"GeneDx"[submitter] AND "VCL"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 58726	GRCh38/hg38 10q21.1-22.2(chr10:58436466-74415216)x1	LOC129390190, LOC129390191 +610 more	Copy number loss	See cases	GPathogenic
Select item 58745	GRCh38/hg38 10q22.1-22.2(chr10:72720628-75612374)x1	LOC130004132, LOC130004133 +150 more	Copy number loss	See cases	GPathogenic
Select item 684057	NM_014000.2(VCL):c.-386A>G	LOC130004108, VCL	Single nucleotide variant	not provided	GBenign
Select item 684060	NM_014000.2(VCL):c.-264A>G	LOC130004108, VCL	Single nucleotide variant	not provided	GBenign
Select item 1205590	NC_000010.11:g.73998025C>T	LOC130004108, VCL	Single nucleotide variant	not provided	GLikely benign
Select item 1188273	NC_000010.11:g.73998048G>A	LOC130004108, VCL	Single nucleotide variant	not provided	GLikely benign
Select item 381051	NM_014000.3(VCL):c.-13G>A	LOC130004109, VCL	Single nucleotide variant (5 prime UTR variant)	not specified	GLikely benign
Select item 2056170	NM_014000.3(VCL):c.4C>G (p.Pro2Ala)	LOC130004109, VCL (P2A)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1W +1 more	GUncertain significance
Select item 640967	NM_014000.3(VCL):c.20G>T (p.Arg7Leu)	VCL, LOC130004109 (R7L)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy 15 +3 more	GUncertain significance
Select item 202152	NM_014000.3(VCL):c.50C>A (p.Ala17Glu)	LOC130004109, VCL (A17E)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 1723062	NM_014000.3(VCL):c.79C>G (p.His27Asp)	LOC130004109, VCL (H27D)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1W +2 more	GUncertain significance
Select item 202145	NM_014000.3(VCL):c.81C>T (p.His27=)	LOC130004109, VCL	Single nucleotide variant (synonymous variant)	not specified +3 more	GConflicting classifications of pathogenicity
Select item 1723116	NM_014000.3(VCL):c.118C>G (p.Leu40Val)	VCL, LOC130004109 (L40V)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1W +2 more	GUncertain significance
Select item 166535	NM_014000.3(VCL):c.120C>T (p.Leu40=)	LOC130004109, VCL	Single nucleotide variant (synonymous variant)	Dilated cardiomyopathy 1W +4 more	GBenign/Likely benign
Select item 1755187	NM_014000.3(VCL):c.122C>T (p.Thr41Ile)	LOC130004109, VCL (T41I)	Single nucleotide variant (missense variant)	not provided +1 more	GUncertain significance
Select item 383287	NM_014000.3(VCL):c.168+20C>A	VCL	Single nucleotide variant (intron variant)	not specified +1 more	GLikely benign
Select item 671495	NM_014000.3(VCL):c.169-290A>G	VCL	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 506391	NM_014000.3(VCL):c.169-11del	VCL	Deletion (intron variant)	Dilated cardiomyopathy 1W +2 more	GBenign/Likely benign
Select item 384031	NM_014000.3(VCL):c.169-18T>A	VCL	Single nucleotide variant (intron variant)	not specified +1 more	GLikely benign
Select item 510503	NM_014000.3(VCL):c.169-10delinsTG	VCL	Indel (intron variant)	Cardiomyopathy +1 more	GConflicting classifications of pathogenicity
Select item 415312	NM_014000.3(VCL):c.169-7C>G	VCL	Single nucleotide variant (intron variant)	Dilated cardiomyopathy 1W +1 more	GLikely benign
Select item 3342945	NM_014000.3(VCL):c.200A>T (p.Asp67Val)	VCL (D67V)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 202151	NM_014000.3(VCL):c.224C>T (p.Pro75Leu)	VCL (P75L)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +2 more	GUncertain significance
Select item 468814	NM_014000.3(VCL):c.225A>G (p.Pro75=)	VCL	Single nucleotide variant (synonymous variant)	not specified +2 more	GLikely benign
Select item 496423	NM_014000.3(VCL):c.238A>C (p.Lys80Gln)	VCL (K80Q)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy 15 +3 more	GUncertain significance
Select item 806509	NM_014000.3(VCL):c.239+6T>G	VCL	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy 15 +2 more	GUncertain significance
Select item 378848	NM_014000.3(VCL):c.239+11G>A	VCL	Single nucleotide variant (intron variant)	Dilated cardiomyopathy 1W +2 more	GLikely benign
Select item 1196923	NM_014000.3(VCL):c.239+148A>T	VCL	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1280602	NM_014000.3(VCL):c.239+210dup	VCL	Duplication (intron variant)	not provided	GBenign
Select item 1206940	NM_014000.3(VCL):c.240-146C>T	VCL	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 450753	NM_014000.3(VCL):c.248A>T (p.Asn83Ile)	VCL (N83I)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 390501	NM_014000.3(VCL):c.261G>A (p.Lys87=)	VCL	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +1 more	GLikely benign
Select item 202164	NM_014000.3(VCL):c.292G>A (p.Asp98Asn)	VCL (D98N)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +1 more	GUncertain significance
Select item 36897	NM_014000.3(VCL):c.339G>A (p.Arg113=)	VCL	Single nucleotide variant (synonymous variant)	Dilated cardiomyopathy 1W +5 more	GBenign/Likely benign
