"GeneDx"[submitter] AND "MLH3"[gene] - ClinVar

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Items: 35

	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 57808	GRCh38/hg38 14q24.3(chr14:73877072-78042422)x1	ABCD4, ACYP1 +227 more	Copy number loss	See cases	GPathogenic
Select item 314342	NM_014239.4(EIF2B2):c.*180G>C	EIF2B2, MLH3	Single nucleotide variant (3 prime UTR variant)	Lynch syndrome +2 more	GBenign/Likely benign
Select item 314345	NM_001040108.2(MLH3):c.*3148A>G	EIF2B2, MLH3	Single nucleotide variant (3 prime UTR variant)	Lynch syndrome +3 more	GBenign/Likely benign
Select item 257253	NM_001040108.2(MLH3):c.4335A>G (p.Gln1445=)	MLH3	Single nucleotide variant (synonymous variant)	not specified +2 more	GBenign
Select item 1235513	NM_001040108.2(MLH3):c.4243-153A>G	MLH3	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1292362	NM_001040108.2(MLH3):c.4242+126C>T	MLH3	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1292361	NM_001040108.2(MLH3):c.4242+43T>C	MLH3	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1269792	NM_001040108.2(MLH3):c.4090+71A>G	MLH3	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1242252	NM_001040108.2(MLH3):c.4012-37G>A	MLH3	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1269616	NM_001040108.2(MLH3):c.3987+116G>T	MLH3	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 314372	NM_001040108.2(MLH3):c.3987+7C>A	MLH3	Single nucleotide variant (intron variant)	not provided +2 more	GBenign/Likely benign
Select item 1292358	NM_001040108.2(MLH3):c.3643+35C>G	MLH3	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1292356	NM_001040108.2(MLH3):c.3643+27T>C	MLH3	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1292478	NM_001040108.2(MLH3):c.3570+124GT[12]	MLH3	Microsatellite (intron variant)	not provided	GBenign
Select item 1242959	NM_001040108.2(MLH3):c.3570+124GT[13]	MLH3	Microsatellite (intron variant)	not provided	GBenign
Select item 1266691	NM_001040108.2(MLH3):c.3570+29AT[21]	MLH3	Microsatellite (intron variant)	not provided	GBenign
Select item 1242130	NM_001040108.2(MLH3):c.3570+29AT[22]	MLH3	Microsatellite (intron variant)	not provided	GBenign
Select item 1292357	NM_001040108.2(MLH3):c.3570+29AT[10]	MLH3	Microsatellite (intron variant)	not provided +1 more	GBenign/Likely benign
Select item 1260308	NM_001040108.2(MLH3):c.3466-157C>T	MLH3	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1283678	NM_001040108.2(MLH3):c.3466-186_3466-174del	MLH3	Deletion (intron variant)	not provided	GBenign
Select item 1268207	NM_001040108.2(MLH3):c.3465+38CTT[4]	MLH3	Microsatellite (intron variant)	not provided +1 more	GBenign
Select item 1230414	NM_001040108.2(MLH3):c.3465+37del	MLH3	Deletion (intron variant)	not provided +1 more	GBenign
Select item 1258149	NM_001040108.2(MLH3):c.3379+38A>G	MLH3	Single nucleotide variant (intron variant)	not specified +1 more	GBenign
Select item 1291857	NM_001040108.2(MLH3):c.3280+165G>A	MLH3	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 1230854	NM_001040108.2(MLH3):c.3280+99_3280+102del	MLH3	Deletion (intron variant)	not provided	GBenign
Select item 314382	NM_001040108.2(MLH3):c.2825C>T (p.Thr942Ile)	MLH3 (T942I)	Single nucleotide variant (missense variant)	not specified +2 more	GBenign/Likely benign
Select item 419010	NM_001040108.2(MLH3):c.2793_2794del (p.Asn932fs)	MLH3 (N932fs)	Microsatellite (frameshift variant)	not specified +2 more	GUncertain significance
Select item 257252	NM_001040108.2(MLH3):c.2531C>T (p.Pro844Leu)	MLH3 (P844L)	Single nucleotide variant (missense variant)	not specified +2 more	GBenign
Select item 257251	NM_001040108.2(MLH3):c.2476A>G (p.Asn826Asp)	MLH3 (N826D)	Single nucleotide variant (missense variant)	not provided +2 more	GBenign
Select item 314383	NM_001040108.2(MLH3):c.2390G>A (p.Arg797His)	MLH3 (R797H)	Single nucleotide variant (missense variant)	Colorectal cancer, hereditary nonpolyposis, type 7 +2 more	GBenign
Select item 314386	NM_001040108.2(MLH3):c.2159A>G (p.Tyr720Cys)	MLH3 (Y720C)	Single nucleotide variant (missense variant)	Colorectal cancer, hereditary nonpolyposis, type 7 +2 more	GBenign/Likely benign
Select item 424101	NM_001040108.2(MLH3):c.2126T>C (p.Ile709Thr)	MLH3 (I709T)	Single nucleotide variant (missense variant)	not specified +2 more	GUncertain significance
Select item 221151	NM_001040108.2(MLH3):c.444G>C (p.Val148=)	MLH3	Single nucleotide variant (synonymous variant)	not specified +2 more	GBenign
Select item 314401	NM_001040108.1(MLH3):c.-204G>A	MLH3	Single nucleotide variant	Colorectal cancer, hereditary nonpolyposis, type 7 +1 more	GBenign/Likely benign
Select item 1242614	NC_000014.9:g.75051627G>A	MLH3	Single nucleotide variant	not provided	GBenign

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Items: 35