"GeneDx"[submitter] AND "SOS1"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 897416	NM_005633.4(SOS1):c.*3569T>C	SOS1	Single nucleotide variant (3 prime UTR variant)	Noonan syndrome 4 +2 more	GBenign/Likely benign
Select item 335973	NM_005633.4(SOS1):c.*3539T>C	SOS1	Single nucleotide variant (3 prime UTR variant)	not provided +2 more	GBenign
Select item 898584	NM_005633.4(SOS1):c.*3458A>C	SOS1	Single nucleotide variant (3 prime UTR variant)	Fibromatosis, gingival, 1 +2 more	GBenign/Likely benign
Select item 335996	NM_005633.4(SOS1):c.1333_1336dup	SOS1	Duplication (3 prime UTR variant)	Fibromatosis, gingival, 1 +4 more	GBenign/Likely benign
Select item 336003	NM_005633.4(SOS1):c.*805C>A	SOS1	Single nucleotide variant (3 prime UTR variant)	Noonan syndrome 4 +2 more	GBenign
Select item 336011	NM_005633.4(SOS1):c.*328A>G	SOS1	Single nucleotide variant (3 prime UTR variant)	Fibromatosis, gingival, 1 +2 more	GBenign
Select item 1268887	NM_005633.4(SOS1):c.*151C>A	SOS1	Single nucleotide variant (3 prime UTR variant)	not provided	GBenign
Select item 895864	NM_005633.4(SOS1):c.*44T>C	SOS1	Single nucleotide variant (3 prime UTR variant)	Fibromatosis, gingival, 1 +2 more	GBenign/Likely benign
Select item 386149	NM_005633.4(SOS1):c.*12C>T	SOS1	Single nucleotide variant (3 prime UTR variant)	not specified	GLikely benign
Select item 381752	NM_005633.4(SOS1):c.*8T>C	SOS1	Single nucleotide variant (3 prime UTR variant)	not specified	GLikely benign
Select item 177950	NM_005633.4(SOS1):c.*4C>T	SOS1	Single nucleotide variant (3 prime UTR variant)	RASopathy	GBenign FDA Recognized database
Select item 385741	NM_005633.4(SOS1):c.3996T>C (p.Ser1332=)	SOS1	Single nucleotide variant (synonymous variant)	not provided	GLikely benign
Select item 3367520	NM_005633.4(SOS1):c.3984G>A (p.Glu1328=)	SOS1	Single nucleotide variant (synonymous variant)	not provided	GUncertain significance
Select item 1694953	NM_005633.4(SOS1):c.3977T>C (p.Leu1326Pro)	SOS1 (L1311P +2 more)	Single nucleotide variant (missense variant)	not provided +1 more	GUncertain significance
Select item 2580022	NM_005633.4(SOS1):c.3974C>T (p.Pro1325Leu)	SOS1 (P1310L +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 452599	NM_005633.4(SOS1):c.3960C>G (p.His1320Gln)	SOS1 (H1320Q +2 more)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 1896891	NM_005633.4(SOS1):c.3959A>C (p.His1320Pro)	SOS1 (H1305P +2 more)	Single nucleotide variant (missense variant)	RASopathy +2 more	GUncertain significance
Select item 181545	NM_005633.4(SOS1):c.3956T>G (p.Met1319Arg)	SOS1 (M1319R +2 more)	Single nucleotide variant (missense variant)	RASopathy +3 more	GConflicting classifications of pathogenicity
Select item 45371	NM_005633.4(SOS1):c.3952T>A (p.Ser1318Thr)	SOS1 (S1318T +2 more)	Single nucleotide variant (missense variant)	not specified +1 more	GUncertain significance
Select item 511656	NM_005633.4(SOS1):c.3948C>T (p.His1316=)	SOS1	Single nucleotide variant (synonymous variant)	not specified	GLikely benign
Select item 181557	NM_005633.4(SOS1):c.3946C>G (p.His1316Asp)	SOS1 (H1316D +2 more)	Single nucleotide variant (missense variant)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 3338752	NM_005633.4(SOS1):c.3938A>T (p.Glu1313Val)	SOS1 (E1298V +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 3365232	NM_005633.4(SOS1):c.3932A>C (p.Lys1311Thr)	SOS1 (K1296T +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 372513	NM_005633.4(SOS1):c.3905T>C (p.Ile1302Thr)	SOS1 (I1302T +2 more)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 518090	NM_005633.4(SOS1):c.3900A>G (p.Gln1300=)	SOS1	Single nucleotide variant (synonymous variant)	not provided +1 more	GLikely benign
Select item 181559	NM_005633.4(SOS1):c.3896_3898del (p.Ser1299_Gln1300delinsTer)	SOS1	Deletion (nonsense)	not provided	GUncertain significance
