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Items: 94

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
MMUT
(L736F)
Single nucleotide variant
(missense variant)
Acute infantile liver failure due to synthesis defect of mtDNA-encoded proteins
+2 more
GConflicting classifications of pathogenicity
MMUT
(V733I)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+2 more
GUncertain significance
MMUT
(R727*)
Single nucleotide variant
(nonsense)
Methylmalonic acidemia
+3 more
GPathogenic
MMUT
(G717V)
Single nucleotide variant
(missense variant)
Methylmalonic acidemia
+2 more
GPathogenic
MMUT
(E711*)
Single nucleotide variant
(nonsense)
not provided
+1 more
GPathogenic/Likely pathogenic
MMUT
Deletion
(frameshift variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GLikely pathogenic
MMUT
(M700K)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic/Likely pathogenic
MMUT
(R694W)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic
MMUT
(A664fs)
Deletion
(frameshift variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GLikely pathogenic
MMUT
Deletion
(frameshift variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GPathogenic
MMUT
Single nucleotide variant
(splice acceptor variant)
not provided
+1 more
GPathogenic
MMUT
Single nucleotide variant
(splice donor variant)
not provided
+1 more
GConflicting classifications of pathogenicity
MMUT
(P649fs)
Deletion
(frameshift variant)
not provided
+2 more
GPathogenic/Likely pathogenic
MMUT
(G642R)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic/Likely pathogenic
MMUT
(G630E)
Single nucleotide variant
(missense variant)
Methylmalonic acidemia
+2 more
GPathogenic/Likely pathogenic
MMUT
(H627R)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+1 more
GPathogenic/Likely pathogenic
MMUT
(G623R)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic/Likely pathogenic
MMUT
(G623R)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic
MMUT
(L617R)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GUncertain significance
MMUT
(R616C)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+2 more
GPathogenic/Likely pathogenic
MMUT
(P615R)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GUncertain significance
MMUT
(I597R)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GUncertain significance
MMUT
(E593*)
Single nucleotide variant
(nonsense)
not provided
+1 more
GPathogenic/Likely pathogenic
MMUT
(R581*)
Single nucleotide variant
(nonsense)
Methylmalonic acidemia
+2 more
GPathogenic
MMUT
(F573S)
Single nucleotide variant
(missense variant)
not provided
GPathogenic/Likely pathogenic
MMUT
(C560Y)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GUncertain significance
MMUT
Single nucleotide variant
(splice acceptor variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+2 more
GPathogenic/Likely pathogenic
MMUT
Single nucleotide variant
(splice acceptor variant)
not provided
+2 more
GPathogenic
MMUT
(R557W)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GUncertain significance
MMUT
Single nucleotide variant
(synonymous variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+1 more
GConflicting classifications of pathogenicity
MMUT
Single nucleotide variant
(splice donor variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+2 more
GPathogenic
MMUT
(R511*)
Single nucleotide variant
(nonsense)
not provided
+2 more
GPathogenic
MMUT
(E497*)
Single nucleotide variant
(nonsense)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GPathogenic/Likely pathogenic
MMUT
(L494*)
Single nucleotide variant
(nonsense)
Methylmalonic acidemia
+2 more
GPathogenic
MMUT
(R474*)
Single nucleotide variant
(nonsense)
not provided
+2 more
GPathogenic
MMUT
(R467*)
Single nucleotide variant
(nonsense)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+2 more
GPathogenic
MMUT
(E451*)
Single nucleotide variant
(nonsense)
not provided
+1 more
GPathogenic/Likely pathogenic
MMUT
Deletion
(splice donor variant)
not provided
+1 more
GPathogenic
MMUT
(Y429*)
Single nucleotide variant
(nonsense)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+2 more
GPathogenic
MMUT
(G427D)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic
MMUT
(N407Y)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GUncertain significance
MMUT
(R403Q)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GUncertain significance
MMUT
(R403*)
Single nucleotide variant
(nonsense)
not provided
+2 more
GPathogenic
MMUT
(H386N)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GUncertain significance
MMUT
(A376fs)
Deletion
(frameshift variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+1 more
GPathogenic/Likely pathogenic
MMUT
(N365fs)
Deletion
(frameshift variant)
not provided
+1 more
GPathogenic/Likely pathogenic
MMUT
(R369H)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+2 more
