"Fulgent Genetics, Fulgent Genetics"[submitter] AND "PALB2"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 128144	NM_024675.4(PALB2):c.3549C>A (p.Tyr1183Ter)	PALB2 (Y1183*)	Single nucleotide variant (nonsense)	Familial cancer of breast	GPathogenic FDA Recognized database
Select item 216757	NM_024675.4(PALB2):c.3538A>G (p.Ile1180Val)	PALB2 (I1180V)	Single nucleotide variant (missense variant)	not provided +5 more	GUncertain significance
Select item 232781	NM_024675.4(PALB2):c.3494C>T (p.Ser1165Leu)	PALB2 (S1165L)	Single nucleotide variant (missense variant)	Familial cancer of breast +4 more	GUncertain significance
Select item 187089	NM_024675.4(PALB2):c.3451C>T (p.Leu1151Phe)	PALB2 (L1151F)	Single nucleotide variant (missense variant)	not provided +4 more	GUncertain significance
Select item 415976	NM_024675.4(PALB2):c.3432C>T (p.Leu1144=)	PALB2	Single nucleotide variant (synonymous variant)	not specified +5 more	GLikely benign
Select item 126741	NM_024675.4(PALB2):c.3428T>C (p.Leu1143Pro)	PALB2 (L1143P)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GUncertain significance
Select item 126740	NM_024675.4(PALB2):c.3428T>A (p.Leu1143His)	PALB2 (L1143H)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GConflicting classifications of pathogenicity
Select item 183828	NM_024675.4(PALB2):c.3418T>G (p.Trp1140Gly)	PALB2 (W1140G)	Single nucleotide variant (missense variant)	Familial cancer of breast +4 more	GUncertain significance
Select item 182775	NM_024675.4(PALB2):c.3404G>A (p.Gly1135Glu)	PALB2 (G1135E)	Single nucleotide variant (missense variant)	not provided +5 more	GConflicting classifications of pathogenicity
Select item 185518	NM_024675.4(PALB2):c.3367G>A (p.Val1123Met)	PALB2 (V1123M)	Single nucleotide variant (missense variant)	not provided +4 more	GUncertain significance
Select item 126736	NM_024675.4(PALB2):c.3350+16T>G	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast +3 more	GLikely benign
Select item 219647	NM_024675.4(PALB2):c.3331C>G (p.Pro1111Ala)	PALB2 (P1111A)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +6 more	GUncertain significance
Select item 410196	NM_024675.4(PALB2):c.3325T>C (p.Cys1109Arg)	PALB2 (C1109R)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GUncertain significance
Select item 126734	NM_024675.4(PALB2):c.3323del (p.Tyr1108fs)	PALB2	Deletion (frameshift variant)	Fanconi anemia complementation group N +5 more	GPathogenic
Select item 141974	NM_024675.4(PALB2):c.3307G>C (p.Val1103Leu)	PALB2 (V1103L)	Single nucleotide variant (missense variant)	Breast and/or ovarian cancer +7 more	GConflicting classifications of pathogenicity
Select item 126730	NM_024675.4(PALB2):c.3300T>G (p.Thr1100=)	PALB2	Single nucleotide variant (synonymous variant)	Breast-ovarian cancer, familial, susceptibility to, 5 +7 more	GBenign/Likely benign
Select item 184415	NM_024675.4(PALB2):c.3297G>A (p.Thr1099=)	PALB2	Single nucleotide variant (synonymous variant)	Familial cancer of breast +7 more	GLikely benign
Select item 410162	NM_024675.4(PALB2):c.3296C>T (p.Thr1099Met)	PALB2 (T1099M)	Single nucleotide variant (missense variant)	Familial cancer of breast +5 more	GUncertain significance
Select item 142504	NM_024675.4(PALB2):c.3296C>G (p.Thr1099Arg)	PALB2 (T1099R)	Single nucleotide variant (missense variant)	not provided +5 more	GConflicting classifications of pathogenicity
Select item 126729	NM_024675.4(PALB2):c.3256C>T (p.Arg1086Ter)	PALB2 (R1086*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +9 more	GPathogenic/Likely pathogenic
Select item 126728	NM_024675.4(PALB2):c.3252G>A (p.Ser1084=)	PALB2	Single nucleotide variant (synonymous variant)	Familial cancer of breast +5 more	GBenign/Likely benign
Select item 126727	NM_024675.4(PALB2):c.3251C>T (p.Ser1084Leu)	PALB2 (S1084L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GConflicting classifications of pathogenicity
Select item 216753	NM_024675.4(PALB2):c.3247G>A (p.Glu1083Lys)	PALB2 (E1083K)	Single nucleotide variant (missense variant)	Familial cancer of breast +6 more	GUncertain significance
