"GeneDx"[submitter] AND "TNNT2"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 57818	GRCh38/hg38 1q32.1(chr1:201226425-202014204)x3	CSRP1, CSRP1-AS1 +49 more	Copy number gain	See cases	GUncertain significance
Select item 1174167	NM_001276345.2(TNNT2):c.*180A>T	TNNT2	Single nucleotide variant (3 prime UTR variant)	not provided	GBenign
Select item 1290330	NM_001276345.2(TNNT2):c.*170C>G	TNNT2	Single nucleotide variant (3 prime UTR variant)	not provided	GBenign
Select item 1257435	NM_001276345.2(TNNT2):c.*150C>T	TNNT2	Single nucleotide variant (3 prime UTR variant)	not provided	GBenign
Select item 1290331	NM_001276345.2(TNNT2):c.*123C>T	TNNT2	Single nucleotide variant (3 prime UTR variant)	not provided	GBenign
Select item 1260013	NM_001276345.2(TNNT2):c.*90del	TNNT2	Deletion (3 prime UTR variant)	not provided	GBenign
Select item 1290329	NM_001276345.2(TNNT2):c.*88C>G	TNNT2	Single nucleotide variant (3 prime UTR variant)	not provided	GBenign
Select item 1239408	NM_001276345.2(TNNT2):c.*71C>T	TNNT2	Single nucleotide variant (3 prime UTR variant)	not provided	GBenign
Select item 294893	NM_001276345.2(TNNT2):c.*66G>A	TNNT2	Single nucleotide variant (3 prime UTR variant)	Familial restrictive cardiomyopathy +7 more	GBenign/Likely benign
Select item 1277246	NM_001276345.2(TNNT2):c.*40A>C	TNNT2	Single nucleotide variant (3 prime UTR variant)	not provided	GBenign
Select item 875245	NM_001276345.2(TNNT2):c.*39C>T	TNNT2	Single nucleotide variant (3 prime UTR variant)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 876211	NM_001276345.2(TNNT2):c.*37C>T	TNNT2	Single nucleotide variant (3 prime UTR variant)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 1275654	NM_001276345.2(TNNT2):c.*31del	TNNT2	Deletion (3 prime UTR variant)	not provided	GBenign
Select item 921153	NM_001276345.2(TNNT2):c.*3C>A	TNNT2	Single nucleotide variant (3 prime UTR variant)	Cardiomyopathy +1 more	GConflicting classifications of pathogenicity
Select item 181636	NM_001276345.2(TNNT2):c.891G>A (p.Trp297Ter)	TNNT2 (W287* +5 more)	Single nucleotide variant (nonsense)	not provided +5 more	GPathogenic/Likely pathogenic
Select item 452905	NM_001276345.2(TNNT2):c.890G>T (p.Trp297Leu)	TNNT2 (W287L +5 more)	Single nucleotide variant (missense variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 177636	NM_001276345.2(TNNT2):c.890G>A (p.Trp297Ter)	TNNT2 (W287* +5 more)	Single nucleotide variant (nonsense)	not provided +7 more	GPathogenic/Likely pathogenic
Select item 43677	NM_001276345.2(TNNT2):c.887G>A (p.Arg296His)	TNNT2 (R286H +5 more)	Single nucleotide variant (missense variant)	Cardiomyopathy +6 more	GUncertain significance
Select item 1275653	NM_001276345.2(TNNT2):c.885G>A (p.Gly295=)	TNNT2	Single nucleotide variant (synonymous variant)	not provided +4 more	GBenign/Likely benign
Select item 180555	NM_001276345.2(TNNT2):c.883G>A (p.Gly295Arg)	TNNT2 (G285R +5 more)	Single nucleotide variant (missense variant)	not provided +5 more	GUncertain significance
Select item 388233	NM_001276345.2(TNNT2):c.882C>T (p.Thr294=)	TNNT2	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +6 more	GLikely benign
Select item 179939	NM_001276345.2(TNNT2):c.866G>A (p.Gly289Glu)	TNNT2 (G279E +5 more)	Single nucleotide variant (missense variant)	not specified +4 more	GUncertain significance
Select item 426271	NM_001276345.2(TNNT2):c.865G>A (p.Gly289Arg)	TNNT2 (G279R +5 more)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 177635	NM_001276345.2(TNNT2):c.863G>C (p.Arg288Pro)	TNNT2 (R278P +5 more)	Single nucleotide variant (missense variant)	not specified +6 more	GConflicting classifications of pathogenicity
Select item 12411	NM_001276345.2(TNNT2):c.862C>T (p.Arg288Cys)	TNNT2 (R278C +5 more)	Single nucleotide variant (missense variant)	Primary familial hypertrophic cardiomyopathy +9 more	GConflicting classifications of pathogenicity
