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Items: 1 to 100 of 126

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
NSD1
(R1202G +4 more)
Single nucleotide variant
(missense variant)
Sotos syndrome
GUncertain significance
ZEB2
(C1057Y +1 more)
Single nucleotide variant
(missense variant)
Mowat-Wilson syndrome
GPathogenic
ZC4H2
(C169Y +2 more)
Single nucleotide variant
(missense variant +1 more)
Wieacker-Wolff syndrome, female-restricted
GPathogenic
USP7
(G293A +3 more)
Single nucleotide variant
(missense variant +1 more)
Hao-Fountain syndrome
GLikely pathogenic
SNHG14, UBE3A
(G124E +5 more)
Single nucleotide variant
(missense variant +1 more)
Angelman syndrome
GLikely pathogenic
LOC129998021, TWIST1
Deletion
(inframe_deletion +1 more)
Saethre-Chotzen syndrome
GPathogenic
TUBA1A
(G109V +1 more)
Single nucleotide variant
(missense variant)
Lissencephaly due to TUBA1A mutation
GPathogenic
KMT5B
(H110D +3 more)
Single nucleotide variant
(missense variant +2 more)
Intellectual disability, autosomal dominant 51
GPathogenic
KMT5B
(N106I +4 more)
Single nucleotide variant
(missense variant +1 more)
Intellectual disability, autosomal dominant 51
GPathogenic
KMT2D
(V2551fs)
Deletion
(frameshift variant)
Kabuki syndrome 1
GPathogenic
KMT2A
(S828*)
Single nucleotide variant
(nonsense)
Wiedemann-Steiner syndrome
GPathogenic
KCNQ2
(L293P)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 7
GPathogenic
KANSL1
(R474C)
Single nucleotide variant
(missense variant)
Koolen-de Vries syndrome
GPathogenic
KANSL1
(D171fs)
Duplication
(frameshift variant)
Koolen-de Vries syndrome
GPathogenic
HDAC8
(D157E +1 more)
Single nucleotide variant
(missense variant +1 more)
Cornelia de Lange syndrome 5
GPathogenic
TSPAN7
(L97fs)
Deletion
(frameshift variant)
Intellectual disability, X-linked 58
GPathogenic
TRMT1
(Q42* +1 more)
Single nucleotide variant
(nonsense +1 more)
Intellectual developmental disorder, autosomal recessive 68
GLikely pathogenic
TRIP12
(V449fs +4 more)
Insertion
(frameshift variant)
Clark-Baraitser syndrome
GPathogenic
TCF20
(L1284fs)
Insertion
(frameshift variant)
Developmental delay with variable intellectual impairment and behavioral abnormalities
GPathogenic
TCF20
(R1741fs)
Microsatellite
(frameshift variant)
Developmental delay with variable intellectual impairment and behavioral abnormalities
GPathogenic
TCF4
(T390I +21 more)
Single nucleotide variant
(missense variant)
Pitt-Hopkins syndrome
GUncertain significance
TBR1
(T378S)
Single nucleotide variant
(missense variant)
Autism, susceptibility to, 5
GPathogenic
TBL1XR1
(S112fs +1 more)
Deletion
(frameshift variant)
Intellectual disability, autosomal dominant 41
GPathogenic
SYT1
(R397* +1 more)
Single nucleotide variant
(nonsense)
Infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome
GPathogenic
GRIN2B
(L643P)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic
GABRB3
(F140L +2 more)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 43
GPathogenic
FOXP1
(S417N +4 more)
Single nucleotide variant
(missense variant +2 more)
Intellectual disability-severe speech delay-mild dysmorphism syndrome
GPathogenic
EVC2
(R9fs)
Deletion
(frameshift variant +1 more)
Ellis-van Creveld syndrome
GPathogenic
EPHB4, LOC126860124
(Q869fs)
Duplication
(frameshift variant)
Capillary malformation-arteriovenous malformation 2
GPathogenic
EFTUD2
Deletion
(intron variant)
Mandibulofacial dysostosis-microcephaly syndrome
GLikely pathogenic
DYNC1H1, LOC126862060
(P3070L)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 13
GLikely pathogenic
DLG4, LOC126862479
Single nucleotide variant
(synonymous variant +1 more)
not provided
+1 more
GPathogenic/Likely pathogenic
