Conserved Protein Domain Family
chlamy_CPAF

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NF033424: chlamy_CPAF 
protease-like activity factor CPAF
CPAF (chlamydial protease/proteasome-like activity factor) is a serine protease secreted various species of the intracellular pathogen Chlamydia. Early attribution of contributions of CPAF to virulence by cleavage of specific host cell substrates contains a number of errors, and the true role of CPAF, and its contributions to virulence, remain under study.
Statistics
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PSSM-Id: 468021
Aligned: 23 rows
Threshold Bit Score: 748.674
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CDZ79675       3 KSLYFLFTFVVSMpLIIYGGLQESNSKAKM----VGNLQIIQNIFEDSYAPSFWKKQLFDWDLKQEIHQAQREILALNSP 78 
WP_052236361   6 LNTFRSCAIFVLFyASLSFASTEDIKKESM----IEDLKMIKHVFDVGYAPLEWKKNYTGLNLDEELNKSIDLILSNPTL 81  Candidatus Prot...
WP_088244863   8 LSLFITIIFPLNE-SLSASQSRTNEPPSLLqqqmLRDLDFVHNNFDAYYAPSEWKKRHFAWDLDTQINKAKASVLANKEV 86  Chlamydiales ba...
OJV11469       3 THRLIGLVL--FI-CISLKPVVQAVQDNKRm---FNDIEAIQNVFQVKYAPAEWKKEYAGWDLSREVERVKS-LIQQQDL 75 
KIC76175       7 NRIFLAVLYSFLLsYLGSTLLASETYHAKM----LGNIDLIKSILASKYAPAEWKKNYIGWDLEVEAQAAKNEVLRRSSL 82 
WP_006342318   3 IKYVINLYLVVVFfSCHALLASDSLLRQEM----VEDLHFIRKNFQIKYVPADWKLLQFGWNLNQQFDNAEAEITSLSSP 78  Parachlamydia a...
OJV07230       3 YIKCLSVIIFFIV-SLPSWGCSDALSDKKQm---ILELEGIKHIFQMQYAPMQWKKEQFAWELEDEIETAKQKVLSFDEV 78 
WP_088206050   8 SFKLSVLLLSLFI-VSAPLSARAEAGDELMrskmLSDIDTMHNLFSYRYAPVEWKEHFASWTLEEATERAKERVMTLRKP 86  Chlamydiales ba...
OJV11468       1 --MFKNFIFLFLI-ISHLFFQTFTFSNPQRm---ATDLEIIKNEFEIYYAPAEWKKKLFNWSLEAAIEHAKQEI-REKPI 73 
WP_042238344   2 VKIIYVLAFLIAS-ICSIEAQDYSLRQSQM----IADLKIIKHEFEINYAPFEWKRKYLHWNLDHEVTKAKEKILSSLSL 76  Neochlamydia sp...
CDZ79675      79 CVDQYQTILRNFFTSTCDHHVNVLFHNKAMSFLLFDLIQIDNRYIVINsLDFpsdeendeeltleEKEMKKSLDIysklK 158
WP_052236361  82 THKDFQRIVKNFLASTKDYHVDVIFFSTETATLPFDVKGVNNRYFITW-IDE-------------LKLPPSTYTI----K 143 Candidatus Prot...
WP_088244863  87 SLKDYHQILRGFFNSTRDYHVSVHSVTTEKATLPFMIKGVKGRYFFVY-LDR-------------DKLPKEIFPF----E 148 Chlamydiales ba...
OJV11469      76 SIRDYQKLLLSFFHSMKDYHVMVNFYATEMSILPFRLHGAKGRYFIAW-LPGev---------gdIELDPEMIRFlknaR 145
KIC76175      83 SIRDYQKILLDFFNSMQDYHVKIDFYATEMSFLPFRLEGVEGRYFVAW-LPKnsq--------syAKIDPSLADMlanmQ 153
WP_006342318  79 TLKDYHKILNKLFTSAADYHVNVSFYSTEMASLPFHLQGAEGRYFITW-INE-------------EKLPEECLDW----S 140 Parachlamydia a...
OJV07230      79 TIQDFHGIVKKIFASLRDFHVNVSFFTTESAYLPIQIRGAEGRYFIVH-VDK-------------KQLSPQLFPI----K 140
WP_088206050  87 TAKEFHRILRDFCYSMKDYHVGILFCSTESAHLPFDVMSAEGRYFISY-IDH-------------SKVSSSQFPF----Q 148 Chlamydiales ba...
