"Ambry Genetics"[submitter] AND "SDHB"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 822405	NM_003000.3(SDHB):c.841T>G (p.Ter281Glu)	SDHB	Single nucleotide variant (stop lost)	Pheochromocytoma +3 more	GUncertain significance
Select item 3223024	NM_003000.3(SDHB):c.837A>C (p.Ser279=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 750812	NM_003000.3(SDHB):c.837A>G (p.Ser279=)	SDHB	Single nucleotide variant (synonymous variant)	Pheochromocytoma +3 more	GLikely benign
Select item 2619609	NM_003000.3(SDHB):c.836C>T (p.Ser279Leu)	SDHB (S261L +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1475264	NM_003000.3(SDHB):c.835_836delinsCT (p.Ser279Leu)	SDHB (S279L)	Indel (missense variant)	Gastrointestinal stromal tumor +3 more	GUncertain significance
Select item 2619620	NM_003000.3(SDHB):c.835T>C (p.Ser279Pro)	SDHB (S261P +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 657450	NM_003000.3(SDHB):c.835T>A (p.Ser279Thr)	SDHB (S279T)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +4 more	GUncertain significance
Select item 668544	NM_003000.3(SDHB):c.834T>C (p.Ala278=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 2562720	NM_003000.3(SDHB):c.833C>T (p.Ala278Val)	SDHB (A260V +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1399652	NM_003000.3(SDHB):c.831del (p.Ala278fs)	SDHB (A278fs)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 1138626	NM_003000.3(SDHB):c.828G>A (p.Lys276=)	SDHB	Single nucleotide variant (synonymous variant)	Gastrointestinal stromal tumor +3 more	GLikely benign
Select item 3075205	NM_003000.3(SDHB):c.821A>T (p.Lys274Met)	SDHB (K256M +1 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +1 more	GUncertain significance
Select item 459174	NM_003000.3(SDHB):c.820A>G (p.Lys274Glu)	SDHB (K274E)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GUncertain significance
Select item 1975969	NM_003000.3(SDHB):c.819T>C (p.Tyr273=)	SDHB	Single nucleotide variant (synonymous variant)	Gastrointestinal stromal tumor +3 more	GLikely benign
Select item 486424	NM_003000.3(SDHB):c.818A>T (p.Tyr273Phe)	SDHB (Y273F)	Single nucleotide variant (missense variant)	Pheochromocytoma +4 more	GUncertain significance
Select item 459173	NM_003000.3(SDHB):c.816C>G (p.Thr272=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GLikely benign
Select item 1445276	NM_003000.3(SDHB):c.815C>T (p.Thr272Ile)	SDHB (T272I)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 412468	NM_003000.3(SDHB):c.814A>G (p.Thr272Ala)	SDHB (T272A)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 1762148	NM_003000.3(SDHB):c.813A>T (p.Ala271=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 827459	NM_003000.3(SDHB):c.810G>A (p.Met270Ile)	SDHB (M270I)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1761868	NM_003000.3(SDHB):c.806del (p.Met269fs)	SDHB (M269fs)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 1761690	NM_003000.3(SDHB):c.801del (p.Lys268_Met269insTer)	SDHB	Deletion (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 1095713	NM_003000.3(SDHB):c.798C>T (p.Ile266=)	SDHB	Single nucleotide variant (synonymous variant)	Gastrointestinal stromal tumor +3 more	GLikely benign
Select item 2625090	NM_003000.3(SDHB):c.794A>G (p.Glu265Gly)	SDHB (E247G +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1062289	NM_003000.3(SDHB):c.793G>A (p.Glu265Lys)	SDHB (E265K)	Single nucleotide variant (missense variant)	Paragangliomas 4 +3 more	GUncertain significance
