"Baylor Genetics"[submitter] AND "MSH6"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 183723	NM_000179.3(MSH6):c.10C>T (p.Gln4Ter)	MSH6 (Q4*)	Single nucleotide variant (nonsense +1 more)	Lynch syndrome 5 +7 more	GPathogenic/Likely pathogenic
Select item 1769374	NM_000179.3(MSH6):c.12G>C (p.Gln4His)	MSH6 (Q4H)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 428380	NM_000179.3(MSH6):c.16A>C (p.Thr6Pro)	MSH6 (T6P)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 421374	NM_000179.3(MSH6):c.19C>A (p.Leu7Met)	MSH6 (L7M)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +5 more	GUncertain significance
Select item 141874	NM_000179.3(MSH6):c.25A>G (p.Ser9Gly)	MSH6 (S9G)	Single nucleotide variant (missense variant +1 more)	not provided +5 more	GConflicting classifications of pathogenicity
Select item 845501	NM_000179.3(MSH6):c.26G>A (p.Ser9Asn)	MSH6 (S9N)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 823854	NM_000179.3(MSH6):c.34C>T (p.Pro12Ser)	MSH6 (P12S)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 141885	NM_000179.3(MSH6):c.34C>A (p.Pro12Thr)	MSH6 (P12T)	Single nucleotide variant (missense variant +1 more)	not provided +6 more	GConflicting classifications of pathogenicity
Select item 632905	NM_000179.3(MSH6):c.35C>T (p.Pro12Leu)	MSH6 (P12L)	Single nucleotide variant (missense variant +1 more)	not specified +3 more	GConflicting classifications of pathogenicity
Select item 920371	NM_000179.3(MSH6):c.37A>C (p.Lys13Gln)	MSH6 (K13Q)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome +4 more	GUncertain significance
Select item 410465	NM_000179.3(MSH6):c.38A>G (p.Lys13Arg)	MSH6 (K13R)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +3 more	GConflicting classifications of pathogenicity
Select item 36596	NM_000179.3(MSH6):c.38A>C (p.Lys13Thr)	MSH6 (K13T)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome 5 +6 more	GUncertain significance
Select item 233451	NM_000179.3(MSH6):c.40T>G (p.Ser14Ala)	MSH6 (S14A)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 216318	NM_000179.3(MSH6):c.41C>T (p.Ser14Phe)	MSH6 (S14F)	Single nucleotide variant (missense variant +1 more)	Breast and/or ovarian cancer +6 more	GConflicting classifications of pathogenicity
Select item 184992	NM_000179.3(MSH6):c.43C>T (p.Pro15Ser)	MSH6 (P15S)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 455333	NM_000179.3(MSH6):c.58dup (p.Ala20fs)	MSH6 (A20fs)	Duplication (frameshift variant +1 more)	Lynch syndrome 5 +3 more	GPathogenic/Likely pathogenic
Select item 485853	NM_000179.3(MSH6):c.61A>G (p.Asn21Asp)	MSH6 (N21D)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 182652	NM_000179.3(MSH6):c.67G>A (p.Ala23Thr)	MSH6 (A23T)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome +5 more	GUncertain significance
Select item 184777	NM_000179.3(MSH6):c.71C>T (p.Ser24Leu)	MSH6 (S24L)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GUncertain significance
Select item 410531	NM_000179.3(MSH6):c.76A>G (p.Arg26Gly)	MSH6 (R26G)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +2 more	GUncertain significance
Select item 2676798	NM_000179.3(MSH6):c.92G>C (p.Gly31Ala)	MSH6 (A13P +1 more)	Single nucleotide variant (non-coding transcript variant +3 more)	Endometrial carcinoma	GUncertain significance
Select item 237219	NM_000179.3(MSH6):c.98G>C (p.Arg33Pro)	MSH6 (R33P)	Single nucleotide variant (missense variant +1 more)	Endometrial carcinoma +6 more	GConflicting classifications of pathogenicity
