2JP3


Conserved Protein Domain Family
FXYD4
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cd20322: FXYD4 
FXYD domain-containing ion transport regulator 4
FXYD domain-containing ion transport regulator 4 (FXYD4), also known as CHIF (channel-inducing factor or corticosteroid hormone-induced factor), evokes K+ conductance in oocytes and is localized in the distal parts of the nephron and in the colon. CHIF, a putative K channel regulator, is regulated by aldosterone in the colon and by K+ intake in the kidney.
Links
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Statistics
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PSSM-Id: 410558
Aligned: 47 rows
Threshold Bit Score: 61.4762
Created: 8-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative trimer
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:putative trimer interface [polypeptide binding site]
Evidence:
  • Comment:based on structures of the Na+/K+ ATPase heterotrimer, composed of alpha, beta, and gamma (FXYD2 or phospholemman-like protein) subunits
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 # # #  ##  ## ##  #  ### ## #          
2JP3_A         1 NGPVDKGSPFYYDWESLQLGGLIFGGLLCIAGIALALSGKCKCRRNHT 48  Norway rat
XP_027293691  13 AGLPALEANDPIDWKSLQLGGMIFGGLLCIAGIAMALSGKCKCRRSHK 60  Chinese hamster
RLQ61928      13 AGLPALEANDPIDWKSLQLGGMIFGGLLCIAGIAMALSGKCKCRRSHK 60  Chinese hamster
XP_030894563  13 AGLPALEANDLVDWESLQLGGMIFGGLLCIAGILIALSGKCKCKYSQK 60  Weddell seal
XP_013004033  84 AGLPVTEAGDLFDWESLQLGGTIFAGLLCIAGFAWALSGKCKCKQSKE 131 domestic guinea pig
DAA14335      12 NVVFGRTSHQQGDWEGLQLGGMICAGLMCIAGLLFALSGKCKCKNKQK 59  cattle
XP_023620471  88 AGLPALEANDLIDWEALQLGGMICAALLCIAGILFALSGKCKCKHNRK 135 little brown bat
XP_007115759  25 NMVFGRTSFQHGDWEGLQLGGVICAALLCIAGILFALSGKCKCKQDHK 72  sperm whale
XP_031528408  23 NMVFGRTSFQQVDWEGLQVGGTICAVLLCIAGILFALSGKCKCKSNQK 70  alpaca
EPQ10937      20 VEGLIDRQFLLPDWGDLQLGGMTCAGLLCVAGIVFALSSKCKCKHSQQ 67  Brandt's bat

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