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Items: 1 to 100 of 350

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
MLH1
Deletion
Colorectal cancer, hereditary nonpolyposis, type 2
GUncertain significance
MLH1
Single nucleotide variant
(genic upstream transcript variant)
Hereditary nonpolyposis colorectal neoplasms
+6 more
GUncertain significance
MLH1
Single nucleotide variant
(5 prime UTR variant)
Colorectal cancer, hereditary nonpolyposis, type 2
+3 more
GUncertain significance
MLH1
Single nucleotide variant
(5 prime UTR variant)
Hereditary nonpolyposis colorectal neoplasms
+7 more
GUncertain significance
MLH1
(S2del)
Deletion
(inframe_deletion +2 more)
Colorectal cancer, hereditary nonpolyposis, type 2
+3 more
GUncertain significance
MLH1
(S2L)
Single nucleotide variant
(missense variant +1 more)
Lynch syndrome
+5 more
GUncertain significance
MLH1
(F3fs)
Deletion
(frameshift variant +1 more)
Hereditary nonpolyposis colorectal neoplasms
+2 more
GPathogenic/Likely pathogenic
MLH1
(F3L)
Single nucleotide variant
(missense variant +1 more)
Colorectal cancer, hereditary nonpolyposis, type 2
GUncertain significance
MLH1
(G6V)
Single nucleotide variant
(missense variant +1 more)
Colorectal cancer, hereditary nonpolyposis, type 2
+1 more
GUncertain significance
MLH1
(R9G)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+3 more
GUncertain significance
MLH1
(R9W)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+3 more
GUncertain significance
MLH1
Single nucleotide variant
(synonymous variant +1 more)
Hereditary nonpolyposis colon cancer
+4 more
GLikely pathogenic
MLH1
(R10W)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+3 more
GUncertain significance
MLH1
(D12E)
Single nucleotide variant
(missense variant +1 more)
Hereditary nonpolyposis colorectal neoplasms
+3 more
GUncertain significance
MLH1
(E13Q)
Single nucleotide variant
(missense variant +1 more)
not provided
+4 more
GUncertain significance
MLH1
(E13K)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+5 more
GUncertain significance
MLH1
(T14I)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+4 more
GUncertain significance
MLH1
(V15A)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+3 more
GUncertain significance
MLH1
(V16L)
Single nucleotide variant
(missense variant +1 more)
not specified
+6 more
GUncertain significance
MLH1
(V16G)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+3 more
GUncertain significance
MLH1
(R18C)
Single nucleotide variant
(missense variant +1 more)
not provided
+5 more
GConflicting classifications of pathogenicity
MLH1
(V24I)
Single nucleotide variant
(missense variant +1 more)
Colorectal cancer, hereditary nonpolyposis, type 2
+1 more
GUncertain significance
MLH1
(Q26R)
Single nucleotide variant
(missense variant +1 more)
Hereditary nonpolyposis colorectal neoplasms
+1 more
GUncertain significance
MLH1
(R27W)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+4 more
GUncertain significance
MLH1
(R27Q)
Single nucleotide variant
(missense variant +1 more)
Hereditary nonpolyposis colorectal neoplasms
+4 more
GConflicting classifications of pathogenicity
MLH1
(A29V)
Single nucleotide variant
(missense variant +1 more)
Colorectal cancer, hereditary nonpolyposis, type 2
GUncertain significance
MLH1
(A29D)
Single nucleotide variant
(missense variant +1 more)
Hereditary nonpolyposis colorectal neoplasms
+2 more
GUncertain significance
MLH1
(I36T)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+3 more
GUncertain significance
MLH1
Single nucleotide variant
(5 prime UTR variant +1 more)
Lynch syndrome
GLikely pathogenic
MLH1
Single nucleotide variant
(5 prime UTR variant +1 more)
Hereditary nonpolyposis colorectal neoplasms
+1 more
GUncertain significance
MLH1
Single nucleotide variant
(5 prime UTR variant +1 more)
not provided
+4 more
GConflicting classifications of pathogenicity
MLH1
(D41V)
Single nucleotide variant
(missense variant +2 more)
Hereditary nonpolyposis colorectal neoplasms
+2 more
GPathogenic/Likely pathogenic
MLH1
(A42V)
Single nucleotide variant
(missense variant +2 more)
Hereditary cancer-predisposing syndrome
+4 more
GUncertain significance
MLH1
(T45A)
Single nucleotide variant