Select item 410435	NM_000179.3(MSH6):c.104C>T (p.Ala35Val)	MSH6 (A35V)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +6 more	GConflicting classifications of pathogenicity
Select item 479864	NM_000179.3(MSH6):c.113C>T (p.Pro38Leu)	MSH6 (P38L)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 2673645	NM_000179.3(MSH6):c.136_158del (p.Gly46fs)	MSH6 (G46fs +1 more)	Deletion (frameshift variant +3 more)	Endometrial carcinoma +1 more	GPathogenic/Likely pathogenic
Select item 216296	NM_000179.3(MSH6):c.136G>C (p.Gly46Arg)	MSH6 (G46R)	Single nucleotide variant (missense variant +1 more)	Endometrial carcinoma +5 more	GConflicting classifications of pathogenicity
Select item 819194	NM_000179.3(MSH6):c.142G>A (p.Ala48Thr)	MSH6 (A48T)	Single nucleotide variant (5 prime UTR variant +1 more)	Endometrial carcinoma +2 more	GUncertain significance
Select item 455145	NM_000179.3(MSH6):c.153C>G (p.Ser51Arg)	MSH6 (S51R)	Single nucleotide variant (missense variant +1 more)	Endometrial carcinoma +4 more	GConflicting classifications of pathogenicity
Select item 968818	NM_000179.3(MSH6):c.154G>A (p.Glu52Lys)	MSH6 (E52K)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 428328	NM_000179.3(MSH6):c.154G>T (p.Glu52Ter)	MSH6 (E52*)	Single nucleotide variant (nonsense +1 more)	Hereditary cancer-predisposing syndrome +3 more	GPathogenic/Likely pathogenic
Select item 483762	NM_000179.3(MSH6):c.158C>A (p.Ala53Asp)	MSH6 (A53D)	Single nucleotide variant (missense variant +1 more)	Endometrial carcinoma +3 more	GUncertain significance
Select item 184901	NM_000179.3(MSH6):c.166_171dup (p.54GP[3])	MSH6	Duplication (inframe_insertion +1 more)	not provided +5 more	GUncertain significance
Select item 234685	NM_000179.3(MSH6):c.172_177dup (p.Arg58_Pro59dup)	MSH6	Duplication (inframe_insertion +1 more)	Hereditary nonpolyposis colorectal neoplasms +4 more	GUncertain significance
Select item 455151	NM_000179.3(MSH6):c.170C>G (p.Pro57Arg)	MSH6 (P57R)	Single nucleotide variant (missense variant +1 more)	Endometrial carcinoma +3 more	GConflicting classifications of pathogenicity
Select item 423368	NM_000179.3(MSH6):c.175C>T (p.Pro59Ser)	MSH6 (P59S)	Single nucleotide variant (missense variant +1 more)	Endometrial carcinoma +4 more	GConflicting classifications of pathogenicity
Select item 1781305	NM_000179.3(MSH6):c.185_186del (p.Arg62fs)	MSH6 (R62fs)	Microsatellite (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic/Likely pathogenic
Select item 439201	NM_000179.3(MSH6):c.184C>T (p.Arg62Cys)	MSH6 (R62C)	Single nucleotide variant (missense variant +1 more)	Mismatch repair cancer syndrome 1 +5 more	GUncertain significance
Select item 230147	NM_000179.3(MSH6):c.185G>T (p.Arg62Leu)	MSH6 (R62L)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 220796	NM_000179.3(MSH6):c.187T>C (p.Ser63Pro)	MSH6 (S63P)	Single nucleotide variant (missense variant +1 more)	Endometrial carcinoma +6 more	GConflicting classifications of pathogenicity
Select item 410430	NM_000179.3(MSH6):c.188C>G (p.Ser63Cys)	MSH6 (S63C)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 127566	NM_000179.3(MSH6):c.188C>A (p.Ser63Tyr)	MSH6 (S63Y)	Single nucleotide variant (missense variant +1 more)	not provided +4 more	GUncertain significance
Select item 216303	NM_000179.3(MSH6):c.203A>G (p.Lys68Arg)	MSH6 (K68R)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +2 more	GUncertain significance