OJV11468      74 NLQQYQQILRDLFNSTQDLHVGVSFYSTEFAILPFLVQGVDQRYFVVW-IDE-------------EWKKMQGVPL----E 135
WP_042238344  77 STKQYHQIIRDLFNSVQDLHTYVRFYATEYAFLPFCVQGVQGHYFVVW-VDN-------------LWAKEQKVSL----Q 138 Neochlamydia sp...
CDZ79675     159 IGDEVIAINDEPIEEVFNRFKKNYFKEDSL--------TNQRFAEIFFTKRFAYTGMNTPKGKISIKIK-------NQN- 222
WP_052236361 144 VGDEIIEFDGRPLVDVIEELKQHGSKNSNPl-------TDQALAEIKLTNRLGWLGDNIPQGPVTIKVH-------SRSk 209 Candidatus Prot...
WP_088244863 149 IGDELLEFDGRPVHDVIQEIKHAELGNDGTkigdandfTDQALAEIYLTSRRDNTN-KIPKGPITLLCRaqkddegKPN- 226 Chlamydiales ba...
OJV11469     146 VGDEVISLNGVSAEAYVQDFCQKIYGNETNg-------TDQMLAEQYLTLRLAEMGHSVEEGPIEIRIK-------HQNs 211
KIC76175     154 IGDEVLAFGNMPIDEYLKKFSLKSFGKALNa-------TDQRLSEQYLTLRLASMGYEVEQGGVPITVR-------HHRs 219
WP_006342318 141 IGDEVIAFDGQDIHEFVQNLRRSEHDRHNEk-------TDQRFAERSLTLRAGMFAEDVPQGNVEVDLI-------HKKt 206 Parachlamydia a...
OJV07230     141 PGDEILYFDDKPIAQAMEDFQIQEFGDNKGk-------TQKTKSEIMFTHRQAGRGHQIPQGPVIIQVK-------HQGv 206
WP_088206050 149 VGDEILYFNHTPIGQVVDELIVTEERGATQe-------TDQRKAENILTHRLGFMGHMVPSGRIKVTGR-------DSD- 213 Chlamydiales ba...
OJV11468     136 KGDEILAFDGRSAAEIIREIHRASYGFCDAe-------SYHRLSEMLLTLREGNCINNVPQGTTEVLYK-------KPHq 201
WP_042238344 139 VGDEILSFDGSPVEEVVEKIRLSAFGANRNe-------TYQHLSEWQLTLREAFRLQDVPQGPIEIVFR-------KPN- 203 Neochlamydia sp...
CDZ79675     223 GAIHEYETTWLHLDELIEQPKQ-LGLKKD------------PIYAYSKLPFLKKKMCLPIFEWQKncqnelsayltknfC 289
WP_052236361 210 EVPLSYQLIWDYRPELIFSPSFfLQTVESf-----------FPNKKISVRSPCMTMMNLTHRKMM--------------S 264 Candidatus Prot...
WP_088244863 227 SKAKEAQLVWDYFPEWVIDSRQaRYAFDPr----------tLQRKQGINNLFNKQMLPGRWPHLM--------------S 282 Chlamydiales ba...
OJV11469     212 EAIDTYVPEWIYVPEEIKNDF---PSIAAkiq-------hkKNKARKEFKFFKAEKVTPIYPQMLraqk------svkkA 275
KIC76175     220 GRINTYTPEWLYVPERITNHFLpANFYSTss--------ggVYARKKGLDLFDKERITPLHRQMEiakksinkfkkenwG 291
WP_006342318 207 GEQKSYVLTWTYHPEQVKEIPLpSLVARGi----------sEKQPFFQRPYYKKMMLTPLYAKFN--------------Q 262 Parachlamydia a...
OJV07230     207 EGVKSYQLTWAYTPEKIIQD---LPLSNKkqanynlgkksnKKNFKEILRSLDKPWMTPYYKPSLnhifepseshkeenD 283
WP_088206050 214 GRMHAAKLQWSYTPERIDTHYThLEDPGSrvtmaqvlnqeeQQGELRQRFYSYAEMKNPEVEFLR--------------K 279 Chlamydiales ba...
OJV11468     202 ENPETCLVEWYYVPEEIENEF---PGIKNp-----------FRSTLAESPIFHRCRALPLFTRLK--------------- 252
WP_042238344 204 SQQAHSFVNWEYAPEEIINNYSlSMPLNL------------ERGEGAKHRFFYQERILPFYASLV--------------N 257 Neochlamydia sp...