DDX3X
(S357L +2 more)
Single nucleotide variant
(missense variant +1 more)
Intellectual disability, X-linked 102
GLikely pathogenic
DCX
(D263G +1 more)
Single nucleotide variant
(missense variant)
Lissencephaly type 1 due to doublecortin gene mutation
GLikely pathogenic
SSR4
Deletion
(splice donor variant)
SSR4-congenital disorder of glycosylation
GPathogenic
SOX9
(R177W)
Single nucleotide variant
(missense variant)
not provided
GLikely pathogenic
SMC1A
(Q369* +1 more)
Single nucleotide variant
(nonsense)
not provided
GPathogenic
SMC1A
(C759R +1 more)
Single nucleotide variant
(missense variant)
Congenital muscular hypertrophy-cerebral syndrome
GPathogenic
SHH
(C157*)
Single nucleotide variant
(3 prime UTR variant +2 more)
Partial agenesis of the corpus callosum
GPathogenic
SETD2
(K539fs +1 more)
Deletion
(frameshift variant +1 more)
Luscan-Lumish syndrome
+1 more
GPathogenic
OLikely oncogenic
SETBP1
(Q593*)
Single nucleotide variant
(nonsense)
Intellectual disability, autosomal dominant 29
GPathogenic
SCN8A
(Y1314fs +1 more)
Deletion
(frameshift variant)
Developmental and epileptic encephalopathy, 13
GPathogenic
LOC102724058, SCN1A
(V1738D +5 more)
Single nucleotide variant
(missense variant +1 more)
Severe myoclonic epilepsy in infancy
GPathogenic
CTNNB1, LOC126806658
(G209R +1 more)
Single nucleotide variant
(missense variant)
Severe intellectual disability-progressive spastic diplegia syndrome
GPathogenic
CNTNAP2
(Y717*)
Single nucleotide variant
(nonsense)
Cortical dysplasia-focal epilepsy syndrome
GPathogenic
CLCN4
(W198* +1 more)
Single nucleotide variant
(nonsense)
Intellectual disability, X-linked 49
GPathogenic
CHAMP1
(S666*)
Duplication
(nonsense)
Intellectual disability, autosomal dominant 40
GPathogenic
CDK13
(K734T)
Single nucleotide variant
(missense variant)
Congenital heart defects, dysmorphic facial features, and intellectual developmental disorder
GPathogenic
CACNA1C
(V1350L +8 more)
Single nucleotide variant
(missense variant)
Timothy syndrome
GPathogenic
BRPF1
(Q186*)
Single nucleotide variant
(nonsense +1 more)
Intellectual developmental disorder with dysmorphic facies and ptosis
GPathogenic
BCL11B
(S764N +3 more)
Single nucleotide variant
(missense variant)
BCL11B-related disorder
+1 more
GConflicting classifications of pathogenicity
AUTS2
(H537Q)
Single nucleotide variant
(missense variant)
Autism spectrum disorder due to AUTS2 deficiency
GLikely pathogenic
ARID1B
(L1083fs +2 more)
Deletion
(frameshift variant)
Coffin-Siris syndrome 1
GPathogenic
ARID1B
(S1333fs +3 more)
Duplication
(frameshift variant)
Coffin-Siris syndrome 1
GPathogenic
RPS6KA3
(F385fs)
Deletion
(frameshift variant)
Coffin-Lowry syndrome
GPathogenic
POGZ
(Q1005* +4 more)
Single nucleotide variant
(nonsense)
Intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome
GPathogenic
PBX1
(R107P +1 more)
Single nucleotide variant
(missense variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GLikely pathogenic
PAFAH1B1
(H379R)
Single nucleotide variant
(missense variant)
Lissencephaly due to LIS1 mutation
GPathogenic
OPHN1
Single nucleotide variant
(splice acceptor variant)
X-linked intellectual disability-cerebellar hypoplasia syndrome
GPathogenic
OPHN1
(V57D)
Single nucleotide variant
(missense variant)
X-linked intellectual disability-cerebellar hypoplasia syndrome
GPathogenic
MED13L
(I774fs)
Deletion
(frameshift variant)
Cardiac anomalies - developmental delay - facial dysmorphism syndrome
GPathogenic
MED13L
Indel
(inframe_indel)
Cardiac anomalies - developmental delay - facial dysmorphism syndrome
GPathogenic
AHDC1
(A605fs)
Indel
(frameshift variant)
AHDC1-related intellectual disability - obstructive sleep apnea - mild dysmorphism syndrome
