"Counsyl"[submitter] AND "CDH1"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 371894	NM_004360.4(CDH1):c.-288del	CDH1	Deletion	Hereditary diffuse gastric adenocarcinoma +1 more	GConflicting classifications of pathogenicity
Select item 221174	NM_004360.5(CDH1):c.-71C>G	CDH1, LOC130059290	Single nucleotide variant (5 prime UTR variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 142469	NM_004360.5(CDH1):c.8C>G (p.Pro3Arg)	CDH1 (P3R)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 548782	NM_004360.5(CDH1):c.12G>A (p.Trp4Ter)	CDH1 (W4*)	Single nucleotide variant (nonsense +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 220798	NM_004360.5(CDH1):c.32TGC[6] (p.Leu15dup)	CDH1	Microsatellite (inframe_insertion +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 182378	NM_004360.5(CDH1):c.48+15_48+16del	CDH1	Deletion (intron variant)	Hereditary cancer-predisposing syndrome +6 more	GBenign/Likely benign
Select item 372019	NM_004360.5(CDH1):c.49-16C>G	CDH1	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 142294	NM_004360.5(CDH1):c.49-3C>T	CDH1	Single nucleotide variant (intron variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 230669	NM_004360.5(CDH1):c.76G>C (p.Glu26Gln)	CDH1 (E26Q)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GUncertain significance FDA Recognized database
Select item 127933	NM_004360.5(CDH1):c.88C>A (p.Pro30Thr)	CDH1 (P30T)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 186186	NM_004360.5(CDH1):c.163+4_163+6dup	CDH1	Duplication (intron variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 132769	NM_004360.5(CDH1):c.164T>G (p.Val55Gly)	CDH1 (V55G)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 127918	NM_004360.5(CDH1):c.177T>G (p.Asp59Glu)	CDH1 (D59E)	Single nucleotide variant (missense variant +1 more)	CDH1-related disorder +3 more	GConflicting classifications of pathogenicity
Select item 406667	NM_004360.5(CDH1):c.199G>A (p.Ala67Thr)	CDH1 (A67T)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 136064	NM_004360.5(CDH1):c.214G>A (p.Asp72Asn)	CDH1 (D72N)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 219521	NM_004360.5(CDH1):c.251C>T (p.Thr84Ile)	CDH1 (T84I)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 182390	NM_004360.5(CDH1):c.268C>T (p.Arg90Trp)	CDH1 (R90W)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 142692	NM_004360.5(CDH1):c.269G>A (p.Arg90Gln)	CDH1 (R90Q)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 220611	NM_004360.5(CDH1):c.286A>G (p.Ile96Val)	CDH1 (I96V)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 184437	NM_004360.5(CDH1):c.300C>G (p.Val100=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 183867	NM_004360.5(CDH1):c.303C>T (p.Tyr101=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Malignant tumor of prostate +9 more	GConflicting classifications of pathogenicity
Select item 142578	NM_004360.5(CDH1):c.304G>A (p.Ala102Thr)	CDH1 (A102T)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 140878	NM_004360.5(CDH1):c.344C>T (p.Thr115Met)	CDH1 (T115M)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 239905	NM_004360.5(CDH1):c.370C>T (p.Arg124Cys)	CDH1 (R124C)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 141538	NM_004360.5(CDH1):c.371G>A (p.Arg124His)	CDH1 (R124H)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 184629	NM_004360.5(CDH1):c.377C>T (p.Pro126Leu)	CDH1 (P126L)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +8 more	GConflicting classifications of pathogenicity
Select item 486824	NM_004360.5(CDH1):c.382del (p.His128fs)	CDH1 (H128fs)	Deletion (frameshift variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 142462	NM_004360.5(CDH1):c.387+5G>A	CDH1	Single nucleotide variant (intron variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 239904	NM_004360.5(CDH1):c.388-4T>C	CDH1	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 142546	NM_004360.5(CDH1):c.394G>A (p.Val132Ile)	CDH1 (V132I)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 186787	NM_004360.5(CDH1):c.446T>C (p.Leu149Pro)	CDH1 (L149P)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 219431	NM_004360.5(CDH1):c.499G>A (p.Glu167Lys)	CDH1 (E167K)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 215836	NM_004360.5(CDH1):c.510A>G (p.Pro170=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	not specified +3 more	GBenign/Likely benign
Select item 186403	NM_004360.5(CDH1):c.582C>T (p.Gly194=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	not specified +3 more	GBenign/Likely benign
Select item 41786	NM_004360.5(CDH1):c.671G>A (p.Arg224His)	CDH1 (R224H)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 372014	NM_004360.5(CDH1):c.687+21del	CDH1	Deletion (intron variant)	not specified +2 more	GLikely benign