Select item 1761257	NM_003000.3(SDHB):c.792A>G (p.Ala264=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3223023	NM_003000.3(SDHB):c.791C>G (p.Ala264Gly)	SDHB (A246G +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 567410	NM_003000.3(SDHB):c.791C>A (p.Ala264Glu)	SDHB (A264E)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 1383549	NM_003000.3(SDHB):c.790G>A (p.Ala264Thr)	SDHB (A264T)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 934413	NM_003000.3(SDHB):c.789del (p.Ile263fs)	SDHB (I263fs)	Deletion (frameshift variant)	Pheochromocytoma +3 more	GConflicting classifications of pathogenicity
Select item 827319	NM_003000.3(SDHB):c.789T>C (p.Ile263=)	SDHB	Single nucleotide variant (synonymous variant)	Pheochromocytoma +3 more	GLikely benign
Select item 421424	NM_003000.3(SDHB):c.784_787dup (p.Ile263fs)	SDHB (I263fs)	Duplication (frameshift variant)	Hereditary cancer-predisposing syndrome +4 more	GLikely pathogenic
Select item 1760984	NM_003000.3(SDHB):c.787A>G (p.Ile263Val)	SDHB (I245V +1 more)	Single nucleotide variant (missense variant)	Pheochromocytoma +3 more	GUncertain significance
Select item 417297	NM_003000.3(SDHB):c.783A>G (p.Lys261=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GLikely benign
Select item 459172	NM_003000.3(SDHB):c.782A>C (p.Lys261Thr)	SDHB (K261T)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 1760756	NM_003000.3(SDHB):c.781A>C (p.Lys261Gln)	SDHB (K243Q +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 576131	NM_003000.3(SDHB):c.780dup (p.Lys261fs)	SDHB (K261fs)	Duplication (frameshift variant)	Paragangliomas 4 +3 more	GLikely pathogenic
Select item 827221	NM_003000.3(SDHB):c.771G>C (p.Leu257=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 584582	NM_003000.3(SDHB):c.769C>G (p.Leu257Val)	SDHB (L257V)	Single nucleotide variant (missense variant)	Cowden syndrome +5 more	GConflicting classifications of pathogenicity
Select item 417304	NM_003000.3(SDHB):c.768T>C (p.Gly256=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GLikely benign
Select item 3316890	NM_003000.3(SDHB):c.765+1721_765+1726delinsTTTT	SDHB	Indel (intron variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 412480	NM_003000.3(SDHB):c.765+5G>A	SDHB	Single nucleotide variant (intron variant)	Hereditary pheochromocytoma-paraganglioma +4 more	GConflicting classifications of pathogenicity
Select item 230780	NM_003000.3(SDHB):c.765+5G>T	SDHB	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 2447651	NM_003000.3(SDHB):c.765+4C>G	SDHB	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 578523	NM_003000.3(SDHB):c.765+4C>T	SDHB	Single nucleotide variant (intron variant)	Paragangliomas 4 +4 more	GConflicting classifications of pathogenicity
Select item 1759965	NM_003000.3(SDHB):c.764A>G (p.Lys255Arg)	SDHB (K237R +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 656886	NM_003000.3(SDHB):c.763A>G (p.Lys255Glu)	SDHB (K255E)	Single nucleotide variant (missense variant)	Pheochromocytoma +3 more	GUncertain significance
Select item 1097988	NM_003000.3(SDHB):c.762T>C (p.Pro254=)	SDHB	Single nucleotide variant (synonymous variant)	Gastrointestinal stromal tumor +4 more	GLikely benign
Select item 3223021	NM_003000.3(SDHB):c.757_760dup (p.Pro254fs)	SDHB (P236fs +1 more)	Duplication (frameshift variant)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 412459	NM_003000.3(SDHB):c.761C>T (p.Pro254Leu)	SDHB (P254L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 1367715	NM_003000.3(SDHB):c.760C>G (p.Pro254Ala)	SDHB (P254A)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 183795	NM_003000.3(SDHB):c.758G>A (p.Cys253Tyr)	SDHB (C253Y)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +4 more	GPathogenic/Likely pathogenic
