"Baylor Genetics"[submitter] AND "SDHA"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 412386	NM_004168.4(SDHA):c.5C>T (p.Ser2Leu)	SDHA (S2L)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +6 more	GConflicting classifications of pathogenicity
Select item 1761600	NM_004168.4(SDHA):c.7G>A (p.Gly3Arg)	SDHA (G3R)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 580088	NM_004168.4(SDHA):c.8G>C (p.Gly3Ala)	SDHA (G3A)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +3 more	GUncertain significance
Select item 968572	NM_004168.4(SDHA):c.10G>A (p.Val4Ile)	SDHA (V4I)	Single nucleotide variant (missense variant)	Paragangliomas 5 +3 more	GUncertain significance
Select item 822169	NM_004168.4(SDHA):c.10G>T (p.Val4Phe)	SDHA (V4F)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +3 more	GUncertain significance
Select item 412384	NM_004168.4(SDHA):c.13C>T (p.Arg5Trp)	SDHA (R5W)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +5 more	GUncertain significance
Select item 239665	NM_004168.4(SDHA):c.23C>G (p.Ser8Trp)	SDHA (S8W)	Single nucleotide variant (missense variant)	Paragangliomas 5 +4 more	GUncertain significance
Select item 412348	NM_004168.4(SDHA):c.44G>C (p.Arg15Pro)	SDHA (R15P)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +3 more	GUncertain significance
Select item 2678620	NM_004168.4(SDHA):c.49G>T (p.Ala17Ser)	SDHA (A17S)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG	GUncertain significance
Select item 3240436	NM_004168.4(SDHA):c.52C>A (p.Leu18Met)	SDHA (L18M)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG	GUncertain significance
Select item 1009443	NM_004168.4(SDHA):c.63+3del	SDHA	Deletion (intron variant)	Dilated cardiomyopathy 1GG +2 more	GUncertain significance
Select item 577148	NM_004168.4(SDHA):c.89C>T (p.Thr30Ile)	SDHA (T30I)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +3 more	GUncertain significance
Select item 142601	NM_004168.4(SDHA):c.91C>T (p.Arg31Ter)	SDHA (R31*)	Single nucleotide variant (nonsense)	Gastrointestinal stromal tumor +9 more	GPathogenic/Likely pathogenic
Select item 239687	NM_004168.4(SDHA):c.92G>A (p.Arg31Gln)	SDHA (R31Q)	Single nucleotide variant (missense variant)	Paragangliomas 5 +5 more	GConflicting classifications of pathogenicity
Select item 568109	NM_004168.4(SDHA):c.106A>T (p.Thr36Ser)	SDHA (T36S)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +3 more	GUncertain significance
Select item 230054	NM_004168.4(SDHA):c.106A>G (p.Thr36Ala)	SDHA (T36A)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +4 more	GUncertain significance
Select item 486382	NM_004168.4(SDHA):c.107C>T (p.Thr36Ile)	SDHA (T36I)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 819388	NM_004168.4(SDHA):c.149C>A (p.Ser50Tyr)	SDHA (S50Y)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +3 more	GUncertain significance
Select item 388610	NM_004168.4(SDHA):c.150+1G>A	SDHA	Single nucleotide variant (splice donor variant)	Dilated cardiomyopathy 1GG +4 more	GConflicting classifications of pathogenicity
Select item 539680	NM_004168.4(SDHA):c.154T>A (p.Ser52Thr)	SDHA (S52T)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 252906	NM_004168.4(SDHA):c.155C>T (p.Ser52Phe)	SDHA (S52F)	Single nucleotide variant (missense variant)	Leigh syndrome +7 more	GUncertain significance
Select item 1460722	NM_004168.4(SDHA):c.166C>A (p.Pro56Thr)	SDHA (P56T)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +3 more	GUncertain significance
Select item 2678631	NM_004168.4(SDHA):c.168del (p.Pro56_Val57insTer)	SDHA	Deletion (frameshift variant)	not provided +3 more	GPathogenic/Likely pathogenic
Select item 1784140	NM_004168.4(SDHA):c.199G>A (p.Val67Ile)	SDHA (V67I)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 239662	NM_004168.4(SDHA):c.205G>A (p.Ala69Thr)	SDHA (A69T)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +6 more	GUncertain significance
Select item 846353	NM_004168.4(SDHA):c.221T>C (p.Leu74Ser)	SDHA (L74S)	Single nucleotide variant (missense variant)	Paragangliomas 5 +2 more	GUncertain significance
