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Items: 59

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
TSR1
(S354F)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
DNAH2
(V3792I)
Single nucleotide variant
(missense variant)
Primary microcephaly
GUncertain significance
DNAH2
(P345T)
Single nucleotide variant
(missense variant)
Primary microcephaly
GUncertain significance
DNAH2
(D1079G)
Single nucleotide variant
(missense variant)
Primary microcephaly
GUncertain significance
DNAH2
(R596* +1 more)
Single nucleotide variant
(nonsense)
Primary microcephaly
GUncertain significance
DNAH2
(G1911A)
Single nucleotide variant
(missense variant)
Primary microcephaly
GUncertain significance
DNAH2
(R244W)
Single nucleotide variant
(missense variant)
Primary microcephaly
GUncertain significance
IGF2BP3
(T308A)
Single nucleotide variant
(missense variant)
Primary microcephaly
GUncertain significance
WDR62
(S1123fs +1 more)
Deletion
(frameshift variant)
Microcephaly 2, primary, autosomal recessive, with or without cortical malformations
GPathogenic
WDR62
(S509L)
Single nucleotide variant
(missense variant)
Microcephaly 2, primary, autosomal recessive, with or without cortical malformations
GLikely pathogenic
WDR62
(A1152fs +1 more)
Deletion
(frameshift variant)
Microcephaly 2, primary, autosomal recessive, with or without cortical malformations
GPathogenic
TRAPPC9
(L80P)
Single nucleotide variant
(missense variant +1 more)
Intellectual disability, autosomal recessive 13
GUncertain significance
MCPH1
(E20K +1 more)
Single nucleotide variant
(missense variant +2 more)
Microcephaly 1, primary, autosomal recessive
GLikely pathogenic
ASPM
(K2900fs)
Indel
(frameshift variant +1 more)
Microcephaly 5, primary, autosomal recessive
GPathogenic
ASPM
(F645fs)
Deletion
(frameshift variant)
Microcephaly 5, primary, autosomal recessive
GPathogenic
RTTN
(R73G +1 more)
Single nucleotide variant
(missense variant)
not provided
GPathogenic
WDR62
(Q1449* +1 more)
Single nucleotide variant
(nonsense)
not provided
GUncertain significance
CEP135
(R331S)
Single nucleotide variant
(missense variant)
Microcephaly 8, primary, autosomal recessive
+2 more
GConflicting classifications of pathogenicity
CDK5RAP2
(E1180K +1 more)
Single nucleotide variant
(missense variant +1 more)
Microcephaly 3, primary, autosomal recessive
GUncertain significance
CEP135
(N820D)
Single nucleotide variant
(missense variant)
Microcephaly 8, primary, autosomal recessive
GUncertain significance
CDK5RAP2
(N459fs)
Deletion
(frameshift variant +1 more)
Microcephaly 3, primary, autosomal recessive
GPathogenic
ASPM
(R2229fs)
Microsatellite
(frameshift variant +1 more)
not provided
+1 more
GPathogenic
ASPM
(L1864fs)
Microsatellite
(frameshift variant +1 more)
Microcephaly 5, primary, autosomal recessive
GPathogenic
ASPM
Microsatellite
(nonsense +1 more)
Microcephaly 5, primary, autosomal recessive
GPathogenic
WDR62
(Q930*)
Single nucleotide variant
(nonsense)
Microcephaly 2, primary, autosomal recessive, with or without cortical malformations
GPathogenic
ASPM
(V2172fs)
Duplication
(frameshift variant +1 more)
Microcephaly 5, primary, autosomal recessive
GPathogenic
LIG4
(K295E +2 more)
Single nucleotide variant
(missense variant)
DNA ligase IV deficiency
GLikely pathogenic
TUBGCP6
(G990R)
Single nucleotide variant
(missense variant)
Microcephaly and chorioretinopathy 1
GLikely pathogenic
TUBGCP6
(V359I)
Single nucleotide variant
(missense variant)