Select item 216304	NM_000179.3(MSH6):c.208A>G (p.Lys70Glu)	MSH6 (K70E)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +4 more	GConflicting classifications of pathogenicity
Select item 820799	NM_000179.3(MSH6):c.214C>T (p.Leu72Phe)	MSH6 (L72F)	Single nucleotide variant (missense variant +1 more)	Endometrial carcinoma +2 more	GUncertain significance
Select item 480915	NM_000179.3(MSH6):c.220G>T (p.Gly74Ter)	MSH6 (G74*)	Single nucleotide variant (nonsense +1 more)	Lynch syndrome 5 +4 more	GPathogenic
Select item 820960	NM_000179.3(MSH6):c.224G>A (p.Gly75Glu)	MSH6 (G75E)	Single nucleotide variant (missense variant +1 more)	Endometrial carcinoma +2 more	GUncertain significance
Select item 628953	NM_000179.3(MSH6):c.226C>G (p.Leu76Val)	MSH6 (L76V)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 455187	NM_000179.3(MSH6):c.229C>T (p.Arg77Trp)	MSH6 (R77W)	Single nucleotide variant (missense variant +1 more)	Endometrial carcinoma +5 more	GConflicting classifications of pathogenicity
Select item 455189	NM_000179.3(MSH6):c.232A>G (p.Arg78Gly)	MSH6 (R78G)	Single nucleotide variant (missense variant +1 more)	Endometrial carcinoma +4 more	GUncertain significance
Select item 1791143	NM_000179.3(MSH6):c.242C>G (p.Ala81Gly)	MSH6 (A81G)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 127571	NM_000179.3(MSH6):c.242C>T (p.Ala81Val)	MSH6 (A81V)	Single nucleotide variant (missense variant +2 more)	Endometrial carcinoma +4 more	GConflicting classifications of pathogenicity
Select item 419824	NM_000179.3(MSH6):c.248C>A (p.Ala83Asp)	LOC129933707, MSH6 (A83D)	Single nucleotide variant (missense variant +2 more)	Lynch syndrome +4 more	GUncertain significance
Select item 548802	NM_000179.3(MSH6):c.254CCA[1] (p.Thr86del)	LOC129933707, MSH6 (T86del)	Microsatellite (inframe_deletion +2 more)	Hereditary nonpolyposis colorectal neoplasms +2 more	GUncertain significance
Select item 480918	NM_000179.3(MSH6):c.257C>T (p.Thr86Ile)	LOC129933707, MSH6 (T86I)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +5 more	GConflicting classifications of pathogenicity
Select item 428349	NM_000179.3(MSH6):c.260G>C (p.Ser87Thr)	LOC129933707, MSH6 (S87T)	Single nucleotide variant (missense variant +2 more)	Endometrial carcinoma +3 more	GConflicting classifications of pathogenicity
Select item 2676797	NM_000179.3(MSH6):c.261-4A>G	MSH6	Single nucleotide variant (5 prime UTR variant +1 more)	Endometrial carcinoma	GUncertain significance
Select item 410457	NM_000179.3(MSH6):c.263G>A (p.Cys88Tyr)	MSH6 (C88Y)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +5 more	GUncertain significance
Select item 921738	NM_000179.3(MSH6):c.286G>T (p.Val96Phe)	MSH6 (V96F)	Single nucleotide variant (missense variant +2 more)	Hereditary nonpolyposis colorectal neoplasms +2 more	GUncertain significance
Select item 1692255	NM_000179.3(MSH6):c.303G>C (p.Glu101Asp)	MSH6 (E101D)	Single nucleotide variant (missense variant +2 more)	Endometrial carcinoma +1 more	GUncertain significance
Select item 1729836	NM_000179.3(MSH6):c.328G>C (p.Val110Leu)	MSH6 (V142L +4 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 231799	NM_000179.3(MSH6):c.328G>A (p.Val110Ile)	MSH6 (V110I)	Single nucleotide variant (missense variant +2 more)	Hereditary nonpolyposis colorectal neoplasms +4 more	GUncertain significance
