3F27,2YUL


Conserved Protein Domain Family
HMG-box_SoxF_SOX17
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cd22047: HMG-box_SoxF_SOX17 
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high mobility group (HMG)-box found in sex determining region Y (SRY)-box 17 (SOX17) and similar proteins
SOX-17 is a developmental transcription regulator involved in endoderm formation, angiogenesis, and carcinogenesis. It acts as a tumor suppressor and modulates WNT signaling. SOX-17 binds target promoter DNA and bends the DNA. It binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. SOX-17 belongs to the group F of SRY-related high-mobility group (HMG) box (Sox) transcription factors.
Links
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Statistics
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PSSM-Id: 438850
Aligned: 9 rows
Threshold Bit Score: 149.852
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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DNA binding
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:3F27; Mus musculus SOX-17 binds DNA, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               ## ## ##   #  #          ###  ##  #  #                             ## ###
3F27_D         1 GSFTSRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRR 80  house mouse
2YUL_A         2 SSGSSGIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKSGPSS 81  human
Q9H6I2        62 AKGESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRR 141 human
Q8AWH3        55 GKAEARIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRR 134 tropical clawed...
NP_001034415  56 GKGEARIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALSLAEKRPFVEEAERLRVQHMQDHPNYKYRPRR 135 chicken
AFK11176      65 AKAEARIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWRGLSIAEKRPFVEEAERLRIQHMQEHPNYKYRPRR 144 elephant shark
XP_005993498  56 SKTEPRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWRALSLAEKRPFVEEAERLRIQHMQDHPNYKYRPRR 135 coelacanth
NP_571362     57 GKSEPRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALPMVDKRPFVEEAERLRVKHMQDHPNYKYRPRR 136 zebrafish
Q90ZH9        52 SKAEGRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALSLAEKRPFVEEAERLRVQHMQDHPNYKYRPRR 131 African clawed ...

Feature 1         
3F27_D        81 R 81  house mouse
2YUL_A        82 G 82  human
Q9H6I2       142 R 142 human
Q8AWH3       135 R 135 tropical clawed frog
NP_001034415 136 R 136 chicken
AFK11176     145 R 145 elephant shark
XP_005993498 136 R 136 coelacanth
NP_571362    137 R 137 zebrafish
Q90ZH9       132 R 132 African clawed frog

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