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Items: 1 to 100 of 402

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
TCOF1
(D247fs)
Deletion
(frameshift variant +1 more)
Treacher Collins syndrome 1
GLikely pathogenic
EMD
(S60fs)
Deletion
(frameshift variant)
Emery-Dreifuss muscular dystrophy 1, X-linked
GPathogenic
ABCF3
(D109E +3 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
SPG11
(P361fs)
Deletion
(frameshift variant)
Hereditary spastic paraplegia 11
GPathogenic
DLL1
(A494fs)
Deletion
(frameshift variant)
not provided
GPathogenic
HECTD4
(L918R)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
SAMD9
(S1566G)
Single nucleotide variant
(missense variant)
MIRAGE syndrome
GLikely pathogenic
FBN1
(G1252S)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
POLR1A
(R216*)
Single nucleotide variant
(nonsense)
not provided
GUncertain significance
DHPS
(D130H +3 more)
Single nucleotide variant
(missense variant +2 more)
not provided
GUncertain significance
CCDC22
(A18E)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
CREBBP
(I2002fs +1 more)
Duplication
(frameshift variant)
Rubinstein-Taybi syndrome due to CREBBP mutations
GPathogenic
TUBB4B
(P259S)
Single nucleotide variant
(missense variant)
not provided
GPathogenic
HECTD4
(A1518T +1 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
VWF
(Q2071*)
Single nucleotide variant
(nonsense)
von Willebrand disease type 1
GPathogenic
LOC125467768, PCDH19
(E754fs)
Microsatellite
(frameshift variant +1 more)
Complex cortical dysplasia with other brain malformations 7
+1 more
GConflicting classifications of pathogenicity
TUBB2B
(G71D)
Single nucleotide variant
(missense variant)
Complex cortical dysplasia with other brain malformations 7
GLikely pathogenic
PITX2
(L159fs +2 more)
Deletion
(frameshift variant)
not provided
GPathogenic
KMT2D
(P3246fs)
Duplication
(frameshift variant)
Kabuki syndrome 1
GPathogenic
LRSAM1
Single nucleotide variant
(intron variant)
Charcot-Marie-Tooth disease axonal type 2P
GUncertain significance
IFIH1
(G795D)
Single nucleotide variant
(missense variant)
Aicardi-Goutieres syndrome 7
GUncertain significance
DNMT3A
(R120C +3 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
NCAPG2
(G745fs)
Deletion
(frameshift variant +1 more)
not provided
GUncertain significance
ATP6V1A
(E356D)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy 93
GLikely pathogenic
NCDN
(P516L +1 more)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder with infantile epileptic spasms
GLikely pathogenic
ZFHX4
(S1144fs +1 more)
Microsatellite
(frameshift variant)
not provided
GLikely pathogenic
MED13L
(E1918fs)
Insertion
(frameshift variant)
Cardiac anomalies - developmental delay - facial dysmorphism syndrome
GPathogenic
NECAP1
(E61V)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
FBXL4
(E173*)
Single nucleotide variant
(nonsense)
Mitochondrial DNA depletion syndrome 13
GPathogenic
TBK1
(Q565*)
Single nucleotide variant
(nonsense)
Frontotemporal dementia and/or amyotrophic lateral sclerosis 4
GPathogenic
NOTCH3
(C959S)
Single nucleotide variant
(missense variant)
not provided
GLikely pathogenic
SPEN
Single nucleotide variant
(splice donor variant)
Radio-Tartaglia syndrome
GPathogenic
FLII
(R597* +2 more)
Single nucleotide variant
(nonsense)
not provided
GUncertain significance
DLG3
(L300H +2 more)
Single nucleotide variant
(missense variant)
Intellectual disability, X-linked 90
+1 more
GUncertain significance
TBL1XR1
(I141fs +1 more)
Duplication
(frameshift variant)
Intellectual disability, autosomal dominant 41
+1 more
GPathogenic
ZNF292
(E540fs +1 more)
Deletion
(frameshift variant)
Intellectual developmental disorder, autosomal dominant 64
GLikely pathogenic
GJB3
(H124R)
Single nucleotide variant