Select item 45612	NM_014000.3(VCL):c.366G>A (p.Leu122=)	VCL	Single nucleotide variant (synonymous variant)	not specified +4 more	GBenign/Likely benign
Select item 45613	NM_014000.3(VCL):c.378C>T (p.Phe126=)	VCL	Single nucleotide variant (synonymous variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 450840	NM_014000.3(VCL):c.379G>A (p.Asp127Asn)	VCL (D127N)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 192100	NM_014000.3(VCL):c.404T>C (p.Ile135Thr)	VCL (I135T)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1W +3 more	GConflicting classifications of pathogenicity
Select item 1740963	NM_014000.3(VCL):c.448G>T (p.Val150Leu)	VCL (V150L)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +2 more	GUncertain significance
Select item 2188940	NM_014000.3(VCL):c.472G>T (p.Val158Phe)	VCL (V158F)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1W +1 more	GUncertain significance
Select item 1312612	NM_014000.3(VCL):c.482C>G (p.Thr161Arg)	VCL (T161R)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy 15 +2 more	GUncertain significance
Select item 3368232	NM_014000.3(VCL):c.485A>C (p.Lys162Thr)	VCL (K162T)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 166536	NM_014000.3(VCL):c.492T>G (p.Leu164=)	VCL	Single nucleotide variant (synonymous variant)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 684059	NM_014000.3(VCL):c.500-281T>C	VCL	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 678671	NM_014000.3(VCL):c.500-236A>G	VCL	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 45615	NM_014000.3(VCL):c.562C>T (p.Arg188Ter)	VCL (R188*)	Single nucleotide variant (nonsense)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 450850	NM_014000.3(VCL):c.565G>T (p.Val189Leu)	VCL (V189L)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 669858	NM_014000.3(VCL):c.571T>C (p.Leu191=)	VCL	Single nucleotide variant (synonymous variant)	Dilated cardiomyopathy 1W +2 more	GLikely benign
Select item 388963	NM_014000.3(VCL):c.582G>A (p.Ser194=)	VCL	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +2 more	GLikely benign
Select item 45617	NM_014000.3(VCL):c.590C>T (p.Thr197Ile)	VCL (T197I)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +4 more	GConflicting classifications of pathogenicity
Select item 1051345	NM_014000.3(VCL):c.597del (p.Glu200fs)	VCL (E200fs)	Deletion (frameshift variant)	Cardiovascular phenotype +2 more	GUncertain significance
Select item 178980	NM_014000.3(VCL):c.610G>C (p.Val204Leu)	VCL (V204L)	Single nucleotide variant (missense variant)	not provided +2 more	GUncertain significance
Select item 229632	NM_014000.3(VCL):c.622+4C>G	VCL	Single nucleotide variant (intron variant)	not specified +3 more	GConflicting classifications of pathogenicity
Select item 166538	NM_014000.3(VCL):c.622+4C>T	VCL	Single nucleotide variant (intron variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 517897	NM_014000.3(VCL):c.622+18T>C	VCL	Single nucleotide variant (intron variant)	Dilated cardiomyopathy 1W +1 more	GLikely benign
Select item 1219348	NM_014000.3(VCL):c.622+35A>G	VCL	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1291293	NM_014000.3(VCL):c.622+88C>G	VCL	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1182341	NM_014000.3(VCL):c.622+107dup	VCL	Duplication (intron variant)	not provided	GBenign
Select item 671212	NM_014000.3(VCL):c.622+158G>A	VCL	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 671213	NM_014000.3(VCL):c.622+191C>T	VCL	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 671214	NM_014000.3(VCL):c.622+211T>C	VCL	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1243888	NM_014000.3(VCL):c.623-181A>C	VCL	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 671497	NM_014000.3(VCL):c.623-83T>C	VCL	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 2135823	NM_014000.3(VCL):c.646A>G (p.Lys216Glu)	VCL (K216E)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1W +1 more	GUncertain significance
Select item 45619	NM_014000.3(VCL):c.660C>T (p.Asn220=)	VCL	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +4 more	GBenign/Likely benign
Select item 2146002	NM_014000.3(VCL):c.668T>C (p.Ile223Thr)	VCL (I223T)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1W +1 more	GUncertain significance
Select item 202153	NM_014000.3(VCL):c.676G>A (p.Ala226Thr)	VCL (A226T)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +2 more	GUncertain significance
Select item 1309830	NM_014000.3(VCL):c.686dup (p.Asn229fs)	VCL (N229fs)	Duplication (frameshift variant)	Dilated cardiomyopathy 1W +2 more	GUncertain significance
Select item 45620	NM_014000.3(VCL):c.688C>T (p.Arg230Cys)	VCL (R230C)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy 15 +4 more	GUncertain significance