Select item 2504802	NM_005633.4(SOS1):c.3869C>T (p.Pro1290Leu)	SOS1 (P1275L +2 more)	Single nucleotide variant (missense variant)	RASopathy +1 more	GUncertain significance
Select item 1193732	NM_005633.4(SOS1):c.3838C>A (p.Gln1280Lys)	SOS1 (Q1265K +2 more)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +2 more	GConflicting classifications of pathogenicity
Select item 572542	NM_005633.4(SOS1):c.3836C>T (p.Thr1279Ile)	SOS1 (T1279I +2 more)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 2571732	NM_005633.4(SOS1):c.3832T>A (p.Leu1278Met)	SOS1 (L1263M +2 more)	Single nucleotide variant (missense variant)	RASopathy +1 more	GUncertain significance
Select item 423682	NM_005633.4(SOS1):c.3826C>T (p.Pro1276Ser)	SOS1 (P1276S +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 280339	NM_005633.4(SOS1):c.3821C>G (p.Pro1274Arg)	SOS1 (P1274R +2 more)	Single nucleotide variant (missense variant)	Noonan syndrome 4 +3 more	GUncertain significance
Select item 40737	NM_005633.4(SOS1):c.3802G>A (p.Gly1268Ser)	SOS1 (G1268S +2 more)	Single nucleotide variant (missense variant)	RASopathy +2 more	GConflicting classifications of pathogenicity
Select item 515139	NM_005633.4(SOS1):c.3801C>T (p.His1267=)	SOS1	Single nucleotide variant (synonymous variant)	not specified +2 more	GLikely benign
Select item 1305667	NM_005633.4(SOS1):c.3794CTC[1] (p.Pro1266del)	SOS1 (P1251del +2 more)	Microsatellite (inframe_deletion)	not provided	GUncertain significance
Select item 3368915	NM_005633.4(SOS1):c.3778C>T (p.Pro1260Ser)	SOS1 (P1245S +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 3368614	NM_005633.4(SOS1):c.3772C>T (p.Pro1258Ser)	SOS1 (P1243S +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 1241051	NM_005633.4(SOS1):c.3771A>G (p.Thr1257=)	SOS1	Single nucleotide variant (synonymous variant)	not provided	GBenign
Select item 1306691	NM_005633.4(SOS1):c.3770C>T (p.Thr1257Ile)	SOS1 (T1242I +2 more)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +2 more	GConflicting classifications of pathogenicity
Select item 195761	NM_005633.4(SOS1):c.3769A>G (p.Thr1257Ala)	SOS1 (T1257A +2 more)	Single nucleotide variant (missense variant)	Fibromatosis, gingival, 1 +4 more	GConflicting classifications of pathogenicity
Select item 1700397	NM_005633.4(SOS1):c.3766T>G (p.Phe1256Val)	SOS1 (F1241V +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 411867	NM_005633.4(SOS1):c.3763C>A (p.Pro1255Thr)	SOS1 (P1255T +2 more)	Single nucleotide variant (missense variant)	RASopathy +4 more	GUncertain significance
Select item 1208648	NM_005633.4(SOS1):c.3737A>G (p.Asn1246Ser)	SOS1 (N1231S +2 more)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +4 more	GConflicting classifications of pathogenicity
Select item 40734	NM_005633.4(SOS1):c.3729C>G (p.Asp1243Glu)	SOS1 (D1243E +2 more)	Single nucleotide variant (missense variant)	RASopathy +4 more	GConflicting classifications of pathogenicity
Select item 2499374	NM_005633.4(SOS1):c.3722A>G (p.Lys1241Arg)	SOS1 (K1226R +2 more)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +2 more	GConflicting classifications of pathogenicity
Select item 45368	NM_005633.4(SOS1):c.3721A>G (p.Lys1241Glu)	SOS1 (K1241E +2 more)	Single nucleotide variant (missense variant)	not specified +6 more	GUncertain significance
Select item 336015	NM_005633.4(SOS1):c.3709C>G (p.Pro1237Ala)	SOS1 (P1237A +2 more)	Single nucleotide variant (missense variant)	RASopathy +7 more	GConflicting classifications of pathogenicity
Select item 45367	NM_005633.4(SOS1):c.3709C>A (p.Pro1237Thr)	SOS1 (P1237T +2 more)	Single nucleotide variant (missense variant)	RASopathy	GLikely benign FDA Recognized database
