"Ambry Genetics"[submitter] AND "FLCN"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 485622	NM_144997.7(FLCN):c.*5T>C	FLCN	Single nucleotide variant (3 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1196117	NM_144997.7(FLCN):c.*1C>T	FLCN	Single nucleotide variant (3 prime UTR variant)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 1779040	NM_144997.7(FLCN):c.1734G>A (p.Arg578=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 819964	NM_144997.7(FLCN):c.1733G>A (p.Arg578Gln)	FLCN (R578Q +1 more)	Single nucleotide variant (missense variant)	Birt-Hogg-Dube syndrome +5 more	GUncertain significance
Select item 651362	NM_144997.7(FLCN):c.1732C>T (p.Arg578Trp)	FLCN (R596W +1 more)	Single nucleotide variant (missense variant)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 3229239	NM_144997.7(FLCN):c.1723_1729delinsCCACAGC (p.Ser575_Ser577delinsProGlnPro)	FLCN	Indel (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1778931	NM_144997.7(FLCN):c.1729T>G (p.Ser577Ala)	FLCN (S595A +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3279025	NM_144997.7(FLCN):c.1728G>A (p.Glu576=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 2496514	NM_144997.7(FLCN):c.1727A>G (p.Glu576Gly)	FLCN (E576G +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 3229241	NM_144997.7(FLCN):c.1726G>C (p.Glu576Gln)	FLCN (E576Q +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 707812	NM_144997.7(FLCN):c.1725G>A (p.Ser575=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 1059893	NM_144997.7(FLCN):c.1724C>T (p.Ser575Leu)	FLCN (S575L +1 more)	Single nucleotide variant (missense variant)	Birt-Hogg-Dube syndrome +1 more	GUncertain significance
Select item 3229240	NM_144997.7(FLCN):c.1723T>C (p.Ser575Pro)	FLCN (S575P +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 944338	NM_144997.7(FLCN):c.1721C>T (p.Ala574Val)	FLCN (A592V +1 more)	Single nucleotide variant (missense variant)	Birt-Hogg-Dube syndrome +1 more	GUncertain significance
Select item 2624777	NM_144997.7(FLCN):c.1720G>A (p.Ala574Thr)	FLCN (A574T +1 more)	Single nucleotide variant (missense variant)	Birt-Hogg-Dube syndrome +1 more	GUncertain significance
Select item 643740	NM_144997.7(FLCN):c.1717A>G (p.Thr573Ala)	FLCN (T573A +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 1778631	NM_144997.7(FLCN):c.1716C>T (p.Pro572=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 653717	NM_144997.7(FLCN):c.1715C>A (p.Pro572His)	FLCN (P572H +1 more)	Single nucleotide variant (missense variant)	Nonpapillary renal cell carcinoma +5 more	GUncertain significance
Select item 1778602	NM_144997.7(FLCN):c.1713C>T (p.Ser571=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 2131850	NM_144997.7(FLCN):c.1654_1709dup (p.Ser571_Pro572insGlyTerSer)	FLCN	Duplication (nonsense +1 more)	Birt-Hogg-Dube syndrome +1 more	GUncertain significance
Select item 1043559	NM_144997.7(FLCN):c.1709G>T (p.Arg570Leu)	FLCN (R588L +1 more)	Single nucleotide variant (missense variant)	Colorectal cancer +6 more	GConflicting classifications of pathogenicity
Select item 229915	NM_144997.7(FLCN):c.1709G>A (p.Arg570His)	FLCN (R570H +1 more)	Single nucleotide variant (missense variant)	not provided +6 more	GConflicting classifications of pathogenicity
Select item 819901	NM_144997.7(FLCN):c.1708C>T (p.Arg570Cys)	FLCN (R570C +1 more)	Single nucleotide variant (missense variant)	not specified +2 more	GUncertain significance
Select item 749853	NM_144997.7(FLCN):c.1707C>T (p.Val569=)	FLCN	Single nucleotide variant (synonymous variant)	Birt-Hogg-Dube syndrome +1 more	GLikely benign