Select item 1759509	NM_003000.3(SDHB):c.755C>T (p.Thr252Ile)	SDHB (T252I +1 more)	Single nucleotide variant (missense variant)	Pheochromocytoma +3 more	GUncertain significance
Select item 1111279	NM_003000.3(SDHB):c.753G>A (p.Arg251=)	SDHB	Single nucleotide variant (synonymous variant)	Gastrointestinal stromal tumor +3 more	GLikely benign
Select item 965957	NM_003000.3(SDHB):c.753G>T (p.Arg251Ser)	SDHB (R251S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 1382661	NM_003000.3(SDHB):c.752G>A (p.Arg251Lys)	SDHB (R251K)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +3 more	GUncertain significance
Select item 371792	NM_003000.3(SDHB):c.749C>T (p.Thr250Ile)	SDHB (T250I)	Single nucleotide variant (missense variant)	Mitochondrial complex 2 deficiency, nuclear type 4 +4 more	GUncertain significance
Select item 1759135	NM_003000.3(SDHB):c.748A>G (p.Thr250Ala)	SDHB (T232A +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2562719	NM_003000.3(SDHB):c.746G>T (p.Cys249Phe)	SDHB (C249F +1 more)	Single nucleotide variant (missense variant)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 428929	NM_003000.3(SDHB):c.744C>G (p.Asn248Lys)	SDHB (N248K)	Single nucleotide variant (missense variant)	Paragangliomas 4 +4 more	GLikely pathogenic
Select item 1024777	NM_003000.3(SDHB):c.741G>A (p.Met247Ile)	SDHB (M247I)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +3 more	GUncertain significance
Select item 459169	NM_003000.3(SDHB):c.739A>G (p.Met247Val)	SDHB (M247V)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +5 more	GUncertain significance
Select item 699234	NM_003000.3(SDHB):c.738C>T (p.Ile246=)	SDHB	Single nucleotide variant (synonymous variant)	Gastrointestinal stromal tumor +3 more	GLikely benign
Select item 827005	NM_003000.3(SDHB):c.737T>C (p.Ile246Thr)	SDHB (I246T)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 412482	NM_003000.3(SDHB):c.736A>G (p.Ile246Val)	SDHB (I246V)	Single nucleotide variant (missense variant)	Pheochromocytoma +5 more	GUncertain significance
Select item 2123099	NM_003000.3(SDHB):c.733A>G (p.Thr245Ala)	SDHB (T227A +1 more)	Single nucleotide variant (missense variant)	Pheochromocytoma +4 more	GUncertain significance
Select item 826947	NM_003000.3(SDHB):c.728G>T (p.Cys243Phe)	SDHB (C243F)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 1758066	NM_003000.3(SDHB):c.727T>C (p.Cys243Arg)	SDHB (C225R +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3223020	NM_003000.3(SDHB):c.725G>T (p.Arg242Leu)	SDHB (R224L +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 12781	NM_003000.3(SDHB):c.725G>A (p.Arg242His)	SDHB (R242H)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +7 more	GPathogenic/Likely pathogenic
Select item 239443	NM_003000.3(SDHB):c.724C>A (p.Arg242Ser)	SDHB (R242S)	Single nucleotide variant (missense variant)	Paragangliomas 4 +5 more	GPathogenic
Select item 186827	NM_003000.3(SDHB):c.724C>T (p.Arg242Cys)	SDHB (R242C)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GPathogenic/Likely pathogenic
Select item 239442	NM_003000.3(SDHB):c.723C>T (p.Tyr241=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GLikely benign
Select item 239441	NM_003000.3(SDHB):c.722A>G (p.Tyr241Cys)	SDHB (Y241C)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 412464	NM_003000.3(SDHB):c.721T>G (p.Tyr241Asp)	SDHB (Y241D)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 201607	NM_003000.3(SDHB):c.718_721del (p.Leu240fs)	SDHB (L240fs)	Deletion (frameshift variant)	Pheochromocytoma +4 more	GPathogenic
