"GeneDx"[submitter] AND "MET"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 59715	GRCh38/hg38 7q31.2(chr7:115042242-116687714)x3	CAV1, CAV2 +48 more	Copy number gain	See cases	GPathogenic
Select item 152912	GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3	AASS, ABCB8 +1547 more	Copy number gain	See cases	GPathogenic
Select item 1166750	NM_000245.4(MET):c.-207C>G	COMETT, MET	Single nucleotide variant (5 prime UTR variant)	Renal cell carcinoma +1 more	GBenign
Select item 1213443	NM_000245.4(MET):c.-81G>T	COMETT, MET	Single nucleotide variant (5 prime UTR variant)	not provided	GLikely benign
Select item 676958	NM_000245.4(MET):c.-15+237del	COMETT, MET	Deletion (intron variant)	not provided	GLikely benign
Select item 381955	NM_000245.4(MET):c.-14-13C>T	MET	Single nucleotide variant (intron variant)	Papillary renal cell carcinoma type 1 +2 more	GBenign
Select item 167291	NM_000245.4(MET):c.-14-4G>A	MET	Single nucleotide variant (intron variant)	not specified +2 more	GBenign/Likely benign
Select item 1320705	NM_000245.4(MET):c.-3A>T	MET	Single nucleotide variant (5 prime UTR variant +1 more)	not provided +1 more	GUncertain significance
Select item 819874	NM_000245.4(MET):c.16G>T (p.Val6Leu)	MET (V6L)	Single nucleotide variant (missense variant +1 more)	not provided +4 more	GUncertain significance
Select item 1367128	NM_000245.4(MET):c.34C>T (p.Leu12Phe)	MET (L12F)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 411901	NM_000245.4(MET):c.37G>A (p.Val13Met)	MET (V13M)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +2 more	GConflicting classifications of pathogenicity
Select item 188112	NM_000245.4(MET):c.40C>T (p.Leu14Phe)	MET (L14F)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 1712672	NM_000245.4(MET):c.55G>C (p.Val19Leu)	MET (V19L)	Single nucleotide variant (missense variant +1 more)	not provided +1 more	GUncertain significance
Select item 1692567	NM_000245.4(MET):c.62G>A (p.Arg21Lys)	MET (R21K)	Single nucleotide variant (missense variant +1 more)	Autosomal recessive nonsyndromic hearing loss 97 +3 more	GConflicting classifications of pathogenicity
Select item 135974	NM_000245.4(MET):c.65G>T (p.Ser22Ile)	MET (S22I)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +3 more	GConflicting classifications of pathogenicity
Select item 134649	NM_000245.4(MET):c.71G>A (p.Gly24Glu)	MET (G24E)	Single nucleotide variant (missense variant +1 more)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 577544	NM_000245.4(MET):c.80A>G (p.Lys27Arg)	MET (K27R)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 485740	NM_000245.4(MET):c.99C>T (p.Ser33=)	MET	Single nucleotide variant (synonymous variant +1 more)	not provided +2 more	GLikely benign
Select item 411897	NM_000245.4(MET):c.100G>A (p.Glu34Lys)	MET (E34K)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +4 more	GConflicting classifications of pathogenicity
Select item 134646	NM_000245.4(MET):c.103A>T (p.Met35Leu)	MET (M35L)	Single nucleotide variant (missense variant +1 more)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 485736	NM_000245.4(MET):c.105G>C (p.Met35Ile)	MET (M35I)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +3 more	GConflicting classifications of pathogenicity
Select item 1318641	NM_000245.4(MET):c.107A>G (p.Asn36Ser)	MET (N36S)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 41610	NM_000245.4(MET):c.110T>C (p.Val37Ala)	MET (V37A)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer +4 more	GBenign/Likely benign
Select item 818558	NM_000245.4(MET):c.119A>T (p.Lys40Met)	MET (K40M)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 454188	NM_000245.4(MET):c.142G>A (p.Ala48Thr)	MET (A48T)	Single nucleotide variant (missense variant +1 more)	Autosomal recessive nonsyndromic hearing loss 97 +6 more	GConflicting classifications of pathogenicity
