	GUncertain significance
Select item 517059	NM_006939.4(SOS2):c.3490-13dup	SOS2	Duplication (intron variant)	Noonan syndrome and Noonan-related syndrome +2 more	GBenign
Select item 475752	NM_006939.4(SOS2):c.3490-13_3490-12dup	SOS2	Duplication (intron variant)	Noonan syndrome 9 +2 more	GBenign
Select item 706888	NM_006939.4(SOS2):c.3490-4del	SOS2	Deletion (intron variant)	Noonan syndrome and Noonan-related syndrome +4 more	GBenign/Likely benign
Select item 384723	NM_006939.4(SOS2):c.3490-18A>C	SOS2	Single nucleotide variant (intron variant)	Noonan syndrome 9 +1 more	GBenign
Select item 496339	NM_006939.4(SOS2):c.3489+19C>T	SOS2	Single nucleotide variant (intron variant)	Noonan syndrome 9 +2 more	GBenign/Likely benign
Select item 579913	NM_006939.4(SOS2):c.3403A>G (p.Ser1135Gly)	SOS2 (S1135G)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +1 more	GUncertain significance
Select item 1098117	NM_006939.4(SOS2):c.3360A>C (p.Pro1120=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +1 more	GLikely benign
Select item 1014207	NM_006939.4(SOS2):c.3356C>T (p.Ala1119Val)	SOS2 (A1119V)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GUncertain significance
Select item 1713951	NM_006939.4(SOS2):c.3341G>A (p.Ser1114Asn)	SOS2 (S1081N +1 more)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GUncertain significance
Select item 928962	NM_006939.4(SOS2):c.3337+4A>G	SOS2	Single nucleotide variant (intron variant)	Noonan syndrome 9 +1 more	GUncertain significance
Select item 1348897	NM_006939.4(SOS2):c.3335G>A (p.Cys1112Tyr)	SOS2 (C1112Y)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +1 more	GUncertain significance
Select item 917789	NM_006939.4(SOS2):c.3302G>A (p.Ser1101Asn)	SOS2 (S1101N)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +2 more	GUncertain significance
Select item 719880	NM_006939.4(SOS2):c.3279A>C (p.Pro1093=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +1 more	GLikely benign
Select item 542409	NM_006939.4(SOS2):c.3250A>G (p.Thr1084Ala)	SOS2 (T1084A)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +2 more	GLikely benign
Select item 475751	NM_006939.4(SOS2):c.3088A>G (p.Thr1030Ala)	SOS2 (T1030A)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +3 more	GBenign/Likely benign
Select item 561959	NM_006939.4(SOS2):c.3076C>T (p.Pro1026Ser)	SOS2 (P1026S)	Single nucleotide variant (missense variant)	not specified +4 more	GConflicting classifications of pathogenicity
Select item 1192235	NM_006939.4(SOS2):c.3076-17A>T	SOS2	Single nucleotide variant (intron variant)	Noonan syndrome 9 +1 more	GBenign/Likely benign
Select item 384712	NM_006939.4(SOS2):c.3075+7C>T	SOS2	Single nucleotide variant (intron variant)	Noonan syndrome 9 +2 more	GBenign
Select item 475750	NM_006939.4(SOS2):c.3066A>G (p.Pro1022=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +1 more	GBenign/Likely benign
Select item 1414228	NM_006939.4(SOS2):c.3064C>A (p.Pro1022Thr)	SOS2 (P1022T)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GUncertain significance
Select item 1172861	NM_006939.4(SOS2):c.3026A>G (p.Asn1009Ser)	SOS2 (N1009S)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +2 more	GUncertain significance
Select item 954118	NM_006939.4(SOS2):c.2986G>A (p.Gly996Arg)	SOS2 (G996R)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GUncertain significance
Select item 1321415	NM_006939.4(SOS2):c.2959-16A>G	SOS2	Single nucleotide variant (intron variant)	Noonan syndrome 9 +1 more	GBenign/Likely benign
Select item 975014	NM_006939.4(SOS2):c.2959-20T>C	SOS2	Single nucleotide variant (intron variant)	Noonan syndrome 9 +1 more	GBenign
Select item 1374935	NM_006939.4(SOS2):c.2939G>A (p.Arg980Gln)	SOS2 (R980Q)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GUncertain significance
Select item 1540988	NM_006939.4(SOS2):c.2916T>C (p.Tyr972=)	SOS2	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +1 more	GLikely benign
Select item 542404	NM_006939.4(SOS2):c.2854G>A (p.Asp952Asn)	SOS2 (D952N)	Single nucleotide variant (missense variant)	not specified +4 more	GBenign/Likely benign
Select item 1110478	NM_006939.4(SOS2):c.2786-18_2786-17dup	SOS2	Duplication (intron variant)	Noonan syndrome and Noonan-related syndrome +2 more	GBenign/Likely benign
Select item 517058	NM_006939.4(SOS2):c.2786-18dup	SOS2	Duplication (intron variant)	not provided +2 more	GBenign
Select item 918120	NM_006939.4(SOS2):c.2786-6del	SOS2	Deletion (intron variant)	not provided +2 more	GBenign
Select item 811274	NM_006939.4(SOS2):c.2712A>G (p.Glu904=)	SOS2	Single nucleotide variant (synonymous variant)	not provided +3 more	GBenign/Likely benign
Select item 1130450	NM_006939.4(SOS2):c.2700C>T (p.Asp900=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +2 more	GBenign/Likely benign
Select item 928729	NM_006939.4(SOS2):c.2668-13T>C	SOS2	Single nucleotide variant (intron variant)	not specified +1 more	GBenign
Select item 561518	NM_006939.4(SOS2):c.2667+43G>A	SOS2	Single nucleotide variant (intron variant)	not provided +1 more	GBenign
