"Ambry Genetics"[submitter] AND "CDH1"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 3076086	NM_004360.5(CDH1):c.-20C>T	CDH1, LOC130059290	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3076085	NM_004360.5(CDH1):c.-11C>T	CDH1, LOC130059290	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 142314	NM_004360.5(CDH1):c.-9C>T	CDH1, LOC130059290	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3076087	NM_004360.5(CDH1):c.-7G>A	CDH1	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 421101	NM_004360.5(CDH1):c.-6C>T	CDH1	Single nucleotide variant (5 prime UTR variant)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 628145	NM_004360.5(CDH1):c.-2C>T	CDH1	Single nucleotide variant (5 prime UTR variant)	not specified +2 more	GConflicting classifications of pathogenicity
Select item 2493701	NM_004360.5(CDH1):c.-1C>T	CDH1	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1784189	NM_004360.5(CDH1):c.-1C>G	CDH1	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 532457	NM_004360.5(CDH1):c.1A>G (p.Met1Val)	CDH1 (M1V)	Single nucleotide variant (missense variant +2 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 486826	NM_004360.5(CDH1):c.2T>C (p.Met1Thr)	CDH1 (M1T)	Single nucleotide variant (missense variant +2 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 239906	NM_004360.5(CDH1):c.3G>A (p.Met1Ile)	CDH1 (M1I)	Single nucleotide variant (missense variant +2 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 183998	NM_004360.5(CDH1):c.4G>A (p.Gly2Ser)	CDH1 (G2S)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 239909	NM_004360.5(CDH1):c.5G>T (p.Gly2Val)	CDH1 (G2V)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GUncertain significance FDA Recognized database
Select item 184107	NM_004360.5(CDH1):c.6C>T (p.Gly2=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GBenign/Likely benign
Select item 418111	NM_004360.5(CDH1):c.7C>T (p.Pro3Ser)	CDH1 (P3S)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GUncertain significance FDA Recognized database
Select item 142469	NM_004360.5(CDH1):c.8C>G (p.Pro3Arg)	CDH1 (P3R)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 1768945	NM_004360.5(CDH1):c.9T>A (p.Pro3=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 463799	NM_004360.5(CDH1):c.9T>C (p.Pro3=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GBenign/Likely benign
Select item 1747171	NM_004360.5(CDH1):c.11G>T (p.Trp4Leu)	CDH1 (W4L)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 918853	NM_004360.5(CDH1):c.11G>A (p.Trp4Ter)	CDH1 (W4*)	Single nucleotide variant (nonsense +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 2577652	NM_004360.5(CDH1):c.12G>C (p.Trp4Cys)	CDH1 (W4C)	Single nucleotide variant (missense variant +1 more)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 548782	NM_004360.5(CDH1):c.12G>A (p.Trp4Ter)	CDH1 (W4*)	Single nucleotide variant (nonsense +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 2561294	NM_004360.5(CDH1):c.13A>C (p.Ser5Arg)	CDH1 (S5R)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 463713	NM_004360.5(CDH1):c.13A>G (p.Ser5Gly)	CDH1 (S5G)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 855406	NM_004360.5(CDH1):c.14G>A (p.Ser5Asn)	CDH1 (S5N)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 3265112	NM_004360.5(CDH1):c.15C>A (p.Ser5Arg)	CDH1 (S5R)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1776136	NM_004360.5(CDH1):c.15C>G (p.Ser5Arg)	CDH1 (S5R)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 184111	NM_004360.5(CDH1):c.15C>T (p.Ser5=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma +2 more	GBenign/Likely benign
Select item 1349815	NM_004360.5(CDH1):c.16C>A (p.Arg6Ser)	CDH1 (R6S)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 1556744	NM_004360.5(CDH1):c.18C>T (p.Arg6=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 184145	NM_004360.5(CDH1):c.18C>A (p.Arg6=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GBenign/Likely benign
Select item 3224166	NM_004360.5(CDH1):c.20G>A (p.Ser7Asn)	CDH1 (S7N)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 820715	NM_004360.5(CDH1):c.20G>C (p.Ser7Thr)	CDH1 (S7T)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 463745	NM_004360.5(CDH1):c.21C>T (p.Ser7=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GLikely benign