Select item 537266	NM_001276345.2(TNNT2):c.861C>A (p.Thr287=)	TNNT2	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy 2 +5 more	GLikely benign
Select item 181634	NM_001276345.2(TNNT2):c.852-1G>T	TNNT2	Single nucleotide variant (splice acceptor variant)	Dilated cardiomyopathy 1D +3 more	GUncertain significance
Select item 419277	NM_001276345.2(TNNT2):c.852-2A>C	TNNT2	Single nucleotide variant (splice acceptor variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 807896	NM_001276345.2(TNNT2):c.852-3C>T	TNNT2	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy 2 +5 more	GConflicting classifications of pathogenicity
Select item 516875	NM_001276345.2(TNNT2):c.852-18G>A	TNNT2	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy 2 +3 more	GLikely benign
Select item 378742	NM_001276345.2(TNNT2):c.852-19C>T	TNNT2	Single nucleotide variant (intron variant)	Dilated cardiomyopathy 1D +3 more	GBenign/Likely benign
Select item 1217922	NM_001276345.2(TNNT2):c.852-23A>G	TNNT2	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy 2 +3 more	GLikely benign
Select item 671447	NM_001276345.2(TNNT2):c.851+43C>T	TNNT2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 36886	NM_001276345.2(TNNT2):c.851+5G>A	TNNT2	Single nucleotide variant (intron variant)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 431937	NM_001276345.2(TNNT2):c.847A>G (p.Lys283Glu)	TNNT2 (K273E +5 more)	Single nucleotide variant (missense variant)	not provided	GPathogenic
Select item 181639	NM_001276345.2(TNNT2):c.844dup (p.Gln282fs)	TNNT2 (Q282fs +5 more)	Duplication (frameshift variant)	Cardiomyopathy	GPathogenic
Select item 1406501	NM_001276345.2(TNNT2):c.842A>G (p.Asn281Ser)	TNNT2 (N265S +5 more)	Single nucleotide variant (missense variant)	Cardiomyopathy, familial restrictive, 3 +3 more	GUncertain significance
Select item 217495	NM_001276345.2(TNNT2):c.842A>T (p.Asn281Ile)	TNNT2 (N268I +5 more)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy 2 +6 more	GConflicting classifications of pathogenicity
Select item 43672	NM_001276345.2(TNNT2):c.837C>T (p.Asn279=)	TNNT2	Single nucleotide variant (synonymous variant)	Cardiomyopathy +6 more	GConflicting classifications of pathogenicity
Select item 181648	NM_001276345.2(TNNT2):c.835A>T (p.Asn279Tyr)	TNNT2 (N269Y +5 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 181646	NM_001276345.2(TNNT2):c.824G>A (p.Arg275Gln)	TNNT2 (R265Q +5 more)	Single nucleotide variant (missense variant)	Cardiomyopathy +4 more	GUncertain significance
Select item 43671	NM_001276345.2(TNNT2):c.815A>G (p.Asn272Ser)	TNNT2 (N262S +5 more)	Single nucleotide variant (missense variant)	Cardiomyopathy +4 more	GUncertain significance
Select item 387170	NM_001276345.2(TNNT2):c.811-19C>G	TNNT2	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 256846	NM_001276345.2(TNNT2):c.811-33C>T	TNNT2	Single nucleotide variant (intron variant)	Dilated cardiomyopathy 1D +4 more	GBenign
Select item 671265	NM_001276345.2(TNNT2):c.811-122C>G	TNNT2	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy 2 +3 more	GBenign
Select item 1179680	NM_001276345.2(TNNT2):c.811-233G>A	TNNT2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 668766	NM_001276345.2(TNNT2):c.810+278A>G	TNNT2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 672964	NM_001276345.2(TNNT2):c.810+181C>T	TNNT2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 675349	NM_001276345.2(TNNT2):c.810+136C>T	TNNT2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 671446	NM_001276345.2(TNNT2):c.810+65G>A	TNNT2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1187516	NM_001276345.2(TNNT2):c.810+64C>G	TNNT2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 188689	NM_001276345.2(TNNT2):c.810+41C>G	TNNT2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1212336	NM_001276345.2(TNNT2):c.810+27G>C	TNNT2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 177655	NM_001276345.2(TNNT2):c.810+6C>T	TNNT2	Single nucleotide variant (intron variant)	not specified +4 more	GConflicting classifications of pathogenicity