Select item 1087486	NM_144997.7(FLCN):c.1704G>C (p.Thr568=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 415623	NM_144997.7(FLCN):c.1704G>A (p.Thr568=)	FLCN	Single nucleotide variant (synonymous variant)	Birt-Hogg-Dube syndrome +2 more	GLikely benign
Select item 460606	NM_144997.7(FLCN):c.1703C>T (p.Thr568Met)	FLCN (T568M +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 232328	NM_144997.7(FLCN):c.1702A>G (p.Thr568Ala)	FLCN (T568A +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 938559	NM_144997.7(FLCN):c.1700C>T (p.Ser567Phe)	FLCN (S567F +1 more)	Single nucleotide variant (missense variant)	Birt-Hogg-Dube syndrome 1 +4 more	GConflicting classifications of pathogenicity
Select item 993694	NM_144997.7(FLCN):c.1697T>C (p.Met566Thr)	FLCN (M566T +1 more)	Single nucleotide variant (missense variant)	Birt-Hogg-Dube syndrome 1 +3 more	GUncertain significance
Select item 1778180	NM_144997.7(FLCN):c.1693C>T (p.Leu565Phe)	FLCN (L583F +1 more)	Single nucleotide variant (missense variant)	not provided +2 more	GUncertain significance
Select item 2037757	NM_144997.7(FLCN):c.1692C>G (p.His564Gln)	FLCN (H564Q +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 184907	NM_144997.7(FLCN):c.1692C>T (p.His564=)	FLCN	Single nucleotide variant (synonymous variant)	Birt-Hogg-Dube syndrome +7 more	GBenign/Likely benign
Select item 2157084	NM_144997.7(FLCN):c.1691A>C (p.His564Pro)	FLCN (H582P +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 1778140	NM_144997.7(FLCN):c.1691A>T (p.His564Leu)	FLCN (H564L +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 480818	NM_144997.7(FLCN):c.1690C>T (p.His564Tyr)	FLCN (H564Y +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 572698	NM_144997.7(FLCN):c.1689del (p.His564fs)	FLCN (H564fs +1 more)	Deletion (frameshift variant)	Birt-Hogg-Dube syndrome +1 more	GUncertain significance
Select item 485630	NM_144997.7(FLCN):c.1685A>G (p.Lys562Arg)	FLCN (K562R +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 1777966	NM_144997.7(FLCN):c.1684A>G (p.Lys562Glu)	FLCN (K580E +1 more)	Single nucleotide variant (missense variant)	Birt-Hogg-Dube syndrome +1 more	GUncertain significance
Select item 1777820	NM_144997.7(FLCN):c.1677G>T (p.Lys559Asn)	FLCN (K559N +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3229238	NM_144997.7(FLCN):c.1674C>T (p.Ser558=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 1777707	NM_144997.7(FLCN):c.1671G>A (p.Leu557=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 241921	NM_144997.7(FLCN):c.1669C>T (p.Leu557=)	FLCN	Single nucleotide variant (synonymous variant)	Birt-Hogg-Dube syndrome +1 more	GLikely benign
Select item 3229237	NM_144997.7(FLCN):c.1668C>T (p.Gly556=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 2566316	NM_144997.7(FLCN):c.1663A>C (p.Thr555Pro)	FLCN (T573P +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 253260	NM_144997.7(FLCN):c.1658G>A (p.Trp553Ter)	FLCN (W553* +1 more)	Single nucleotide variant (nonsense)	Birt-Hogg-Dube syndrome +1 more	GPathogenic
Select item 428647	NM_144997.7(FLCN):c.1657T>C (p.Trp553Arg)	FLCN (W553R +1 more)	Single nucleotide variant (missense variant)	Birt-Hogg-Dube syndrome +6 more	GPathogenic/Likely pathogenic
Select item 2586492	NM_144997.7(FLCN):c.1648C>G (p.Leu550Val)	FLCN (L550V +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 819721	NM_144997.7(FLCN):c.1647G>A (p.Leu549=)	FLCN	Single nucleotide variant (synonymous variant)	Birt-Hogg-Dube syndrome +1 more	GLikely benign
