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Items: 36

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
TTN, TTN-AS1
(E18482fs +5 more)
Deletion
(frameshift variant)
Dilated cardiomyopathy 1G
GLikely pathogenic
CASK
Single nucleotide variant
(splice acceptor variant)
Syndromic X-linked intellectual disability Najm type
+1 more
GPathogenic
NOTCH3
(C174S)
Single nucleotide variant
(missense variant)
Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1
GPathogenic
CHD2
(D209fs)
Deletion
(frameshift variant)
Developmental and epileptic encephalopathy 94
GPathogenic
EZH2
(V623L +4 more)
Single nucleotide variant
(missense variant)
Weaver syndrome
GLikely pathogenic
NOTCH3
(C206Y)
Single nucleotide variant
(missense variant)
Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1
+3 more
GPathogenic/Likely pathogenic
ABCD1
Single nucleotide variant
(splice donor variant)
Adrenoleukodystrophy
GPathogenic
CACNA1A
Single nucleotide variant
(splice donor variant)
Developmental and epileptic encephalopathy, 42
+2 more
GPathogenic/Likely pathogenic
COL11A2
(R558* +2 more)
Single nucleotide variant
(nonsense)
not provided
+1 more
GPathogenic
CFTR
Single nucleotide variant
(missense variant)
Cystic fibrosis
GLikely pathogenic
ABCD1
(G277W)
Single nucleotide variant
(missense variant)
Adrenoleukodystrophy
+1 more
GPathogenic/Likely pathogenic
ABCD1
(G607D)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+1 more
GConflicting classifications of pathogenicity
DMD
(Q591* +5 more)
Single nucleotide variant
(nonsense)
Becker muscular dystrophy
+1 more
GPathogenic/Likely pathogenic
ALDH7A1
(Y370fs +2 more)
Deletion
(frameshift variant)
Pyridoxine-dependent epilepsy
+1 more
GPathogenic/Likely pathogenic
EIF3F
(F232V)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder
+5 more
GPathogenic/Likely pathogenic
ABCD1
(G512S)
Single nucleotide variant
(missense variant)
ABCD1-related disorder
+2 more
GPathogenic/Likely pathogenic
FBN1
(C2000Y)
Single nucleotide variant
(missense variant)
Familial thoracic aortic aneurysm and aortic dissection
+1 more
GPathogenic/Likely pathogenic
ABCD1
(R189W)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic/Likely pathogenic
APOB
(E137*)
Single nucleotide variant
(nonsense)
Hypercholesterolemia, autosomal dominant, type B
+2 more
GPathogenic/Likely pathogenic
LDLR
(R350* +3 more)
Single nucleotide variant
(nonsense)
Hypercholesterolemia, familial, 1
GPathogenic
CFTR
(L967S)
Single nucleotide variant
(missense variant)
Bronchiectasis with or without elevated sweat chloride 1
+5 more
GConflicting classifications of pathogenicity
DMD
Single nucleotide variant
(splice donor variant)
Duchenne muscular dystrophy
+4 more
GPathogenic/Likely pathogenic
CFTR
Duplication
(inframe_insertion)
Cystic fibrosis
GPathogenic
CFTR, LOC111674472
(W1098R)
Single nucleotide variant
(missense variant)
Cystic fibrosis
GPathogenic
LOC111674472, CFTR
(P1013L)
Single nucleotide variant
(missense variant)
Cystic fibrosis
+2 more
GConflicting classifications of pathogenicity
PKP2
(H689fs +1 more)
Indel
(frameshift variant)
Arrhythmogenic right ventricular cardiomyopathy
+5 more
GPathogenic
CEP85L, PLN
(R14del)
Microsatellite
(inframe_indel +2 more)
SUDDEN INFANT DEATH SYNDROME
+6 more
GConflicting classifications of pathogenicity
MYBPC3
(R502W)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+7 more
GPathogenic/Likely pathogenic
ADAR
(G1007R +5 more)
Single nucleotide variant
(missense variant)
Symmetrical dyschromatosis of extremities
+2 more
GPathogenic/Likely pathogenic
ALDH7A1
(N273I +1 more)
Single nucleotide variant
(missense variant)
Pyridoxine-dependent epilepsy
+1 more
GPathogenic/Likely pathogenic
GRN
(R493*)
Single nucleotide variant
(nonsense)
GRN-related frontotemporal lobar degeneration with Tdp43 inclusions
+2 more
GPathogenic
LOC126861898, MYH7
(R870H)
Single nucleotide variant
(missense variant)
Hypertrophic cardiomyopathy
GPathogenic
ABCD1
(R617C)
Single nucleotide variant
(missense variant)
Adrenoleukodystrophy
+1 more
GPathogenic/Likely pathogenic
NOTCH3
(R133C)
Single nucleotide variant
(missense variant)
Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1
+4 more
GPathogenic/Likely pathogenic
CFTR
Single nucleotide variant
(splice acceptor variant)
Cystic fibrosis
GPathogenic
PKP2
Single nucleotide variant
(splice acceptor variant)
Arrhythmogenic right ventricular dysplasia 9
+4 more
GPathogenic
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