"Ambry Genetics"[submitter] AND "KRAS"[gene] - ClinVar

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Items: 37

	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 700718	NM_033360.4(KRAS):c.*103A>G	KRAS	Single nucleotide variant (3 prime UTR variant +1 more)	Cardiovascular phenotype +1 more	GLikely benign
Select item 45129	NM_004985.5(KRAS):c.528GAA[1] (p.Lys180del)	KRAS (K180del)	Microsatellite (3 prime UTR variant +1 more)	RASopathy	GBenign FDA Recognized database
Select item 41449	NM_004985.5(KRAS):c.519T>C (p.Asp173=)	KRAS	Single nucleotide variant (3 prime UTR variant +1 more)	RASopathy	GBenign FDA Recognized database
Select item 2478131	NM_004985.5(KRAS):c.506A>G (p.Lys169Arg)	KRAS (K169R)	Single nucleotide variant (3 prime UTR variant +1 more)	Cardiovascular phenotype	GUncertain significance
Select item 1742817	NM_004985.5(KRAS):c.474A>G (p.Thr158=)	KRAS	Single nucleotide variant (3 prime UTR variant +1 more)	Cardiovascular phenotype	GLikely benign
Select item 308124	NM_033360.4(KRAS):c.*16T>C	KRAS	Single nucleotide variant (3 prime UTR variant +1 more)	Cardiovascular phenotype +2 more	GConflicting classifications of pathogenicity
Select item 12587	NM_004985.5(KRAS):c.458A>T (p.Asp153Val)	KRAS (D153V)	Single nucleotide variant (3 prime UTR variant +1 more)	Noonan syndrome	GPathogenic FDA Recognized database
Select item 2239063	NM_033360.4(KRAS):c.560T>C (p.Ile187Thr)	KRAS (I187T)	Single nucleotide variant (missense variant +1 more)	Cardiovascular phenotype	GUncertain significance
Select item 46540	NM_004985.5(KRAS):c.451-5565G>A	KRAS (G179S)	Single nucleotide variant (missense variant +1 more)	not specified +2 more	GBenign/Likely benign
Select item 46538	NM_004985.5(KRAS):c.451-5617=	KRAS	Single nucleotide variant (no sequence alteration +1 more)	Cardiovascular phenotype +2 more	GBenign
Select item 1732986	NM_004985.5(KRAS):c.358T>C (p.Leu120=)	KRAS	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype	GLikely benign
Select item 3224559	NM_004985.5(KRAS):c.350A>C (p.Lys117Thr)	KRAS (K117T)	Single nucleotide variant (missense variant)	Cardiovascular phenotype	GLikely pathogenic
Select item 2454058	NM_004985.5(KRAS):c.348T>C (p.Asn116=)	KRAS	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype	GLikely benign
Select item 1729613	NM_004985.5(KRAS):c.326T>A (p.Val109Glu)	KRAS (V109E)	Single nucleotide variant (missense variant)	Cardiovascular phenotype	GUncertain significance
Select item 40456	NM_033360.4(KRAS):c.249C>T (p.Ala83=)	KRAS	Single nucleotide variant (synonymous variant)	RASopathy +2 more	GConflicting classifications of pathogenicity
Select item 3224558	NM_004985.5(KRAS):c.234T>C (p.Phe78=)	KRAS	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype	GLikely benign
Select item 985492	NM_004985.5(KRAS):c.196G>T (p.Ala66Ser)	KRAS (A66S)	Single nucleotide variant (missense variant)	Inborn genetic diseases	GUncertain significance
Select item 985491	NM_004985.5(KRAS):c.191A>C (p.Tyr64Ser)	KRAS (Y64S)	Single nucleotide variant (missense variant)	Inborn genetic diseases	GUncertain significance
Select item 986027	NM_004985.5(KRAS):c.190T>A (p.Tyr64Asn)	KRAS (Y64N)	Single nucleotide variant (missense variant)	Inborn genetic diseases	GUncertain significance
Select item 177881	NM_004985.5(KRAS):c.183A>C (p.Gln61His)	KRAS (Q61H)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity STier II - Potential OOncogenic
Select item 3116215	NM_004985.5(KRAS):c.180_181delinsAA (p.Gln61Lys)	KRAS (Q61K)	Indel (missense variant)	Cardiovascular phenotype	GUncertain significance
Select item 12586	NM_004985.5(KRAS):c.178G>C (p.Gly60Arg)	KRAS (G60R)	Single nucleotide variant (missense variant)	Cardio-facio-cutaneous syndrome	GPathogenic FDA Recognized database
Select item 2454057	NM_004985.5(KRAS):c.168C>T (p.Leu56=)	KRAS	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype	GLikely benign
Select item 1775477	NM_004985.5(KRAS):c.156C>T (p.Leu52=)	KRAS	Single nucleotide variant (synonymous variant)	RASopathy +1 more	GLikely benign
Select item 1774834	NM_004985.5(KRAS):c.153T>G (p.Cys51Trp)	KRAS (C51W)	Single nucleotide variant (missense variant)	Cardiovascular phenotype	GUncertain significance
Select item 2156411	NM_004985.5(KRAS):c.141T>C (p.Asp47=)	KRAS	Single nucleotide variant (synonymous variant)	RASopathy +1 more	GLikely benign
Select item 163768	NM_004985.5(KRAS):c.108A>G (p.Ile36Met)	KRAS (I36M)	Single nucleotide variant (missense variant)	not provided +5 more	GPathogenic/Likely pathogenic
Select item 195234	NM_033360.4(KRAS):c.93A>G (p.Glu31=)	KRAS	Single nucleotide variant (synonymous variant)	RASopathy +2 more	GConflicting classifications of pathogenicity
Select item 2568296	NM_004985.5(KRAS):c.69A>G (p.Leu23=)	KRAS	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype	GLikely benign
Select item 12589	NM_004985.5(KRAS):c.40G>A (p.Val14Ile)	KRAS (V14I)	Single nucleotide variant (missense variant)	Noonan syndrome	GPathogenic FDA Recognized database
Select item 12580	NM_004985.5(KRAS):c.38G>A (p.Gly13Asp)	KRAS (G13D)	Single nucleotide variant (missense variant)	RASopathy +6 more	GPathogenic OOncogenic
Select item 1734094	NM_004985.5(KRAS):c.36T>G (p.Gly12=)	KRAS	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype	GLikely benign
Select item 1734090	NM_004985.5(KRAS):c.36T>A (p.Gly12=)	KRAS	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype	GLikely benign
Select item 12582	NM_004985.5(KRAS):c.35G>A (p.Gly12Asp)	KRAS (G12D)	Single nucleotide variant (missense variant)	RASopathy +6 more	GPathogenic/Likely pathogenic OOncogenic
Select item 45119	NM_004985.5(KRAS):c.24A>G (p.Val8=)	KRAS	Single nucleotide variant (synonymous variant)	RASopathy	GLikely benign FDA Recognized database
Select item 12594	NM_033360.4(KRAS):c.15A>T (p.Lys5Asn)	KRAS (K5N)	Single nucleotide variant (missense variant)	Noonan syndrome	GPathogenic FDA Recognized database
Select item 1744676	NM_004985.5(KRAS):c.4A>C (p.Thr2Pro)	KRAS (T2P)	Single nucleotide variant (missense variant)	Cardiovascular phenotype	GUncertain significance

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Items: 37