GPathogenic
MMUT
(R369C)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic
MMUT
Single nucleotide variant
(splice acceptor variant)
not provided
+1 more
GPathogenic/Likely pathogenic
MMUT
Single nucleotide variant
(intron variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+2 more
GPathogenic/Likely pathogenic
MMUT
Single nucleotide variant
(splice donor variant)
not provided
+1 more
GLikely pathogenic
MMUT
(L347del)
Microsatellite
(inframe_deletion)
not provided
+1 more
GPathogenic/Likely pathogenic
MMUT
(S342*)
Single nucleotide variant
(nonsense)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+2 more
GPathogenic
MMUT
(N341fs)
Duplication
(frameshift variant)
Methylmalonic acidemia
+2 more
GPathogenic
MMUT
(M336fs)
Deletion
(frameshift variant)
not provided
GPathogenic
MMUT
(L328P)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+1 more
GPathogenic/Likely pathogenic
MMUT
(L328F)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic/Likely pathogenic
MMUT
(A324T)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+2 more
GPathogenic/Likely pathogenic
MMUT
(S306F)
Single nucleotide variant
(missense variant)
not specified
+2 more
GConflicting classifications of pathogenicity
MMUT
(L305S)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic/Likely pathogenic
MMUT
(G284*)
Single nucleotide variant
(nonsense)
Methylmalonic acidemia
+2 more
GPathogenic
MMUT
Single nucleotide variant
(splice acceptor variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+1 more
GPathogenic/Likely pathogenic
MMUT
Single nucleotide variant
(splice donor variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+2 more
GPathogenic
MMUT
(D244fs)
Insertion
(frameshift variant)
Methylmalonic acidemia
+2 more
GPathogenic
MMUT
(Y231*)
Single nucleotide variant
(nonsense)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GPathogenic
MMUT
(R228*)
Single nucleotide variant
(nonsense)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+2 more
GPathogenic
MMUT
(V227fs)
Duplication
(frameshift variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+2 more
GPathogenic
MMUT
Duplication
(inframe_insertion)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GUncertain significance
MMUT
(E224*)
Single nucleotide variant
(nonsense)
Methylmalonic acidemia
+2 more
GPathogenic/Likely pathogenic
MMUT
(N219Y)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic
MMUT
(Q218H)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic/Likely pathogenic
MMUT
(G215C)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic/Likely pathogenic
MMUT
(G203R)
Single nucleotide variant
(missense variant)
Methylmalonic acidemia
+2 more
GPathogenic
MMUT
(A191E)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+3 more
GPathogenic
MMUT
(M186V)
Single nucleotide variant
(missense variant)
not specified
+2 more
GConflicting classifications of pathogenicity
MMUT
(R152*)
Single nucleotide variant
(nonsense)
not provided
+2 more
GPathogenic
MMUT
(A141T)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GUncertain significance
MMUT
Single nucleotide variant
(intron variant)
not provided
+1 more
GPathogenic/Likely pathogenic
MMUT
Single nucleotide variant
(splice donor variant)
not provided
+1 more
GPathogenic/Likely pathogenic
MMUT
(K121*)
Duplication
(nonsense)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GPathogenic
MMUT
(E117*)
Single nucleotide variant
(nonsense)
not provided
+1 more
GPathogenic
MMUT
(R108H)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+3 more
GPathogenic
MMUT
(W105R)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic/Likely pathogenic
MMUT
(W105fs)
Deletion
(frameshift variant)
not provided
+1 more
GPathogenic/Likely pathogenic
MMUT
(R93C)
Single nucleotide variant
(missense variant)
not provided
GLikely pathogenic
MMUT
(G87E)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GUncertain significance
MMUT
(P86L)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+2 more
GPathogenic/Likely pathogenic
MMUT
(K54*)
Single nucleotide variant
(nonsense)
not provided
+1 more
GPathogenic
MMUT
(W43*)
Single nucleotide variant
(nonsense)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GPathogenic
MMUT
(R31*)
Single nucleotide variant
(nonsense)
Methylmalonic acidemia
+3 more
GPathogenic
MMUT
(Q18*)
Single nucleotide variant
(nonsense)
not provided
+2 more
GPathogenic/Likely pathogenic
MMUT
(H14L)
Single nucleotide variant
(missense variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GUncertain significance
MMUT
(L10fs)
Duplication
(frameshift variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
+1 more
GPathogenic
MMUT
Single nucleotide variant
(5 prime UTR variant)
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency
GUncertain significance
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