Select item 459168	NM_003000.3(SDHB):c.720A>G (p.Leu240=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GLikely benign
Select item 428914	NM_003000.3(SDHB):c.719T>C (p.Leu240Pro)	SDHB (L240P)	Single nucleotide variant (missense variant)	Paragangliomas 4 +3 more	GUncertain significance
Select item 12782	NM_003000.3(SDHB):c.716_719del (p.Ser239fs)	SDHB (S239fs)	Microsatellite (frameshift variant)	Paragangliomas 4 +4 more	GPathogenic
Select item 1757579	NM_003000.3(SDHB):c.718C>G (p.Leu240Val)	SDHB (L222V +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 826895	NM_003000.3(SDHB):c.718C>T (p.Leu240=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 412481	NM_003000.3(SDHB):c.717dup (p.Leu240fs)	SDHB (L240fs)	Duplication (frameshift variant)	Hereditary cancer-predisposing syndrome +3 more	GPathogenic
Select item 577973	NM_003000.3(SDHB):c.716C>A (p.Ser239Tyr)	SDHB (S239Y)	Single nucleotide variant (missense variant)	Pheochromocytoma +3 more	GUncertain significance
Select item 412475	NM_003000.3(SDHB):c.716C>T (p.Ser239Phe)	SDHB (S239F)	Single nucleotide variant (missense variant)	Carney-Stratakis syndrome +6 more	GUncertain significance
Select item 161385	NM_003000.3(SDHB):c.716C>G (p.Ser239Cys)	SDHB (S239C)	Single nucleotide variant (missense variant)	Paragangliomas 4 +5 more	GUncertain significance
Select item 3223019	NM_003000.3(SDHB):c.714C>T (p.Phe238=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 459165	NM_003000.3(SDHB):c.714C>A (p.Phe238Leu)	SDHB (F238L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 486420	NM_003000.3(SDHB):c.713T>C (p.Phe238Ser)	SDHB (F238S)	Single nucleotide variant (missense variant)	Pheochromocytoma +3 more	GUncertain significance
Select item 233795	NM_003000.3(SDHB):c.713del (p.Phe238fs)	SDHB (F238fs)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome +4 more	GPathogenic
Select item 1138923	NM_003000.3(SDHB):c.711A>G (p.Pro237=)	SDHB	Single nucleotide variant (synonymous variant)	Gastrointestinal stromal tumor +3 more	GLikely benign
Select item 239438	NM_003000.3(SDHB):c.710C>G (p.Pro237Arg)	SDHB (P237R)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GUncertain significance
Select item 371795	NM_003000.3(SDHB):c.709C>T (p.Pro237Ser)	SDHB (P237S)	Single nucleotide variant (missense variant)	Ovarian cancer +5 more	GConflicting classifications of pathogenicity
Select item 826804	NM_003000.3(SDHB):c.705G>C (p.Gln235His)	SDHB (Q235H)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 3223017	NM_003000.3(SDHB):c.703C>G (p.Gln235Glu)	SDHB (Q217E +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1756775	NM_003000.3(SDHB):c.702G>A (p.Leu234=)	SDHB	Single nucleotide variant (synonymous variant)	Pheochromocytoma +3 more	GLikely benign
Select item 186390	NM_003000.3(SDHB):c.701T>A (p.Leu234Gln)	SDHB (L234Q)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 1756664	NM_003000.3(SDHB):c.700C>G (p.Leu234Val)	SDHB (L234V +1 more)	Single nucleotide variant (missense variant)	Pheochromocytoma +3 more	GUncertain significance
Select item 293809	NM_003000.3(SDHB):c.700C>T (p.Leu234=)	SDHB	Single nucleotide variant (synonymous variant)	Carney-Stratakis syndrome +6 more	GConflicting classifications of pathogenicity
Select item 528754	NM_003000.3(SDHB):c.696C>T (p.Ala232=)	SDHB	Single nucleotide variant (synonymous variant)	Pheochromocytoma +5 more	GLikely benign
Select item 459164	NM_003000.3(SDHB):c.695C>T (p.Ala232Val)	SDHB (A232V)	Single nucleotide variant (missense variant)	Paragangliomas 4 +4 more	GUncertain significance

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