Select item 1410393	NM_004360.5(CDH1):c.22C>T (p.Leu8Phe)	CDH1 (L8F)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 821055	NM_004360.5(CDH1):c.22C>G (p.Leu8Val)	CDH1 (L8V)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 3265131	NM_004360.5(CDH1):c.25dup (p.Ser9fs)	CDH1 (S9fs)	Duplication (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 630530	NM_004360.5(CDH1):c.24C>G (p.Leu8=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GBenign/Likely benign
Select item 532470	NM_004360.5(CDH1):c.25T>G (p.Ser9Ala)	CDH1 (S9A)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 479485	NM_004360.5(CDH1):c.26C>T (p.Ser9Leu)	CDH1 (S9L)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 479527	NM_004360.5(CDH1):c.27G>C (p.Ser9=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GLikely benign
Select item 184065	NM_004360.5(CDH1):c.27G>A (p.Ser9=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	not specified +3 more	GConflicting classifications of pathogenicity
Select item 649532	NM_004360.5(CDH1):c.28G>A (p.Ala10Thr)	CDH1 (A10T)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +2 more	GUncertain significance
Select item 584912	NM_004360.5(CDH1):c.29C>A (p.Ala10Glu)	CDH1 (A10E)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 532451	NM_004360.5(CDH1):c.29C>T (p.Ala10Val)	CDH1 (A10V)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 220798	NM_004360.5(CDH1):c.32TGC[6] (p.Leu15dup)	CDH1	Microsatellite (inframe_insertion +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 142455	NM_004360.5(CDH1):c.32TGC[7] (p.Leu14_Leu15dup)	CDH1	Microsatellite (inframe_insertion +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 491533	NM_004360.5(CDH1):c.30G>T (p.Ala10=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GBenign/Likely benign
Select item 1728782	NM_004360.5(CDH1):c.31C>G (p.Leu11Val)	CDH1 (L11V)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 584913	NM_004360.5(CDH1):c.32T>G (p.Leu11Arg)	CDH1 (L11R)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 182377	NM_004360.5(CDH1):c.33G>C (p.Leu11=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 414047	NM_004360.5(CDH1):c.34C>T (p.Leu12=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GBenign/Likely benign
Select item 184548	NM_004360.5(CDH1):c.42G>A (p.Leu14=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3265111	NM_004360.5(CDH1):c.43C>T (p.Leu15=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GBenign/Likely benign
Select item 576714	NM_004360.5(CDH1):c.44T>A (p.Leu15Gln)	CDH1 (L15Q)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 919859	NM_004360.5(CDH1):c.45G>A (p.Leu15=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma +3 more	GBenign/Likely benign
Select item 2128748	NM_004360.5(CDH1):c.47A>G (p.Gln16Arg)	CDH1 (Q16R)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 1040346	NM_004360.5(CDH1):c.48G>C (p.Gln16His)	CDH1 (Q16H)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 449341	NM_004360.5(CDH1):c.48+1G>A	CDH1	Single nucleotide variant (splice donor variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 1743193	NM_004360.5(CDH1):c.48+4C>T	CDH1	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 825188	NM_004360.5(CDH1):c.48+5C>A	CDH1	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 491543	NM_004360.5(CDH1):c.48+5C>T	CDH1	Single nucleotide variant (intron variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 491542	NM_004360.5(CDH1):c.48+5_48+6delinsGT	CDH1	Indel (intron variant)	Hereditary diffuse gastric adenocarcinoma +1 more	GConflicting classifications of pathogenicity
Select item 491541	NM_004360.5(CDH1):c.48+5_48+6delinsAT	CDH1	Indel (intron variant)	Hereditary diffuse gastric adenocarcinoma +1 more	GConflicting classifications of pathogenicity
Select item 491540	NM_004360.5(CDH1):c.48+5_48+6delinsTT	CDH1	Indel (intron variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 140784	NM_004360.5(CDH1):c.48+5C>G	CDH1	Single nucleotide variant (intron variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 136692	NM_004360.5(CDH1):c.48+6C>T	CDH1	Single nucleotide variant (intron variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GBenign FDA Recognized database
Select item 142318	NM_004360.5(CDH1):c.48+7C>T	CDH1	Single nucleotide variant (intron variant)	not provided +2 more	GLikely benign
Select item 142330	NM_004360.5(CDH1):c.48+16T>C	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma +1 more	GLikely benign
