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Items: 38

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
GCKR
(G106R)
Single nucleotide variant
(missense variant)
Fasting plasma glucose level quantitative trait locus 5
GUncertain significance
INSR
(A550V)
Single nucleotide variant
(missense variant)
Insulin-resistant diabetes mellitus AND acanthosis nigricans
GUncertain significance
FASTKD2
(L166fs)
Deletion
(frameshift variant)
Combined oxidative phosphorylation deficiency 44
GLikely pathogenic
NDUFAF5
(R119P +3 more)
Single nucleotide variant
(missense variant +1 more)
Mitochondrial complex 1 deficiency, nuclear type 16
GUncertain significance
CHEK2
Deletion
(inframe_deletion +1 more)
Familial cancer of breast
GLikely pathogenic
BLM
(R1086fs +1 more)
Duplication
(frameshift variant)
Colorectal cancer
+2 more
GPathogenic
CAPN3
(Y49H +2 more)
Single nucleotide variant
(missense variant)
Autosomal recessive limb-girdle muscular dystrophy type 2A
GConflicting classifications of pathogenicity
KLF11
(R444Q +1 more)
Single nucleotide variant
(missense variant)
not provided
GLikely benign
ALMS1
(G483A +1 more)
Single nucleotide variant
(missense variant)
Alstrom syndrome
GUncertain significance
KANK1
(E107K +1 more)
Single nucleotide variant
(missense variant +1 more)
not specified
+1 more
GUncertain significance
WFS1
(G736S)
Single nucleotide variant
(missense variant)
Wolfram syndrome 1
+1 more
GPathogenic/Likely pathogenic
FH
(L453P)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic/Likely pathogenic
NIPAL4
(P217A +3 more)
Single nucleotide variant
(missense variant)
Erythrokeratodermia variabilis et progressiva 1
GLikely pathogenic
FOXRED1
(V421M)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GConflicting classifications of pathogenicity
ABCC8
(V84I)
Single nucleotide variant
(missense variant +1 more)
not provided
+3 more
GConflicting classifications of pathogenicity
ALMS1
(T3207I +1 more)
Single nucleotide variant
(missense variant)
Alstrom syndrome
+2 more
GLikely benign
LOC126859771, RFX6
(R578P)
Single nucleotide variant
(missense variant)
Monogenic diabetes
+3 more
GConflicting classifications of pathogenicity
KANK1
(C551Y +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+2 more
GUncertain significance
PPP1R3A
(P756L)
Single nucleotide variant
(missense variant)
Monogenic diabetes
GLikely benign
BRCA1
(A760fs +20 more)
Duplication
(frameshift variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
TTC8
(D65G +1 more)
Single nucleotide variant
(missense variant +2 more)
not specified
+3 more
GConflicting classifications of pathogenicity
BRCA2
(I2552fs)
Duplication
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
C11orf65, ATM
(E2039K)
Single nucleotide variant
(missense variant +1 more)
Ataxia-telangiectasia syndrome
+3 more
GPathogenic/Likely pathogenic
BBS12
(G119S)
Single nucleotide variant
(missense variant)
not provided
+3 more
GBenign/Likely benign
GFM2
(R190Q +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GConflicting classifications of pathogenicity
CHEK2
Single nucleotide variant
(intron variant)
Hereditary breast ovarian cancer syndrome
+6 more
GPathogenic/Likely pathogenic
BRCA1
(A224fs +1 more)
Duplication
(frameshift variant +2 more)
Hereditary breast ovarian cancer syndrome
+3 more
GConflicting classifications of pathogenicity
BRCA1
(R7fs)
Deletion
(frameshift variant +2 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
BRCA1
(E1017* +20 more)
Single nucleotide variant
(nonsense +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
BRCA1
(R24fs +1 more)
Duplication
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
BRCA1
(Q538* +20 more)
Single nucleotide variant
(nonsense +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
BRCA2
Single nucleotide variant
(splice acceptor variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
Deletion
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
(K437fs)
Microsatellite
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA1
(T1677fs +3 more)
Deletion
(frameshift variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
BRCA1
(K812fs +20 more)
Deletion
(frameshift variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
BRCA1
(Q1756fs +3 more)
Duplication
(frameshift variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
PDX1
(D76N)
Single nucleotide variant
(missense variant)
Maturity-onset diabetes of the young type 4
+5 more
GConflicting classifications of pathogenicity
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