Select item 1200609	NM_005633.4(SOS1):c.3707C>T (p.Pro1236Leu)	SOS1 (P1221L +2 more)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 179112	NM_005633.4(SOS1):c.3706C>A (p.Pro1236Thr)	SOS1 (P1236T +2 more)	Single nucleotide variant (missense variant)	Noonan syndrome 4 +4 more	GConflicting classifications of pathogenicity
Select item 1309697	NM_005633.4(SOS1):c.3703C>A (p.Pro1235Thr)	SOS1 (P1220T +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 280523	NM_005633.4(SOS1):c.3697C>A (p.Leu1233Ile)	SOS1 (L1233I +2 more)	Single nucleotide variant (missense variant)	Fibromatosis, gingival, 1 +3 more	GUncertain significance
Select item 1938858	NM_005633.4(SOS1):c.3671A>T (p.Asp1224Val)	SOS1 (D1209V +2 more)	Single nucleotide variant (missense variant)	RASopathy +1 more	GUncertain significance
Select item 1800617	NM_005633.4(SOS1):c.3656C>G (p.Pro1219Arg)	SOS1 (P1204R +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 426930	NM_005633.4(SOS1):c.3649C>T (p.Arg1217Ter)	SOS1 (R1217* +2 more)	Single nucleotide variant (nonsense)	not provided	GUncertain significance
Select item 3371512	NM_005633.4(SOS1):c.3629G>A (p.Ser1210Asn)	SOS1 (S1195N +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 181533	NM_005633.4(SOS1):c.3620C>G (p.Pro1207Arg)	SOS1 (P1207R +2 more)	Single nucleotide variant (missense variant)	not specified	GLikely benign
Select item 561742	NM_005633.4(SOS1):c.3601C>T (p.Arg1201Trp)	SOS1 (R1201W +2 more)	Single nucleotide variant (missense variant)	not specified +3 more	GConflicting classifications of pathogenicity
Select item 40733	NM_005633.4(SOS1):c.3600C>G (p.Asp1200Glu)	SOS1 (D1200E +2 more)	Single nucleotide variant (missense variant)	Noonan syndrome and Noonan-related syndrome	GLikely benign FDA Recognized database
Select item 139229	NM_005633.4(SOS1):c.3585A>G (p.Arg1195=)	SOS1	Single nucleotide variant (synonymous variant)	Fibromatosis, gingival, 1 +4 more	GConflicting classifications of pathogenicity
Select item 3365845	NM_005633.4(SOS1):c.3571G>C (p.Ala1191Pro)	SOS1 (A1176P +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 448939	NM_005633.4(SOS1):c.3552T>G (p.Pro1184=)	SOS1	Single nucleotide variant (synonymous variant)	RASopathy	GBenign FDA Recognized database
Select item 848887	NM_005633.4(SOS1):c.3534T>A (p.Ser1178Arg)	SOS1 (S1178R +2 more)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 1310153	NM_005633.4(SOS1):c.3533G>C (p.Ser1178Thr)	SOS1 (S1163T +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 450090	NM_005633.4(SOS1):c.3532A>G (p.Ser1178Gly)	SOS1 (S1178G +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 181555	NM_005633.4(SOS1):c.3531C>A (p.Asp1177Glu)	SOS1 (D1177E +2 more)	Single nucleotide variant (missense variant)	RASopathy +3 more	GUncertain significance
Select item 40732	NM_005633.4(SOS1):c.3524A>C (p.His1175Pro)	SOS1 (H1175P +2 more)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 418501	NM_005633.4(SOS1):c.3511-14_3511-10del	SOS1	Deletion (intron variant)	RASopathy +1 more	GConflicting classifications of pathogenicity
Select item 561798	NM_005633.4(SOS1):c.3511-18A>T	SOS1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1217557	NM_005633.4(SOS1):c.3511-133A>G	SOS1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1272670	NM_005633.4(SOS1):c.3511-274G>A	SOS1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1294228	NM_005633.4(SOS1):c.3510+7T>C	SOS1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1309566	NM_005633.4(SOS1):c.3508A>C (p.Lys1170Gln)	SOS1 (K1155Q +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 3368570	NM_005633.4(SOS1):c.3491C>A (p.Ala1164Glu)	SOS1 (A1149E +2 more)	Single nucleotide variant (missense variant)	not provided	GUncertain significance
Select item 1731751	NM_005633.4(SOS1):c.3472C>T (p.Arg1158Ter)	SOS1 (R1158* +2 more)	Single nucleotide variant (nonsense)	RASopathy +2 more	GUncertain significance