Microcephaly and chorioretinopathy 1
GLikely pathogenic
BLM
(Q562* +1 more)
Single nucleotide variant
(nonsense)
Bloom syndrome
GPathogenic
BLM
(K509fs +1 more)
Deletion
(frameshift variant)
Bloom syndrome
GPathogenic
KIF11
(A373fs)
Duplication
(frameshift variant)
Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
GPathogenic
MCPH1
Single nucleotide variant
(splice acceptor variant)
not provided
+1 more
GConflicting classifications of pathogenicity
MCPH1
(R106fs +2 more)
Duplication
(frameshift variant +1 more)
Microcephaly 1, primary, autosomal recessive
+1 more
GPathogenic
CEP152
(V1084fs)
Deletion
(frameshift variant)
not provided
+1 more
GPathogenic/Likely pathogenic
ERCC8, ERCC8-AS1
(R41fs +1 more)
Indel
(frameshift variant +1 more)
not provided
+1 more
GPathogenic
WDR62
(T547M)
Single nucleotide variant
(missense variant)
Microcephaly 2, primary, autosomal recessive, with or without cortical malformations
+1 more
GUncertain significance
WDR62
Single nucleotide variant
(synonymous variant)
not provided
+1 more
GUncertain significance
WDR62
(V85M)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+3 more
GConflicting classifications of pathogenicity
LIG4
(K357fs +2 more)
Deletion
(frameshift variant)
not provided
+3 more
GPathogenic
CDK5RAP2
(Y668C +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+3 more
GConflicting classifications of pathogenicity
AP4M1
(R338* +1 more)
Single nucleotide variant
(nonsense)
Hereditary spastic paraplegia 50
+1 more
GPathogenic
CEP135
(V213A)
Single nucleotide variant
(missense variant)
not specified
+1 more
GBenign/Likely benign
WDR62
Single nucleotide variant
(intron variant)
not provided
+1 more
GConflicting classifications of pathogenicity
TUBA1A
(R2H)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
+5 more
GPathogenic/Likely pathogenic
ASPM
(K2712fs)
Deletion
(frameshift variant +1 more)
Inborn genetic diseases
+2 more
GPathogenic
TRMT10A
(R127*)
Single nucleotide variant
(nonsense)
Microcephaly, short stature, and impaired glucose metabolism 1
GPathogenic/Likely pathogenic
CEP152
(W960R)
Single nucleotide variant
(missense variant)
Seckel syndrome 5
+2 more
GConflicting classifications of pathogenicity
KNL1
(M2041I +1 more)
Single nucleotide variant
(missense variant)
Microcephaly 4, primary, autosomal recessive
GPathogenic
WDR62
(V1308fs +1 more)
Duplication
(frameshift variant)
not provided
GPathogenic
WDR62
(D511N)
Single nucleotide variant
(missense variant)
Primary microcephaly type 2
+1 more
GPathogenic
ASPM
(R3281* +1 more)
Single nucleotide variant
(nonsense)
Microcephaly 5, primary, autosomal recessive
GPathogenic
ASPM
(K2595fs)
Deletion
(frameshift variant +1 more)
Inborn genetic diseases
+3 more
GPathogenic
ASPM
(Y544fs)
Deletion
(frameshift variant)
not provided
GPathogenic
ASPM
(E456*)
Single nucleotide variant
(nonsense)
Microcephaly 5, primary, autosomal recessive
GPathogenic
ASPM
(R797*)
Single nucleotide variant
(nonsense)
Microcephaly 5, primary, autosomal recessive
+1 more
GPathogenic
ASPM
(T1399fs)
Duplication
(frameshift variant +1 more)
Microcephaly 5, primary, autosomal recessive
GConflicting classifications of pathogenicity
PNKP
(T424fs)
Duplication
(frameshift variant)
Intellectual disability
+5 more
GPathogenic
CEP152
(R987*)
Single nucleotide variant
(nonsense)
Microcephaly 9, primary, autosomal recessive
+1 more
GPathogenic/Likely pathogenic
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