Select item 491545	NM_004360.5(CDH1):c.49-19T>C	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma +1 more	GConflicting classifications of pathogenicity
Select item 925068	NM_004360.5(CDH1):c.49-5C>T	CDH1	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 3265139	NM_004360.5(CDH1):c.49-4C>T	CDH1	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1108677	NM_004360.5(CDH1):c.49-4C>G	CDH1	Single nucleotide variant (intron variant)	Hereditary diffuse gastric adenocarcinoma +1 more	GConflicting classifications of pathogenicity
Select item 421050	NM_004360.5(CDH1):c.49-3C>A	CDH1	Single nucleotide variant (intron variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GUncertain significance FDA Recognized database
Select item 142294	NM_004360.5(CDH1):c.49-3C>T	CDH1	Single nucleotide variant (intron variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 1744170	NM_004360.5(CDH1):c.49-2A>C	CDH1	Single nucleotide variant (splice acceptor variant)	not provided +1 more	GPathogenic
Select item 406631	NM_004360.5(CDH1):c.49-2A>G	CDH1	Single nucleotide variant (splice acceptor variant)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 2836868	NM_004360.5(CDH1):c.49-1G>A	CDH1	Single nucleotide variant (splice acceptor variant)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic/Likely pathogenic
Select item 1744673	NM_004360.5(CDH1):c.49G>T (p.Val17Phe)	CDH1 (V17F)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 799036	NM_004360.5(CDH1):c.51C>T (p.Val17=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GBenign/Likely benign
Select item 1747946	NM_004360.5(CDH1):c.54C>T (p.Ser18=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 406626	NM_004360.5(CDH1):c.55T>G (p.Ser19Ala)	CDH1 (S19A)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 825908	NM_004360.5(CDH1):c.56C>T (p.Ser19Phe)	CDH1 (S19F)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 479528	NM_004360.5(CDH1):c.56C>G (p.Ser19Cys)	CDH1 (S19C)	Single nucleotide variant (missense variant +1 more)	Familial cancer of breast +3 more	GUncertain significance
Select item 640183	NM_004360.5(CDH1):c.59G>C (p.Trp20Ser)	CDH1 (W20S)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 187239	NM_004360.5(CDH1):c.60G>A (p.Trp20Ter)	CDH1 (W20*)	Single nucleotide variant (nonsense +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 230175	NM_004360.5(CDH1):c.61C>G (p.Leu21Val)	CDH1 (L21V)	Single nucleotide variant (missense variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GUncertain significance FDA Recognized database
Select item 216596	NM_004360.5(CDH1):c.61C>T (p.Leu21Phe)	CDH1 (L21F)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 421115	NM_004360.5(CDH1):c.62T>C (p.Leu21Pro)	CDH1 (L21P)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 798538	NM_004360.5(CDH1):c.63C>T (p.Leu21=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GBenign/Likely benign
Select item 479510	NM_004360.5(CDH1):c.65G>A (p.Cys22Tyr)	CDH1 (C22Y)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 232158	NM_004360.5(CDH1):c.66C>T (p.Cys22=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GBenign/Likely benign
Select item 3265153	NM_004360.5(CDH1):c.67C>G (p.Gln23Glu)	CDH1 (Q23E)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 946040	NM_004360.5(CDH1):c.67C>T (p.Gln23Ter)	CDH1 (Q23*)	Single nucleotide variant (nonsense +1 more)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic
Select item 186050	NM_004360.5(CDH1):c.69G>A (p.Gln23=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GLikely benign FDA Recognized database
Select item 826837	NM_004360.5(CDH1):c.70G>A (p.Glu24Lys)	CDH1 (E24K)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 12240	NM_004360.5(CDH1):c.70G>T (p.Glu24Ter)	CDH1 (E24*)	Single nucleotide variant (nonsense +1 more)	CDH1-related diffuse gastric and lobular breast cancer syndrome	GPathogenic FDA Recognized database
Select item 2587438	NM_004360.5(CDH1):c.72G>T (p.Glu24Asp)	CDH1 (E24D)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 827086	NM_004360.5(CDH1):c.74C>T (p.Pro25Leu)	CDH1 (P25L)	Single nucleotide variant (missense variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GUncertain significance
Select item 185752	NM_004360.5(CDH1):c.75G>A (p.Pro25=)	CDH1	Single nucleotide variant (synonymous variant +1 more)	Hereditary diffuse gastric adenocarcinoma +1 more	GBenign/Likely benign

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