(missense variant +2 more)
Hereditary nonpolyposis colorectal neoplasms
+2 more
GUncertain significance
MLH1
(S46N)
Single nucleotide variant
(missense variant +2 more)
Hereditary cancer-predisposing syndrome
+2 more
GUncertain significance
MLH1
(Q48H)
Single nucleotide variant
(missense variant +2 more)
Hereditary cancer-predisposing syndrome
+3 more
GUncertain significance
MLH1
(V51fs)
Deletion
(frameshift variant +2 more)
not provided
+1 more
GPathogenic/Likely pathogenic
MLH1
(K52*)
Single nucleotide variant
(nonsense +2 more)
Colorectal cancer, hereditary nonpolyposis, type 2
+1 more
GPathogenic/Likely pathogenic
MLH1
(K52fs)
Deletion
(frameshift variant +2 more)
not provided
+1 more
GPathogenic
MLH1
(G54R)
Single nucleotide variant
(missense variant +2 more)
Hereditary nonpolyposis colorectal neoplasms
+2 more
GUncertain significance
MLH1
(G55S)
Single nucleotide variant
(intron variant +2 more)
Colorectal cancer, hereditary nonpolyposis, type 2
+3 more
GUncertain significance
MLH1
(K57Q)
Single nucleotide variant
(missense variant +2 more)
Hereditary nonpolyposis colorectal neoplasms
+4 more
GUncertain significance
MLH1
(D63N)
Single nucleotide variant
(missense variant +2 more)
Hereditary nonpolyposis colorectal neoplasms
+4 more
GPathogenic/Likely pathogenic
MLH1
(N64fs)
Deletion
(frameshift variant +2 more)
Lynch syndrome
GPathogenic
MLH1
(N64S)
Single nucleotide variant
(missense variant +2 more)
Muir-Torré syndrome
+10 more
GConflicting classifications of pathogenicity
MLH1
(G65fs)
Indel
(frameshift variant +2 more)
Hereditary cancer-predisposing syndrome
+2 more
GPathogenic/Likely pathogenic
MLH1
(G67R)
Single nucleotide variant
(missense variant +2 more)
Lynch syndrome
GPathogenic
MLH1
(I68M)
Single nucleotide variant
(missense variant +2 more)
not provided
+4 more
GUncertain significance
MLH1
Single nucleotide variant
(splice donor variant +1 more)
Lynch syndrome
GLikely pathogenic
MLH1
(E71del)
Microsatellite
(inframe_deletion +2 more)
Lynch syndrome
GPathogenic
MLH1
(D72N)
Single nucleotide variant
(missense variant +2 more)
Colorectal cancer, hereditary nonpolyposis, type 2
+2 more
GUncertain significance
MLH1
(D72V)
Single nucleotide variant
(missense variant +2 more)
Colorectal cancer, hereditary nonpolyposis, type 2
GUncertain significance
MLH1
(D74V)
Single nucleotide variant
(missense variant +2 more)
Hereditary cancer-predisposing syndrome
+3 more
GUncertain significance
MLH1
(V76I)
Single nucleotide variant
(missense variant +2 more)
not specified
+8 more
GUncertain significance
MLH1
(C77Y)
Single nucleotide variant
(missense variant +2 more)
Lynch syndrome
GPathogenic
MLH1
(T81I)
Single nucleotide variant
(missense variant +2 more)
not provided
+6 more
GUncertain significance
MLH1
(T82A)
Single nucleotide variant
(missense variant +2 more)
Lynch syndrome 1
GLikely pathogenic
MLH1
(T82I)
Single nucleotide variant
(missense variant +2 more)
Lynch syndrome
GPathogenic
MLH1
(T96A)
Single nucleotide variant
(missense variant +2 more)
not provided
+3 more
GConflicting classifications of pathogenicity
MLH1
(T96I)
Single nucleotide variant
(missense variant +2 more)
not provided
+3 more
GUncertain significance
MLH1
(Y97C +1 more)
Single nucleotide variant
(missense variant +3 more)
Colorectal cancer, hereditary nonpolyposis, type 2
+5 more
GConflicting classifications of pathogenicity
MLH1
(G98S +1 more)
Single nucleotide variant
(missense variant +3 more)
Hereditary nonpolyposis colorectal neoplasms
+2 more
GConflicting classifications of pathogenicity
MLH1
(R100*)
Single nucleotide variant
(nonsense +3 more)
Lynch syndrome
GPathogenic
MLH1
(R100Q +1 more)
Single nucleotide variant
(5 prime UTR variant +2 more)
Colorectal cancer, hereditary nonpolyposis, type 2
+7 more
GUncertain significance
MLH1
(E102K)
Single nucleotide variant
(missense variant +2 more)
Lynch syndrome 1
GLikely pathogenic
MLH1
(E102D)
Single nucleotide variant
(missense variant +2 more)
Lynch syndrome
GUncertain significance
MLH1
Single nucleotide variant
(intron variant)
Lynch syndrome
GUncertain significance
MLH1
(T116A +2 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+3 more
GUncertain significance
MLH1
(T117M +2 more)
Single nucleotide variant