Select item 181633	NM_001276345.2(TNNT2):c.810+5G>A	TNNT2	Single nucleotide variant (intron variant)	Cardiomyopathy +4 more	GUncertain significance
Select item 430315	NM_001276345.2(TNNT2):c.808G>A (p.Glu270Lys)	TNNT2 (E260K +5 more)	Single nucleotide variant (missense variant)	Primary dilated cardiomyopathy +4 more	GUncertain significance
Select item 450191	NM_001276345.2(TNNT2):c.806A>G (p.Tyr269Cys)	TNNT2 (Y259C +5 more)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +4 more	GUncertain significance
Select item 181632	NM_001276345.2(TNNT2):c.805T>C (p.Tyr269His)	TNNT2 (Y259H +5 more)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 43670	NM_001276345.2(TNNT2):c.803A>T (p.Lys268Ile)	TNNT2 (K258I +5 more)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +8 more	GConflicting classifications of pathogenicity
Select item 43669	NM_001276345.2(TNNT2):c.788A>G (p.Lys263Arg)	TNNT2 (K253R +5 more)	Single nucleotide variant (missense variant)	Dilated Cardiomyopathy, Dominant +11 more	GBenign/Likely benign
Select item 181631	NM_001276345.2(TNNT2):c.781C>A (p.Gln261Lys)	TNNT2 (Q251K +5 more)	Single nucleotide variant (missense variant)	not specified	GUncertain significance
Select item 404398	NM_001276345.2(TNNT2):c.779T>C (p.Leu260Pro)	TNNT2 (L250P +5 more)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy 2 +5 more	GUncertain significance
Select item 181630	NM_001276345.2(TNNT2):c.775G>A (p.Asp259Asn)	TNNT2 (D249N +5 more)	Single nucleotide variant (missense variant)	not provided +5 more	GUncertain significance
Select item 43668	NM_001276345.2(TNNT2):c.774C>T (p.Phe258=)	TNNT2	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +6 more	GLikely benign
Select item 181645	NM_001276345.2(TNNT2):c.772T>G (p.Phe258Val)	TNNT2 (F248V +5 more)	Single nucleotide variant (missense variant)	Cardiomyopathy +4 more	GUncertain significance
Select item 181629	NM_001276345.2(TNNT2):c.772T>C (p.Phe258Leu)	TNNT2 (F248L +5 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1D +5 more	GUncertain significance
Select item 181628	NM_001276345.2(TNNT2):c.767A>G (p.Glu256Gly)	TNNT2 (E246G +5 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 177873	NM_001276345.2(TNNT2):c.764C>T (p.Ala255Val)	TNNT2 (A245V +5 more)	Single nucleotide variant (missense variant)	not specified +7 more	GUncertain significance
Select item 43667	NM_001276345.2(TNNT2):c.762G>T (p.Glu254Asp)	TNNT2 (E244D +5 more)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +8 more	GConflicting classifications of pathogenicity
Select item 191800	NM_001276345.2(TNNT2):c.752A>G (p.Tyr251Cys)	TNNT2 (Y241C +5 more)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +5 more	GUncertain significance
Select item 43664	NM_001276345.2(TNNT2):c.720-4G>T	TNNT2	Single nucleotide variant (intron variant)	Cardiovascular phenotype +7 more	GConflicting classifications of pathogenicity
Select item 181605	NM_001276345.2(TNNT2):c.720-5T>G	TNNT2	Single nucleotide variant (intron variant)	Cardiovascular phenotype +9 more	GConflicting classifications of pathogenicity
Select item 43665	NM_001276345.2(TNNT2):c.720-6G>A	TNNT2	Single nucleotide variant (intron variant)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 43666	NM_001276345.2(TNNT2):c.720-7C>T	TNNT2	Single nucleotide variant (intron variant)	Cardiomyopathy +4 more	GConflicting classifications of pathogenicity
Select item 43663	NM_001276345.2(TNNT2):c.720-13_720-11del	TNNT2	Deletion (intron variant)	not provided +5 more	GConflicting classifications of pathogenicity