CDZ79675     290 KDCKAIDhp-fsIGKKDSSLPPLGKILFKTDEs-----YSYDAYLFELENGKVGGFIRIPNYMLGeEQNISEWQELISIF 363
WP_052236361 265 ETKRDGT-----LCARKSFIPTLGPRVWMFDKidkekeISWYAYIYKISEEEKIGYIRIPHYIGY-KEESKEFGELLNYL 338 Candidatus Prot...
WP_088244863 283 LQNHLPScs-hnLGSKKSFLPRLGKIVWEAPEs-----CPFDAYLFLDGMERLIGYVRIPHYVAG-APHVNEFAELMKEF 355 Chlamydiales ba...
OJV11469     276 FKGSHADtdffiLGQHKSFVPPLGPLIWEDSH------SHHYSYIFQ-WKGKKIGYVRIPTYAVF-GYEYRDFEKVMRFF 347
KIC76175     292 LEEDNSEcdyiaLGQYQSFVPELGEVLWRATS------LHYYSYIFQTASNKKIGYLRIPIYTAD-ENEYKELETIIQHF 364
WP_006342318 263 PESRVVEdv-hnLGARKSFVPPLGSIVWQSPPd-----SPFHAYICETPSRQRIGYIRIATYDGT-DDEVVEFAKLIDYF 335 Parachlamydia a...
OJV07230     284 PKEEENEsp-fiLGAKKSMLPPLGRIWWKNEK------KYWNAYIFETPERRLVGYLRIPHYVDYlGESVKELAEIIQLF 356
WP_088206050 280 LSPESCQsa-hsAGDREGFLPELGDIVWQSKGk-----DLFHAYISVTPAGQRIGYVRVPTYMPSkGAE-KAFGNLIARF 352 Chlamydiales ba...
OJV11468     253 SYAKNYEtq--lLGGKKSLFPPLGEILWKSNS------PEFEAYIYSLKGCKSVGYIRISDFMGG-RHEVDQFRHLIAMM 323
WP_042238344 258 HSSCLANka-klLGAKANLFPALGPVLWRADL------PDFEAYIYSLKGSKNIGYIRIPDFQGS-EYRVEQFQQIIAKM 329 Neochlamydia sp...
CDZ79675     364 EQQSDFLVIDQLNNPGGSMFCLYGILSYLTDKPMQVPAHRISLTQAEIVSYVDILQEIEILEEAPEeeIKEALGDS-IEG 442
WP_052236361 339 EQKTDALVIDQVHNGGGYASFQYELASMLALNPLKTPKHQMKITQKDVLTAYQILDVIEKIQQGID--------DE-IEE 409 Candidatus Prot...
WP_088244863 356 ELKTKALVIDQVNNPGGSVFYLYSLASIFAEHPFSTPKHRMKIGQDEVMFSRSCLERFSYISNNQE--AKWAFGGSnIDG 433 Chlamydiales ba...
OJV11469     348 QQETDALVIDQLNNPGGMVVYLFALLSMLTDQPLELPLERITITQQDVSEALDILDSPEEYLEAWE--------QG-MAG 418
KIC76175     365 QNETDALVIDQLNNPGGSSAHLLFLLSLLSEYSLDLPLERITITQQDVAKALMIVNNPHHILNDLI-----ENGPS---- 435
WP_006342318 336 NPRTQALVVDQVNNPGGSVFYSYGLLSLLTDQPLELPKYKMAITQEEVMEALETLDTLKEITNDEE--AIDVCGPS-LHG 412 Parachlamydia a...
OJV07230     357 EERTDALVIDQLNNPGGLIFYMYSIASLLSNQALTTPRHHIKLTHADVFNALECIPALEDVSDDLE--AEFLFGRH-YGG 433
WP_088206050 353 EADTDLLIFDQMNNSGGSVLYGYNLLSMLVNEATPLPKDRMKLTQKKIHSLLEDSDWFSSIKNDKE--AQWYLGKY-FLG 429 Chlamydiales ba...
OJV11468     324 EASTHALIIDVMNNPGGFAFYTYALLSMLSDKPLMNLREKMAITQEEIFLCLEDMQLLEEVTTDHE--AKGLIGED-ICG 400
WP_042238344 330 ESCADALIVDVMNNPGGFSFYTYALASMLTCKPLTNLKQFLSITQEDVYLAVQTASSLKNIVTDHE--AAQALGPD-ING 406 Neochlamydia sp...
