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Items: 31

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
FA2H
(L225P)
Single nucleotide variant
(missense variant)
Hereditary spastic paraplegia 35
GPathogenic
SACS
(L3335fs +1 more)
Deletion
(frameshift variant)
Charlevoix-Saguenay spastic ataxia
GPathogenic
PTPRQ
(L1965M)
Single nucleotide variant
(missense variant)
Hearing loss, autosomal dominant 73
GUncertain significance
NF1
(K63fs)
Deletion
(frameshift variant)
Neurofibromatosis, type 1
GPathogenic
ERCC8
(A133del +2 more)
Deletion
(inframe_indel +1 more)
Cockayne syndrome type 1
GLikely pathogenic
VLDLR
(C674Y +1 more)
Single nucleotide variant
(missense variant)
Cerebellar ataxia, intellectual disability, and dysequilibrium syndrome 1
GLikely pathogenic
ERCC8
(S117P +2 more)
Single nucleotide variant
(missense variant)
Cockayne syndrome type 1
GLikely pathogenic
SPG11
(Y800fs)
Deletion
(frameshift variant)
Hereditary spastic paraplegia 11
GPathogenic
NT5C2
(Y179fs +4 more)
Deletion
(frameshift variant +1 more)
Hereditary spastic paraplegia 45
GPathogenic
ZFYVE26
(C419fs)
Duplication
(frameshift variant)
Hereditary spastic paraplegia 15
GPathogenic
MFSD8
Single nucleotide variant
(synonymous variant +1 more)
Neuronal ceroid lipofuscinosis 7
GUncertain significance
SIL1
Single nucleotide variant
(splice donor variant)
Marinesco-Sjögren syndrome
GPathogenic
ABHD16A
(R114* +1 more)
Single nucleotide variant
(nonsense +1 more)
Spastic paraplegia 86, autosomal recessive
+1 more
GPathogenic
ABHD16A
(R424Q +1 more)
Single nucleotide variant
(missense variant +1 more)
Spastic paraplegia 86, autosomal recessive
+1 more
GPathogenic
HUWE1
(M4213I)
Single nucleotide variant
(missense variant)
Intellectual disability, X-linked syndromic, Turner type
GUncertain significance
ATP2B3
(R696C)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+1 more
GUncertain significance
CCDC82
(R156* +1 more)
Single nucleotide variant
(nonsense)
Syndromic intellectual disability
+1 more
GConflicting classifications of pathogenicity
DMXL2
(K1594Q +3 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+2 more
GUncertain significance
CCDC88C
(E665K)
Single nucleotide variant
(missense variant)
Spinocerebellar ataxia type 40
GLikely pathogenic
PRUNE1
Single nucleotide variant
(splice donor variant)
not provided
+1 more
GPathogenic
ARG1, MED23
(V145E +1 more)
Single nucleotide variant
(missense variant +2 more)
Arginase deficiency
GPathogenic
HERC2
(P3619S)
Single nucleotide variant
(missense variant)
Developmental delay with autism spectrum disorder and gait instability
GUncertain significance
DARS2
(R188Q)
Single nucleotide variant
(missense variant)
Leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome
GLikely pathogenic
AP5Z1
(G222R +1 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary spastic paraplegia 48
+2 more
GConflicting classifications of pathogenicity
ERCC6
Single nucleotide variant
(splice acceptor variant)
Cockayne syndrome type 2
+3 more
GConflicting classifications of pathogenicity
DDHD2
(R329* +1 more)
Single nucleotide variant
(nonsense +1 more)
not provided
+1 more
GPathogenic
POLR3A
Single nucleotide variant
(intron variant)
Neonatal pseudo-hydrocephalic progeroid syndrome
+4 more
GPathogenic/Likely pathogenic
MCOLN1
(R172*)
Single nucleotide variant
(nonsense)
Mucolipidosis type IV
GPathogenic/Likely pathogenic
ADAT3, SCAMP4
(V144M +1 more)
Single nucleotide variant
(missense variant +1 more)
Intellectual disability-strabismus syndrome
+1 more
GPathogenic/Likely pathogenic
NT5C2
Single nucleotide variant
(splice donor variant +1 more)
Hereditary spastic paraplegia 45
GPathogenic
SPG11
(E2134fs +1 more)
Deletion
(frameshift variant)
not provided
+4 more
GPathogenic
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