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Items: 71

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
PCSK9
Single nucleotide variant
(5 prime UTR variant)
Hypobetalipoproteinemia
+1 more
GUncertain significance
PCSK9
Single nucleotide variant
(synonymous variant)
Hypercholesterolemia, autosomal dominant, 3
+1 more
GLikely benign
PCSK9
(P12T)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+2 more
GUncertain significance
PCSK9
Microsatellite
(inframe_insertion)
Hypercholesterolemia, autosomal dominant, 3
+2 more
GUncertain significance
PCSK9
(E34K)
Single nucleotide variant
(missense variant)
not provided
+5 more
GUncertain significance
PCSK9
(R46L)
Single nucleotide variant
(missense variant)
not specified
+6 more
GBenign/Likely benign
PCSK9
(E48K)
Single nucleotide variant
(missense variant)
not provided
+3 more
GUncertain significance
PCSK9
(A53G)
Single nucleotide variant
(missense variant)
not specified
+4 more
GUncertain significance
PCSK9
(A53V)
Single nucleotide variant
(missense variant)
not specified
+6 more
GBenign/Likely benign
PCSK9
Single nucleotide variant
(synonymous variant)
Familial hypercholesterolemia
+1 more
GLikely benign
PCSK9
(P56S)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+2 more
GUncertain significance
PCSK9
(C67R)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+1 more
GUncertain significance
PCSK9
(K83E)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+1 more
GUncertain significance
PCSK9
(S89L)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+2 more
GUncertain significance
PCSK9
Single nucleotide variant
(synonymous variant)
Cardiovascular phenotype
+4 more
GBenign/Likely benign
PCSK9
(R105Q)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+4 more
GUncertain significance
PCSK9
(G106V)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+3 more
GUncertain significance
PCSK9
(A134D)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+2 more
GUncertain significance
PCSK9
(P138S)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+1 more
GUncertain significance
PCSK9
(W156*)
Single nucleotide variant
(nonsense)
Hypercholesterolemia, autosomal dominant, 3
GUncertain significance
PCSK9
(W156*)
Single nucleotide variant
(nonsense)
Hypercholesterolemia, autosomal dominant, 3
GUncertain significance
PCSK9
(R160W)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+2 more
GUncertain significance
PCSK9
(R160Q)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+4 more
GUncertain significance
PCSK9
(R165Q)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+3 more
GUncertain significance
PCSK9
(P174S)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+3 more
GUncertain significance
PCSK9
Deletion
(splice acceptor variant)
Familial hypercholesterolemia
+2 more
GUncertain significance
PCSK9
Single nucleotide variant
(intron variant)
Hypercholesterolemia, autosomal dominant, 3
GUncertain significance
PCSK9
(S178N +4 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+1 more
GUncertain significance
PCSK9
(Q219E +4 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+2 more
GUncertain significance
PCSK9
Single nucleotide variant
(splice donor variant)
Hypercholesterolemia, autosomal dominant, 3
+1 more
GUncertain significance
PCSK9
(Q220P)
Single nucleotide variant
(missense variant +1 more)
Hypercholesterolemia, autosomal dominant, 3
+1 more
GUncertain significance
PCSK9
(G236S +5 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+4 more
GUncertain significance
PCSK9
(V241M +5 more)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+1 more
GUncertain significance
PCSK9
(A242T +5 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+2 more
GUncertain significance
PCSK9
(R251H +5 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+1 more
GUncertain significance
PCSK9
(V252M +5 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+1 more
GUncertain significance
PCSK9
(R272W +5 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+1 more
GUncertain significance
PCSK9
Single nucleotide variant
(synonymous variant +1 more)
Cardiovascular phenotype
+2 more
GLikely benign
PCSK9
(R357H +5 more)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+3 more
GUncertain significance
PCSK9
(C375G +5 more)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+1 more
GUncertain significance
PCSK9
(T377N +5 more)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+1 more
GUncertain significance
PCSK9
Single nucleotide variant
(synonymous variant +1 more)
Cardiovascular phenotype
+3 more
GLikely benign
PCSK9
(G394S +5 more)
Single nucleotide variant
(missense variant)
not specified
+5 more
GUncertain significance
PCSK9
(G394V +5 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+2 more
GUncertain significance
PCSK9
(R434Q +5 more)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+1 more
GUncertain significance
PCSK9
(V460M +6 more)
Indel
(missense variant)
Familial hypercholesterolemia
+2 more
GUncertain significance
PCSK9
(T472I +6 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+1 more
GUncertain significance
PCSK9
Single nucleotide variant
(synonymous variant +2 more)
Cardiovascular phenotype
+1 more
GLikely benign
PCSK9
(A475T +6 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+1 more
GLikely benign
PCSK9
(R495W +6 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+1 more
GUncertain significance
PCSK9
(R495L +6 more)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+2 more
GUncertain significance
PCSK9
(R495Q +6 more)
Single nucleotide variant
(missense variant)
not specified
+2 more
GUncertain significance
PCSK9
(R499L +6 more)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+3 more
GUncertain significance
PCSK9
Single nucleotide variant
(synonymous variant +2 more)
Familial hypercholesterolemia
+2 more
GUncertain significance
PCSK9
(N513D +7 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, familial, 1
+4 more
GConflicting classifications of pathogenicity
PCSK9
(G516V +7 more)
Single nucleotide variant
(missense variant)
not specified
+4 more
GUncertain significance
PCSK9
(Q531* +7 more)
Single nucleotide variant
(nonsense)
Familial hypercholesterolemia
+1 more
GConflicting classifications of pathogenicity
PCSK9
Single nucleotide variant
(intron variant)
Familial hypercholesterolemia
+3 more
GBenign/Likely benign
PCSK9
(S564A +8 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+1 more
GUncertain significance
PCSK9
(A598T +8 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+4 more
GConflicting classifications of pathogenicity
PCSK9
Single nucleotide variant
(splice donor variant)
Hypercholesterolemia, autosomal dominant, 3
+2 more
GUncertain significance
PCSK9
(A649T +8 more)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+1 more
GUncertain significance
PCSK9
(C654R +8 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+2 more
GUncertain significance
PCSK9
Single nucleotide variant
(synonymous variant +1 more)
Hypercholesterolemia, autosomal dominant, 3
+3 more
GBenign/Likely benign
PCSK9
(V661I +8 more)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+2 more
GUncertain significance
PCSK9
(T664I +8 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+2 more
GUncertain significance
PCSK9
(S668G +8 more)
Single nucleotide variant
(missense variant)
not provided
+4 more
GUncertain significance
PCSK9
(S668R +8 more)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+2 more
GUncertain significance
PCSK9
(V672M +8 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+2 more
GUncertain significance
PCSK9
(V675fs)
Deletion
(frameshift variant)
Familial hypercholesterolemia
+1 more
GUncertain significance
PCSK9
Single nucleotide variant
(3 prime UTR variant)
Hypobetalipoproteinemia
+1 more
GUncertain significance
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