(missense variant)
Erythrokeratodermia variabilis et progressiva 1
GUncertain significance
CELSR1
(N2599K)
Single nucleotide variant
(missense variant)
Lymphatic malformation 9
GUncertain significance
DNMT3A
(G503V +3 more)
Single nucleotide variant
(missense variant +1 more)
Tatton-Brown-Rahman overgrowth syndrome
GPathogenic
DDX3X
(A216fs +2 more)
Deletion
(frameshift variant +1 more)
Intellectual disability, X-linked 102
GPathogenic
CAPRIN1
(R297fs)
Deletion
(frameshift variant)
Juvenile myoclonic epilepsy
GPathogenic
COL11A2
(E1085G +6 more)
Single nucleotide variant
(missense variant)
Otospondylomegaepiphyseal dysplasia, autosomal dominant
GUncertain significance
TRAPPC4
(L125P +2 more)
Single nucleotide variant
(missense variant +1 more)
Neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy
GLikely pathogenic
EGR2
(S125Y +2 more)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease type 1D
GUncertain significance
USP9X
(A1830G +1 more)
Single nucleotide variant
(missense variant)
Intellectual disability, X-linked 99
GUncertain significance
ATP2B1
(E800* +7 more)
Single nucleotide variant
(nonsense +1 more)
Intellectual disability, autosomal dominant 30
GLikely pathogenic
MYO5B
(N661K)
Single nucleotide variant
(missense variant)
Congenital microvillous atrophy
GLikely pathogenic
MYCBP2
(G1709R)
Single nucleotide variant
(missense variant)
Autism spectrum disorder due to AUTS2 deficiency
GUncertain significance
TTN
(E4603fs +4 more)
Deletion
(frameshift variant +1 more)
Dilated cardiomyopathy 1G
GLikely pathogenic
AUTS2
Deletion
(inframe_indel)
Autism spectrum disorder due to AUTS2 deficiency
GUncertain significance
MAN2C1
(I290M +1 more)
Single nucleotide variant
(missense variant)
Congenital disorder of deglycosylation 2
GUncertain significance
SMARCA2
(A1161P +1 more)
Single nucleotide variant
(missense variant)
Nicolaides-Baraitser syndrome
GPathogenic
ZNF335
(D491H)
Single nucleotide variant
(missense variant)
Microcephalic primordial dwarfism due to ZNF335 deficiency
GUncertain significance
ZNF335
(T583M)
Single nucleotide variant
(missense variant)
Microcephalic primordial dwarfism due to ZNF335 deficiency
GUncertain significance
AGK
(R210*)
Single nucleotide variant
(nonsense)
Sengers syndrome
GPathogenic
SURF1
(A13fs)
Deletion
(5 prime UTR variant +1 more)
Mitochondrial complex IV deficiency, nuclear type 1
+1 more
GPathogenic
TCEAL1
Duplication
(inframe_insertion)
Neurodevelopmental disorder with gait disturbance, dysmorphic facies, and behavioral abnormalities, X-linked
GUncertain significance
EP300
(L1607R +1 more)
Single nucleotide variant
(missense variant)
Menke-Hennekam syndrome 2
GLikely pathogenic
PORCN
Single nucleotide variant
(splice donor variant)
Focal dermal hypoplasia
GUncertain significance
SCN2A
(A993P)
Single nucleotide variant
(missense variant)
Seizures, benign familial infantile, 3
GUncertain significance
CERT1
(G243A +1 more)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 34
GLikely pathogenic
GLUL
(P58R)
Single nucleotide variant
(missense variant)
Congenital brain dysgenesis due to glutamine synthetase deficiency
GUncertain significance
POLR3B
(I285T +1 more)
Single nucleotide variant
(missense variant)
Hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism
GLikely pathogenic
POLR3B
Single nucleotide variant
(splice donor variant)
Hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism
GLikely pathogenic
HUWE1
(R162G)
Single nucleotide variant
(missense variant)
Intellectual disability, X-linked 99
GUncertain significance
ABCA2
Deletion
(splice donor variant)
Intellectual developmental disorder with poor growth and with or without seizures or ataxia
GPathogenic
FLNC, FLNC-AS1
(G2631R +1 more)
Single nucleotide variant
(missense variant)
