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Items: 1 to 100 of 192

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
CACNA1D
(I2072V +2 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
USP9X
(N13S)
Single nucleotide variant
(missense variant)
Intellectual disability, X-linked 99
GUncertain significance
CRYM
(G84D)
Single nucleotide variant
(missense variant)
Autosomal dominant nonsyndromic hearing loss 40
GUncertain significance
TBCEL-TECTA, TECTA
(S366C +1 more)
Single nucleotide variant
(missense variant)
Autosomal dominant nonsyndromic hearing loss 12
GUncertain significance
POGZ
(L1312M +5 more)
Single nucleotide variant
(missense variant)
Intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome
GLikely benign
COL12A1
(A809V)
Single nucleotide variant
(missense variant +1 more)
Bethlem myopathy 2
GUncertain significance
DYNC1H1
Indel
(inframe_indel)
Intellectual disability, autosomal dominant 13
GLikely pathogenic
NF1
(E438*)
Single nucleotide variant
(nonsense)
Neurofibromatosis, type 1
GPathogenic
DIS3L2
(D373fs)
Deletion
(frameshift variant +1 more)
Perlman syndrome
GLikely pathogenic
TGFB2
(K396E +1 more)
Single nucleotide variant
(missense variant +1 more)
Loeys-Dietz syndrome 4
GUncertain significance
ANK1
Single nucleotide variant
(splice donor variant)
Hereditary spherocytosis type 1
GLikely pathogenic
PAX2
(D278Y +2 more)
Single nucleotide variant
(missense variant)
Focal segmental glomerulosclerosis 7
GUncertain significance
MEIS2
Single nucleotide variant
(splice acceptor variant)
Cardiac malformation, cleft lip/palate, microcephaly, and digital anomalies
GUncertain significance
BARD1
Deletion
(splice acceptor variant +2 more)
Familial cancer of breast
GPathogenic
BRCA1
(L561fs +20 more)
Deletion
(frameshift variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GLikely pathogenic
PMS1
(R204* +3 more)
Single nucleotide variant
(nonsense +1 more)
not provided
GUncertain significance
LOC123493235, TLL1
(R329*)
Single nucleotide variant
(nonsense)
Atrial septal defect 6
GUncertain significance
NIPBL
(E1647G)
Single nucleotide variant
(missense variant)
Cornelia de Lange syndrome 1
GLikely benign
GRIA3
(S95L)
Single nucleotide variant
(missense variant)
Syndromic X-linked intellectual disability 94
GLikely benign
DYNC1H1
(I4164V)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 13
GLikely benign
NLRP12
(T128I)
Single nucleotide variant
(missense variant)
Familial cold autoinflammatory syndrome 2
GUncertain significance
COL1A2
(G802fs)
Insertion
(frameshift variant)
Ehlers-Danlos syndrome, cardiac valvular type
GLikely pathogenic
IQCB1
(W311* +1 more)
Single nucleotide variant
(nonsense +1 more)
Senior-Loken syndrome 5
GPathogenic
ANKRD11
(K1376fs)
Duplication
(frameshift variant)
KBG syndrome
GPathogenic
SYNGAP1, SYNGAP1-AS1
(R321C)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 5
GLikely benign
PRSS12
(P38L)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal recessive 1
GUncertain significance
LRRK2
(R1538L)
Single nucleotide variant
(missense variant)
Autosomal dominant Parkinson disease 8
GUncertain significance
EIF4G1
(K328E +5 more)
Single nucleotide variant
(missense variant)
Parkinson disease 18, autosomal dominant, susceptibility to
GUncertain significance
NF1
Indel
(splice acceptor variant)
Neurofibromatosis, type 1
GLikely pathogenic
MFAP5
(K63fs +3 more)
Deletion
(frameshift variant +2 more)
Aortic aneurysm, familial thoracic 9
GLikely pathogenic
GJA8
(R198W)
Single nucleotide variant
(missense variant)
Cataract 1 multiple types
+2 more
GConflicting classifications of pathogenicity
CTNNA3
(K780N)
Single nucleotide variant
(missense variant)
Arrhythmogenic right ventricular dysplasia 13
GUncertain significance
RECQL
(S361*)
Single nucleotide variant
(nonsense)
not provided
GLikely pathogenic
TCF4
Deletion
Pitt-Hopkins syndrome