Select item 485623	NM_144997.7(FLCN):c.1647G>T (p.Leu549=)	FLCN	Single nucleotide variant (synonymous variant)	Birt-Hogg-Dube syndrome +1 more	GLikely benign
Select item 529996	NM_144997.7(FLCN):c.1645C>G (p.Leu549Val)	FLCN (L549V +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 3229236	NM_144997.7(FLCN):c.1644G>A (p.Lys548=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 485598	NM_144997.7(FLCN):c.1644G>C (p.Lys548Asn)	FLCN (K548N +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1777071	NM_144997.7(FLCN):c.1642A>G (p.Lys548Glu)	FLCN (K548E +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 460605	NM_144997.7(FLCN):c.1641C>A (p.Val547=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 1400006	NM_144997.7(FLCN):c.1639G>T (p.Val547Phe)	FLCN (V565F +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 3001443	NM_144997.7(FLCN):c.1638T>C (p.Asn546=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 485586	NM_144997.7(FLCN):c.1637A>G (p.Asn546Ser)	FLCN (N546S +1 more)	Single nucleotide variant (missense variant)	not specified +7 more	GConflicting classifications of pathogenicity
Select item 1776931	NM_144997.7(FLCN):c.1636A>G (p.Asn546Asp)	FLCN (N546D +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2586505	NM_144997.7(FLCN):c.1635del (p.Asp545fs)	FLCN (D545fs +1 more)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 184253	NM_144997.7(FLCN):c.1635C>G (p.Asp545Glu)	FLCN (D545E +1 more)	Single nucleotide variant (missense variant)	Birt-Hogg-Dube syndrome +7 more	GConflicting classifications of pathogenicity
Select item 485607	NM_144997.7(FLCN):c.1632G>A (p.Glu544=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 1776825	NM_144997.7(FLCN):c.1630G>A (p.Glu544Lys)	FLCN (E562K +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 579044	NM_144997.7(FLCN):c.1627G>A (p.Glu543Lys)	FLCN (E543K +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 697386	NM_144997.7(FLCN):c.1626C>T (p.Ser542=)	FLCN	Single nucleotide variant (synonymous variant)	Birt-Hogg-Dube syndrome +2 more	GLikely benign
Select item 1776654	NM_144997.7(FLCN):c.1623G>T (p.Ala541=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 415621	NM_144997.7(FLCN):c.1623G>A (p.Ala541=)	FLCN	Single nucleotide variant (synonymous variant)	Birt-Hogg-Dube syndrome +1 more	GLikely benign
Select item 1044208	NM_144997.7(FLCN):c.1622C>T (p.Ala541Val)	FLCN (A541V +1 more)	Single nucleotide variant (missense variant)	Birt-Hogg-Dube syndrome +1 more	GConflicting classifications of pathogenicity
Select item 651413	NM_144997.7(FLCN):c.1607_1622del (p.Leu536fs)	FLCN (L536fs +1 more)	Deletion (frameshift variant)	not provided +2 more	GPathogenic
Select item 1776619	NM_144997.7(FLCN):c.1621G>A (p.Ala541Thr)	FLCN (A541T +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 1776608	NM_144997.7(FLCN):c.1620T>C (p.Gly540=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 2898977	NM_144997.7(FLCN):c.1618G>A (p.Gly540Ser)	FLCN (G540S +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 1076330	NM_144997.7(FLCN):c.1616dup (p.Ala541fs)	FLCN (A541fs +1 more)	Duplication (frameshift variant)	Birt-Hogg-Dube syndrome +1 more	GPathogenic/Likely pathogenic
Select item 1776474	NM_144997.7(FLCN):c.1615dup (p.Leu539fs)	FLCN (L557fs +1 more)	Duplication (frameshift variant)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic/Likely pathogenic
