"GeneDx"[submitter] AND "RAD51C"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 151500	GRCh38/hg38 17q22-23.1(chr17:57418806-59735464)x1	C17orf47, CCDC182 +168 more	Copy number loss	See cases	GPathogenic
Select item 1217059	NC_000017.11:g.58692375C>T	LOC130061309, RAD51C	Single nucleotide variant (genic upstream transcript variant)	not provided	GLikely benign
Select item 1250767	NC_000017.11:g.58692526G>A	RAD51C	Single nucleotide variant (genic upstream transcript variant)	not provided	GBenign
Select item 386066	NM_058216.2(RAD51C):c.-49C>G	RAD51C	Single nucleotide variant (non-coding transcript variant)	not specified	GLikely benign
Select item 379465	NM_058216.2(RAD51C):c.-48G>T	RAD51C	Single nucleotide variant (non-coding transcript variant)	not specified	GBenign
Select item 1292622	NM_058216.3(RAD51C):c.-41T>C	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	not provided	GBenign
Select item 378456	NM_058216.3(RAD51C):c.-41T>A	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	not specified	GLikely benign
Select item 378457	NM_058216.3(RAD51C):c.-39C>G	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	not specified	GLikely benign
Select item 384535	NM_058216.3(RAD51C):c.-36A>G	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	not specified	GLikely benign
Select item 422269	NM_058216.3(RAD51C):c.-35del	RAD51C	Deletion (5 prime UTR variant +1 more)	not specified	GLikely benign
Select item 379144	NM_058216.3(RAD51C):c.-29C>T	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	not specified	GLikely benign
Select item 385254	NM_058216.3(RAD51C):c.-28T>G	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	not specified	GLikely benign
Select item 324173	NM_058216.3(RAD51C):c.-26C>T	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	Fanconi anemia +2 more	GBenign/Likely benign
Select item 511163	NM_058216.3(RAD51C):c.-24C>T	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	not specified	GLikely benign
Select item 387037	NM_058216.3(RAD51C):c.-24C>G	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	not specified	GLikely benign
Select item 386941	NM_058216.3(RAD51C):c.-24C>A	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	not specified	GLikely benign
Select item 388066	NM_058216.3(RAD51C):c.-22G>C	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	not specified	GLikely benign
Select item 492355	NM_058216.3(RAD51C):c.-19G>T	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 378458	NM_058216.3(RAD51C):c.-19G>A	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 492352	NM_058216.3(RAD51C):c.-13A>G	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GBenign/Likely benign
Select item 378459	NM_058216.3(RAD51C):c.-8A>G	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	not specified +2 more	GLikely benign
Select item 382213	NM_058216.3(RAD51C):c.-7G>A	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 230283	NM_058216.3(RAD51C):c.-5C>T	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	not provided +1 more	GUncertain significance
Select item 492358	NM_058216.3(RAD51C):c.-4T>A	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 230827	NM_058216.3(RAD51C):c.-2C>T	RAD51C	Single nucleotide variant (5 prime UTR variant +1 more)	not provided +2 more	GUncertain significance
Select item 230796	NM_058216.3(RAD51C):c.3G>A (p.Met1Ile)	RAD51C (M1I)	Single nucleotide variant (missense variant +2 more)	Fanconi anemia complementation group O +2 more	GUncertain significance
Select item 216798	NM_058216.3(RAD51C):c.3G>T (p.Met1Ile)	RAD51C (M1I)	Single nucleotide variant (missense variant +2 more)	Breast-ovarian cancer, familial, susceptibility to, 3 +3 more	GUncertain significance
Select item 184411	NM_058216.3(RAD51C):c.7G>A (p.Gly3Arg)	RAD51C (G3R)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 186623	NM_058216.3(RAD51C):c.9G>C (p.Gly3=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GLikely benign
Select item 128203	NM_058216.3(RAD51C):c.14C>T (p.Thr5Met)	RAD51C (T5M)	Single nucleotide variant (missense variant +1 more)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 409849	NM_058216.3(RAD51C):c.17T>A (p.Phe6Tyr)	RAD51C (F6Y)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 566354	NM_058216.3(RAD51C):c.18C>A (p.Phe6Leu)	RAD51C (F6L)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O +2 more	GUncertain significance
Select item 538779	NM_058216.3(RAD51C):c.19C>A (p.Arg7Ser)	RAD51C (R7S)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O +2 more	GConflicting classifications of pathogenicity
Select item 817095	NM_058216.3(RAD51C):c.28del (p.Met10fs)	RAD51C (M10fs)	Deletion (frameshift variant +1 more)	not provided	GLikely pathogenic
Select item 182841	NM_058216.3(RAD51C):c.29T>G (p.Met10Arg)	RAD51C (M10R)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GUncertain significance
