2JUO


Conserved Protein Domain Family
GABP-alpha

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pfam11620: GABP-alpha 
GA-binding protein alpha chain
This family of proteins represents the transcription factor GABP alpha. This alpha domain is a five-stranded beta-sheet crossed by a distorted helix termed an OST domain. The surface of the GABP alpha OST domain contains two clusters of negatively-charged residues suggesting there are positively-charged partner proteins. The OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300, a direct link between GABP and transcriptional machinery has been made.
Statistics
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PSSM-Id: 463311
Aligned: 13 rows
Threshold Bit Score: 96.6159
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2JUO_A         7 QAIDINEPIGNLKKLL-EPRL-QCSLDAHEICLQDIQ-LDPDRSLFDQGVKTDGT-VQ---LSVQVISYQgMEP-KLNIL 78 
XP_002428175  77 EHMDIQCPLYTLRNIL-QKRF-NIDLSEYTFWLQDAQmLEPHKNLVDQCVQGEGL-VQ---INVEIKIEG-DSK-KINII 148
EEC09200       4 QHMDITEPLTSLKSLL-EQRL-AVSLHDYAFFLQDTQeLNASKNLVDQCVQGEGL-VQ---VNVEIINKD-GVR-KINIV 75 
Q16VF8         8 VHMDLRENLSTLRGLV-EQRI-GVSLKHYEFWLQDTQmLESHKNLVDQCVQGEGL-VQ---INVQVQT---AKR-RINIA 77  yellow fever mo...
ETN62145      48 VHMDLRESLSKLRSLI-EERT-GIVLADYKFYLQDTTlLESHKNLVDQCVQGEGL-VQ---INVQVKP---SRR-RINIA 117
XP_011134976  78 QHMEIREPLSTLRSLL-ESKL-QIDLSDYSFWLQDAQmLESDKTLAAQCIEGQGV-VQ---VSVQIKITKdNER-RINIV 150
XP_009014716 174 QCMDITEPLSTLRRLL-EERF-VADYSAYELWLQDSVqLDPSKNLVSQCLEGTGT-VQ---INVEFKV---GYP-RINIL 243
XP_015792889  62 EGIELNASVKTLCQLL---KVkYEDIESYDFYLQDNK-LTFNKSIIEQCNLVEGArQQtklINIKLIVELeSR--RVTIL 135
Q4H3F7        28 QNIDIKTPIKVLKDVL-SRRLrKSDLSKHDIYLQDFY-LDPDLSLFEQGVKIHGS-VE---LSIQVQSSSt-NP-KLIIV 99  vase tunicate
EEN48075      15 QAIHINEPIGALRQLL-EPRV-QSSLENHNIYLQEIP-LDPGQSLFDQGVKTDGV-VQ---LSVQIVSNTgEEP-RLNIL 86 
XP_012399822  40 QAIDINEPIGNLKKLL-ERRL-QCSLDAHEICLQDIQ-LDPDRSLFDQGVKTDGT-VQ---LSVQVISYQgIEP-KLNIL 111
Q9I9E8        40 QDIDINEPIGNLKKLL-EPRL-QIPLDGYDICLQDIQ-LHPDHSLFDQGVKTDGT-VQ---LSVQIVTKPg-EE-KLNIL 110 zebrafish
ESN96619     141 QQLDLSQPLWYIRDLLvSDGIiDGNVKKVEYWLQNNDkLDESKSLKWCCVEMEGEnIQ---VNIDVRARLdNKKiRINIS 217
2JUO_A        79 EIVKTAET 86 
XP_002428175 149 DVLKPTDE 156
EEC09200      76 DVLKPAEE 83 
Q16VF8        78 DVLKPTDE 85  yellow fever mosquito
ETN62145     118 DVLKPTDE 125
XP_011134976 151 DVLKPAEN 158
XP_009014716 244 DVLKPVED 251
XP_015792889 136 DILKPPDN 143
Q4H3F7       100 EIVKPMQD 107 vase tunicate
EEN48075      87 EVVKPIQE 94 
XP_012399822 112 EIVKPAET 119
Q9I9E8       111 EIVKPVET 118 zebrafish
ESN96619     218 DILVPCDE 225
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