Select item 837444	NM_000179.3(MSH6):c.332A>G (p.Tyr111Cys)	MSH6 (Y111C)	Single nucleotide variant (missense variant +2 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GUncertain significance
Select item 2587317	NM_000179.3(MSH6):c.336_337dup (p.His113fs)	MSH6 (H14fs +4 more)	Duplication (frameshift variant +3 more)	Endometrial carcinoma +1 more	GPathogenic/Likely pathogenic
Select item 428411	NM_000179.3(MSH6):c.356dup (p.Ile120fs)	MSH6 (I120fs)	Duplication (frameshift variant +2 more)	Endometrial carcinoma +4 more	GPathogenic/Likely pathogenic
Select item 1353437	NM_000179.3(MSH6):c.359T>G (p.Ile120Ser)	MSH6 (I120S)	Single nucleotide variant (missense variant +2 more)	Endometrial carcinoma +2 more	GUncertain significance
Select item 229725	NM_000179.3(MSH6):c.359T>C (p.Ile120Thr)	MSH6 (I120T)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +5 more	GConflicting classifications of pathogenicity
Select item 219881	NM_000179.3(MSH6):c.361C>T (p.Arg121Cys)	MSH6 (R121C)	Single nucleotide variant (missense variant +2 more)	not provided +5 more	GConflicting classifications of pathogenicity
Select item 427607	NM_000179.3(MSH6):c.362G>A (p.Arg121His)	MSH6 (R121H)	Single nucleotide variant (missense variant +2 more)	Endometrial carcinoma +7 more	GConflicting classifications of pathogenicity
Select item 2676822	NM_000179.3(MSH6):c.364G>T (p.Glu122Ter)	MSH6 (E122* +4 more)	Single nucleotide variant (nonsense +3 more)	Endometrial carcinoma	GLikely pathogenic
Select item 485869	NM_000179.3(MSH6):c.373A>G (p.Lys125Glu)	MSH6 (K125E)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 483864	NM_000179.3(MSH6):c.379G>A (p.Val127Ile)	MSH6 (V127I)	Single nucleotide variant (missense variant +2 more)	Endometrial carcinoma +2 more	GUncertain significance
Select item 89473	NM_000179.3(MSH6):c.383G>T (p.Arg128Leu)	MSH6 (R128L)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +7 more	GUncertain significance
Select item 185466	NM_000179.3(MSH6):c.397_410del (p.Phe133fs)	MSH6 (F133fs)	Deletion (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GPathogenic
Select item 1380478	NM_000179.3(MSH6):c.395A>G (p.Gln132Arg)	MSH6 (Q132R)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 1723055	NM_000179.3(MSH6):c.407A>C (p.Asp136Ala)	MSH6 (D110A +4 more)	Single nucleotide variant (missense variant +2 more)	Endometrial carcinoma +1 more	GUncertain significance
Select item 234916	NM_000179.3(MSH6):c.419G>T (p.Arg140Met)	MSH6 (R140M)	Single nucleotide variant (missense variant +2 more)	Endometrial carcinoma +3 more	GUncertain significance
Select item 89519	NM_000179.3(MSH6):c.426G>A (p.Trp142Ter)	MSH6 (W142*)	Single nucleotide variant (nonsense +2 more)	Lynch syndrome	GPathogenic
Select item 920743	NM_000179.3(MSH6):c.430A>G (p.Ser144Gly)	MSH6 (S144G)	Single nucleotide variant (missense variant +2 more)	Hereditary nonpolyposis colorectal neoplasms +3 more	GUncertain significance
Select item 490020	NM_000179.3(MSH6):c.435A>C (p.Lys145Asn)	MSH6 (K145N)	Single nucleotide variant (missense variant +2 more)	Lynch syndrome +5 more	GConflicting classifications of pathogenicity
Select item 410397	NM_000179.3(MSH6):c.442_443del (p.Leu148fs)	MSH6 (L148fs)	Deletion (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome +3 more	GPathogenic/Likely pathogenic
Select item 142360	NM_000179.3(MSH6):c.448C>T (p.Pro150Ser)	MSH6 (P150S)	Single nucleotide variant (missense variant +2 more)	Hereditary nonpolyposis colorectal neoplasms +5 more	GUncertain significance