Select item 675348	NM_001276345.2(TNNT2):c.720-71C>T	TNNT2	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 672958	NM_001276345.2(TNNT2):c.720-86T>C	TNNT2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 674193	NM_001276345.2(TNNT2):c.720-232C>T	TNNT2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1307997	NM_001276345.2(TNNT2):c.719+1G>C	TNNT2	Single nucleotide variant (splice donor variant)	not provided +3 more	GUncertain significance
Select item 1315138	NM_001276345.2(TNNT2):c.716T>C (p.Leu239Pro)	TNNT2 (L196P +5 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 181627	NM_001276345.2(TNNT2):c.712C>G (p.Gln238Glu)	TNNT2 (Q228E +5 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1D +4 more	GUncertain significance
Select item 181626	NM_001276345.2(TNNT2):c.706G>A (p.Glu236Lys)	TNNT2 (E226K +5 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1D +5 more	GUncertain significance
Select item 181604	NM_001276345.2(TNNT2):c.692T>C (p.Ile231Thr)	TNNT2 (I221T +5 more)	Single nucleotide variant (missense variant)	Cardiomyopathy +8 more	GConflicting classifications of pathogenicity
Select item 373778	NM_001276345.2(TNNT2):c.667G>C (p.Ala223Pro)	TNNT2 (A213P +5 more)	Single nucleotide variant (missense variant)	not specified	GUncertain significance
Select item 43659	NM_001276345.2(TNNT2):c.650AGA[3] (p.Lys220del)	TNNT2 (K210del +5 more)	Microsatellite (inframe_deletion)	Cardiovascular phenotype +6 more	GPathogenic/Likely pathogenic
Select item 165539	NM_001276345.2(TNNT2):c.644G>A (p.Arg215Gln)	TNNT2 (R205Q +5 more)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy 2 +4 more	GConflicting classifications of pathogenicity
Select item 514326	NM_001276345.2(TNNT2):c.643C>A (p.Arg215=)	TNNT2	Single nucleotide variant (synonymous variant)	not specified	GLikely benign
Select item 180554	NM_001276345.2(TNNT2):c.643C>T (p.Arg215Trp)	TNNT2 (R205W +5 more)	Single nucleotide variant (missense variant)	Primary familial dilated cardiomyopathy +6 more	GConflicting classifications of pathogenicity
Select item 933456	NM_001276345.2(TNNT2):c.614A>G (p.Glu205Gly)	TNNT2 (E192G +5 more)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 426997	NM_001276345.2(TNNT2):c.610-1G>A	TNNT2	Single nucleotide variant (splice acceptor variant)	not provided	GLikely pathogenic
Select item 811582	NM_001276345.2(TNNT2):c.610-81C>T	TNNT2	Single nucleotide variant (intron variant)	not provided +4 more	GBenign
Select item 627650	NM_001276345.2(TNNT2):c.610-90G>A	TNNT2	Single nucleotide variant (intron variant)	not specified +5 more	GBenign
Select item 672957	NM_001276345.2(TNNT2):c.609+179T>C	TNNT2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1223834	NM_001276345.2(TNNT2):c.609+135A>G	TNNT2	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 389960	NM_001276345.2(TNNT2):c.609+15C>T	TNNT2	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 132940	NM_001276345.2(TNNT2):c.601-1G>A	TNNT2	Single nucleotide variant (intron variant +1 more)	Hypertrophic cardiomyopathy 2 +7 more	GConflicting classifications of pathogenicity
Select item 43656	NM_001276345.2(TNNT2):c.601-7G>A	TNNT2	Single nucleotide variant (intron variant)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 43657	NM_001276345.2(TNNT2):c.601-8C>T	TNNT2	Single nucleotide variant (intron variant)	Dilated Cardiomyopathy, Dominant +9 more	GConflicting classifications of pathogenicity
Select item 256845	NM_001276345.2(TNNT2):c.601-32A>C	TNNT2	Single nucleotide variant (intron variant)	Cardiomyopathy, familial restrictive, 3 +4 more	GBenign
Select item 671946	NM_001276345.2(TNNT2):c.601-142G>T	TNNT2	Single nucleotide variant (intron variant)	not provided	GBenign

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