Select item 182842	NM_058216.3(RAD51C):c.32A>G (p.Gln11Arg)	RAD51C (Q11R)	Single nucleotide variant (missense variant +1 more)	Hereditary breast ovarian cancer syndrome +3 more	GConflicting classifications of pathogenicity
Select item 409837	NM_058216.3(RAD51C):c.34C>T (p.Arg12Trp)	RAD51C (R12W)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GUncertain significance
Select item 1044672	NM_058216.3(RAD51C):c.46A>G (p.Ser16Gly)	RAD51C (S16G)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O +2 more	GUncertain significance
Select item 632964	NM_058216.3(RAD51C):c.50T>C (p.Phe17Ser)	RAD51C (F17S)	Single nucleotide variant (missense variant +1 more)	not specified +3 more	GUncertain significance
Select item 232581	NM_058216.3(RAD51C):c.52C>T (p.Pro18Ser)	RAD51C (P18S)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 514630	NM_058216.3(RAD51C):c.55C>T (p.Leu19=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 422986	NM_058216.3(RAD51C):c.55C>A (p.Leu19Met)	RAD51C (L19M)	Single nucleotide variant (missense variant +1 more)	not provided	GUncertain significance
Select item 538775	NM_058216.3(RAD51C):c.59C>T (p.Ser20Phe)	RAD51C (S20F)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 142510	NM_058216.3(RAD51C):c.62C>T (p.Pro21Leu)	RAD51C (P21L)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O +2 more	GUncertain significance
Select item 480517	NM_058216.3(RAD51C):c.66G>C (p.Ala22=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	not specified +2 more	GLikely benign
Select item 233868	NM_058216.3(RAD51C):c.66G>A (p.Ala22=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Fanconi anemia complementation group O +2 more	GLikely benign
Select item 421982	NM_058216.3(RAD51C):c.71G>T (p.Arg24Leu)	RAD51C (R24L)	Single nucleotide variant (missense variant +1 more)	not provided +1 more	GUncertain significance
Select item 229691	NM_058216.3(RAD51C):c.71G>A (p.Arg24Gln)	RAD51C (R24Q)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 1303346	NM_058216.3(RAD51C):c.73G>C (p.Val25Leu)	RAD51C (V25L)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O +2 more	GUncertain significance
Select item 835764	NM_058216.3(RAD51C):c.73G>T (p.Val25Leu)	RAD51C (V25L)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O +2 more	GUncertain significance
Select item 184900	NM_058216.3(RAD51C):c.79C>T (p.Leu27=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3 +4 more	GLikely benign
Select item 140837	NM_058216.3(RAD51C):c.80T>C (p.Leu27Pro)	RAD51C (L27P)	Single nucleotide variant (missense variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3 +3 more	GUncertain significance
Select item 232301	NM_058216.3(RAD51C):c.86C>T (p.Ser29Phe)	RAD51C (S29F)	Single nucleotide variant (missense variant +1 more)	not specified +4 more	GUncertain significance
Select item 186825	NM_058216.3(RAD51C):c.87T>C (p.Ser29=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 480944	NM_058216.3(RAD51C):c.89C>T (p.Ala30Val)	RAD51C (A30V)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 182847	NM_058216.3(RAD51C):c.93del (p.Phe32fs)	RAD51C (F32fs)	Deletion (frameshift variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3 +5 more	GPathogenic
Select item 140913	NM_058216.3(RAD51C):c.90G>A (p.Ala30=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Fanconi anemia complementation group O +5 more	GBenign
Select item 389267	NM_058216.3(RAD51C):c.93G>A (p.Gly31=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Fanconi anemia complementation group O +1 more	GLikely benign
Select item 142534	NM_058216.3(RAD51C):c.97C>T (p.Gln33Ter)	RAD51C (Q33*)	Single nucleotide variant (nonsense +1 more)	Hereditary breast ovarian cancer syndrome +4 more	GPathogenic
Select item 390710	NM_058216.3(RAD51C):c.102T>G (p.Thr34=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GLikely benign
Select item 471430	NM_058216.3(RAD51C):c.104C>G (p.Ala35Gly)	RAD51C (A35G)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 216803	NM_058216.3(RAD51C):c.106G>A (p.Glu36Lys)	RAD51C (E36K)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O +4 more	GConflicting classifications of pathogenicity
Select item 419845	NM_058216.3(RAD51C):c.109G>C (p.Glu37Gln)	RAD51C (E37Q)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 538768	NM_058216.3(RAD51C):c.113T>C (p.Leu38Pro)	RAD51C (L38P)	Single nucleotide variant (missense variant +1 more)	not provided +1 more	GUncertain significance
Select item 1182923	NM_058216.3(RAD51C):c.115C>A (p.Leu39Ile)	RAD51C (L39I)	Single nucleotide variant (missense variant +1 more)	not provided	GUncertain significance
Select item 185535	NM_058216.3(RAD51C):c.115C>G (p.Leu39Val)	RAD51C (L39V)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GUncertain significance
Select item 188123	NM_058216.3(RAD51C):c.118G>A (p.Glu40Lys)	RAD51C (E40K)	Single nucleotide variant (missense variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3 +3 more	GUncertain significance
Select item 492361	NM_058216.3(RAD51C):c.121G>A (p.Val41Met)	RAD51C (V41M)	Single nucleotide variant (missense variant +1 more)	not specified +4 more	GConflicting classifications of pathogenicity