Select item 1329530	NM_005633.4(SOS1):c.3451C>T (p.Pro1151Ser)	SOS1 (P1136S +2 more)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 40729	NM_005633.4(SOS1):c.3418T>A (p.Leu1140Ile)	SOS1 (L1140I +2 more)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 1691169	NM_005633.4(SOS1):c.3413T>A (p.Ile1138Lys)	SOS1 (I1123K +2 more)	Single nucleotide variant (missense variant)	RASopathy +1 more	GUncertain significance
Select item 181544	NM_005633.4(SOS1):c.3412A>G (p.Ile1138Val)	SOS1 (I1138V +2 more)	Single nucleotide variant (missense variant)	Fibromatosis, gingival, 1 +5 more	GConflicting classifications of pathogenicity
Select item 40728	NM_005633.4(SOS1):c.3392G>A (p.Arg1131Lys)	SOS1 (R1131K +2 more)	Single nucleotide variant (missense variant)	Noonan syndrome 4 +5 more	GUncertain significance
Select item 1291489	NM_005633.4(SOS1):c.3392-89T>G	SOS1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 45362	NM_005633.4(SOS1):c.3391+7A>G	SOS1	Single nucleotide variant (intron variant)	RASopathy	GBenign FDA Recognized database
Select item 633001	NM_005633.4(SOS1):c.3391+3_3391+6del	SOS1	Deletion (splice donor variant +1 more)	Cardiovascular phenotype +5 more	GUncertain significance
Select item 633430	NM_005633.4(SOS1):c.3391+3T>C	SOS1	Single nucleotide variant (intron variant)	not specified +3 more	GConflicting classifications of pathogenicity
Select item 561458	NM_005633.4(SOS1):c.3384T>C (p.His1128=)	SOS1	Single nucleotide variant (synonymous variant +1 more)	Fibromatosis, gingival, 1 +4 more	GLikely benign
Select item 1691146	NM_005633.4(SOS1):c.3382C>T (p.His1128Tyr)	SOS1 (H1121Y +1 more)	Single nucleotide variant (missense variant +1 more)	RASopathy +2 more	GConflicting classifications of pathogenicity
Select item 45360	NM_005633.4(SOS1):c.3357C>T (p.Thr1119=)	SOS1	Single nucleotide variant (synonymous variant +1 more)	Noonan syndrome 4 +5 more	GBenign/Likely benign
Select item 280899	NM_005633.4(SOS1):c.3350A>G (p.Asn1117Ser)	SOS1 (N1117S +1 more)	Single nucleotide variant (missense variant +1 more)	Cardiovascular phenotype +2 more	GBenign/Likely benign
Select item 40726	NM_005633.4(SOS1):c.3347-1G>A	SOS1	Single nucleotide variant (splice acceptor variant +1 more)	not specified +7 more	GUncertain significance
Select item 336017	NM_005633.4(SOS1):c.3347-3C>T	SOS1	Single nucleotide variant (intron variant)	Cardiovascular phenotype +4 more	GConflicting classifications of pathogenicity
Select item 1211305	NM_005633.4(SOS1):c.3347-103A>G	SOS1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 561358	NM_005633.4(SOS1):c.3347-243del	SOS1	Deletion (intron variant)	not provided	GBenign
Select item 561828	NM_005633.4(SOS1):c.3347-318A>G	SOS1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1208752	NM_005633.4(SOS1):c.3346+261T>G	SOS1	Single nucleotide variant (intron variant)	not provided	GLikely benign
Select item 1215160	NM_005633.4(SOS1):c.3346+134_3346+136del	SOS1	Microsatellite (intron variant)	not provided	GLikely benign
Select item 1267610	NM_005633.4(SOS1):c.3346+32A>G	SOS1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1248260	NM_005633.4(SOS1):c.3346+13A>G	SOS1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 448940	NM_005633.4(SOS1):c.3330G>C (p.Ser1110=)	SOS1	Single nucleotide variant (synonymous variant)	RASopathy	GLikely benign FDA Recognized database
Select item 372623	NM_005633.4(SOS1):c.3329C>T (p.Ser1110Leu)	SOS1 (S1110L +1 more)	Single nucleotide variant (missense variant)	RASopathy +2 more	GConflicting classifications of pathogenicity
Select item 181543	NM_005633.4(SOS1):c.3329C>G (p.Ser1110Trp)	SOS1 (S1110W +1 more)	Single nucleotide variant (missense variant)	RASopathy +4 more	GConflicting classifications of pathogenicity

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