Select item 186946	NM_024675.4(PALB2):c.3244A>G (p.Ser1082Gly)	PALB2 (S1082G)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GUncertain significance
Select item 230775	NM_024675.4(PALB2):c.3225T>A (p.Ser1075Arg)	PALB2 (S1075R)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GConflicting classifications of pathogenicity
Select item 421293	NM_024675.4(PALB2):c.3220C>G (p.Leu1074Val)	PALB2 (L1074V)	Single nucleotide variant (missense variant)	not provided +4 more	GUncertain significance
Select item 460982	NM_024675.4(PALB2):c.3217G>T (p.Val1073Phe)	PALB2 (V1073F)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GUncertain significance
Select item 216752	NM_024675.4(PALB2):c.3209T>C (p.Leu1070Pro)	PALB2 (L1070P)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GUncertain significance
Select item 233338	NM_024675.4(PALB2):c.3204G>T (p.Gly1068=)	PALB2	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GLikely benign
Select item 371966	NM_024675.4(PALB2):c.3202-1G>A	PALB2	Single nucleotide variant (intron variant +1 more)	not provided +4 more	GPathogenic/Likely pathogenic
Select item 141785	NM_024675.4(PALB2):c.3146T>C (p.Met1049Thr)	PALB2 (M1049T)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +6 more	GConflicting classifications of pathogenicity
Select item 126716	NM_024675.4(PALB2):c.3128G>C (p.Gly1043Ala)	PALB2 (G1043A)	Single nucleotide variant (missense variant)	Familial cancer of breast +5 more	GUncertain significance
Select item 126715	NM_024675.4(PALB2):c.3116del (p.Asn1039fs)	PALB2	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome +6 more	GPathogenic/Likely pathogenic
Select item 188131	NM_024675.4(PALB2):c.3106G>C (p.Val1036Leu)	PALB2 (V1036L)	Single nucleotide variant (missense variant)	Familial cancer of breast +5 more	GUncertain significance
Select item 219857	NM_024675.4(PALB2):c.3103A>T (p.Ile1035Phe)	PALB2 (I1035F)	Single nucleotide variant (missense variant)	Familial cancer of breast +4 more	GUncertain significance
Select item 126707	NM_024675.4(PALB2):c.3048del (p.Phe1016fs)	PALB2 (F1016fs)	Deletion (frameshift variant)	Familial cancer of breast +5 more	GPathogenic/Likely pathogenic
Select item 574028	NM_024675.4(PALB2):c.3037A>G (p.Ile1013Val)	PALB2 (I1013V)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GConflicting classifications of pathogenicity
Select item 419928	NM_024675.4(PALB2):c.3025C>T (p.Pro1009Ser)	PALB2 (P1009S)	Single nucleotide variant (missense variant)	not provided +5 more	GUncertain significance
Select item 126701	NM_024675.4(PALB2):c.2996+17T>C	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast +7 more	GBenign/Likely benign
Select item 126699	NM_024675.4(PALB2):c.2993G>A (p.Gly998Glu)	PALB2 (G998E)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +7 more	GBenign/Likely benign
Select item 186365	NM_024675.4(PALB2):c.2985A>T (p.Ala995=)	PALB2	Single nucleotide variant (synonymous variant)	not provided +4 more	GLikely benign
Select item 232056	NM_024675.4(PALB2):c.2978C>T (p.Thr993Met)	PALB2 (T993M)	Single nucleotide variant (missense variant)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 141560	NM_024675.4(PALB2):c.2964del (p.Gln988_Val989insTer)	PALB2	Deletion (frameshift variant)	not provided +5 more	GPathogenic
Select item 126696	NM_024675.4(PALB2):c.2920_2921del (p.Lys974fs)	PALB2	Deletion (frameshift variant)	not provided +5 more	GPathogenic
Select item 484159	NM_024675.4(PALB2):c.2920A>G (p.Lys974Glu)	PALB2 (K974E)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 128136	NM_024675.4(PALB2):c.2897T>C (p.Ile966Thr)	PALB2 (I966T)	Single nucleotide variant (missense variant)	Familial cancer of breast +6 more	GConflicting classifications of pathogenicity
Select item 188387	NM_024675.4(PALB2):c.2896A>G (p.Ile966Val)	PALB2 (I966V)	Single nucleotide variant (missense variant)	Familial cancer of breast +6 more	GUncertain significance
Select item 186696	NM_024675.4(PALB2):c.2881C>T (p.Leu961=)	PALB2	Single nucleotide variant (synonymous variant)	Familial cancer of breast +5 more	GBenign/Likely benign
Select item 422509	NM_024675.4(PALB2):c.2878del (p.Leu960fs)	PALB2	Deletion (frameshift variant)	Familial cancer of breast +4 more	GPathogenic/Likely pathogenic