Select item 524907	NM_000245.4(MET):c.143C>T (p.Ala48Val)	MET (A48V)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +2 more	GConflicting classifications of pathogenicity
Select item 93567	NM_000245.4(MET):c.144G>A (p.Ala48=)	MET	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +4 more	GBenign
Select item 819297	NM_000245.4(MET):c.146A>C (p.Glu49Ala)	MET (E49A)	Single nucleotide variant (missense variant +1 more)	Autosomal recessive nonsyndromic hearing loss 97 +3 more	GConflicting classifications of pathogenicity
Select item 184359	NM_000245.4(MET):c.146A>G (p.Glu49Gly)	MET (E49G)	Single nucleotide variant (missense variant +1 more)	Autosomal recessive nonsyndromic hearing loss 97 +4 more	GConflicting classifications of pathogenicity
Select item 661993	NM_000245.4(MET):c.173A>G (p.His58Arg)	MET (H58R)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 1695482	NM_000245.4(MET):c.175G>A (p.Glu59Lys)	MET (E59K)	Single nucleotide variant (missense variant +1 more)	not provided	GUncertain significance
Select item 454198	NM_000245.4(MET):c.180T>A (p.His60Gln)	MET (H60Q)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +2 more	GConflicting classifications of pathogenicity
Select item 1115115	NM_000245.4(MET):c.255G>A (p.Lys85=)	MET	Single nucleotide variant (synonymous variant +1 more)	Renal cell carcinoma +2 more	GLikely benign
Select item 2574777	NM_000245.4(MET):c.259G>T (p.Gly87Trp)	MET (G87W)	Single nucleotide variant (missense variant +1 more)	not provided	GUncertain significance
Select item 821758	NM_000245.4(MET):c.274C>G (p.His92Asp)	MET (H92D)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 581576	NM_000245.4(MET):c.280G>C (p.Asp94His)	MET (D94H)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 454223	NM_000245.4(MET):c.280G>A (p.Asp94Asn)	MET (D94N)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 411883	NM_000245.4(MET):c.280G>T (p.Asp94Tyr)	MET (D94Y)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +2 more	GUncertain significance
Select item 821849	NM_000245.4(MET):c.281A>G (p.Asp94Gly)	MET (D94G)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 93571	NM_000245.4(MET):c.289C>G (p.Pro97Ala)	MET (P97A)	Single nucleotide variant (missense variant +1 more)	Autosomal recessive nonsyndromic hearing loss 97 +4 more	GConflicting classifications of pathogenicity
Select item 1006887	NM_000245.4(MET):c.319T>G (p.Leu107Val)	MET (L107V)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 454240	NM_000245.4(MET):c.341A>T (p.Asp114Val)	MET (D114V)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +5 more	GConflicting classifications of pathogenicity
Select item 246638	NM_000245.4(MET):c.345C>T (p.Asn115=)	MET	Single nucleotide variant (synonymous variant +1 more)	Renal cell carcinoma +2 more	GLikely benign
Select item 524875	NM_000245.4(MET):c.346A>G (p.Ile116Val)	MET (I116V)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +2 more	GUncertain significance
Select item 454242	NM_000245.4(MET):c.356C>T (p.Ala119Val)	MET (A119V)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +3 more	GUncertain significance
Select item 2504797	NM_000245.4(MET):c.361G>A (p.Val121Ile)	MET (V121I)	Single nucleotide variant (missense variant +1 more)	not provided +1 more	GUncertain significance
Select item 824062	NM_000245.4(MET):c.367G>A (p.Asp123Asn)	MET (D123N)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GUncertain significance
Select item 516046	NM_000245.4(MET):c.369C>T (p.Asp123=)	MET	Single nucleotide variant (synonymous variant +1 more)	Renal cell carcinoma +1 more	GLikely benign
Select item 1347908	NM_000245.4(MET):c.381T>A (p.Asp127Glu)	MET (D127E)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +2 more	GUncertain significance
Select item 93573	NM_000245.4(MET):c.390C>T (p.Leu130=)	MET	Single nucleotide variant (synonymous variant +1 more)	not provided +4 more	GBenign
