2KK1,1ZZP


Conserved Protein Domain Family
FABD
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smart00808: FABD 
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F-actin binding domain (FABD)
FABD is the F-actin binding domain of Bcr-Abl and its cellular counterpart c-Abl. The Bcr-Abl tyrosine kinase causes different forms of leukemia in humans. Depending on its position within the cell, Bcr-Abl differentially affects cellular growth. The FABD forms a compact left-handed four-helix bundle in solution.
Links
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Statistics
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PSSM-Id: 197885
Aligned: 11 rows
Threshold Bit Score: 151.494
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2KK1_A         16 AGTKVALRKTK--------------QAAEKISADKISKEALLECADLLSSALT----------EPVPNSQLV---DTGHQ 68   human
XP_968668    1232 IMAKPANLENKt------------pEDDVKDPTDKVGKDNILELSQALESTLRsik-----snDSVSTTTWLqlsDKIGL 1294 red flour beetle
P00522       1481 IQQKPAVPHKPtkltiyatpiakltEPASSASSTQISRESILELVGLLEGSLKhp-------vNAIAGSQWLqlsDKLNI 1553 fruit fly
CAG07989     1013 AASKVALRRTR--------------QQAERVPLERISREALLECAECLSSALHas------seSPASSQVL----DAGHQ 1068 Tetraodon nig...
AAY86039     1063 AGTKVALRKTK--------------QAAEKISADKISKEALLECADLLSSAIT----------EPVPNSQLV---DTGHQ 1115 house mouse
XP_001068096 1062 AGTKVALRKTK--------------QAAEKISADKISKAALLECAGLLSSAIT----------EPVPHSQLV---DTGHQ 1114 Norway rat
CAF99203     1351 VNTRRSLRKTAp------------rQASERTPNSAVTRDMVLEGTELSARPFAatr-----srRVATAPYW--------R 1405 Tetraodon nig...
BAD92693     1043 ISTRVSLRKTR--------------QPPERIASGAITKGVVLDSTEALCLAISrn------seQMASHSAVL---EAGKN 1099 human
AAA51561     1007 ISTRVSLRKTR--------------QPPER-ASGAITKGVVLDSTEALCLAISgn------seQMASHSAVL---EAGKN 1062 human
P03949       1091 LKHVVPPRKNRn------------qDESGSIDEEPVSKDMIVSLLKVIQKEFVnlfnlasseiTDEKLQQFVimaDNVQK 1158 Caenorhabditi...
1ZZP_A          4 ASTRVSLRKTR--------------QPPERIASGAITKGVVLDSTEALCLAISrn------seQMASHSAVL---EAGKN 60   human

2KK1_A         69 LLDYCSGYVDCi-PQTRNKFAFREAVSKLELSLQELQv---SSAAAGVPGTNPVLNNLLSCVQEISDVVQR 135  human
XP_968668    1295 LHGSCMDYADNv-VPAHTKFQFRELLTRLETQARQLR----SAGSRNSTENTRYINEVNNTIRDVVNVVFR 1360 red flour beetle
P00522       1554 LHNSCVIFAENgaMPPHSKFQFRELVTRVEAQSQHLR----SAGSKNVQDNERLVAEVGQSLRQISNALNR 1620 fruit fly
CAG07989     1069 LLDYCSGYVDCi-PQMRNKFAFREAVGKLELSLQELRasssGAGGLSGLGPNTVLDNLHSSIKEISDVVQR 1138 Tetraodon nigroviridis
AAY86039     1116 LLDYCSGYVDSi-PQTRNKFAFREAVSKLELSLQELQvsstAAG---VPGTNPVLNNLLSCVQEISDVVQR 1182 house mouse
XP_001068096 1115 LLHYCSGYVDCi-PHTRNKFAFREAVSKLELSLQELQvsstAAG---VPGTNPVLNNLLSCVQEISDVVQR 1181 Norway rat
CAF99203     1406 PVKTCPTDEEQv-RLPRSHQQAGEQPPRAADLPRRHR----------SANAQQDFSKLLSSVKEISDIVQR 1465 Tetraodon nigroviridis
BAD92693     1100 LYTFCVSYVDSi-QQMRNKFAFREAINKLENNLRELQicpaTAGS--GPAATQDFSKLLSSVKEISDIVQR 1167 human
AAA51561     1063 LYTFCVSYVDSi-QQMRNKFAFREAINKLENNLRELQicpaSAGS--GPAATQDFSKLLSSVKEISDIVQR 1130 human
P03949       1159 LHSTCSVYAEQ--ISPHSKFRFKELLSQLEIYNRQIKf---SHNPRAKPVDDKLKMAFQDCFDQIMRLVDR 1224 Caenorhabditis elegans
1ZZP_A         61 LYSFCVSYVDSi-QQMRNKFAFREAINKLENNLRELQicpaTAGS--GPAATQDFSKLLSSVKEISDIVQR 128  human
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