(missense variant +1 more)
Lynch syndrome
GPathogenic
MLH1
(A120G +2 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+4 more
GUncertain significance
MLH1
(K123fs +2 more)
Deletion
(frameshift variant +1 more)
Colorectal cancer, hereditary nonpolyposis, type 2
+1 more
GPathogenic/Likely pathogenic
MLH1
(A125T +2 more)
Single nucleotide variant
(missense variant +1 more)
Colorectal cancer, hereditary nonpolyposis, type 2
GUncertain significance
MLH1
(Y126N +2 more)
Single nucleotide variant
(missense variant +1 more)
Breast and/or ovarian cancer
+5 more
GConflicting classifications of pathogenicity
MLH1
Single nucleotide variant
(splice donor variant)
Lynch syndrome
GLikely pathogenic
MLH1
(S129N +2 more)
Single nucleotide variant
(missense variant +1 more)
Colorectal cancer, hereditary nonpolyposis, type 2
+2 more
GUncertain significance
MLH1
(Y130* +2 more)
Single nucleotide variant
(nonsense +1 more)
Colorectal cancer, hereditary nonpolyposis, type 2
+2 more
GPathogenic
MLH1
(D99fs +2 more)
Deletion
(frameshift variant +1 more)
Hereditary nonpolyposis colorectal neoplasms
+2 more
GPathogenic/Likely pathogenic
MLH1
(L102fs +2 more)
Deletion
(frameshift variant +1 more)
Lynch syndrome
GPathogenic
MLH1
(A104G +2 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary nonpolyposis colorectal neoplasms
+1 more
GUncertain significance
MLH1
(P139A +2 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary nonpolyposis colorectal neoplasms
+4 more
GUncertain significance
MLH1
(C142R +2 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+3 more
GUncertain significance
MLH1
(N145S +2 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary nonpolyposis colorectal neoplasms
+3 more
GUncertain significance
MLH1
(G147R +2 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+2 more
GConflicting classifications of pathogenicity
MLH1
(I150L +2 more)
Single nucleotide variant
(missense variant +1 more)
Colorectal cancer, hereditary nonpolyposis, type 2
+1 more
GUncertain significance
MLH1
(T151M +2 more)
Single nucleotide variant
(missense variant +1 more)
Ovarian cancer
+6 more
GConflicting classifications of pathogenicity
MLH1
Single nucleotide variant
(synonymous variant +1 more)
Lynch syndrome 1
GUncertain significance
MLH1
Single nucleotide variant
(splice donor variant)
Lynch syndrome
GLikely pathogenic
MLH1
Single nucleotide variant
(intron variant)
Lynch syndrome
GLikely pathogenic
MLH1
(F156L +2 more)
Single nucleotide variant
(missense variant +2 more)
Colorectal cancer, hereditary nonpolyposis, type 2
+3 more
GUncertain significance
MLH1
(R129K +2 more)
Single nucleotide variant
(missense variant +2 more)
Colorectal cancer, hereditary nonpolyposis, type 2
GUncertain significance
MLH1
(K134R +2 more)
Single nucleotide variant
(missense variant +2 more)
Hereditary nonpolyposis colorectal neoplasms
+2 more
GUncertain significance
MLH1
(P169L +2 more)
Single nucleotide variant
(missense variant +2 more)
Hereditary nonpolyposis colorectal neoplasms
+4 more
GUncertain significance
MLH1
(S137C +2 more)
Single nucleotide variant
(missense variant +2 more)
not provided
+1 more
GUncertain significance
MLH1
(S170G +2 more)
Single nucleotide variant
(missense variant +2 more)
Hereditary cancer-predisposing syndrome
+3 more
GUncertain significance
MLH1
(G141R +2 more)
Single nucleotide variant
(missense variant +2 more)
Lynch syndrome
+4 more
GUncertain significance
MLH1
(L177S +2 more)
Single nucleotide variant
(missense variant +2 more)
Hereditary nonpolyposis colorectal neoplasms
+3 more
GConflicting classifications of pathogenicity
MLH1
(E178Q +2 more)
Single nucleotide variant
(missense variant +2 more)
not provided
+3 more
GUncertain significance
MLH1
(E178K +2 more)
Single nucleotide variant
(missense variant +2 more)
Hereditary nonpolyposis colorectal neoplasms
+2 more
GUncertain significance
MLH1
(V180G +2 more)
Single nucleotide variant
(missense variant +2 more)
Colorectal cancer, hereditary nonpolyposis, type 2
+5 more
GConflicting classifications of pathogenicity
MLH1
(S184L +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+4 more
GUncertain significance
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