Select item 645035	NM_000245.4(MET):c.400G>A (p.Gly134Ser)	MET (G134S)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 416926	NM_000245.4(MET):c.405C>T (p.Ser135=)	MET	Single nucleotide variant (synonymous variant +1 more)	not provided +2 more	GLikely benign
Select item 142059	NM_000245.4(MET):c.406G>A (p.Val136Ile)	MET (V136I)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +8 more	GConflicting classifications of pathogenicity
Select item 524854	NM_000245.4(MET):c.428G>A (p.Arg143Gln)	MET (R143Q)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +3 more	GUncertain significance
Select item 454252	NM_000245.4(MET):c.433G>A (p.Val145Ile)	MET (V145I)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 1441069	NM_000245.4(MET):c.451A>G (p.Thr151Ala)	MET (T151A)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +2 more	GUncertain significance
Select item 824975	NM_000245.4(MET):c.452C>T (p.Thr151Ile)	MET (T151I)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 135971	NM_000245.4(MET):c.467C>T (p.Ser156Leu)	MET (S156L)	Single nucleotide variant (missense variant +1 more)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 1499687	NM_000245.4(MET):c.472G>T (p.Val158Phe)	MET (V158F)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +2 more	GUncertain significance
Select item 3364678	NM_000245.4(MET):c.490C>T (p.Pro164Ser)	MET (P164S)	Single nucleotide variant (missense variant +1 more)	not provided	GUncertain significance
Select item 2444722	NM_000245.4(MET):c.493C>T (p.Gln165Ter)	MET (Q165*)	Single nucleotide variant (nonsense +1 more)	not provided	GUncertain significance
Select item 411895	NM_000245.4(MET):c.495G>C (p.Gln165His)	MET (Q165H)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +1 more	GUncertain significance
Select item 825340	NM_000245.4(MET):c.497T>G (p.Ile166Arg)	MET (I166R)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 41627	NM_000245.4(MET):c.504G>T (p.Glu168Asp)	MET (E168D)	Single nucleotide variant (missense variant +1 more)	not specified +4 more	GConflicting classifications of pathogenicity
Select item 134647	NM_000245.4(MET):c.510C>G (p.Ser170Arg)	MET (S170R)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 1056543	NM_000245.4(MET):c.527T>C (p.Val176Ala)	MET (V176A)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +2 more	GUncertain significance
Select item 93578	NM_000245.4(MET):c.534C>T (p.Ser178=)	MET	Single nucleotide variant (synonymous variant +1 more)	Autosomal recessive nonsyndromic hearing loss 97 +5 more	GBenign
Select item 844841	NM_000245.4(MET):c.535G>A (p.Ala179Thr)	MET (A179T)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 654224	NM_000245.4(MET):c.538C>G (p.Leu180Val)	MET (L180V)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +2 more	GConflicting classifications of pathogenicity
Select item 853501	NM_000245.4(MET):c.541G>A (p.Gly181Arg)	MET (G181R)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 699840	NM_000245.4(MET):c.546C>A (p.Ala182=)	MET	Single nucleotide variant (synonymous variant +1 more)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 1001112	NM_000245.4(MET):c.554T>A (p.Leu185His)	MET (L185H)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +2 more	GUncertain significance
Select item 246647	NM_000245.4(MET):c.572G>A (p.Arg191Gln)	MET (R191Q)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 186144	NM_000245.4(MET):c.599C>A (p.Thr200Asn)	MET (T200N)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 702358	NM_000245.4(MET):c.600C>G (p.Thr200=)	MET	Single nucleotide variant (synonymous variant +1 more)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 1513000	NM_000245.4(MET):c.608CTT[1] (p.Ser204del)	MET (S204del)	Microsatellite (inframe_deletion +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 41628	NM_000245.4(MET):c.607T>A (p.Ser203Thr)	MET (S203T)	Single nucleotide variant (missense variant +1 more)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 1036075	NM_000245.4(MET):c.610T>C (p.Ser204Pro)	MET (S204P)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +1 more	GUncertain significance
Select item 1320342	NM_000245.4(MET):c.617T>C (p.Phe206Ser)	MET (F206S)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 141889	NM_000245.4(MET):c.623A>G (p.Asp208Gly)	MET (D208G)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 216513	NM_000245.4(MET):c.632T>G (p.Leu211Trp)	MET (L211W)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +4 more	GConflicting classifications of pathogenicity
Select item 416929	NM_000245.4(MET):c.633G>A (p.Leu211=)	MET	Single nucleotide variant (synonymous variant +1 more)	Renal cell carcinoma +2 more	GLikely benign
Select item 485746	NM_000245.4(MET):c.654G>T (p.Arg218Ser)	MET (R218S)	Single nucleotide variant (missense variant +1 more)	Autosomal recessive nonsyndromic hearing loss 97 +3 more	GConflicting classifications of pathogenicity
Select item 93579	NM_000245.4(MET):c.654G>A (p.Arg218=)	MET	Single nucleotide variant (synonymous variant +1 more)	not provided +3 more	GBenign/Likely benign
Select item 216514	NM_000245.4(MET):c.665C>T (p.Thr222Met)	MET (T222M)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 135975	NM_000245.4(MET):c.689C>T (p.Thr230Met)	MET (T230M)	Single nucleotide variant (missense variant +1 more)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 411884	NM_000245.4(MET):c.704T>C (p.Ile235Thr)	MET (I235T)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +3 more	GUncertain significance
Select item 135976	NM_000245.4(MET):c.713T>C (p.Leu238Ser)	MET (L238S)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 826881	NM_000245.4(MET):c.716C>T (p.Pro239Leu)	MET (P239L)	Single nucleotide variant (missense variant +1 more)	Autosomal recessive nonsyndromic hearing loss 97 +3 more	GUncertain significance
Select item 652232	NM_000245.4(MET):c.724A>G (p.Arg242Gly)	MET (R242G)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +2 more	GUncertain significance
Select item 485741	NM_000245.4(MET):c.743A>T (p.Lys248Met)	MET (K248M)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +3 more	GConflicting classifications of pathogenicity
Select item 568449	NM_000245.4(MET):c.762A>C (p.Glu254Asp)	MET (E254D)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +6 more	GConflicting classifications of pathogenicity
Select item 1426999	NM_000245.4(MET):c.774del (p.Phe258fs)	MET (F258fs)	Deletion (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 485747	NM_000245.4(MET):c.788C>T (p.Thr263Met)	MET (T263M)	Single nucleotide variant (missense variant +1 more)	Autosomal recessive nonsyndromic hearing loss 97 +4 more	GUncertain significance
Select item 135977	NM_000245.4(MET):c.789G>A (p.Thr263=)	MET	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GBenign/Likely benign
Select item 219395	NM_000245.4(MET):c.798G>A (p.Arg266=)	MET	Single nucleotide variant (synonymous variant +1 more)	Renal cell carcinoma +2 more	GBenign/Likely benign
Select item 485756	NM_000245.4(MET):c.805C>T (p.Leu269=)	MET	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 411915	NM_000245.4(MET):c.808G>C (p.Asp270His)	MET (D270H)	Single nucleotide variant (missense variant +1 more)	Renal cell carcinoma +3 more	GConflicting classifications of pathogenicity
Select item 827518	NM_000245.4(MET):c.821T>C (p.Phe274Ser)	MET (F274S)	Single nucleotide variant (missense variant +1 more)	Autosomal recessive nonsyndromic hearing loss 97 +3 more	GConflicting classifications of pathogenicity
Select item 485748	NM_000245.4(MET):c.840G>T (p.Arg280Ser)	MET (R280S)	Single nucleotide variant (missense variant +1 more)	Autosomal recessive nonsyndromic hearing loss 97 +3 more	GUncertain significance

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