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Items: 1 to 100 of 452

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
EP300
(N1485I +1 more)
Single nucleotide variant
(missense variant)
Rubinstein-Taybi syndrome due to EP300 haploinsufficiency
GUncertain significance
PACS2
(R490Q +2 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
KCNT1
(G1052V +1 more)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 14
+1 more
GUncertain significance
KCNA2
(A348T)
Single nucleotide variant
(missense variant +1 more)
Developmental and epileptic encephalopathy, 32
GUncertain significance
KMT2C
(R4225Q)
Single nucleotide variant
(missense variant)
Kleefstra syndrome 2
+1 more
GUncertain significance
GNAI1
(P113A +1 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
LOC112543452, MAST1
(P771T)
Single nucleotide variant
(missense variant)
Mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations
GUncertain significance
DEAF1
(V66G)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GUncertain significance
CASK
(R554W +1 more)
Single nucleotide variant
(missense variant)
Intellectual disability, CASK-related, X-linked
GUncertain significance
LZTR1
(L824V)
Single nucleotide variant
(missense variant)
not provided
+3 more
GUncertain significance
UNC80
(Y2408fs +2 more)
Deletion
(frameshift variant)
Hypotonia, infantile, with psychomotor retardation and characteristic facies 2
GLikely pathogenic
OGT
(K1000R +1 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
CAMK2B
(I525V)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GUncertain significance
SET
(N69Y +3 more)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 58
GUncertain significance
TBCEL-TECTA, TECTA
(V415L +1 more)
Single nucleotide variant
(missense variant)
Autosomal recessive nonsyndromic hearing loss 21
GUncertain significance
ZMYND11
(L100V +3 more)
Single nucleotide variant
(intron variant +2 more)
Intellectual disability, autosomal dominant 30
GUncertain significance
TRIO
(L1311V)
Single nucleotide variant
(missense variant +1 more)
Intellectual developmental disorder, autosomal dominant 63, with macrocephaly
GUncertain significance
PPP2R5D
(G116V +2 more)
Indel
(5 prime UTR variant +1 more)
Hogue-Janssens syndrome 1
GUncertain significance
GATA3
(T418M +1 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
MKKS
(G317fs)
Deletion
(frameshift variant)
Bardet-Biedl syndrome 6
+2 more
GPathogenic/Likely pathogenic
PLCE1
(T458I +1 more)
Single nucleotide variant
(missense variant)
Nephrotic syndrome
GUncertain significance
ODAD2
(L234V +2 more)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GUncertain significance
DNAH5
(E3282G)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GUncertain significance
DNAH1
(I3439M)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GUncertain significance
DNAH9
(T3375R)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+1 more
GUncertain significance
CCDC40
(Q420E)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GUncertain significance
NPHS1
(L237Q)
Single nucleotide variant
(missense variant)
Microscopic hematuria
+2 more
GUncertain significance
DNAH5
(N1105S)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GUncertain significance
DNAH9
(P1868S)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
+1 more
GUncertain significance
DNAH9
(F103fs)
Deletion
(frameshift variant)
not provided
+1 more
GPathogenic/Likely pathogenic
NPHS1
(R496S)
Single nucleotide variant
(missense variant)
Microscopic hematuria
+2 more
GConflicting classifications of pathogenicity
CRYBA1
(L183*)
Single nucleotide variant
(nonsense)
Cataract 10 multiple types
GUncertain significance
GRIK2
(T69A)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder with impaired language and ataxia and with or without seizures
+1 more
GUncertain significance
CIC
(T1397M +3 more)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 45
+1 more
GUncertain significance
DNAH11
(R2040C)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GConflicting classifications of pathogenicity
DNAI2
(S298R)
Single nucleotide variant
(missense variant +1 more)
Primary ciliary dyskinesia
GUncertain significance
DNAH5
(G2525R)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GConflicting classifications of pathogenicity
DNAH9
(R2395W)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+2 more
GUncertain significance
DNAH8
(R590Q +1 more)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GUncertain significance
DNAAF5
(G232S)
Single nucleotide variant
(missense variant +1 more)
Primary ciliary dyskinesia
GUncertain significance
DNAH5
(K1653N)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GUncertain significance
DNAAF2
(G464D)
Single nucleotide variant
(missense variant +1 more)
Primary ciliary dyskinesia
GUncertain significance
OFD1
Deletion
(inframe_deletion)
Primary ciliary dyskinesia
GUncertain significance
DNAH9
(Q2390P)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
RPGR
(E652K)
Single nucleotide variant
(missense variant +1 more)
Primary ciliary dyskinesia
GUncertain significance
DNAH1
(T1568A)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GUncertain significance
DNAAF1
(E417K +1 more)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
+1 more
GUncertain significance
DNAH1
(M3640T)
Single nucleotide variant
(missense variant)
not specified
+3 more
GUncertain significance
DNAH11
(H458Y)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GUncertain significance
DNAH5
(K2787fs)
Insertion
(frameshift variant)
Primary ciliary dyskinesia
+1 more
GLikely pathogenic
DNAH8, DNAH8-AS1
(E3571D +1 more)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GUncertain significance