Select item 246163	NM_058216.3(RAD51C):c.121G>C (p.Val41Leu)	RAD51C (V41L)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 140940	NM_058216.3(RAD51C):c.134A>G (p.Glu45Gly)	RAD51C (E45G)	Single nucleotide variant (missense variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3 +6 more	GConflicting classifications of pathogenicity
Select item 246164	NM_058216.3(RAD51C):c.135G>C (p.Glu45Asp)	RAD51C (E45D)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 185138	NM_058216.3(RAD51C):c.141C>T (p.Ser47=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	not provided +4 more	GBenign/Likely benign
Select item 423572	NM_058216.3(RAD51C):c.145G>A (p.Glu49Lys)	RAD51C (E49K)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O +1 more	GUncertain significance
Select item 233766	NM_058216.3(RAD51C):c.145+1G>T	RAD51C	Single nucleotide variant (splice donor variant)	not provided +3 more	GPathogenic/Likely pathogenic
Select item 138870	NM_058216.3(RAD51C):c.145+12T>G	LOC130061310, RAD51C	Single nucleotide variant (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 3 +4 more	GConflicting classifications of pathogenicity
Select item 517907	NM_058216.3(RAD51C):c.145+17G>T	LOC130061310, RAD51C	Single nucleotide variant (intron variant)	not specified +1 more	GLikely benign
Select item 421274	NM_058216.3(RAD51C):c.146-17del	RAD51C	Deletion (intron variant)	not specified	GLikely benign
Select item 136156	NM_058216.3(RAD51C):c.146-8A>G	RAD51C	Single nucleotide variant (intron variant)	Hereditary breast ovarian cancer syndrome +6 more	GConflicting classifications of pathogenicity
Select item 939186	NM_058216.3(RAD51C):c.146-7C>G	RAD51C	Single nucleotide variant (intron variant)	not provided +3 more	GUncertain significance
Select item 449772	NM_058216.3(RAD51C):c.146-1G>A	RAD51C	Single nucleotide variant (splice acceptor variant)	not provided	GLikely pathogenic
Select item 182830	NM_058216.3(RAD51C):c.154A>C (p.Ile52Leu)	RAD51C (I52L)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 231616	NM_058216.3(RAD51C):c.158C>G (p.Ser53Cys)	RAD51C (S53C)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 482160	NM_058216.3(RAD51C):c.163G>A (p.Ala55Thr)	RAD51C (A55T)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O +3 more	GUncertain significance
Select item 182831	NM_058216.3(RAD51C):c.164C>T (p.Ala55Val)	RAD51C (A55V)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 187716	NM_058216.3(RAD51C):c.181_182del (p.Leu61fs)	RAD51C (L61fs)	Microsatellite (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome +4 more	GPathogenic
Select item 141999	NM_058216.3(RAD51C):c.186_187del (p.Gln62fs)	RAD51C (Q62fs)	Deletion (frameshift variant +1 more)	Fanconi anemia complementation group O +3 more	GPathogenic
Select item 439294	NM_058216.3(RAD51C):c.186A>C (p.Gln62His)	RAD51C (Q62H)	Single nucleotide variant (non-coding transcript variant +1 more)	not provided +3 more	GUncertain significance
Select item 138869	NM_058216.3(RAD51C):c.186A>G (p.Gln62=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3 +5 more	GBenign/Likely benign
Select item 182825	NM_058216.3(RAD51C):c.189T>C (p.Ile63=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	not specified +2 more	GBenign/Likely benign
Select item 486272	NM_058216.3(RAD51C):c.190A>G (p.Ile64Val)	RAD51C (I64V)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 482168	NM_058216.3(RAD51C):c.190A>T (p.Ile64Phe)	RAD51C (I64F)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 480514	NM_058216.3(RAD51C):c.193A>G (p.Arg65Gly)	RAD51C (R65G)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 1196279	NM_058216.3(RAD51C):c.194G>C (p.Arg65Thr)	RAD51C (R65T)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 136157	NM_058216.3(RAD51C):c.195A>G (p.Arg65=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Fanconi anemia +7 more	GBenign/Likely benign
Select item 182832	NM_058216.3(RAD51C):c.200A>G (p.Glu67Gly)	RAD51C (E67G)	Single nucleotide variant (missense variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3 +4 more	GUncertain significance
Select item 538783	NM_058216.3(RAD51C):c.206T>C (p.Leu69Pro)	RAD51C (L69P)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 389916	NM_058216.3(RAD51C):c.207C>T (p.Leu69=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Fanconi anemia complementation group O +2 more	GLikely benign
Select item 232705	NM_058216.3(RAD51C):c.211A>T (p.Asn71Tyr)	RAD51C (N71Y)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GUncertain significance
Select item 182844	NM_058216.3(RAD51C):c.224dup (p.Tyr75Ter)	RAD51C (Y75*)	Duplication (nonsense +1 more)	Hereditary breast ovarian cancer syndrome +4 more	GPathogenic
Select item 422429	NM_058216.3(RAD51C):c.225del (p.Arg74_Tyr75insTer)	RAD51C	Deletion (nonsense +1 more)	not provided +1 more	GPathogenic

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