Select item 202165	NM_014000.3(VCL):c.736C>T (p.Arg246Cys)	VCL (R246C)	Single nucleotide variant (missense variant)	not provided +1 more	GUncertain significance
Select item 36898	NM_014000.3(VCL):c.768T>C (p.Asp256=)	VCL	Single nucleotide variant (synonymous variant)	Dilated cardiomyopathy 1W +5 more	GBenign/Likely benign
Select item 1304883	NM_014000.3(VCL):c.780C>G (p.Ser260Arg)	VCL (S260R)	Single nucleotide variant (missense variant)	not provided +1 more	GUncertain significance
Select item 387383	NM_014000.3(VCL):c.780C>T (p.Ser260=)	VCL	Single nucleotide variant (synonymous variant)	not specified +2 more	GLikely benign
Select item 567280	NM_014000.3(VCL):c.783+5G>A	VCL	Single nucleotide variant (intron variant)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 1202386	NM_014000.3(VCL):c.783+250C>T	VCL	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 671287	NM_014000.3(VCL):c.784-60G>A	VCL	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 468824	NM_014000.3(VCL):c.787A>T (p.Thr263Ser)	VCL (T263S)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +3 more	GConflicting classifications of pathogenicity
Select item 937677	NM_014000.3(VCL):c.788C>G (p.Thr263Ser)	VCL (T263S)	Single nucleotide variant (missense variant)	not provided +2 more	GUncertain significance
Select item 300784	NM_014000.3(VCL):c.789T>C (p.Thr263=)	VCL	Single nucleotide variant (synonymous variant)	Dilated cardiomyopathy 1W +2 more	GConflicting classifications of pathogenicity
Select item 1016938	NM_014000.3(VCL):c.818T>C (p.Ile273Thr)	VCL (I273T)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1W +2 more	GUncertain significance
Select item 12198	NM_014000.3(VCL):c.829C>A (p.Leu277Met)	VCL (L277M)	Single nucleotide variant (missense variant)	Primary familial dilated cardiomyopathy +7 more	GConflicting classifications of pathogenicity
Select item 1306605	NM_014000.3(VCL):c.844G>T (p.Gly282Cys)	VCL (G282C)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +3 more	GUncertain significance
Select item 166541	NM_014000.3(VCL):c.874+7C>G	VCL	Single nucleotide variant (intron variant)	not specified +1 more	GLikely benign
Select item 669418	NM_014000.3(VCL):c.875-324dup	VCL	Duplication (intron variant)	not provided	GBenign
Select item 498457	NM_014000.3(VCL):c.875-24T>A	VCL	Single nucleotide variant (intron variant)	not specified +3 more	GBenign
Select item 45622	NM_014000.3(VCL):c.945C>A (p.Gly315=)	VCL	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +4 more	GBenign/Likely benign
Select item 946690	NM_014000.3(VCL):c.953G>T (p.Arg318Leu)	VCL (R318L)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1W +1 more	GUncertain significance
Select item 1310591	NM_014000.3(VCL):c.1006G>A (p.Ala336Thr)	VCL (A336T)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +2 more	GUncertain significance
Select item 202155	NM_014000.3(VCL):c.1015C>T (p.Arg339Cys)	VCL (R339C)	Single nucleotide variant (missense variant)	not provided +2 more	GUncertain significance
Select item 676783	NM_014000.3(VCL):c.1022+172TTTA[3]	VCL	Microsatellite (intron variant)	not provided	GLikely benign
Select item 408944	NM_014000.3(VCL):c.1031G>C (p.Gly344Ala)	VCL (G344A)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1W +2 more	GUncertain significance
Select item 657948	NM_014000.3(VCL):c.1039C>T (p.Pro347Ser)	VCL (P347S)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1W +4 more	GUncertain significance
Select item 300786	NM_014000.3(VCL):c.1040C>T (p.Pro347Leu)	VCL (P347L)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1W +3 more	GUncertain significance
Select item 380681	NM_014000.3(VCL):c.1074G>A (p.Gln358=)	VCL	Single nucleotide variant (synonymous variant)	not specified	GLikely benign
Select item 383210	NM_014000.3(VCL):c.1092A>G (p.Thr364=)	VCL	Single nucleotide variant (synonymous variant)	not specified +1 more	GLikely benign
Select item 2503384	NM_014000.3(VCL):c.1097A>T (p.Lys366Ile)	VCL (K366I)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 1306476	NM_014000.3(VCL):c.1105A>G (p.Asn369Asp)	VCL (N369D)	Single nucleotide variant (missense variant)	not provided +1 more	GUncertain significance
Select item 192102	NM_014000.3(VCL):c.1157A>G (p.Lys386Arg)	VCL (K386R)	Single nucleotide variant (missense variant)	Cardiomyopathy +5 more	GConflicting classifications of pathogenicity
Select item 706653	NM_014000.3(VCL):c.1164C>T (p.Ile388=)	VCL	Single nucleotide variant (synonymous variant)	not provided +2 more	GBenign/Likely benign
Select item 509656	NM_014000.3(VCL):c.1170T>C (p.Ala390=)	VCL	Single nucleotide variant (synonymous variant)	not specified +2 more	GLikely benign

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