Select item 747706	NM_006939.4(SOS2):c.2643A>G (p.Val881=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +1 more	GLikely benign
Select item 542413	NM_006939.4(SOS2):c.2640A>G (p.Ser880=)	SOS2	Single nucleotide variant (synonymous variant)	not provided +4 more	GBenign/Likely benign
Select item 475748	NM_006939.4(SOS2):c.2625A>T (p.Ala875=)	SOS2	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +2 more	GBenign
Select item 578603	NM_006939.4(SOS2):c.2605G>A (p.Val869Ile)	SOS2 (V869I)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +1 more	GBenign/Likely benign
Select item 475747	NM_006939.4(SOS2):c.2604C>T (p.Gly868=)	SOS2	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +2 more	GBenign/Likely benign
Select item 496338	NM_006939.4(SOS2):c.2520A>G (p.Ala840=)	SOS2	Single nucleotide variant (synonymous variant)	not provided +2 more	GBenign/Likely benign
Select item 1306512	NM_006939.4(SOS2):c.2471G>A (p.Arg824His)	SOS2 (R824H)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +1 more	GUncertain significance
Select item 280818	NM_006939.4(SOS2):c.2443A>G (p.Asn815Asp)	SOS2 (N815D)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +1 more	GUncertain significance
Select item 1301363	NM_006939.4(SOS2):c.2397G>A (p.Pro799=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +2 more	GLikely benign
Select item 567315	NM_006939.4(SOS2):c.2396C>T (p.Pro799Leu)	SOS2 (P799L)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GUncertain significance
Select item 706139	NM_006939.4(SOS2):c.2328A>G (p.Thr776=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +1 more	GLikely benign
Select item 377127	NM_006939.4(SOS2):c.2317G>C (p.Asp773His)	SOS2 (D773H)	Single nucleotide variant (missense variant)	not specified +3 more	GBenign/Likely benign
Select item 1581765	NM_006939.4(SOS2):c.2253C>T (p.Thr751=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +1 more	GLikely benign
Select item 1482671	NM_006939.4(SOS2):c.2245A>G (p.Asn749Asp)	SOS2 (N749D)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GUncertain significance
Select item 384710	NM_006939.4(SOS2):c.2232C>T (p.Asn744=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +3 more	GBenign
Select item 1148491	NM_006939.4(SOS2):c.2220A>C (p.Gln740His)	SOS2 (Q740H)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +2 more	GBenign/Likely benign
Select item 1361688	NM_006939.4(SOS2):c.2217G>T (p.Lys739Asn)	SOS2 (K739N)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +2 more	GUncertain significance
Select item 542407	NM_006939.4(SOS2):c.2217G>A (p.Lys739=)	SOS2	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +2 more	GBenign/Likely benign
Select item 1609837	NM_006939.4(SOS2):c.2184A>C (p.Val728=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +1 more	GLikely benign
Select item 580477	NM_006939.4(SOS2):c.2168C>T (p.Ala723Val)	SOS2 (A723V)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +1 more	GUncertain significance
Select item 1392321	NM_006939.4(SOS2):c.2166A>T (p.Lys722Asn)	SOS2 (K722N)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GUncertain significance
Select item 387330	NM_006939.4(SOS2):c.2162-4C>A	SOS2	Single nucleotide variant (intron variant)	Noonan syndrome and Noonan-related syndrome +3 more	GBenign
Select item 475743	NM_006939.4(SOS2):c.2162-10C>T	SOS2	Single nucleotide variant (intron variant)	not provided +2 more	GBenign/Likely benign
Select item 1266724	NM_006939.4(SOS2):c.2057+38C>T	SOS2	Single nucleotide variant (intron variant)	not provided +1 more	GBenign
Select item 1298259	NM_006939.4(SOS2):c.2057+34T>C	SOS2	Single nucleotide variant (intron variant)	Noonan syndrome 9 +1 more	GBenign
Select item 420654	NM_006939.4(SOS2):c.2057+19_2057+20del	SOS2	Deletion (intron variant)	Noonan syndrome 9 +2 more	GBenign/Likely benign
Select item 506385	NM_006939.4(SOS2):c.2057+19T>A	SOS2	Single nucleotide variant (intron variant)	not specified +1 more	GBenign/Likely benign
Select item 1545284	NM_006939.4(SOS2):c.2049A>G (p.Val683=)	SOS2	Single nucleotide variant (synonymous variant)	Noonan syndrome 9 +1 more	GLikely benign
Select item 445827	NM_006939.4(SOS2):c.2014C>A (p.Leu672Ile)	SOS2 (L672I)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +3 more	GBenign/Likely benign
Select item 928960	NM_006939.4(SOS2):c.2010A>G (p.Ala670=)	SOS2	Single nucleotide variant (synonymous variant)	not specified +2 more	GBenign/Likely benign
Select item 846991	NM_006939.4(SOS2):c.1976T>C (p.Leu659Ser)	SOS2 (L659S)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GConflicting classifications of pathogenicity
Select item 987786	NM_006939.4(SOS2):c.1935-20C>G	SOS2	Single nucleotide variant (intron variant)	not specified +1 more	GBenign
Select item 542401	NM_006939.4(SOS2):c.1868G>A (p.Arg623His)	SOS2 (R623H)	Single nucleotide variant (missense variant)	Noonan syndrome 9	GUncertain significance
Select item 493142	NM_006939.4(SOS2):c.1861T>G (p.Phe621Val)	SOS2 (F621V)	Single nucleotide variant (missense variant)	Noonan syndrome 9 +1 more	GUncertain significance

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