Conserved Protein Domain Family
TRPM_tetra
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pfam16519: TRPM_tetra 
tetramerization domain of TRPM
TRPM7_tetra is a short anti-parallel coiled-coil tetramerization domain of the transient receptor potential cation channel subfamily M member proteins 1-8. It is held together by extensive core packing and interstrand polar interactions. Transient receptor potential (TRP) channels comprise a large family of tetrameric cation-selective ion channels that respond to diverse forms of sensory input. The presence of cytoplasmic domains that direct channel assembly appears to be a feature of many voltage-gated ion channel superfamily members.
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Statistics
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PSSM-Id: 465156
Aligned: 16 rows
Threshold Bit Score: 75.8264
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EKC26700     1275 DERIRVINERVENMTMRMDDINQKENSIKLSLQTMDYRMSKLEDVALQTNDTLSVL 1330
XP_013127048 1181 KNRIKVTAERTEEMCMMVGEVSEKVNFIQDNLSELDSQLGHLQDLSALAVDTLTFL 1236
XP_023814357 1182 IKKIRAIAERAEEMSVMVGEISEKVNCIQHSLSELDCQMGQLQDLSALAVDTLTLL 1237
XP_015222636 1219 vHRIKTTLEKVEEMCLQLKDVAEKVFFVKETLQSLDNQLGHLQDLSALTVDTLSVI 1274
XP_004176385 1183 SERIRLTTERVEEMFQQLKEVHEKVFYIKESLLSLDTQLGHLQDLSALTVDILKVL 1238
XP_016082803  196 EERIRVTTERVAEMCFQMKEVHERVFYIKDSLVSLDSHLGHLQDLSALTVDTLKVI 251 
XP_008254529 1234 DERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERL 1289
XP_028286263 1227 DERIKVTSERVENMFMRLEEVNERENTMKASLQTVDLRLAQLEEIHGRMAVALEKL 1282
XP_023423228 1178 DERIRVTCERVENMSMRLEEINERENFMKTSLQTVDLRLSQLEELSGRMVNALENL 1233
XP_021208485 1217 EERVRNTTDRVEHITTKMEDLNQKANCQIQSMQSVEFRLRKLEDIAEQTMSHLAVi 1272
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