2OPV,2JVZ


Conserved Protein Domain Family
KH-I_FUBP2_rpt2

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cd22482: KH-I_FUBP2_rpt2 
second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
FUBP2, also called FUSE-binding protein 2, or KH type-splicing regulatory protein (KSRP), or p75, is a single-strand nucleic acid binding protein implicated in a variety of cellular processes, including splicing in the nucleus, mRNA decay, maturation of miRNA, and transcriptional control of proto-oncogenes such as c-myc. It regulates the stability and/or translatability of many mRNA species, encoding immune-relevant proteins, either by binding to AU-rich elements (AREs) of mRNA 3'UTR or by facilitating miRNA biogenesis to target mRNA. FUBP2 contains four K-homology (KH) RNA-binding domains. The model corresponds to the second one.
Statistics
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PSSM-Id: 411910
Aligned: 9 rows
Threshold Bit Score: 129.645
Created: 18-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putativeGXXG motif
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  # ### #####  ##  ##    ####                                    
2OPV_A        13 GTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQntNVDKPLRIIGDPYKVQQACEMVMDILRE 85  human
2JVZ_A         1 GTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQntNVDKPLRIIGDPYKVQQACEMVMDILRE 73  human
AAN77160     181 GSLQEIMIPAGKAGLIIGKGGETIKQLQERAGVKMILIQDGSQntNMDKPLRIVGEPFKVQQACEMVMDLLKE 253 African clawed frog
NP_989608    296 GTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMIFIQDGSQntNVDKPLRIIGDPYKVQQACEMVMDILRE 368 chicken
Q92945       233 GTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQntNVDKPLRIIGDPYKVQQACEMVMDILRE 305 human
XP_014348579 224 GTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQatNVDKPLRIIGDPYKVQQACEMVMEILRD 296 coelacanth
XP_007905349 214 GSIQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQnsNVDKPLRIIGDPFKVQQARDMVMEILHE 286 elephant shark
AAI39702     192 GHMQEMVIPAGKAGLIIGKGGETIKQLQERAGVKMILIQDASQgpNMDKPLRIIGDPYKVQQAREMVQEILRE 264 zebrafish
XP_021481561 119 GSGQEMMIPAGKAGLIIGKGGETIKQLQERAGVKMILIQDASQgpNMDKPLRIIGEPYKVEQAMELVQEILRE 191 rainbow trout

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