Select item 379539	NM_004360.5(CDH1):c.688-14C>T	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma +2 more	GLikely benign
Select item 132709	NM_004360.5(CDH1):c.715G>A (p.Gly239Arg)	CDH1 (G239R)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 136069	NM_004360.5(CDH1):c.719A>G (p.Asn240Ser)	CDH1 (N240S)	Single nucleotide variant (missense variant +1 more)	not specified +4 more	GConflicting classifications of pathogenicity
Select item 428631	NM_004360.5(CDH1):c.720del (p.Asn240fs)	CDH1 (N240fs)	Deletion (frameshift variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 142011	NM_004360.5(CDH1):c.808T>G (p.Ser270Ala)	CDH1 (S270A)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 230201	NM_004360.5(CDH1):c.826C>G (p.Leu276Val)	CDH1 (L276V)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 371959	NM_004360.5(CDH1):c.832+17G>A	CDH1	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 182379	NM_004360.5(CDH1):c.832+17G>C	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma +2 more	GConflicting classifications of pathogenicity
Select item 183900	NM_004360.5(CDH1):c.867G>A (p.Ala289=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GBenign/Likely benign
Select item 185413	NM_004360.5(CDH1):c.901G>A (p.Ala301Thr)	CDH1 (A301T)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 127905	NM_004360.5(CDH1):c.1004G>A (p.Arg335Gln)	CDH1 (R335Q)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 491486	NM_004360.5(CDH1):c.1009-14C>G	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma +1 more	GLikely benign
Select item 371993	NM_004360.5(CDH1):c.1009-14C>T	CDH1	Single nucleotide variant (intron variant)	not specified +2 more	GConflicting classifications of pathogenicity
Select item 141450	NM_004360.5(CDH1):c.1019C>T (p.Thr340Met)	CDH1 (T340M)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 182380	NM_004360.5(CDH1):c.1020G>A (p.Thr340=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Breast and/or ovarian cancer +4 more	GBenign/Likely benign
Select item 239875	NM_004360.5(CDH1):c.1036C>G (p.Gln346Glu)	CDH1 (Q346E)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 232434	NM_004360.5(CDH1):c.1090A>T (p.Thr364Ser)	CDH1 (T364S)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 142968	NM_004360.5(CDH1):c.1136C>T (p.Thr379Met)	CDH1 (T379M)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 156499	NM_004360.5(CDH1):c.1137G>A (p.Thr379=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 548872	NM_004360.5(CDH1):c.1138-15C>G	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma +1 more	GConflicting classifications of pathogenicity
Select item 184346	NM_004360.5(CDH1):c.1138-3C>T	CDH1	Single nucleotide variant (intron variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 182395	NM_004360.5(CDH1):c.1143G>C (p.Lys381Asn)	CDH1 (K381N)	Single nucleotide variant (5 prime UTR variant +2 more)	not specified +3 more	GConflicting classifications of pathogenicity
Select item 184387	NM_004360.5(CDH1):c.1161C>T (p.Asn387=)	CDH1	Single nucleotide variant (5 prime UTR variant +2 more)	not specified +3 more	GConflicting classifications of pathogenicity
Select item 127906	NM_004360.5(CDH1):c.1162G>A (p.Glu388Lys)	CDH1 (E388K)	Single nucleotide variant (5 prime UTR variant +2 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 184651	NM_004360.5(CDH1):c.1171G>A (p.Val391Ile)	CDH1 (V391I)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +7 more	GConflicting classifications of pathogenicity
Select item 136056	NM_004360.5(CDH1):c.1173C>T (p.Val391=)	CDH1	Single nucleotide variant (5 prime UTR variant +2 more)	Breast and/or ovarian cancer +4 more	GBenign/Likely benign
Select item 220109	NM_004360.5(CDH1):c.1223C>G (p.Ala408Gly)	CDH1 (A408G)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 127908	NM_004360.5(CDH1):c.1223C>T (p.Ala408Val)	CDH1 (A408V)	Single nucleotide variant (5 prime UTR variant +2 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 136057	NM_004360.5(CDH1):c.1224G>A (p.Ala408=)	CDH1	Single nucleotide variant (5 prime UTR variant +2 more)	Breast and/or ovarian cancer +4 more	GBenign/Likely benign
Select item 142029	NM_004360.5(CDH1):c.1234G>A (p.Val412Ile)	CDH1 (V412I)	Single nucleotide variant (5 prime UTR variant +2 more)	Familial cancer of breast +6 more	GUncertain significance
Select item 184347	NM_004360.5(CDH1):c.1239C>T (p.Tyr413=)	CDH1	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +4 more	GBenign/Likely benign
Select item 185874	NM_004360.5(CDH1):c.1266A>G (p.Gln422=)	CDH1	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +3 more	GBenign/Likely benign