Select item 3279017	NM_144997.7(FLCN):c.1614C>G (p.Ile538Met)	FLCN (I556M +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1463042	NM_144997.7(FLCN):c.1612A>G (p.Ile538Val)	FLCN (I538V +1 more)	Single nucleotide variant (missense variant)	Birt-Hogg-Dube syndrome +1 more	GUncertain significance
Select item 1352071	NM_144997.7(FLCN):c.1612A>C (p.Ile538Leu)	FLCN (I556L +1 more)	Single nucleotide variant (missense variant)	Birt-Hogg-Dube syndrome +1 more	GUncertain significance
Select item 1776396	NM_144997.7(FLCN):c.1611C>T (p.Ser537=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 1776286	NM_144997.7(FLCN):c.1606C>A (p.Leu536Met)	FLCN (L554M +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 1776266	NM_144997.7(FLCN):c.1605G>A (p.Leu535=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 2566333	NM_144997.7(FLCN):c.1603C>T (p.Leu535=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 819648	NM_144997.7(FLCN):c.1602G>A (p.Lys534=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 579021	NM_144997.7(FLCN):c.1599G>C (p.Gln533His)	FLCN (Q533H +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GConflicting classifications of pathogenicity
Select item 234040	NM_144997.7(FLCN):c.1597_1598del (p.Gln533fs)	FLCN (Q551fs +1 more)	Microsatellite (frameshift variant)	Birt-Hogg-Dube syndrome +1 more	GPathogenic
Select item 96480	NM_144997.7(FLCN):c.1597C>T (p.Gln533Ter)	FLCN (Q533* +1 more)	Single nucleotide variant (nonsense)	not specified +4 more	GConflicting classifications of pathogenicity
Select item 1776009	NM_144997.7(FLCN):c.1596A>G (p.Thr532=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 819626	NM_144997.7(FLCN):c.1594A>C (p.Thr532Pro)	FLCN (T532P +1 more)	Single nucleotide variant (missense variant)	Birt-Hogg-Dube syndrome +1 more	GUncertain significance
Select item 1775770	NM_144997.7(FLCN):c.1584C>T (p.Pro528=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 428639	NM_144997.7(FLCN):c.1584del (p.Glu530fs)	FLCN (E548fs +1 more)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome +2 more	GPathogenic/Likely pathogenic
Select item 1775752	NM_144997.7(FLCN):c.1583C>T (p.Pro528Leu)	FLCN (P528L +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2091921	NM_144997.7(FLCN):c.1582C>T (p.Pro528Ser)	FLCN (P546S +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 3279026	NM_144997.7(FLCN):c.1581A>T (p.Arg527=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 2566314	NM_144997.7(FLCN):c.1580G>T (p.Arg527Leu)	FLCN (R545L +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1775692	NM_144997.7(FLCN):c.1580G>C (p.Arg527Pro)	FLCN (R545P +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 460603	NM_144997.7(FLCN):c.1580G>A (p.Arg527Gln)	FLCN (R527Q +1 more)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 253259	NM_144997.7(FLCN):c.1579_1580insA (p.Arg527fs)	FLCN (R527fs +1 more)	Insertion (frameshift variant)	not provided +3 more	GPathogenic/Likely pathogenic
Select item 253258	NM_144997.7(FLCN):c.1579C>T (p.Arg527Ter)	FLCN (R527* +1 more)	Single nucleotide variant (nonsense)	Birt-Hogg-Dube syndrome +2 more	GPathogenic/Likely pathogenic
Select item 1775450	NM_144997.7(FLCN):c.1569G>A (p.Lys523=)	FLCN	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 1026080	NM_144997.7(FLCN):c.1565C>A (p.Thr522Asn)	FLCN (T522N +1 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 937060	NM_144997.7(FLCN):c.1565C>G (p.Thr522Ser)	FLCN (T540S +1 more)	Single nucleotide variant (missense variant)	Birt-Hogg-Dube syndrome +1 more	GUncertain significance

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