GPathogenic
DEPDC5
Single nucleotide variant
(splice donor variant)
Epilepsy, familial focal, with variable foci 1
GLikely pathogenic
CASK
Single nucleotide variant
(intron variant)
Syndromic X-linked intellectual disability Najm type
GLikely benign
COL11A1
Single nucleotide variant
(intron variant)
Stickler syndrome type 2
GUncertain significance
KCNC1
(N516D)
Single nucleotide variant
(missense variant)
Progressive myoclonic epilepsy type 7
GUncertain significance
DYNC1H1
(I3290V)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 13
GUncertain significance
PHKB
Single nucleotide variant
(intron variant)
Glycogen storage disease IXb
GUncertain significance
RNF213
(W3282del +1 more)
Deletion
(inframe_deletion)
Moyamoya disease 2
GLikely benign
WASHC5
(L832P +1 more)
Single nucleotide variant
(missense variant)
Hereditary spastic paraplegia 8
GUncertain significance
LOC129995449, SQSTM1
(Y67C)
Single nucleotide variant
(missense variant +1 more)
Frontotemporal dementia and/or amyotrophic lateral sclerosis 3
+1 more
GUncertain significance
CNNM2, LOC130004628
(I163T)
Single nucleotide variant
(missense variant)
Hypomagnesemia, seizures, and intellectual disability 1
GUncertain significance
IL1RAPL1
Duplication
Intellectual disability, X-linked 21
GUncertain significance
SPAST
(W147fs +1 more)
Indel
(frameshift variant)
Hereditary spastic paraplegia 4
GLikely pathogenic
CACNA1A
Duplication
(splice acceptor variant)
Episodic ataxia type 2
GPathogenic
KBTBD13
(F87L)
Single nucleotide variant
(missense variant)
Nemaline myopathy 6
GUncertain significance
BRCA1, LOC126862571
(S1112fs +21 more)
Deletion
(frameshift variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GLikely pathogenic
BICD2
(M75T)
Single nucleotide variant
(missense variant)
Autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures
GUncertain significance
MLH1
(S171fs +3 more)
Deletion
(frameshift variant +1 more)
Colorectal cancer, hereditary nonpolyposis, type 2
GPathogenic
SMAD3
Single nucleotide variant
(synonymous variant)
Aneurysm-osteoarthritis syndrome
GUncertain significance
TNXB
(R2776W)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+2 more
GUncertain significance
ANK2
(M1086I +38 more)
Single nucleotide variant
(missense variant)
Cardiac arrhythmia, ankyrin-B-related
GUncertain significance
KMT2D, LOC126861520
(R1322fs)
Deletion
(frameshift variant)
Kabuki syndrome 1
GPathogenic
ARID1B
(T1581A +6 more)
Single nucleotide variant
(missense variant)
Coffin-Siris syndrome 1
GLikely benign
CLCN1
(D592N)
Single nucleotide variant
(missense variant +1 more)
Congenital myotonia, autosomal recessive form
GUncertain significance
FAS
(W176R +1 more)
Single nucleotide variant
(missense variant +2 more)
Autoimmune lymphoproliferative syndrome type 1
GUncertain significance
CLCN1
(Y367fs)
Deletion
(frameshift variant +1 more)
Congenital myotonia, autosomal recessive form
GLikely pathogenic
BRCA1, LOC126862571
Deletion
(frameshift variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
PRDM16
(E871K)
Single nucleotide variant
(missense variant)
Left ventricular noncompaction 8
GUncertain significance
KIF5A
(V377F +1 more)
Single nucleotide variant
(missense variant)
Hereditary spastic paraplegia 10
GLikely benign
BRIP1
Deletion
Familial ovarian cancer
GPathogenic
LOC102724058, SCN1A
(A1005S +5 more)
Single nucleotide variant
(missense variant +1 more)
Generalized epilepsy with febrile seizures plus, type 2
+2 more
GUncertain significance
MYBPC3
Single nucleotide variant
(splice donor variant)
Hypertrophic cardiomyopathy 4
GLikely pathogenic
DMD
(E1590Q +7 more)
Single nucleotide variant
(missense variant)
Becker muscular dystrophy
GUncertain significance
CLCN1
Single nucleotide variant
(splice donor variant)
Congenital myotonia, autosomal recessive form
GLikely pathogenic
JAG1
Single nucleotide variant
