3MNM,5CN1,2DWX


Conserved Protein Domain Family
Alpha_adaptinC2

?
pfam02883: Alpha_adaptinC2 
Adaptin C-terminal domain
Alpha adaptin is a heterotetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This ig-fold domain is found in alpha, beta and gamma adaptins.
Statistics
?
PSSM-Id: 460735
Aligned: 97 rows
Threshold Bit Score: 44.2371
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3MNM_A     9 ARTLVNQSPNLKIEFEISReSNSVIRIXSFFTNLS-SSPISNLVFLLAVPKSMSLXLQPQSSNFMI-GnaKDGISQEGTI 86   baker's yeast
EDW28585 713 NNGVLFENEMLQIGVKSEF-RQNLGRLGLFYGNKT-QVPLSNFNPVLQWSAEETLKLNVQMKAVEPtLeaGAQIQQLLTA 790 
P17426   751 NSGVLFENQLLQIGVKSEF-RQNLGRMYLFYGNKT-SVQFQNFLPTVVHPGDLQTQLAVQTKRVAAqVdgGAQVQQVLNI 828  house mouse
Q0IHS1   730 NNGVLFENQLLQIGVKSEF-RQNLGRMYLFYGNKT-SVQFQSFTPTVNYPGELQSQVNIQTKPVDPvVegGAQVQQVLNI 807  tropical clawed frog
Q4SW01   730 NNGVIFENQLLQIGLKSEY-RQNLGRIYIFYGNKT-STQFLSFSSNVNIL-NYSSQLIVHAKTVDPiIegGAQVQQILNI 806  spotted green puff...
Q5BJ37   713 NNGVLFENQLLQIGVKSEF-RQNLGRMFIFFGNKM-SSQFQNFTSTVICSDELSASLNVQSKPAEDtVdgGAQVQQVVNV 790  African clawed frog
Q5F3T4   712 NNGVLFENQLLQIGLKSEF-RQNLGRMFIFYGNKT-STQFLNFTPTVICSDDLQPSLNLQTKPVDPtVdgGAQVQQVVNI 789  chicken
CAP34239 694 SNAILWEDDYIQVGCKLET-RNNLGRLGMFYGNKT-SQPFNKFTPIITCPGALAVQLQAQAKPVEPlVaaGTQVQQLINF 771 
Q1EQ20   664 NEGIIFQDQNIQIGYRSKV-IDNVVGIQLFYGNIS-PFPIT-VNIHIIVPDGLTSSLQQDNLTIES----HQQINHIIQF 736  Entamoeba histolytica
Q22E31   711 SIGQVYESNELTVQFKSDY-QQHMGKIAMQFESKIgRMENVSFVIANSDQNGLDFNISPIKYDEHP-----QIMMQVMST 784  Tetrahymena thermo...
3MNM_A    87 enapaNPSKALXVKWKVNYS-VNSTQAEETA--VFTLP 121  baker's yeast
EDW28585 791 e---cIEDYADAPTIEISFR-YNG--TQQKF--SIKLP 820 
P17426   829 e---cLRDFLTPPLLSVRFR-YGG--TAQSL--TLKLP 858  house mouse
Q0IHS1   808 e---cLSDFDEAPLINIKFR-YGGTLQNI----TLKLP 837  tropical clawed frog
Q4SW01   807 e---cVSDFMEAPVLNIQFR-YGGALQNI----AVKLP 836  spotted green pufferfish
Q5BJ37   791 e---cVQEFTDHPLLNIQFR-YGGAFQNVSV----KLP 820  African clawed frog
Q5F3T4   790 e---cVSDFMEAPILNIQFR-YGGTFQNLSV----KLP 819  chicken
CAP34239 772 vcvqeF-QKMPIMNIKFTFTdRAGAIQNFDK--NFYLP 806 
Q1EQ20   737 k---lNATFLEPPQLQLDYH-----FNSTSAsvSLPLP 766  Entamoeba histolytica
Q22E31   785 ---------DPRQQMPIGLLaYDVNGQNKRI--EIPLP 811  Tetrahymena thermophila SB210
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap