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Items: 26

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
SMPD1, LOC130005193
(Q19R)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+3 more
GConflicting classifications of pathogenicity
SMPD1
(W32*)
Single nucleotide variant
(nonsense +2 more)
Niemann-Pick disease, type A
+1 more
GPathogenic/Likely pathogenic
SMPD1
Microsatellite
(inframe_deletion +2 more)
not specified
+3 more
GBenign
SMPD1
Single nucleotide variant
(synonymous variant +2 more)
Niemann-Pick disease, type A
+1 more
GLikely benign
SMPD1
(A71T)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type B
+2 more
GUncertain significance
SMPD1
(R81*)
Single nucleotide variant
(nonsense +2 more)
Niemann-Pick disease, type A
+1 more
GPathogenic/Likely pathogenic
SMPD1
(L105P)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+1 more
GPathogenic/Likely pathogenic
SMPD1
(V114M +1 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+5 more
GUncertain significance
SMPD1
(C159R +1 more)
Single nucleotide variant
(missense variant +2 more)
Sphingomyelin/cholesterol lipidosis
+3 more
GPathogenic/Likely pathogenic
SMPD1
(P186L +1 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+3 more
GPathogenic
SMPD1
(G244R +1 more)
Single nucleotide variant
(missense variant +2 more)
not specified
+4 more
GConflicting classifications of pathogenicity
SMPD1
(S250R +1 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type A
+3 more
GPathogenic/Likely pathogenic
SMPD1
(L262fs +1 more)
Deletion
(frameshift variant +2 more)
Niemann-Pick disease, type A
+3 more
GPathogenic
SMPD1
(V274L +1 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type B
+1 more
GUncertain significance
SMPD1
(R291H +1 more)
Single nucleotide variant
(missense variant +2 more)
Inborn genetic diseases
+5 more
GUncertain significance
SMPD1
(L304P +1 more)
Single nucleotide variant
Niemann-Pick disease, type A
+3 more
GPathogenic/Likely pathogenic
SMPD1
(F332fs +2 more)
Deletion
(frameshift variant +1 more)
Niemann-Pick disease, type A
+3 more
GPathogenic
SMPD1
(P332L +2 more)
Single nucleotide variant
(missense variant +1 more)
Niemann-Pick disease, type A
+2 more
GConflicting classifications of pathogenicity
SMPD1
(A21T +2 more)
Single nucleotide variant
(missense variant +1 more)
Niemann-Pick disease, type B
+1 more
GUncertain significance
SMPD1
(E351* +1 more)
Single nucleotide variant
(nonsense +2 more)
not provided
+3 more
GPathogenic/Likely pathogenic
SMPD1
(R443* +3 more)
Single nucleotide variant
(nonsense +1 more)
Sphingomyelin/cholesterol lipidosis
+4 more
GPathogenic
SMPD1
(S179R +3 more)
Single nucleotide variant
(missense variant +1 more)
Niemann-Pick disease, type A
+2 more
GPathogenic/Likely pathogenic
SMPD1
(R498H +4 more)
Single nucleotide variant
(missense variant +1 more)
Abnormality of metabolism/homeostasis
+4 more
GPathogenic/Likely pathogenic
SMPD1
(V559I +3 more)
Single nucleotide variant
(missense variant +2 more)
not provided
+2 more
GConflicting classifications of pathogenicity
SMPD1
(R591C +3 more)
Single nucleotide variant
(missense variant +2 more)
Niemann-Pick disease, type B
+2 more
GUncertain significance
SMPD1
(H304Q +3 more)
Single nucleotide variant
(missense variant +2 more)
not specified
+2 more
GUncertain significance
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