Select item 209127	NM_004168.4(SDHA):c.223C>T (p.Arg75Ter)	SDHA (R75*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +5 more	GPathogenic/Likely pathogenic
Select item 845269	NM_004168.4(SDHA):c.236G>A (p.Gly79Asp)	SDHA (G79D)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 539673	NM_004168.4(SDHA):c.260C>T (p.Thr87Ile)	SDHA (T87I)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +4 more	GUncertain significance
Select item 1056465	NM_004168.4(SDHA):c.266G>A (p.Cys89Tyr)	SDHA (C89Y)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +3 more	GUncertain significance
Select item 2201396	NM_004168.4(SDHA):c.272C>T (p.Thr91Ile)	SDHA (T91I)	Single nucleotide variant (missense variant)	Paragangliomas 5 +2 more	GUncertain significance
Select item 239666	NM_004168.4(SDHA):c.287C>T (p.Thr96Ile)	SDHA (T96I)	Single nucleotide variant (missense variant)	B-lymphoblastic leukemia/lymphoma with hypodiploidy +5 more	GUncertain significance
Select item 539690	NM_004168.4(SDHA):c.290G>C (p.Arg97Thr)	SDHA (R97T)	Single nucleotide variant (missense variant)	not provided +5 more	GUncertain significance
Select item 646704	NM_004168.4(SDHA):c.293C>T (p.Ser98Leu)	SDHA (S98L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 230564	NM_004168.4(SDHA):c.310_311dup (p.Gln104fs)	SDHA (Q104fs)	Microsatellite (frameshift variant)	Mitochondrial complex II deficiency, nuclear type 1 +3 more	GPathogenic/Likely pathogenic
Select item 412378	NM_004168.4(SDHA):c.319A>G (p.Ile107Val)	SDHA (I107V)	Single nucleotide variant (missense variant +1 more)	Mitochondrial complex II deficiency, nuclear type 1 +3 more	GUncertain significance
Select item 412323	NM_004168.4(SDHA):c.371A>G (p.Tyr124Cys)	SDHA (Y124C)	Single nucleotide variant (missense variant +1 more)	Mitochondrial complex II deficiency, nuclear type 1 +3 more	GUncertain significance
Select item 472290	NM_004168.4(SDHA):c.378del (p.Thr126_Val127insTer)	SDHA	Deletion (frameshift variant +1 more)	SDHA-related disorder +5 more	GPathogenic/Likely pathogenic
Select item 480780	NM_004168.4(SDHA):c.391G>A (p.Asp131Asn)	SDHA (D131N)	Single nucleotide variant (missense variant +1 more)	Dilated cardiomyopathy 1GG +5 more	GUncertain significance
Select item 955565	NM_004168.4(SDHA):c.396G>T (p.Trp132Cys)	SDHA (W132C)	Single nucleotide variant (missense variant +1 more)	Mitochondrial complex II deficiency, nuclear type 1 +3 more	GUncertain significance
Select item 1737279	NM_004168.4(SDHA):c.403G>T (p.Asp135Tyr)	SDHA (D135Y)	Single nucleotide variant (missense variant +1 more)	Dilated cardiomyopathy 1GG +1 more	GUncertain significance
Select item 2678612	NM_004168.4(SDHA):c.407A>G (p.Gln136Arg)	SDHA (Q136R)	Single nucleotide variant (missense variant +1 more)	Dilated cardiomyopathy 1GG	GUncertain significance
Select item 1480686	NM_004168.4(SDHA):c.411T>G (p.Asp137Glu)	SDHA (D137E)	Single nucleotide variant (missense variant +1 more)	Dilated cardiomyopathy 1GG +3 more	GUncertain significance
Select item 2924630	NM_004168.4(SDHA):c.418C>T (p.His140Tyr)	SDHA (H140Y)	Single nucleotide variant (missense variant +1 more)	Mitochondrial complex II deficiency, nuclear type 1 +2 more	GUncertain significance
Select item 412367	NM_004168.4(SDHA):c.428C>T (p.Thr143Met)	SDHA (T143M)	Single nucleotide variant (missense variant +1 more)	Dilated cardiomyopathy 1GG +4 more	GUncertain significance
Select item 239668	NM_004168.4(SDHA):c.442G>A (p.Ala148Thr)	SDHA (A148T)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +6 more	GConflicting classifications of pathogenicity
Select item 486367	NM_004168.4(SDHA):c.445G>A (p.Ala149Thr)	SDHA (A149T)	Single nucleotide variant (missense variant +1 more)	Paragangliomas 5 +4 more	GUncertain significance
Select item 486371	NM_004168.4(SDHA):c.448G>A (p.Val150Met)	SDHA (V150M)	Single nucleotide variant (missense variant +1 more)	Paragangliomas 5 +6 more	GUncertain significance
Select item 239669	NM_004168.4(SDHA):c.451G>A (p.Val151Ile)	SDHA (V151I)	Single nucleotide variant (missense variant +1 more)	Dilated cardiomyopathy 1GG +4 more	GUncertain significance