Select item 127910	NM_004360.5(CDH1):c.1297G>A (p.Asp433Asn)	CDH1 (D433N)	Single nucleotide variant (5 prime UTR variant +2 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 141810	NM_004360.5(CDH1):c.1298A>G (p.Asp433Gly)	CDH1 (D433G)	Single nucleotide variant (5 prime UTR variant +2 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 141484	NM_004360.5(CDH1):c.1300G>C (p.Gly434Arg)	CDH1 (G434R)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary diffuse gastric adenocarcinoma +3 more	GUncertain significance
Select item 220738	NM_004360.5(CDH1):c.1303A>G (p.Ile435Val)	CDH1 (I435V)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 136058	NM_004360.5(CDH1):c.1308G>A (p.Leu436=)	CDH1	Single nucleotide variant (5 prime UTR variant +2 more)	not specified +5 more	GBenign/Likely benign
Select item 184950	NM_004360.5(CDH1):c.1315G>A (p.Ala439Thr)	CDH1 (A439T)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +3 more	GUncertain significance
Select item 219581	NM_004360.5(CDH1):c.1319A>G (p.Lys440Arg)	CDH1 (K440R)	Single nucleotide variant (5 prime UTR variant +2 more)	Familial cancer of breast +3 more	GUncertain significance
Select item 548722	NM_004360.5(CDH1):c.1321-19_1321-16del	CDH1	Deletion (intron variant)	Hereditary diffuse gastric adenocarcinoma	GLikely benign
Select item 184324	NM_004360.5(CDH1):c.1359C>T (p.His453=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GBenign/Likely benign
Select item 127912	NM_004360.5(CDH1):c.1360G>A (p.Val454Ile)	CDH1 (V454I +1 more)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 133845	NM_004360.5(CDH1):c.1370C>T (p.Thr457Met)	CDH1 (T457M +1 more)	Single nucleotide variant (missense variant +1 more)	not provided +8 more	GConflicting classifications of pathogenicity
Select item 127913	NM_004360.5(CDH1):c.1409C>T (p.Thr470Ile)	CDH1 (T470I +1 more)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 136059	NM_004360.5(CDH1):c.1416C>T (p.Thr472=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 127914	NM_004360.5(CDH1):c.1417G>A (p.Val473Ile)	CDH1 (V473I +1 more)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 184488	NM_004360.5(CDH1):c.1488C>T (p.Ser496=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma +3 more	GConflicting classifications of pathogenicity
Select item 183803	NM_004360.5(CDH1):c.1500C>T (p.Gly500=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 142357	NM_004360.5(CDH1):c.1501G>A (p.Val501Met)	CDH1 (V501M +1 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 216588	NM_004360.5(CDH1):c.1565C>T (p.Thr522Ile)	CDH1 (T522I +2 more)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 127915	NM_004360.5(CDH1):c.1565+1G>A	CDH1	Single nucleotide variant (splice donor variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 141014	NM_004360.5(CDH1):c.1568A>G (p.Tyr523Cys)	CDH1 (Y523C +2 more)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 230466	NM_004360.5(CDH1):c.1570C>T (p.Arg524Trp)	CDH1 (R524W +2 more)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +3 more	GUncertain significance
Select item 184348	NM_004360.5(CDH1):c.1570C>G (p.Arg524Gly)	CDH1 (R524G +2 more)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 220445	NM_004360.5(CDH1):c.1585A>G (p.Thr529Ala)	CDH1 (T529A +2 more)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GUncertain significance FDA Recognized database
Select item 182399	NM_004360.5(CDH1):c.1610C>T (p.Pro537Leu)	CDH1 (P537L +2 more)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +3 more	GConflicting classifications of pathogenicity
Select item 216590	NM_004360.5(CDH1):c.1633C>G (p.Arg545Gly)	CDH1 (R545G +2 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 188085	NM_004360.5(CDH1):c.1679C>T (p.Thr560Met)	CDH1 (T560M +2 more)	Single nucleotide variant (missense variant +1 more)	not specified +4 more	GUncertain significance
Select item 141854	NM_004360.5(CDH1):c.1684A>G (p.Thr562Ala)	CDH1 (T562A +2 more)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 185204	NM_004360.5(CDH1):c.1697T>C (p.Ile566Thr)	CDH1 (I566T +2 more)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 414050	NM_004360.5(CDH1):c.1712-8T>C	CDH1	Single nucleotide variant (intron variant)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 188218	NM_004360.5(CDH1):c.1738A>G (p.Thr580Ala)	CDH1 (T580A +2 more)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 184624	NM_004360.5(CDH1):c.1774G>T (p.Ala592Ser)	CDH1 (A592S +2 more)	Single nucleotide variant (missense variant +1 more)	not provided +8 more	GUncertain significance
Select item 12241	NM_004360.5(CDH1):c.1792C>T (p.Arg598Ter)	CDH1 (R598* +2 more)	Single nucleotide variant (nonsense +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database

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