Select item 89534	NM_000179.3(MSH6):c.467C>G (p.Ser156Ter)	MSH6 (S156*)	Single nucleotide variant (nonsense +2 more)	Lynch syndrome	GPathogenic
Select item 134848	NM_000179.3(MSH6):c.476C>T (p.Ala159Val)	MSH6 (A159V)	Single nucleotide variant (missense variant +2 more)	Endometrial carcinoma +4 more	GConflicting classifications of pathogenicity
Select item 2676809	NM_000179.3(MSH6):c.478C>A (p.Gln160Lys)	MSH6 (Q104K +5 more)	Single nucleotide variant (intron variant +3 more)	Endometrial carcinoma	GUncertain significance
Select item 854939	NM_000179.3(MSH6):c.511G>A (p.Glu171Lys)	MSH6 (E171K)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 182656	NM_000179.3(MSH6):c.532C>T (p.Arg178Cys)	MSH6 (R178C)	Single nucleotide variant (missense variant +2 more)	Hereditary nonpolyposis colorectal neoplasms +7 more	GConflicting classifications of pathogenicity
Select item 188269	NM_000179.3(MSH6):c.533G>A (p.Arg178His)	MSH6 (R178H)	Single nucleotide variant (missense variant +2 more)	not specified +6 more	GConflicting classifications of pathogenicity
Select item 232472	NM_000179.3(MSH6):c.545C>T (p.Ala182Val)	MSH6 (A182V)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 422416	NM_000179.3(MSH6):c.552_555del (p.Asn184fs)	MSH6 (N184fs)	Microsatellite (frameshift variant +2 more)	Lynch syndrome 5 +4 more	GPathogenic/Likely pathogenic
Select item 1370225	NM_000179.3(MSH6):c.552T>G (p.Asn184Lys)	MSH6 (N184K)	Single nucleotide variant (missense variant +2 more)	Endometrial carcinoma +1 more	GUncertain significance
Select item 2676811	NM_000179.3(MSH6):c.565A>G (p.Lys189Glu)	MSH6 (K133E +6 more)	Single nucleotide variant (missense variant +3 more)	Endometrial carcinoma	GUncertain significance
Select item 479869	NM_000179.3(MSH6):c.566A>T (p.Lys189Met)	MSH6 (K189M)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 183724	NM_000179.3(MSH6):c.578del (p.Leu193fs)	MSH6 (L193fs)	Deletion (frameshift variant +2 more)	Hereditary nonpolyposis colon cancer +5 more	GPathogenic/Likely pathogenic
Select item 525808	NM_000179.3(MSH6):c.589G>C (p.Asp197His)	MSH6 (D197H)	Single nucleotide variant (missense variant +2 more)	Endometrial carcinoma +5 more	GConflicting classifications of pathogenicity
Select item 479937	NM_000179.3(MSH6):c.590A>G (p.Asp197Gly)	MSH6 (D197G)	Single nucleotide variant (missense variant +2 more)	Endometrial carcinoma +1 more	GUncertain significance
Select item 234621	NM_000179.3(MSH6):c.599C>G (p.Ser200Ter)	MSH6 (S200*)	Single nucleotide variant (nonsense +2 more)	Hereditary nonpolyposis colorectal neoplasms +4 more	GPathogenic
Select item 924241	NM_000179.3(MSH6):c.613G>A (p.Glu205Lys)	MSH6 (E205K)	Single nucleotide variant (missense variant +2 more)	Endometrial carcinoma +2 more	GUncertain significance
Select item 3073839	NM_000179.3(MSH6):c.616G>A (p.Glu206Lys)	MSH6 (E107K +6 more)	Single nucleotide variant (missense variant +3 more)	Endometrial carcinoma +1 more	GUncertain significance
Select item 490025	NM_000179.3(MSH6):c.621G>T (p.Glu207Asp)	MSH6 (E207D)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 142490	NM_000179.3(MSH6):c.622A>G (p.Met208Val)	MSH6 (M208V)	Single nucleotide variant (missense variant +2 more)	Lynch syndrome 5 +6 more	GUncertain significance

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