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Items: 47

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
BCKDHB
(L110* +1 more)
Indel
(nonsense +1 more)
Maple syrup urine disease
GPathogenic/Likely pathogenic
GJB2
(F83del)
Deletion
(inframe_deletion)
Autosomal recessive nonsyndromic hearing loss 1A
GLikely pathogenic
COL4A1
(I780fs)
Deletion
(frameshift variant)
Brain small vessel disease 1 with or without ocular anomalies
GLikely pathogenic
FANCA
(Y503*)
Single nucleotide variant
(nonsense)
Fanconi anemia complementation group A
GLikely pathogenic
SCN5A
(L1842fs +5 more)
Deletion
(frameshift variant)
Brugada syndrome
GLikely pathogenic
MSH6
(Q183* +2 more)
Single nucleotide variant
(nonsense)
Lynch syndrome
GLikely pathogenic
CDH23
(G2085fs)
Insertion
(frameshift variant)
Usher syndrome type 1D
GLikely pathogenic
RAD50
(D700fs)
Deletion
(frameshift variant)
Hereditary cancer-predisposing syndrome
GLikely pathogenic
PTCH1
(K60fs)
Deletion
(frameshift variant +1 more)
Gorlin syndrome
GLikely pathogenic
RECQL4
(Q1114*)
Single nucleotide variant
(nonsense)
Baller-Gerold syndrome
GPathogenic/Likely pathogenic
BRCA2
(V2503fs)
Insertion
(frameshift variant)
Hereditary breast ovarian cancer syndrome
GLikely pathogenic
MSH6
Insertion
(splice donor variant)
Lynch syndrome
GLikely pathogenic
CDH23
(F2086fs)
Insertion
(frameshift variant)
Usher syndrome type 1D
GLikely pathogenic
PALB2
(K862fs)
Deletion
(frameshift variant)
Hereditary cancer-predisposing syndrome
+1 more
GPathogenic/Likely pathogenic
HEXA
(Y366* +1 more)
Single nucleotide variant
(nonsense)
Tay-Sachs disease
GPathogenic/Likely pathogenic
GBA1, LOC106627981
(T69fs)
Duplication
(frameshift variant +1 more)
Lewy body dementia
+9 more
GPathogenic/Likely pathogenic
MYO7A
(Y2035* +2 more)
Single nucleotide variant
(nonsense)
Usher syndrome type 1
GLikely pathogenic
ELAC2
(E30*)
Single nucleotide variant
(nonsense)
not provided
+1 more
GPathogenic/Likely pathogenic
NBN
(Q581* +1 more)
Single nucleotide variant
(nonsense)
Hereditary cancer-predisposing syndrome
+2 more
GPathogenic/Likely pathogenic
BCKDHB
(K96* +1 more)
Single nucleotide variant
(nonsense +1 more)
Maple syrup urine disease
GPathogenic/Likely pathogenic
GBA1, LOC106627981
(T75del)
Deletion
(inframe_deletion +1 more)
Lewy body dementia
+9 more
GPathogenic/Likely pathogenic
RECQL4
(P965fs)
Deletion
(frameshift variant)
Baller-Gerold syndrome
GPathogenic/Likely pathogenic
BLM
(M576fs +1 more)
Deletion
(frameshift variant)
Hereditary cancer-predisposing syndrome
+1 more
GPathogenic/Likely pathogenic
HEXA
(S310fs +1 more)
Microsatellite
(frameshift variant +1 more)
Tay-Sachs disease
+1 more
GPathogenic
GJB3
(R235*)
Single nucleotide variant
(nonsense)
not provided
+1 more
GConflicting classifications of pathogenicity
GJB6
(R108*)
Single nucleotide variant
(nonsense)
not specified
+1 more
GConflicting classifications of pathogenicity
GBE1
(Y560*)
Single nucleotide variant
(nonsense)
Glycogen storage disease, type IV
GLikely pathogenic
CA12
(V248fs +2 more)
Microsatellite
(frameshift variant +1 more)
Isolated hyperchlorhidrosis
GLikely pathogenic
USH2A
(E4051*)
Single nucleotide variant
(nonsense)
not provided
+2 more
GPathogenic/Likely pathogenic
GJB6
(L163fs)
Deletion
(frameshift variant)
Nonsyndromic Deafness
GLikely pathogenic
SCNN1B
(R563Q)
Single nucleotide variant
(missense variant)
Low renin, low aldosterone hypertension
GLikely pathogenic
MYO7A
(Q1336* +1 more)
Single nucleotide variant
(nonsense)
not provided
+4 more
GPathogenic/Likely pathogenic
AKAP9
(W3622* +2 more)
Single nucleotide variant
(nonsense)
Long QT syndrome
+1 more
GConflicting classifications of pathogenicity
PCDH15
(P1761fs +8 more)
Deletion
(frameshift variant +1 more)
Usher syndrome type 1F
+2 more
GConflicting classifications of pathogenicity
USH2A
(S2498fs)
Deletion
(frameshift variant)
Retinitis pigmentosa 39
+2 more
GPathogenic/Likely pathogenic
ELP1
(P100fs +1 more)
Deletion
(frameshift variant +1 more)
Medulloblastoma
+3 more
GPathogenic/Likely pathogenic
USH2A, USH2A-AS2
(S1849fs)
Deletion
(frameshift variant)
Usher syndrome type 2A
+1 more
GPathogenic/Likely pathogenic
CDH1
(P219fs)
Deletion
(frameshift variant +1 more)
CDH1-related diffuse gastric and lobular breast cancer syndrome
GPathogenic
TGFBR2
(K153fs +1 more)
Deletion
(frameshift variant)
not specified
+3 more
GConflicting classifications of pathogenicity
OLikely oncogenic
PCDH15
(E1468fs +8 more)
Duplication
(frameshift variant +1 more)
not provided
+3 more
GConflicting classifications of pathogenicity
MUTYH
(G216E +7 more)
Single nucleotide variant
(missense variant +1 more)
Familial adenomatous polyposis 2
+2 more
GConflicting classifications of pathogenicity
MSH6
(A500T +2 more)
Single nucleotide variant
(missense variant)
Hereditary nonpolyposis colorectal neoplasms
+3 more
GConflicting classifications of pathogenicity
BRIP1
(L842F)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+2 more
GUncertain significance
CHEK2
(T476M +4 more)
Single nucleotide variant
(missense variant)
CHEK2-related cancer predisposition
+9 more
GConflicting classifications of pathogenicity
NBN
(L421S +1 more)
Single nucleotide variant
(missense variant)
Microcephaly, normal intelligence and immunodeficiency
+6 more
GConflicting classifications of pathogenicity
PAH
(Y206*)
Single nucleotide variant
(nonsense)
Phenylketonuria
GPathogenic
NBN
(I171V +1 more)
Single nucleotide variant
(missense variant)
Hereditary breast ovarian cancer syndrome
+9 more
GConflicting classifications of pathogenicity
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