2NLK,3QCL,3QCM


Conserved Protein Domain Family
R-PTPc-G-1
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cd17667: R-PTPc-G-1 
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catalytic domain of receptor-type tyrosine-protein phosphatase G, repeat 1
Receptor-type tyrosine-protein phosphatase G (PTPRG), also called protein-tyrosine phosphatase gamma (R-PTP-gamma), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRG is an important tumor suppressor gene in multiple human cancers such as lung, ovarian, and breast cancers. It is widely expressed in many tissues, including the central nervous system, where it plays a role during neuroinflammation processes. It can dephosphorylate platelet-derived growth factor receptor beta (PDGFRB) and may play a role in PDGFRB-related infantile myofibromatosis. PTPRG has four splicing isoforms: three transmembrane isoforms, PTPRG-A, B, and C, and one secretory isoform, PTPRG-S, which are expressed in many tissues including the brain. PTPRG is a type 1 integral membrane protein consisting of an extracellular region with a carbonic anhydrase-like (CAH) and a fibronectin type III (FN3) domains, and an intracellular region with a catalytic PTP domain (repeat 1) proximal to the membrane, and a catalytically inactive PTP-fold domain (repeat 2) distal to the membrane. This model represents the catalytic PTP domain (repeat 1).
Links
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Statistics
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PSSM-Id: 350505
Aligned: 8 rows
Threshold Bit Score: 609.344
Created: 12-Jun-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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catalytic siteactive site
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic site [active site], 2 residue positions
Conserved feature residue pattern:C RClick to see conserved feature residue pattern help
Evidence:
  • Comment:the catalytic cysteine initiates a nucleophilic attack on the phosphate group of the substrate, forming a transient phosphoenzyme intermediate and releasing the substrate dephosphorylated; the transition state is stabilized by the arginine present in the catalytic pocket
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
2NLK_A         23 FSEDFEEVQRCtadmNITAEHSNHPENKHKNRYINILAYDHsRVKLRPLPgkdsKHSDYINANYVDGYNKAKAYIATQGP 102  human
3QCL_A         30 FSEDFEEVQRStadmNITAEHSNHPENKHKNRYINILAYDHsRVKLRPLPgkdsKHSDYINANYVDGYNKAKAYIATQGP 109  human
3QCM_A         30 FSEDFEEVQRCtadmNITAEHSNHPENKHKNRYINILAYDHsRVKLRPLPgkdsKHSDYINANYVDGYNKAKAYIATQGP 109  human
OCT83494      722 GDAVYDEVQRCtadmSITAEHSNHPDNKHKNRYINIVAYDHsRVKLRPLPgkdsKHSEYINANYVDGYNKAKAYVATQGP 801  African clawe...
XP_014346989  639 FSEEFEEVQRCtadmSITAEHSNHPDNKHKNRYINIVAYDHsRVKLRPLAgkdsKHSDYINANYVDGYNKAKAYIATQGP 718  coelacanth
XP_007893436  856 FSEEFEEVQRCtadmNITAEHSNHPDNKHKNRYINIVAYDHsRVKLRPLAgkdsKHSDYINANYVDGYNKAKAYIATQGP 935  elephant shark
NP_001316793  817 FSDDFEEVQRCtadmKITAEHSNHPDNKHKNRYINIIAYDHsRVKLRPLAgkdsKHSDYINANYVDGYNKPKAYIAAQGP 896  zebrafish
Q98936        825 FSEDFEEVQRCtadmNITAEHSNHPDNKHKNRYINILAYDHsRVKLRPLPgkdsKHSDYINANYVSGYNKAKAYIATQGP 904  chicken

Feature 1                                                                                         
2NLK_A        103 LKstfeDFWRMIWEQntGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHacYTVRRFSIRntkvkkgqk- 181  human
3QCL_A        110 LKstfeDFWRMIWEQntGIIVMITNLVEKGRRKCDQYWPTENTEEYGNIIVTLKSTKIHacYTVRRFSIRntkvkkgqk- 188  human
3QCM_A        110 LKstfeDFWRMIWEQntGIIIMITNLVEKGRRKCDQYWPTENTEEYGNIIVTLKSTKIHacYTVRRFSIRntkvkkgqk- 188  human
OCT83494      802 LKstfeDFWRMIWEQntGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIMVTLKSTRVYacYTVRRFTIRnvkmkkgqk- 880  African clawe...
XP_014346989  719 LKstfdDFWRMIWEQntGIIVMITNLVEKGRRKCDQYWPTENSEEYGNLIVTLKSTKIHacYTLRRFTVRntkvkkvmgq 798  coelacanth
XP_007893436  936 LKptfeDFWRMIWEQntGIIVMITNLVEKGRRKCDQYWPSENNEEYGNIIVTLKSTKVRacCTVRRFSIRntklkrgqk- 1014 elephant shark
NP_001316793  897 LKstfeDFWRMVWEQntGIIVMITNLVEKGRRKCDQYWPSENSEEYGNIVVTLKRTKVMacYTLRIFTIRntkvkkgqk- 975  zebrafish
Q98936        905 LKstfeDFWRMIWAQhtGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTNIHacYTVRPLHGQehkdekgse- 983  chicken

Feature 1                                                               #     #                   
2NLK_A        182 -gnpkgrqneRVVIQYHYTQWPDMGVPeyALPVLTFVRRSSAArmPETGPVLVHCSAGVGRTGTYIVIDSMLQQIkdkST 260  human
3QCL_A        189 -gnpkgrqneRVVIQYHYTQWPDMGVPeyALPVLTFVRRSSAArmPETGPVLVHCSAGVGRTGTYIVIDSMLQQIkdkST 267  human
3QCM_A        189 -gnpkgrqneRVVIQYHYTQWPDMGVPeyALPVLTFVRRSSAArmPETGPVLVHCSAGVGRTGTYIVIDSMLQQIkdkST 267  human
OCT83494      881 -gntkgrhneRTVMQYHYTQWPDMGVPeyALPVLTFVRRSSAAqlPEMGPVLVHCSAGVGRTGTYIVIDSMLQQIkdkST 959  African clawe...
XP_014346989  799 kgnpkgrqneRTVIQYHYTQWPDMGVPeyALPVLTFVRRSSAArtSDMGPVLVHCSAGVGRTGTYIVIDSMLQQIqdkST 878  coelacanth
XP_007893436 1015 -gnpkgrqneRMVIQYHYTQWPDMGVPeySLPVLTFVRKSSAArtPDMGPVVVHCSAGVGRTGTYIVLDSMLQQIkdkST 1093 elephant shark
NP_001316793  976 -gntkgrqseRTVLQYHYTQWPDMGVPeyTLPVLTFVRKSSAAqtPDMGPMLVHCSAGVGRTGTYIVIDSMLQQLkdkGA 1054 zebrafish
Q98936        984 -rkpkgrqneRTVIQYHYTQWPDMGVPeyALPVLTFVRRSSAArtPHMGPVVVHCSAGVGRTGTYIVIDSMLQQIkdkST 1062 chicken

Feature 1                                             
2NLK_A        261 VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIL 296  human
3QCL_A        268 VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIL 303  human
3QCM_A        268 VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIL 303  human
OCT83494      960 VNALGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIL 995  African clawed frog
XP_014346989  879 VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIL 914  coelacanth
XP_007893436 1094 VNILGFLKHIRTQRNYLVQTEEQYIFIHETLREAIH 1129 elephant shark
NP_001316793 1055 VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALMEAIL 1090 zebrafish
Q98936       1063 VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIL 1098 chicken

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