DNAH8
(N2539S +1 more)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GUncertain significance
INF2
(I685T)
Single nucleotide variant
(missense variant)
Glomerulonephritis
+2 more
GUncertain significance
LAMB2
(Q1313*)
Single nucleotide variant
(nonsense)
Nephrotic syndrome
+1 more
GLikely pathogenic
LAMB2
Single nucleotide variant
(intron variant)
Pierson syndrome
+2 more
GUncertain significance
PLCE1
(G1183S +2 more)
Single nucleotide variant
(missense variant)
not provided
+4 more
GConflicting classifications of pathogenicity
INF2
(E955Q)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease dominant intermediate E
+2 more
GUncertain significance
COL4A3, MFF-DT
(G1009fs)
Deletion
(frameshift variant)
not provided
+1 more
GPathogenic/Likely pathogenic
PLCE1
(D1034G +1 more)
Single nucleotide variant
(missense variant)
Microscopic hematuria
GUncertain significance
PLCE1, NOC3L
(D1906N +2 more)
Single nucleotide variant
(missense variant)
Focal segmental glomerulosclerosis
GUncertain significance
DNAH5
(T372A)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia 3
+2 more
GConflicting classifications of pathogenicity
ACTN4
(Q392E)
Single nucleotide variant
(missense variant)
Focal segmental glomerulosclerosis
+1 more
GConflicting classifications of pathogenicity
DNAH5
(R4592*)
Single nucleotide variant
(nonsense)
Primary ciliary dyskinesia
+1 more
GPathogenic/Likely pathogenic
B9D1
(R114Q)
Single nucleotide variant
(missense variant +1 more)
Meckel-Gruber syndrome
+4 more
GLikely pathogenic
FAT4
(H1246Q)
Single nucleotide variant
(missense variant)
Van Maldergem syndrome 2
GUncertain significance
BLTP1
(R3598Q +1 more)
Single nucleotide variant
(missense variant)
Alkuraya-Kucinskas syndrome
GUncertain significance
BLTP1
(G1016S)
Single nucleotide variant
(missense variant)
Alkuraya-Kucinskas syndrome
+1 more
GUncertain significance
MYH3
(S119L)
Single nucleotide variant
(missense variant)
Freeman-Sheldon syndrome
GUncertain significance
CACNA1G
Single nucleotide variant
(splice donor variant +1 more)
Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits
+1 more
GUncertain significance
SCN8A
(R1866W +1 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
KCNQ5
(A633fs +4 more)
Deletion
(frameshift variant)
Intellectual disability, autosomal dominant 46
+1 more
GUncertain significance
MAOA
(V136I +1 more)
Single nucleotide variant
(missense variant)
Brunner syndrome
GUncertain significance
MED12
(S1461L)
Single nucleotide variant
(missense variant)
FG syndrome 1
GUncertain significance
TRIO
(R440Q)
Single nucleotide variant
(missense variant +1 more)
Intellectual developmental disorder, autosomal dominant 63, with macrocephaly
+1 more
GUncertain significance
TRIP12
(T1298N +11 more)
Single nucleotide variant
(missense variant)
Clark-Baraitser syndrome
GUncertain significance
PTEN
(G251D +2 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
BSND
(G22S)
Single nucleotide variant
(missense variant)
Bartter disease type 4A
GUncertain significance
CHD8
(R1252H +1 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
BRPF1
(M1R)
Single nucleotide variant
(missense variant +2 more)
Intellectual developmental disorder with dysmorphic facies and ptosis
GLikely pathogenic
KMT2D
(M1605T)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+1 more
GUncertain significance
ARID2
(L550V)
Single nucleotide variant
(missense variant)
Coffin-Siris syndrome 6
GUncertain significance
SHANK2
(R219H +1 more)
Single nucleotide variant
(missense variant)
Autism spectrum disorder
GUncertain significance
ZC4H2
(Q59H +1 more)
Single nucleotide variant
(missense variant +1 more)
Wieacker-Wolff syndrome, female-restricted
+1 more
GUncertain significance
DISP1
(G1138fs +1 more)
Deletion
(frameshift variant)
Microform holoprosencephaly
+1 more
GUncertain significance
KMT2C
(E1640Q)
Single nucleotide variant
(missense variant)
See cases
+1 more
GUncertain significance
INTS1
(E1742K)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies
GUncertain significance
INTS1
(R801fs)
Indel
(frameshift variant)
Neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies
GLikely pathogenic
ZEB2
(K770E +1 more)
Single nucleotide variant
(missense variant)
Mowat-Wilson syndrome
GUncertain significance
ZMYND11
(K13E)
Single nucleotide variant
(missense variant +3 more)
Intellectual disability, autosomal dominant 30
+2 more
GUncertain significance
FBN1
(L2836H)
Single nucleotide variant
(missense variant)
Marfan syndrome
GUncertain significance
DNM1, LOC113839516
(P195L)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 31A
GUncertain significance
ODAD2
(P132T)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
+1 more
GUncertain significance
COL4A4
Single nucleotide variant
(synonymous variant)
Autosomal recessive Alport syndrome
+3 more
GUncertain significance
DNAH11
(V3962M)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GConflicting classifications of pathogenicity
DNAJB13
(S36A)
Single nucleotide variant
(5 prime UTR variant +1 more)
Primary ciliary dyskinesia
+1 more
GUncertain significance
ODAD3
(L136V +2 more)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
+1 more
GUncertain significance
CCNO
(A14S)
Single nucleotide variant
(missense variant +1 more)
Primary ciliary dyskinesia
GUncertain significance
DNAH1
(I2905V)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GUncertain significance
OFD1
(D231N +2 more)
Single nucleotide variant
(missense variant)
OFD1-related disorder
+3 more
GUncertain significance
OFD1
(L606V +2 more)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GUncertain significance
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