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Items: 76

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
LOC130061370, TLK2
Single nucleotide variant
(splice donor variant +1 more)
not provided
GUncertain significance
TLK2
(K101R +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
TLK2
(N104K +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
TLK2
(R61* +1 more)
Single nucleotide variant
(nonsense +1 more)
not provided
+1 more
GPathogenic
TLK2
(R109W +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
TLK2
(K122Q +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
TLK2
(T98A)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GUncertain significance
TLK2
(T98N)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
TLK2
(R109Q)
Single nucleotide variant
(missense variant +1 more)
not provided
GLikely pathogenic
TLK2
(N118S)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
TLK2
(R122* +2 more)
Single nucleotide variant
(nonsense +1 more)
Intellectual disability, autosomal dominant 57
+1 more
GPathogenic
TLK2
(R91* +2 more)
Single nucleotide variant
(nonsense +1 more)
not provided
GPathogenic
TLK2
(R123Q +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
TLK2
(M118L +3 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
TLK2
(V120E +3 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(T129fs +3 more)
Microsatellite
(frameshift variant)
not provided
GLikely pathogenic
TLK2
(F143V +3 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(H161L +3 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
TLK2
(N190fs +3 more)
Deletion
(frameshift variant)
not provided
GPathogenic
TLK2
(L206S +3 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
TLK2
(R113* +3 more)
Single nucleotide variant
(nonsense)
Intellectual disability, autosomal dominant 57
+1 more
GPathogenic
TLK2
(S278P +3 more)
Single nucleotide variant
(missense variant)
not provided
GLikely pathogenic
TLK2
(Q131fs +4 more)
Deletion
(frameshift variant)
not provided
GPathogenic
TLK2
(L145S +4 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
LOC126862611, TLK2
(R154* +3 more)
Single nucleotide variant
(nonsense)
not provided
+1 more
GPathogenic
LOC126862611, TLK2
(A157T +4 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
LOC126862611, TLK2
(Y316fs +3 more)
Deletion
(frameshift variant)
not provided
GPathogenic
LOC126862611, TLK2
(A168V +4 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
LOC126862611, TLK2
Single nucleotide variant
(splice donor variant)
not provided
GPathogenic
TLK2, LOC126862611
Single nucleotide variant
(intron variant)
not provided
GUncertain significance
TLK2
(R190W +3 more)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 57
+1 more
GConflicting classifications of pathogenicity
TLK2
(R190Q +3 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
TLK2
(M192fs +3 more)
Deletion
(frameshift variant)
not provided
GPathogenic
TLK2
(R196Q +4 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(P348del +4 more)
Microsatellite
(inframe_deletion +1 more)
not provided
GUncertain significance
TLK2
(A254T +4 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(R214W +3 more)
Single nucleotide variant
(missense variant)
not provided
GLikely pathogenic
TLK2
Insertion
(splice donor variant)
not provided
GUncertain significance
TLK2
Single nucleotide variant
(splice donor variant)
Intellectual disability, autosomal dominant 57
+1 more
GPathogenic/Likely pathogenic
TLK2
(R258G +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
Single nucleotide variant
(synonymous variant)
not provided
GUncertain significance
TLK2
(T286A +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(T286P +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(S303N +4 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(S303R +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(D310Y +4 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(E334del +5 more)
Deletion
(inframe_deletion)
not provided
GUncertain significance
TLK2
(H337del +4 more)
Deletion
(inframe_deletion)
not provided
+1 more
GUncertain significance
TLK2
(H337Q +4 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(I355R +5 more)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 57
+1 more
GUncertain significance
TLK2
Single nucleotide variant
(splice donor variant)
not provided
+1 more
GPathogenic/Likely pathogenic
TLK2
(E374G +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(R397G +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(R397W +4 more)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 57
+1 more
GPathogenic/Likely pathogenic
TLK2
(R397P +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(I399L +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(P424A +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
Duplication
(splice donor variant)
not provided
GUncertain significance
TLK2
(I438R +4 more)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 57
+2 more
GConflicting classifications of pathogenicity
TLK2
(D442G +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(S446W +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(S446L +4 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic/Likely pathogenic
TLK2
(W620* +4 more)
Single nucleotide variant
(nonsense)
not provided
GLikely pathogenic
TLK2
(S637* +4 more)
Single nucleotide variant
(nonsense)
not provided
GPathogenic
TLK2
(W643* +4 more)
Single nucleotide variant
(nonsense)
not provided
GPathogenic
TLK2
(P537L +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
Single nucleotide variant
(intron variant)
not provided
GUncertain significance
TLK2
(R697* +4 more)
Single nucleotide variant
(nonsense)
not provided
GPathogenic/Likely pathogenic
TLK2
(R698* +4 more)
Single nucleotide variant
(nonsense)
not provided
+1 more
GConflicting classifications of pathogenicity
TLK2
(C550R +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(R554* +4 more)
Single nucleotide variant
(nonsense)
Intellectual disability, autosomal dominant 57
+1 more
GPathogenic
TLK2
(C566S +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TLK2
(R575* +4 more)
Single nucleotide variant
(nonsense)
Intellectual disability, autosomal dominant 57
+1 more
GConflicting classifications of pathogenicity
TLK2
(S577fs +5 more)
Deletion
(frameshift variant)
not provided
GUncertain significance
TANC2, DDX42
+66 more
Copy number gain
See cases
GPathogenic
TLK2
(V124A +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
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