2JNS,6CUI


Conserved Protein Domain Family
BET
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pfam17035: BET 
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Bromodomain extra-terminal - transcription regulation
The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.
Links
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Statistics
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PSSM-Id: 435704
Aligned: 156 rows
Threshold Bit Score: 37.4747
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2JNS_A         17 PMSYEEKRQLSLDINKLPGEKLGRVVHIIQSRE--PSLKNsNP-DEIEIDFETLKPSTLRELERYVTS 81  
Q55C84        966 KVTTEEKTKLGAEITQLPVDLLPSILQIIHNTNslPEQ-K-PG-SEVVIDLMKFDDDILRRLSKFVEQ 1030 Dictyostelium discoideum
EFA83405      684 PMTLDEKTHLGAAINALHPSNLPKLIQVISHTLdq---nT-AQ-EEIEIDLEKLDTGTLRRLEQFVIS 746 
XP_004350359  599 QMTLEEKTQLGTNISFLPPERLRDLISIVSHTLp----nT-AQ-DEIVIDLEKLDNSTLRKMEQFVFS 660 
EIJ89205      291 EYGYEEKLKLKRRIESLAPSKLRPLIVYIQENIphVM--L-DEmESLEVNLDALDQKSLRGLSNIVRE 355 
EHY65945      285 EFGYEEKLKLKKMIDAIPLARLAPLLTYIQENVphVM--F-SElDVLEVNLDVLDQKTLRSLSNVVRE 349 
A0EI75        143 TISHNEKVEFSNNLKQLNPDQIGGIVQIIQTNSpsAFIVV-NK-ERFQIVIDNIDFDTFVKCQNQIQT 208  Paramecium tetraurelia
XP_004031797  172 PMSLQETLSFSQKIKSLPAEQIGMIVHMIQNSSsqAYKDI-DK-EKCQIHVDLIDRDTFKKINQQIDM 237 
XP_004035165  202 IITQQEKLQISQKIKQLPNQQLGIIVNIIQNNCmqAFKDS-DK-EQCQIHVNLIDYETFKKINQQIIF 267 
EEY66191      122 APSLEEKIYFSQNIYKVNPKDLGAIVQLLQEQCpkALDKS-SP-DELDIVVDHIDNKTFRDLEKFVLE 187
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