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Items: 37

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
LDLRAP1
(E217*)
Single nucleotide variant
(nonsense)
Autosomal recessive inheritance
GPathogenic
LDLR
Single nucleotide variant
(splice acceptor variant)
Familial type 3 hyperlipoproteinemia
GPathogenic
LDLR
(C211* +3 more)
Duplication
(nonsense)
Familial hypercholesterolemia
+2 more
GPathogenic
EIF2B4, GTF3C2-AS2
(S258N +7 more)
Single nucleotide variant
(missense variant)
Vanishing white matter disease
GUncertain significance
ASPA, SPATA22
(S120F)
Single nucleotide variant
(missense variant +1 more)
Spongy degeneration of central nervous system
GUncertain significance
FUCA1
(V28fs)
Deletion
(frameshift variant)
Fucosidosis
GPathogenic
L2HGDH
Single nucleotide variant
(splice donor variant)
L-2-hydroxyglutaric aciduria
GPathogenic
GALC
(S251N +2 more)
Single nucleotide variant
(missense variant)
Galactosylceramide beta-galactosidase deficiency
+1 more
GPathogenic/Likely pathogenic
GJC2
(T195fs)
Duplication
(frameshift variant)
Hypomyelinating leukodystrophy 2
GPathogenic
LOC125446261, MLC1
(C61*)
Single nucleotide variant
(nonsense +3 more)
Megalencephalic leukoencephalopathy with subcortical cysts 1
GPathogenic
GJC2
(C245S)
Single nucleotide variant
(missense variant)
Hypomyelinating leukodystrophy 2
GLikely pathogenic
L2HGDH
(R405G)
Single nucleotide variant
(missense variant)
L-2-hydroxyglutaric aciduria
GUncertain significance
GJC2
(A40P)
Single nucleotide variant
(missense variant)
Hypomyelinating leukodystrophy 2
GLikely pathogenic
HEXA
Single nucleotide variant
(splice acceptor variant)
Tay-Sachs disease
GPathogenic
SUCLA2
(D333Y)
Single nucleotide variant
(missense variant)
Mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria
GLikely pathogenic
GLB1
(L109Q +2 more)
Single nucleotide variant
(missense variant +1 more)
Infantile GM1 gangliosidosis
GLikely pathogenic
SURF1
(E161fs +1 more)
Deletion
(frameshift variant)
Leigh syndrome
GPathogenic
NDUFS1
(V318M +4 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
ABCD1
(E302M)
Indel
(missense variant)
Adrenoleukodystrophy
GLikely pathogenic
ABCD1
(T668A)
Single nucleotide variant
(missense variant)
Adrenoleukodystrophy
GConflicting classifications of pathogenicity
RNASET2
(S78* +1 more)
Single nucleotide variant
(nonsense)
Cystic leukoencephalopathy without megalencephaly
GPathogenic
HEXB
(I219del)
Microsatellite
(inframe_deletion +1 more)
Sandhoff disease
GPathogenic
CLN6
(Y220S)
Single nucleotide variant
(missense variant)
Ceroid lipofuscinosis, neuronal, 6A
GUncertain significance
ABCD1
(R280P)
Single nucleotide variant
(missense variant)
Adrenoleukodystrophy
GConflicting classifications of pathogenicity
ASPA, SPATA22
(S146fs)
Deletion
(frameshift variant +1 more)
Spongy degeneration of central nervous system
+1 more
GPathogenic/Likely pathogenic
GJC2
(Q295*)
Single nucleotide variant
(nonsense)
Hypomyelinating leukodystrophy 2
GLikely pathogenic
MLC1
(F273L +5 more)
Single nucleotide variant
(missense variant +1 more)
Megalencephalic leukoencephalopathy with subcortical cysts 1
GUncertain significance
GALC
(K648* +2 more)
Single nucleotide variant
(nonsense)
not provided
+1 more
GConflicting classifications of pathogenicity
SLC17A5
(E262D)
Single nucleotide variant
(missense variant)
not provided
+1 more
GLikely pathogenic
ABCD1
(P543R)
Single nucleotide variant
(missense variant)
Adrenoleukodystrophy
GLikely pathogenic
POLR3B
(N700T +1 more)
Single nucleotide variant
(missense variant)
Hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism
GLikely pathogenic
LOC130064279, SDHAF1
(Q10P)
Single nucleotide variant
(missense variant)
Mitochondrial complex II deficiency, nuclear type 1
GUncertain significance
NDUFS7
(D139N)
Single nucleotide variant
(missense variant)
Mitochondrial complex 1 deficiency, nuclear type 3
GLikely pathogenic
HEXA
(R252C +1 more)
Single nucleotide variant
(missense variant +1 more)
Tay-Sachs disease
GPathogenic/Likely pathogenic
PLA2G6
(R6C)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
+5 more
GUncertain significance
FUCA1, LOC126805661
(G141V)
Single nucleotide variant
(missense variant)
not specified
+2 more
GConflicting classifications of pathogenicity
POLG
Single nucleotide variant
(intron variant)
Hereditary spastic paraplegia
+8 more
GConflicting classifications of pathogenicity
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