(intron variant)
Alagille syndrome due to a JAG1 point mutation
GUncertain significance
NOTCH2
(D966H)
Single nucleotide variant
(missense variant)
Alagille syndrome due to a NOTCH2 point mutation
GUncertain significance
GRIN2B
(D1253N)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 6
GUncertain significance
COL11A1
(Y347H +2 more)
Single nucleotide variant
(missense variant +2 more)
Hearing loss, autosomal dominant 37
GUncertain significance
TYR
(M370K)
Single nucleotide variant
(missense variant)
Oculocutaneous albinism type 1B
+1 more
GLikely pathogenic
MSH3
Deletion
Familial adenomatous polyposis 4
GLikely pathogenic
PALB2
(I1038fs +10 more)
Indel
(frameshift variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 5
GLikely pathogenic
BRCA2
(M1890I)
Single nucleotide variant
(missense variant +2 more)
Breast-ovarian cancer, familial, susceptibility to, 2
GUncertain significance
MSH6
(S143T +8 more)
Single nucleotide variant
(missense variant +2 more)
Lynch syndrome 5
GUncertain significance
TSC2
Single nucleotide variant
(synonymous variant +1 more)
Tuberous sclerosis 2
GUncertain significance
NF1
(R2162fs +1 more)
Deletion
(frameshift variant)
Neurofibromatosis, type 1
GPathogenic
BRCA2
(E2220*)
Single nucleotide variant
(nonsense +2 more)
Familial cancer of breast
+1 more
GLikely pathogenic
CDH1
Deletion
(frameshift variant +1 more)
Hereditary diffuse gastric adenocarcinoma
+2 more
GConflicting classifications of pathogenicity
RAD51D
Deletion
Breast-ovarian cancer, familial, susceptibility to, 4
GUncertain significance
FANCC
(Q136*)
Single nucleotide variant
(nonsense)
Fanconi anemia complementation group C
GLikely pathogenic
NF1
(P1232fs)
Indel
(frameshift variant)
Neurofibromatosis, type 1
GLikely pathogenic
PMS1
(H244fs +3 more)
Deletion
(frameshift variant +1 more)
not provided
GUncertain significance
ELN
(Q372L +6 more)
Single nucleotide variant
(missense variant)
Cutis laxa, autosomal dominant 1
GUncertain significance
PALB2
(I64T +1 more)
Single nucleotide variant
(missense variant +2 more)
Breast-ovarian cancer, familial, susceptibility to, 5
GUncertain significance
APOB
(F2936V)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, type B
GUncertain significance
CNNM4
(L345*)
Single nucleotide variant
(nonsense)
Jalili syndrome
GPathogenic
SLC40A1
(C326Y)
Single nucleotide variant
(missense variant)
Hemochromatosis type 4
GPathogenic
SCN4A
(L673V)
Single nucleotide variant
(missense variant)
Hypokalemic periodic paralysis, type 2
+1 more
GUncertain significance
ARID1B
Single nucleotide variant
(synonymous variant)
Coffin-Siris syndrome 1
GUncertain significance
ALG8
(C277fs)
Microsatellite
(frameshift variant)
Polycystic liver disease 3 with or without kidney cysts
Gno classifications from unflagged records
NF1
(S1630R +1 more)
Single nucleotide variant
(missense variant)
Neurofibromatosis-Noonan syndrome
+1 more
GUncertain significance
BRCA2
(G2195D)
Single nucleotide variant
(missense variant +2 more)
Breast-ovarian cancer, familial, susceptibility to, 2
GUncertain significance
HDAC4
(E129A)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder with central hypotonia and dysmorphic facies
GUncertain significance
KAT6B
(G1089A +7 more)
Single nucleotide variant
(missense variant)
Blepharophimosis - intellectual disability syndrome, SBBYS type
GUncertain significance
RAD51C
Deletion
Breast-ovarian cancer, familial, susceptibility to, 3
GLikely pathogenic
MED13L
(P204A)
Single nucleotide variant
(missense variant)
Cardiac anomalies - developmental delay - facial dysmorphism syndrome
GUncertain significance
FLNC, FLNC-AS1
Deletion
(nonsense)
Myofibrillar myopathy 5
GLikely pathogenic
SETX
(N2454D +1 more)
Single nucleotide variant
(missense variant)
Amyotrophic lateral sclerosis type 4
GUncertain significance
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