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Items: 1 to 100 of 549

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
COL4A3, MFF-DT
(G575E)
Single nucleotide variant
(missense variant)
Autosomal dominant Alport syndrome
GLikely pathogenic
TMEM147
Single nucleotide variant
(splice acceptor variant)
Neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-pelger-huet anomaly
GLikely pathogenic
CTNND1, TMX2-CTNND1
Single nucleotide variant
(splice donor variant)
Blepharocheilodontic syndrome 2
GPathogenic
SPTBN2
Deletion
Spinocerebellar ataxia type 5
GLikely pathogenic
KCNJ1
(C134S +2 more)
Single nucleotide variant
(missense variant)
Bartter disease type 2
GUncertain significance
CLCN4
(E588fs +1 more)
Deletion
(frameshift variant)
Intellectual disability, X-linked 49
GLikely pathogenic
FBN1
(E2294*)
Single nucleotide variant
(nonsense)
Marfan syndrome
GPathogenic
COL11A1
(G845D +3 more)
Single nucleotide variant
(missense variant +1 more)
Stickler syndrome type 2
GLikely pathogenic
SYNGAP1, SYNGAP1-AS1
(W657C)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 5
GUncertain significance
MYLK
Single nucleotide variant
(splice acceptor variant)
Aortic aneurysm, familial thoracic 7
GUncertain significance
PPM1D
(N402*)
Duplication
(nonsense)
Intellectual developmental disorder with gastrointestinal difficulties and high pain threshold
GUncertain significance
MDFIC
(Q195* +1 more)
Indel
(nonsense)
Lymphatic malformation 12
GLikely pathogenic
PKD1
(V300fs)
Deletion
(frameshift variant)
Polycystic kidney disease, adult type
GPathogenic
CNOT1
(Y946* +1 more)
Single nucleotide variant
(nonsense +1 more)
Vissers-Bodmer syndrome
GLikely pathogenic
COL9A3
Single nucleotide variant
(splice acceptor variant)
Epiphyseal dysplasia, multiple, 3
GPathogenic
PBX1
(T231fs +1 more)
Duplication
(frameshift variant)
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
GPathogenic
GRIN2B
(A828V)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 6
GUncertain significance
PDGFA
(W120* +3 more)
Single nucleotide variant
(nonsense +1 more)
Hepatic fibrosis
+2 more
GUncertain significance
COL1A2
(G310S)
Single nucleotide variant
(missense variant)
Osteogenesis imperfecta, perinatal lethal
GPathogenic
KCNQ2
(S352W)
Single nucleotide variant
(missense variant)
Seizures, benign familial neonatal, 1
GLikely pathogenic
PKD1
(P755fs)
Duplication
(frameshift variant)
Polycystic kidney disease, adult type
GLikely pathogenic
TSC2
Deletion
(inframe_deletion +1 more)
Tuberous sclerosis 2
GUncertain significance
COL4A5
(G141D)
Single nucleotide variant
(missense variant)
X-linked Alport syndrome
GLikely pathogenic
AGO1
(F105L +1 more)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures
GUncertain significance
CNOT1
(K1236R +1 more)
Single nucleotide variant
(missense variant +1 more)
Vissers-Bodmer syndrome
GUncertain significance
TCOF1
(S1127fs +5 more)
Microsatellite
(frameshift variant)
Treacher Collins syndrome 1
GPathogenic
STRC
(Q1607*)
Single nucleotide variant
(nonsense)
Autosomal recessive nonsyndromic hearing loss 16
GPathogenic
DYNC1H1
(D317Y)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease axonal type 2O
GUncertain significance
OBSCN
(P2496fs +1 more)
Deletion
(frameshift variant)
Rhabdomyolysis, susceptibility to, 1
GLikely pathogenic
CDK19
(A352S +2 more)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 87
GUncertain significance
FBN1
(D2013N)
Single nucleotide variant
(missense variant)
Marfan syndrome
GLikely pathogenic
DNAJB11
(P182fs)
Deletion
(frameshift variant +2 more)
Polycystic kidney disease 6 with or without polycystic liver disease
GLikely pathogenic
FBN1
Single nucleotide variant
(intron variant)
Marfan syndrome
GUncertain significance
FBN1
(N57fs)
Duplication
(frameshift variant)
Marfan syndrome
GPathogenic
IGF1R
(I1204N +1 more)
Single nucleotide variant
(missense variant)
Growth delay due to insulin-like growth factor I resistance