Select item 126694	NM_024675.4(PALB2):c.2869A>C (p.Lys957Gln)	PALB2 (K957Q)	Single nucleotide variant (missense variant)	not provided +5 more	GUncertain significance
Select item 530081	NM_024675.4(PALB2):c.2861A>G (p.Glu954Gly)	PALB2 (E954G)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 241553	NM_024675.4(PALB2):c.2840T>C (p.Leu947Ser)	PALB2 (L947S)	Single nucleotide variant (missense variant)	Familial cancer of breast +4 more	GConflicting classifications of pathogenicity
Select item 925492	NM_024675.4(PALB2):c.2834+13C>G	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast +3 more	GLikely benign
Select item 516437	NM_024675.4(PALB2):c.2834+13C>A	PALB2	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +4 more	GLikely benign
Select item 182771	NM_024675.4(PALB2):c.2834+1G>A	PALB2	Single nucleotide variant (splice donor variant)	not provided +5 more	GPathogenic/Likely pathogenic
Select item 143968	NM_024675.4(PALB2):c.2834+1G>T	PALB2	Single nucleotide variant (splice donor variant)	Hereditary cancer-predisposing syndrome +4 more	GPathogenic/Likely pathogenic
Select item 629080	NM_024675.4(PALB2):c.2827G>A (p.Glu943Lys)	PALB2 (E943K)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 460961	NM_024675.4(PALB2):c.2821A>G (p.Ile941Val)	PALB2 (I941V)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 530124	NM_024675.4(PALB2):c.2804C>G (p.Ala935Gly)	PALB2 (A935G)	Single nucleotide variant (missense variant)	not provided +4 more	GUncertain significance
Select item 126682	NM_024675.4(PALB2):c.2794G>A (p.Val932Met)	PALB2 (V932M)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +7 more	GBenign/Likely benign
Select item 641703	NM_024675.4(PALB2):c.2785_2786delinsAT (p.Tyr929Ile)	PALB2 (Y929I)	Indel (missense variant)	Familial cancer of breast +3 more	GUncertain significance
Select item 460959	NM_024675.4(PALB2):c.2784G>A (p.Val928=)	PALB2	Single nucleotide variant (synonymous variant)	Familial cancer of breast +4 more	GLikely benign
Select item 530106	NM_024675.4(PALB2):c.2777C>T (p.Pro926Leu)	PALB2 (P926L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 460958	NM_024675.4(PALB2):c.2774T>C (p.Val925Ala)	PALB2 (V925A)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GUncertain significance
Select item 126681	NM_024675.4(PALB2):c.2773G>C (p.Val925Leu)	PALB2 (V925L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GConflicting classifications of pathogenicity
Select item 410165	NM_024675.4(PALB2):c.2730T>A (p.Tyr910Ter)	PALB2 (Y910*)	Single nucleotide variant (nonsense)	Familial cancer of breast +4 more	GPathogenic/Likely pathogenic
Select item 182742	NM_024675.4(PALB2):c.2727_2728del (p.Thr911fs)	PALB2	Deletion (frameshift variant)	Familial cancer of breast +5 more	GPathogenic/Likely pathogenic
Select item 126675	NM_024675.4(PALB2):c.2718G>A (p.Trp906Ter)	PALB2 (W906*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +5 more	GPathogenic
Select item 182769	NM_024675.4(PALB2):c.2699C>T (p.Ala900Val)	PALB2 (A900V)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 576302	NM_024675.4(PALB2):c.2659A>G (p.Ile887Val)	PALB2 (I887V)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GUncertain significance
Select item 241549	NM_024675.4(PALB2):c.2653C>A (p.Pro885Thr)	PALB2 (P885T)	Single nucleotide variant (missense variant)	not specified +5 more	GUncertain significance
Select item 126670	NM_024675.4(PALB2):c.2612A>G (p.Asp871Gly)	PALB2 (D871G)	Single nucleotide variant (missense variant)	Familial cancer of breast +4 more	GUncertain significance
Select item 126669	NM_024675.4(PALB2):c.2590C>T (p.Pro864Ser)	PALB2 (P864S)	Single nucleotide variant (missense variant)	not specified +7 more	GBenign/Likely benign
Select item 1617787	NM_024675.4(PALB2):c.2587-12C>T	PALB2	Single nucleotide variant (intron variant)	Familial cancer of breast +2 more	GLikely benign
Select item 142600	NM_024675.4(PALB2):c.2557G>A (p.Gly853Ser)	PALB2 (G853S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GUncertain significance
Select item 566330	NM_024675.4(PALB2):c.2540C>G (p.Ser847Cys)	PALB2 (S847C)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GConflicting classifications of pathogenicity
