1QUU,1CUN


Conserved Protein Domain Family
SPEC
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cd00176: SPEC 
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Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here
Links
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Statistics
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PSSM-Id: 238103
Aligned: 168 rows
Threshold Bit Score: 54.374
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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linker region
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:linker region
Evidence:
  • Comment:may form stabilizing contacts that favor dimerization
  • Comment:dimerization occurs in an antiparallel fashion
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      
1QUU_A      15 LAEKFRQKASTHETWAygKEQILLQKdyesa-slteVRALLRKHEAFESDLa---aHQDRVEQIAAIAQELneldy---- 86   human
7303255   3674 LSEHFADSHQGLTAWLddMEQQISRLsmpal-rpdqITLQQDKNERLLQSIa---eHKPLLDKLNKTGEALgalvad--- 3746 fruit fly
8928460    282 QLRLFEQDAEKMFDWIthNKGLFLNSyteigtshphAMELQTQHNHFAMNCm---nVYVNINRIMSVANRLvesgh---- 354  human
8928460    508 QLCVFQQEVQQVLDWIenHGEAFLSKhtgvgkslhrARALQKRHEDFEEVAq---nTYTNADKLLEAAEQLaqtg----- 579  human
8928460   1080 QYVVFERSAKQALEWIhdNGEFYLSThtstgssiqhTQELLKEHEEFQITAk---qTKERVKLLIQLADGFcekgh---- 1152 human
6014925    352 QLRHFEQGFREVKTTLdsMSQKIAAFt--------dVGNSLAHVQHLLKDLt---aFEEKSSVAVDKARALslegq---- 416  house mouse
118279     223 FEQDFQQLVTEVEFLLnqQAELADVTgti-----aqVKQKIKKLENLDENSq---eLLSKAQFVILHGHKLaa------- 287  human
4240211    193 FEHDFCKAKLALDNLLeeQAEFTGIGdsv-----mhVEQILKEHKKLEEKSq---eSLEKAQLLALVGDQLiq------- 257  human
7292359   3520 DTQLFLKDAEILEQWIssREPQLKDTklgd--sipqVEDLLRRHEDFEKTVaaqeeKFQAIKRITMLEQLFrhql----- 3592 fruit fly
2511779    115 EVLVFGRDAGMAEAWLcsQEPLVRSAelgc--tvdeVESLIKRHEAFQKSAvaweeRFCALEKLTALEEREkerkrkree 192  human

Feature 1                                         ######                                       
1QUU_A      87 --hdavnVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQlhlefak---------raapfnNWMEGAMEDLQDm 155  human
7303255   3747 --ddgakINEILDTDNARYAALRLELRERQQALESALQESSQFSDkle----------------gmlRALANTVDQVNQl 3808 fruit fly
8928460    355 --yasqqIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKyms----------------nvdSWCKACGEVDLPs 416  human
8928460    580 ----ecdPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHvke-----------------lwTWLEELQKELLDd 638  human
8928460   1153 --ahaaeIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKsskslql--------diipasiPGSEVKLRDAAHe 1222 human
6014925    417 --qlienRHYAVDSIHPKCEELQHLCDHFASEVTRRRGLLSKSLElhsll-------------etsmKWSDEGIFLLASq 481  house mouse
118279     288 ------nHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFKmhkll-------------qqarQCCDEGECLLANq 348  human
4240211    258 ------sHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEfhrql-------------dkvsQWCEAGIYLLASq 318  human
7292359   3593 ---eqekISKLQEKERLEKERLEQLKQRELQRLADERRRAEKQHEhrqnaasqektpifsspmvtpaQTSGPQSPALSQv 3669 fruit fly
2511779    193 eerrkqpPAPEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQApsvn---------------gvcTDGEPSQPLLGQq 257  human

Feature 1                                                                                      
1QUU_A     156 fivh-------------------------------sieeiQSLITAHEQFKATLp--------eADGERQSIMAIQNEVE 196  human
7303255   3809 dplsa------------------------------lpqkiREQIEDNDALMDDLd--------kRQDAFSAVQRAANDVI 3850 fruit fly
8928460    417 el-----------------------------------qdlEDAIHHHQGIYEHItla----yseVSQDGKSLLDKLQRPL 457  human
8928460    639 vyae-------------------------------sveavQDLIKRFGQQQQTTlqvtvnvikeGEDLIQQLRDSAISSN 687  human
8928460   1223 lneekrks------------------------arrkefimAELIQTEKAYVRDLre-------cMDTYLWEMTSGVEEIP 1271 human
6014925    482 pvdkc-----------------------------qsqdgaEASFQEIEKFLETG----------AENKIQELNEIYKEYE 522  house mouse
118279     349 eidkf-----------------------------qskedaQKALQDIENFLEMAlp-------fINYEPETLQYEFDVIL 392  human
4240211    319 avdkc-----------------------------qsregvDIALNDIATFLGTV----------KEYPLLSPKEFYNEFE 359  human
7292359   3670 qlrppfgddnehlalqkssssgmfgdrlrrgsadanvkraESMKVQPKQAKRTPsftt---rrrAQSFRKNQKGEGFDLP 3746 fruit fly
2511779    258 rlehssfpe---------------------gpgpgsgdeaNGPRGERQTRTRGPap-------sAMPQSRSTESAHAATL 309  human

Feature 1                                                               
1QUU_A     197 Kviqsyniris-----------ssnpystvtMDELRTKWDKVKQLVPIRDQSLQEEL 242  human
7303255   3851 Akagnkadp--------------avrdikakLEKLNNLWNDVQNATKKRGSSLDDIL 3893 fruit fly
8928460    458 Tpgssdsltasan-------yskavhhvldvIHEVLHHQRHVRTIWQHRKVRLHQRL 507  human
8928460    688 Ktphnssi-----------------nhietvLQQLDEAQSQMEELFQERKIKLELFL 727  human
8928460   1272 Pgivnkeliifgnmq---eiyefhnniflkeLEKYEQLPEDVGHCFVTWADKFQMYV 1325 human
6014925    523 CilnqdllehvqkvfqkqesteemfhrrqasLKKLAAKQTRPVQPVAPRPEALTKSP 579  house mouse
118279     393 Spel------------------------kvqMKTIQLKLENIRSIFENQQAGFRNLA 425  human
4240211    360 Llltld---------------------akakAQKVLQRLDDVQEIFHKRQVSLMKLA 395  human
7292359   3747 Pveiqgslerkh---------glqsggkkapVRSWKQFHTVLCGQLVCFFKDENDFL 3794 fruit fly
2511779    310 Pprgp-----------------------epsAQEQMEGMLCRKQEMEAFGKKAANRS 343  human

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