GLikely pathogenic
TGFBR2
(A241D +10 more)
Single nucleotide variant
(missense variant)
Loeys-Dietz syndrome 2
GLikely pathogenic
PKHD1, LOC126859690
(S1734fs)
Deletion
(frameshift variant)
Polycystic kidney disease 4
GLikely pathogenic
COL4A4
(L330fs)
Deletion
(frameshift variant)
Hematuria, benign familial, 1
GLikely pathogenic
CUL3
(R285fs +2 more)
Deletion
(frameshift variant)
Neurodevelopmental disorder with or without autism or seizures
GLikely pathogenic
OTOG
(Q899* +1 more)
Single nucleotide variant
(nonsense)
Autosomal recessive nonsyndromic hearing loss 18B
GPathogenic
C1R
(Y222N +1 more)
Single nucleotide variant
(missense variant)
Ehlers-Danlos syndrome, periodontal type 1
GUncertain significance
PHEX, PTCHD1-AS
(V717G)
Single nucleotide variant
(missense variant +1 more)
Familial X-linked hypophosphatemic vitamin D refractory rickets
GLikely pathogenic
PKD2
(C344L)
Indel
(missense variant +1 more)
Polycystic kidney disease 2
GUncertain significance
TTN, TTN-AS1
(V17770fs +5 more)
Deletion
(frameshift variant)
Dilated cardiomyopathy 1G
GLikely pathogenic
GLS
(M508K)
Single nucleotide variant
(missense variant)
Infantile cataract, skin abnormalities, glutamate excess, and impaired intellectual development
GUncertain significance
WNT1
(G146V)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
UNC45B
(E686K +2 more)
Single nucleotide variant
(missense variant)
Myofibrillar myopathy 11
GUncertain significance
TTN, TTN-AS1
(S26034fs +5 more)
Microsatellite
(frameshift variant)
Early-onset myopathy with fatal cardiomyopathy
GLikely pathogenic
COL4A5
(P1271fs +1 more)
Deletion
(frameshift variant)
X-linked Alport syndrome
GLikely pathogenic
AUTS2
(D805* +1 more)
Duplication
(nonsense)
Autism spectrum disorder due to AUTS2 deficiency
GLikely pathogenic
FBN1
(T1371A)
Single nucleotide variant
(missense variant)
Marfan syndrome
GUncertain significance
ENO3
(R284S +2 more)
Single nucleotide variant
(missense variant)
Glycogen storage disease due to muscle beta-enolase deficiency
GUncertain significance
KIF26A
(A1363fs)
Duplication
(frameshift variant)
Cortical dysplasia, complex, with other brain malformations 11
GPathogenic
COL1A2
(G205D)
Single nucleotide variant
(missense variant)
Osteogenesis imperfecta, perinatal lethal
GLikely pathogenic
ATAD3A
(A482F +2 more)
Indel
(missense variant)
Harel-Yoon syndrome
+1 more
GUncertain significance
SEC24D
(G575A +1 more)
Single nucleotide variant
(missense variant)
Cole-Carpenter syndrome 2
GLikely pathogenic
TGM5
(F39I)
Single nucleotide variant
(missense variant)
Acral peeling skin syndrome
GLikely pathogenic
B4GAT1
(E364*)
Duplication
(nonsense)
Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A13
GUncertain significance
SCN2A
(K1863R)
Single nucleotide variant
(missense variant)
Seizures, benign familial infantile, 3
GUncertain significance
DNAAF3, DNAAF3-AS1
(Q26* +1 more)
Single nucleotide variant
(nonsense +1 more)
Primary ciliary dyskinesia 2
GPathogenic
TTN, TTN-AS1
Single nucleotide variant
(synonymous variant)
Hypertrophic cardiomyopathy 9
GLikely benign
IPO8
(L504P +1 more)
Single nucleotide variant
(missense variant)
VISS syndrome
GUncertain significance
SEC24D
(L352* +1 more)
Single nucleotide variant
(nonsense)
Cole-Carpenter syndrome 2
GLikely pathogenic
FBN1
Single nucleotide variant
(intron variant)
Marfan syndrome
GLikely pathogenic
TSFM
(W81*)
Single nucleotide variant
(nonsense)
Fatal mitochondrial disease due to combined oxidative phosphorylation defect type 3
GUncertain significance
TAF8
(H145D)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder with severe motor impairment, absent language, cerebral hypomyelination, and brain atrophy
GUncertain significance
COL4A5
Single nucleotide variant
(intron variant)
X-linked Alport syndrome
GPathogenic
SLC7A9
Deletion
(splice donor variant)
Cystinuria
GPathogenic
SCN8A
(I938F)
Single nucleotide variant
(missense variant)
Cognitive impairment with or without cerebellar ataxia