CDZ79675     443 YNIDRTFIKDLKTFCLKVLDQWRNGKTLTDPLF--LYGVKNIYPNPKIHYSKPIYVLINELDISCADFFPAVLQDNNRAT 520
WP_052236361 410 GPIDYQHLLFLKAFYEFTIQEWDGQRTLTDPTH--LEGCDWINPHSDYRYTKPILMLINELDFSGGDFMPAIMQDNQRAV 487 Candidatus Prot...
WP_088244863 434 YPINYQFIQLLKSYCQFIIDEWNEGKMFTDPYH--LYGVDKIHVSPKAKYTKDILLLTNELDFSGGDFFPAIMQDNKRAK 511 Chlamydiales ba...
OJV11469     419 YSISKEDSSALIAYFKNIIQEWNSGRIFTAPLY--YYGISSVKPHPEVRYTKPILVLVNALDFSCADFFPAILQDNGRAK 496
KIC76175     436 FLISPENTEGVTAFFQTILDEWNAGRTFTQPLH--YCGITSVPPNPHTHYNKPILILVNALDFSCADLFPAILQDNQRAK 513
WP_006342318 413 YAVSFELVQSVIQYFQFVLSEWEEGKYVTSPVH--LL-VNTIAPSPFVTYDKPMVVLVNEFDISCGDSFPCILQDNQRAL 489 Parachlamydia a...
OJV07230     434 YPVSYQFCQCWLHYCRFIQEEWTQGKTFTDAIH--LLGVDAVNPHPAA-FTKPILLLINELDFSCGDFFPAILQDNQRVT 510
WP_088206050 430 VSVTYELVKQMKIFTEVMIDEWNSGKSMTEPVHngLFG-DAVYPHPTHCYSKPILCLINEQDFSMADQIPAILQDTERAV 508 Chlamydiales ba...
OJV11468     401 FNVDKQFVNCVLKHARFIKDQFKKGKYLTDLYP--LEGLEYIYPNPKTHYTKPLLVLVNSLSISCADLFPAILQENKRAK 478
WP_042238344 407 YAVDKRLACYLFKYAKYIQDQFKQGKYFTDLYP--MDGVETIYPHPTTQYTKPLFVLTNPLSISCAELLVALLKDNERAI 484 Neochlamydia sp...
CDZ79675     521 LIGTGTSGAGGYVNSVSFPNK-MGVAAFSYTGSLALRKNS-KPIENLGVTPDIPYTLTQEDLTNNLIDYSAFIKKLLLRS 598
WP_052236361 488 LFGTRTSGAGGFVLQASFPNN-NGIAAFSYTGSIAERPETlLKIENLGVTPDIVYSLTVDDLQNGYQGYKAAVNEAIQAL 566 Candidatus Prot...
WP_088244863 512 IMGARTAGAGGYVLQTSHPNN-LGVDSFSVTGSIAERVDN-NPIENLGVSPDWSYEITEKDVQGEYEGYKNEILSVLTMM 589 Chlamydiales ba...
OJV11469     497 IFGSKTAGAGGYVLNHEYPNL-FGIKGFSYTGSIAYRTNQ-QPLENLGVTPDFVYEMTDEDLMNNYQPYSEALLKALDSL 574
KIC76175     514 VFGSPTAGAGGFVLEHEYPNL-FGIASFSYTGSIVYRAGD-RPIENLGVTPDFPYEITVDDLMYNYKGYTKAVLQALEDL 591
WP_006342318 490 IFGTRTAGAGGTVLGGGHPNR-LGIAGYSYTASLLERHTDgTPIENLGVTPDVSYSLTPEDFQNGYKGYKAALQEAIDGL 568 Parachlamydia a...
OJV07230     511 TMGVQTAGAGGFVTFTPLKSR-FSIGGFNITGSIAERADK-SYIENAGVIPDVHYEISASDYQNHFFSFKEAILNELCKI 588
WP_088206050 509 LMGTRTAGAGGSVEDDENPDLfFGVWSISYTVSIGERTNGgDPIENLGVEPDVPYSLTVEDLQNNFSPFVSAIQEQVSVM 588 Chlamydiales ba...
OJV11468     479 ILGTRSAGAGGYVLAKKYSNR-FGVADFTLTGSIISRANG-DPLENLGVSPDFPYTFSAEDYTQNFSGFVEYLNRIMYYY 556
WP_042238344 485 ILGGQTAGAGGTIVRRKYSNR-FGIADLVFTGSLVCRYNE-QPLENRGVKPDVAYRWTTEDYTKDHANFIDFVNGIVSCS 562 Neochlamydia sp...
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