GPathogenic
FOXP2
(R563* +3 more)
Single nucleotide variant
(nonsense +1 more)
Childhood apraxia of speech
+1 more
GPathogenic
CFAP46
(R651W)
Single nucleotide variant
(missense variant)
Heterotaxy
GUncertain significance
DNAH6
(R2061*)
Single nucleotide variant
(nonsense)
Heterotaxy
GUncertain significance
CELSR1
(V1833M)
Single nucleotide variant
(missense variant)
Heterotaxy
GUncertain significance
PKD1L1
(D1803fs)
Duplication
(frameshift variant)
Heterotaxy
GLikely pathogenic
DAND5
(Y133fs)
Microsatellite
(frameshift variant)
not provided
+1 more
GConflicting classifications of pathogenicity
CFAP53
Single nucleotide variant
(synonymous variant)
Heterotaxy
GLikely pathogenic
CFAP298, CFAP298-TCP10L
(A103D)
Single nucleotide variant
(missense variant +2 more)
Heterotaxy
GPathogenic
ODAD4
(T660fs)
Deletion
(3 prime UTR variant +2 more)
Heterotaxy
GPathogenic
CCDC40
Duplication
(inframe_insertion +1 more)
Heterotaxy
GPathogenic
CFAP300
(Y208fs +1 more)
Insertion
(frameshift variant)
Heterotaxy
GPathogenic
CFAP53
Single nucleotide variant
(splice acceptor variant)
not provided
GPathogenic
CERS1, GDF1
(W203*)
Single nucleotide variant
(3 prime UTR variant +1 more)
Inborn genetic diseases
+1 more
GPathogenic/Likely pathogenic
SCUBE3
(R928* +1 more)
Single nucleotide variant
(nonsense)
Abnormality of the dentition
+3 more
GPathogenic
VPS13B
(W1328*)
Single nucleotide variant
(nonsense)
not provided
+2 more
GPathogenic/Likely pathogenic
NF1
Single nucleotide variant
(splice donor variant)
Neurofibromatosis, type 1
+1 more
GPathogenic
SCN2A
Single nucleotide variant
(splice donor variant)
not provided
GPathogenic
ANKRD11
(D1104fs)
Duplication
(frameshift variant)
KBG syndrome
+1 more
GPathogenic
STXBP1
(P65L +1 more)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 4
GLikely pathogenic
PPP2CA
(D158H +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GPathogenic/Likely pathogenic
YWHAG
(R57C)
Single nucleotide variant
(missense variant)
Intellectual disability
+9 more
GPathogenic
COL1A1
(G425S)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic
KCNMA1
(R1128W +9 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
TRMT1
(Y409fs +3 more)
Deletion
(frameshift variant)
Intellectual developmental disorder, autosomal recessive 68
GPathogenic
CASK
(T542fs +1 more)
Deletion
(frameshift variant)
not provided
+2 more
GPathogenic
CCDC39
(I624fs)
Deletion
(frameshift variant)
Primary ciliary dyskinesia
+2 more
GPathogenic
STXBP1
Single nucleotide variant
(splice donor variant)
Developmental and epileptic encephalopathy, 4
GPathogenic
TSEN54
(G124V)
Single nucleotide variant
(missense variant)
not provided
+3 more
GConflicting classifications of pathogenicity
ARID1A
(L1011F)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
AHDC1
(R688*)
Single nucleotide variant
(nonsense)
not provided
+1 more
GPathogenic
ZSWIM6
(R913*)
Single nucleotide variant
(nonsense)
not provided
+3 more
GPathogenic/Likely pathogenic
CUL4B
(I318fs +3 more)
Deletion
(frameshift variant)
not provided
+1 more
GPathogenic
ARID1B
(R35fs +3 more)
Deletion
(frameshift variant)
Coffin-Siris syndrome 1
+1 more
GPathogenic/Likely pathogenic
SETD1A
Deletion
(splice acceptor variant)
Neurodevelopmental disorder with speech impairment and dysmorphic facies
GLikely pathogenic
SYNGAP1, SYNGAP1-AS1
(G391fs)
Deletion
(frameshift variant)
not provided
+2 more
GPathogenic
DNAH5
(R3909*)
Single nucleotide variant
(nonsense)
Primary ciliary dyskinesia 3
+1 more
GPathogenic
SATB2
(R429*)
Single nucleotide variant
(nonsense)
not provided
+1 more
GPathogenic
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