Select item 230460	NM_024675.4(PALB2):c.2512C>G (p.Gln838Glu)	PALB2 (Q838E)	Single nucleotide variant (missense variant)	Familial cancer of breast +4 more	GUncertain significance
Select item 231405	NM_024675.4(PALB2):c.2506G>C (p.Val836Leu)	PALB2 (V836L)	Single nucleotide variant (missense variant)	B lymphoblastic leukemia lymphoma with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1) +4 more	GConflicting classifications of pathogenicity
Select item 402299	NM_024675.4(PALB2):c.2473A>G (p.Arg825Gly)	PALB2 (R825G)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GConflicting classifications of pathogenicity
Select item 246424	NM_024675.4(PALB2):c.2435C>T (p.Pro812Leu)	PALB2 (P812L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GConflicting classifications of pathogenicity
Select item 530189	NM_024675.4(PALB2):c.2430_2431del (p.Pro811fs)	PALB2 (P811fs)	Deletion (frameshift variant)	not provided +3 more	GPathogenic/Likely pathogenic
Select item 415991	NM_024675.4(PALB2):c.2424A>C (p.Gly808=)	PALB2	Single nucleotide variant (synonymous variant)	Familial cancer of breast +3 more	GLikely benign
Select item 418604	NM_024675.4(PALB2):c.2411C>T (p.Ser804Phe)	PALB2 (S804F)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 187278	NM_024675.4(PALB2):c.2356C>T (p.His786Tyr)	PALB2 (H786Y)	Single nucleotide variant (missense variant)	not provided +5 more	GUncertain significance
Select item 186885	NM_024675.4(PALB2):c.2344C>T (p.Pro782Ser)	PALB2 (P782S)	Single nucleotide variant (missense variant)	Familial cancer of breast +5 more	GConflicting classifications of pathogenicity
Select item 628628	NM_024675.4(PALB2):c.2336C>T (p.Ser779Leu)	PALB2 (S779L)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GConflicting classifications of pathogenicity
Select item 230502	NM_024675.4(PALB2):c.2273C>G (p.Pro758Arg)	PALB2 (P758R)	Single nucleotide variant (missense variant)	Familial cancer of breast +4 more	GUncertain significance
Select item 410199	NM_024675.4(PALB2):c.2263T>C (p.Cys755Arg)	PALB2 (C755R)	Single nucleotide variant (missense variant)	Familial cancer of breast +4 more	GUncertain significance
Select item 480232	NM_024675.4(PALB2):c.2234A>G (p.Lys745Arg)	PALB2 (K745R)	Single nucleotide variant (missense variant)	Familial cancer of breast +4 more	GUncertain significance
Select item 410178	NM_024675.4(PALB2):c.2231A>G (p.Glu744Gly)	PALB2 (E744G)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 1012396	NM_024675.4(PALB2):c.2216C>T (p.Pro739Leu)	PALB2 (P739L)	Single nucleotide variant (missense variant)	Familial cancer of breast +2 more	GUncertain significance
Select item 241541	NM_024675.4(PALB2):c.2201C>A (p.Thr734Asn)	PALB2 (T734N)	Single nucleotide variant (missense variant)	not provided +5 more	GConflicting classifications of pathogenicity
Select item 246024	NM_024675.4(PALB2):c.2197A>G (p.Thr733Ala)	PALB2 (T733A)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 136132	NM_024675.4(PALB2):c.2167_2168del (p.Met723fs)	PALB2	Deletion (frameshift variant)	Familial cancer of breast +8 more	GPathogenic
Select item 245657	NM_024675.4(PALB2):c.2148T>A (p.Asn716Lys)	PALB2 (N716K)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 126637	NM_024675.4(PALB2):c.2135C>T (p.Ala712Val)	PALB2 (A712V)	Single nucleotide variant (missense variant)	Familial cancer of breast +6 more	GBenign/Likely benign
Select item 186485	NM_024675.4(PALB2):c.2134G>C (p.Ala712Pro)	PALB2 (A712P)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 410177	NM_024675.4(PALB2):c.2129C>T (p.Thr710Met)	PALB2 (T710M)	Single nucleotide variant (missense variant)	Familial cancer of breast +5 more	GUncertain significance
Select item 182765	NM_024675.4(PALB2):c.2128A>G (p.Thr710Ala)	PALB2 (T710A)	Single nucleotide variant (missense variant)	PALB2-related disorder +6 more	GConflicting classifications of pathogenicity
Select item 231670	NM_024675.4(PALB2):c.2096C>G (p.Ser699Cys)	PALB2 (S699C)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GUncertain significance

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