Select item 472390	NM_004168.4(SDHA):c.454G>A (p.Glu152Lys)	SDHA (E152K)	Single nucleotide variant (missense variant +1 more)	Paragangliomas 5 +4 more	GConflicting classifications of pathogenicity
Select item 942329	NM_004168.4(SDHA):c.456G>A (p.Glu152=)	SDHA	Single nucleotide variant (synonymous variant +1 more)	Mitochondrial complex II deficiency, nuclear type 1 +3 more	GUncertain significance
Select item 853431	NM_004168.4(SDHA):c.456+3_456+4delinsCT	SDHA	Indel (intron variant)	Dilated cardiomyopathy 1GG +2 more	GUncertain significance
Select item 239672	NM_004168.4(SDHA):c.457-2_457del	SDHA	Deletion (splice acceptor variant)	Paragangliomas 5 +4 more	GPathogenic
Select item 472393	NM_004168.4(SDHA):c.464A>G (p.Asn155Ser)	SDHA (N155S +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 232064	NM_004168.4(SDHA):c.476C>T (p.Pro159Leu)	SDHA (P159L +1 more)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +3 more	GUncertain significance
Select item 412358	NM_004168.4(SDHA):c.480T>G (p.Phe160Leu)	SDHA (F160L +1 more)	Single nucleotide variant (missense variant)	Paragangliomas 5 +3 more	GConflicting classifications of pathogenicity
Select item 1057047	NM_004168.4(SDHA):c.493G>A (p.Asp165Asn)	SDHA (D117N +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 1745142	NM_004168.4(SDHA):c.506A>G (p.Tyr169Cys)	SDHA (Y121C +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +3 more	GUncertain significance
Select item 141875	NM_004168.4(SDHA):c.512G>A (p.Arg171His)	SDHA (R171H +1 more)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +7 more	GUncertain significance
Select item 825814	NM_004168.4(SDHA):c.553C>G (p.Gln185Glu)	SDHA (Q137E +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 480771	NM_004168.4(SDHA):c.553C>T (p.Gln185Ter)	SDHA (Q185* +1 more)	Single nucleotide variant (nonsense)	Dilated cardiomyopathy 1GG +4 more	GPathogenic
Select item 1063638	NM_004168.4(SDHA):c.572G>C (p.Cys191Ser)	SDHA (C143S +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +2 more	GUncertain significance
Select item 855207	NM_004168.4(SDHA):c.583C>T (p.Arg195Trp)	SDHA (R195W +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +6 more	GUncertain significance
Select item 2678617	NM_004168.4(SDHA):c.584G>C (p.Arg195Pro)	SDHA (R147P +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG	GUncertain significance
Select item 646346	NM_004168.4(SDHA):c.595T>A (p.Ser199Thr)	SDHA (S151T +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 1427310	NM_004168.4(SDHA):c.598C>A (p.Leu200Ile)	SDHA (L200I +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 412349	NM_004168.4(SDHA):c.607A>G (p.Thr203Ala)	SDHA (T203A +1 more)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +5 more	GUncertain significance
Select item 947167	NM_004168.4(SDHA):c.608C>T (p.Thr203Ile)	SDHA (T155I +1 more)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +3 more	GUncertain significance
Select item 412329	NM_004168.4(SDHA):c.613T>C (p.Tyr205His)	SDHA (Y205H +1 more)	Single nucleotide variant (missense variant)	Paragangliomas 5 +5 more	GUncertain significance
Select item 2678622	NM_004168.4(SDHA):c.623C>T (p.Ser208Phe)	SDHA (S160F +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG	GUncertain significance
Select item 539663	NM_004168.4(SDHA):c.628C>T (p.Arg210Ter)	SDHA (R210* +1 more)	Single nucleotide variant (nonsense)	Paragangliomas 5 +5 more	GPathogenic/Likely pathogenic
Select item 567705	NM_004168.4(SDHA):c.629G>A (p.Arg210Gln)	SDHA (R210Q +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 2678618	NM_004168.4(SDHA):c.637A>G (p.Thr213Ala)	SDHA (T165A +1 more)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +3 more	GUncertain significance
Select item 141876	NM_004168.4(SDHA):c.667del (p.Asp223fs)	SDHA (D175fs +1 more)	Deletion (frameshift variant)	Dilated cardiomyopathy 1GG +4 more	GPathogenic/Likely pathogenic
Select item 2678629	NM_004168.4(SDHA):c.668dup (p.Asp223fs)	SDHA (D175fs +1 more)	Duplication (frameshift variant)	Dilated cardiomyopathy 1GG	GLikely pathogenic