GLikely pathogenic
USH1C
Single nucleotide variant
(splice acceptor variant)
Autosomal recessive nonsyndromic hearing loss 18A
GLikely pathogenic
TCF20
(G857fs)
Duplication
(frameshift variant)
Developmental delay with variable intellectual impairment and behavioral abnormalities
GPathogenic/Likely pathogenic
COL2A1
(G732S +1 more)
Single nucleotide variant
(missense variant)
Achondrogenesis type II
GLikely pathogenic
PIEZO2
(L787R)
Single nucleotide variant
(missense variant)
Arthrogryposis- oculomotor limitation-electroretinal anomalies syndrome
GUncertain significance
ASXL3
(E873fs)
Deletion
(frameshift variant)
Severe feeding difficulties-failure to thrive-microcephaly due to ASXL3 deficiency syndrome
GLikely pathogenic
NUP93
Single nucleotide variant
(splice acceptor variant)
Nephrotic syndrome, type 12
GLikely pathogenic
TMEM147, TMEM147-AS1
(Q46P)
Single nucleotide variant
(non-coding transcript variant +2 more)
Neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-pelger-huet anomaly
GUncertain significance
MMP21
(T209R)
Single nucleotide variant
(missense variant)
Heterotaxy, visceral, 7, autosomal
GUncertain significance
MMP21
(S435fs)
Deletion
(frameshift variant)
Heterotaxy, visceral, 7, autosomal
GLikely pathogenic
CFH
(L992*)
Single nucleotide variant
(nonsense)
Hemolytic uremic syndrome, atypical, susceptibility to, 1
GLikely pathogenic
FANCA
(F456S)
Single nucleotide variant
(missense variant)
Fanconi anemia complementation group A
GLikely pathogenic
PUF60
(Y117C +9 more)
Single nucleotide variant
(missense variant)
8q24.3 microdeletion syndrome
GUncertain significance
SIN3A
Duplication
(splice acceptor variant)
SIN3A-related intellectual disability syndrome due to a point mutation
GPathogenic
NPR2
(R165fs)
Deletion
(frameshift variant)
Acromesomelic dysplasia 1, Maroteaux type
GLikely pathogenic
WDR19
(D806G +1 more)
Single nucleotide variant
(missense variant)
Senior-Loken syndrome 8
GUncertain significance
WDR19
(S177F +1 more)
Single nucleotide variant
(missense variant)
Senior-Loken syndrome 8
GUncertain significance
ATOH7
(R52G)
Single nucleotide variant
(missense variant)
Persistent hyperplastic primary vitreous, autosomal recessive
GLikely pathogenic
MEF2C
(K30T)
Single nucleotide variant
(missense variant)
Intellectual disability, autosomal dominant 20
GLikely pathogenic
TRIO
(Y1362C)
Single nucleotide variant
(missense variant +1 more)
Intellectual developmental disorder, autosomal dominant 63, with macrocephaly
GLikely pathogenic
DNAI2
(D30fs)
Duplication
(non-coding transcript variant +1 more)
Primary ciliary dyskinesia 9
GLikely pathogenic
COL4A5
(G1134fs)
Deletion
(frameshift variant)
X-linked Alport syndrome
GLikely pathogenic
PKD1
(E1073fs)
Deletion
(frameshift variant)
Polycystic kidney disease, adult type
GLikely pathogenic
EBP
(Y104*)
Single nucleotide variant
(nonsense)
Chondrodysplasia punctata 2 X-linked dominant
GPathogenic
TTN, TTN-AS1
(E16209fs +5 more)
Deletion
(frameshift variant)
Dilated cardiomyopathy 1G
GLikely pathogenic
TTN, TTN-AS1
(E22681G +5 more)
Single nucleotide variant
(missense variant)
Dilated cardiomyopathy 1G
GUncertain significance
COL1A1
(G335V)
Single nucleotide variant
(missense variant)
Osteogenesis imperfecta, perinatal lethal
GLikely pathogenic
NOTCH3
(C568R)
Single nucleotide variant
(missense variant)
Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1
GLikely pathogenic
GRIN2A
(E1073fs)
Deletion
(frameshift variant)
Landau-Kleffner syndrome
GLikely pathogenic
RORB
(E357fs +1 more)
Deletion
(frameshift variant)
Epilepsy, idiopathic generalized, susceptibility to, 15
GPathogenic
SCN8A
(T1573N +1 more)
Single nucleotide variant
(missense variant)
Seizures, benign familial infantile, 5
GLikely pathogenic
TAPT1
(L108W)
Single nucleotide variant
(missense variant)
Reduced bone mineral density
+4 more
GUncertain significance
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