Distal myopathy with posterior leg and anterior hand involvement
GUncertain significance
PIEZO2
Single nucleotide variant
(synonymous variant)
Arthrogryposis, distal, with impaired proprioception and touch
GUncertain significance
FA2H
Single nucleotide variant
(intron variant)
Hereditary spastic paraplegia 35
GUncertain significance
SALL4
(Q1020fs +1 more)
Deletion
(frameshift variant)
Duane-radial ray syndrome
GLikely pathogenic
USP9X
(R6C)
Single nucleotide variant
(missense variant)
Intellectual disability, X-linked 99
GUncertain significance
KDM5C
(W1141* +2 more)
Single nucleotide variant
(nonsense +1 more)
Syndromic X-linked intellectual disability Claes-Jensen type
GPathogenic
ASS1
(Q311E)
Single nucleotide variant
(missense variant)
Citrullinemia type I
GUncertain significance
TRIO
Single nucleotide variant
(synonymous variant +1 more)
Micrognathia-recurrent infections-behavioral abnormalities-mild intellectual disability syndrome
GLikely pathogenic
COA6
(A15G +2 more)
Single nucleotide variant
(missense variant)
Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 4
GUncertain significance
PUM1
Single nucleotide variant
(intron variant)
not provided
GUncertain significance
ITPR3
(I917L)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
KSR2
(R647H)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TMEM63B
(Q477E)
Single nucleotide variant
(missense variant)
not provided
GLikely pathogenic
MED12
(I604F)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
MAST1
(P1177L)
Single nucleotide variant
(missense variant)
not provided
GLikely pathogenic
TRPM3
(S1111P +12 more)
Single nucleotide variant
(missense variant)
not provided
GLikely pathogenic
DHX30
(R740C +2 more)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder with severe motor impairment and absent language
GUncertain significance
VIPAS39
(R190* +4 more)
Single nucleotide variant
(nonsense +2 more)
not provided
+2 more
GPathogenic
ATP6AP1
(L74V)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
HUWE1
(E4315K)
Single nucleotide variant
(missense variant)
Intellectual disability, X-linked syndromic, Turner type
+1 more
GUncertain significance
VCP
(G226D +1 more)
Single nucleotide variant
(missense variant)
not provided
GLikely pathogenic
NAXE
(R254C)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
SLC12A6
(R1125Q +4 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
ERCC6
(L685P)
Single nucleotide variant
(missense variant)
Cockayne syndrome type 2
+1 more
GConflicting classifications of pathogenicity
CHD7
Single nucleotide variant
(intron variant)
CHARGE syndrome
GLikely pathogenic
FGFR1
(E117fs +2 more)
Deletion
(frameshift variant +1 more)
not provided
+2 more
GPathogenic
LOC130004775, NHLRC2
(E33del)
Deletion
(inframe_deletion)
Fibrosis, neurodegeneration, and cerebral angiomatosis
GUncertain significance
NHLRC2
(F462S)
Single nucleotide variant
(missense variant)
Fibrosis, neurodegeneration, and cerebral angiomatosis
GUncertain significance
NHLRC2
(Q365P)
Single nucleotide variant
(missense variant)
Fibrosis, neurodegeneration, and cerebral angiomatosis
GUncertain significance
NHLRC2
(D692Y)
Single nucleotide variant
(missense variant)
Fibrosis, neurodegeneration, and cerebral angiomatosis
GUncertain significance
NHLRC2
Deletion
(nonsense)
Fibrosis, neurodegeneration, and cerebral angiomatosis
GLikely pathogenic
SLC31A1
(L79P)
Single nucleotide variant
(missense variant)
not provided
GLikely pathogenic
ITPR3
(R2524C)
Single nucleotide variant
(missense variant)
not provided
+1 more
GLikely pathogenic
SETD1A
(E1337A)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder with speech impairment and dysmorphic facies
GUncertain significance
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