Select item 1755035	NM_004168.4(SDHA):c.670C>T (p.Leu224Phe)	SDHA (L176F +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +3 more	GUncertain significance
Select item 472291	NM_004168.4(SDHA):c.688del (p.Glu230fs)	SDHA (E182fs +1 more)	Deletion (frameshift variant)	not provided +5 more	GPathogenic/Likely pathogenic
Select item 539679	NM_004168.4(SDHA):c.688G>C (p.Glu230Gln)	SDHA (E230Q +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 221076	NM_004168.4(SDHA):c.704T>C (p.Ile235Thr)	SDHA (I235T +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +6 more	GUncertain significance
Select item 472399	NM_004168.4(SDHA):c.706G>A (p.Ala236Thr)	SDHA (A236T +1 more)	Single nucleotide variant (missense variant)	Paragangliomas 5 +3 more	GUncertain significance
Select item 826859	NM_004168.4(SDHA):c.712T>G (p.Cys238Gly)	SDHA (C190G +1 more)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +3 more	GUncertain significance
Select item 2416121	NM_004168.4(SDHA):c.716T>G (p.Ile239Arg)	SDHA (I191R +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +3 more	GUncertain significance
Select item 2678611	NM_004168.4(SDHA):c.723_730dup (p.Ile244fs)	SDHA (I196fs +1 more)	Duplication (frameshift variant)	Dilated cardiomyopathy 1GG	GLikely pathogenic
Select item 239682	NM_004168.4(SDHA):c.724G>A (p.Gly242Arg)	SDHA (G242R +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 851117	NM_004168.4(SDHA):c.737G>A (p.Arg246His)	SDHA (R198H +1 more)	Single nucleotide variant (missense variant)	Paragangliomas 5 +3 more	GUncertain significance
Select item 232828	NM_004168.4(SDHA):c.739A>G (p.Ile247Val)	SDHA (I247V +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +5 more	GConflicting classifications of pathogenicity
Select item 3240435	NM_004168.4(SDHA):c.761T>C (p.Val254Ala)	SDHA (V206A +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG	GUncertain significance
Select item 412346	NM_004168.4(SDHA):c.762_770+17del	SDHA	Deletion (splice donor variant)	Mitochondrial complex II deficiency, nuclear type 1 +4 more	GPathogenic/Likely pathogenic
Select item 1067316	NM_004168.4(SDHA):c.771-1G>C	SDHA	Single nucleotide variant (splice acceptor variant)	Paragangliomas 5 +3 more	GLikely pathogenic
Select item 412357	NM_004168.4(SDHA):c.778G>A (p.Gly260Arg)	SDHA (G260R +1 more)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +4 more	GPathogenic/Likely pathogenic
Select item 539677	NM_004168.4(SDHA):c.781C>T (p.Arg261Cys)	SDHA (R261C +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 658469	NM_004168.4(SDHA):c.785C>T (p.Thr262Ile)	SDHA (T214I +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 839818	NM_004168.4(SDHA):c.809A>T (p.His270Leu)	SDHA (H222L +1 more)	Single nucleotide variant (missense variant)	Mitochondrial complex II deficiency, nuclear type 1 +4 more	GUncertain significance
Select item 539686	NM_004168.4(SDHA):c.830C>A (p.Thr277Lys)	SDHA (T277K +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 222817	NM_004168.4(SDHA):c.830C>T (p.Thr277Met)	SDHA (T277M +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +7 more	GConflicting classifications of pathogenicity
Select item 2562378	NM_004168.4(SDHA):c.841A>C (p.Thr281Pro)	SDHA (T233P +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +1 more	GUncertain significance
Select item 548821	NM_004168.4(SDHA):c.841A>G (p.Thr281Ala)	SDHA (T281A +1 more)	Single nucleotide variant (missense variant)	Paragangliomas 5 +6 more	GUncertain significance
Select item 2166705	NM_004168.4(SDHA):c.842C>G (p.Thr281Ser)	SDHA (T281S +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +2 more	GUncertain significance
Select item 2678614	NM_004168.4(SDHA):c.854T>C (p.Leu285Pro)	SDHA (L237P +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG	GUncertain significance
Select item 847930	NM_004168.4(SDHA):c.869T>C (p.Leu290Pro)	SDHA (L242P +1 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1GG +4 more	GUncertain significance

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