Conserved Protein Domain Family
sex-lethal
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TIGR01659: sex-lethal 
sex-lethal family splicing factor
This model describes the sex-lethal family of splicing factors found in Dipteran insects. The sex-lethal phenotype, however, may be limited to the Melanogasters and closely related species. In Drosophila the protein acts as an inhibitor of splicing. This subfamily is most closely related to the ELAV/HUD subfamily of splicing factors (TIGR01661).
Links
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Statistics
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PSSM-Id: 273740
Aligned: 3 rows
Threshold Bit Score: 503.781
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O61374     1 MYG------NMNNGGHAPYGYNGyRPSGGRMWGMSHSLPSGMSRYAFSPEDTDFTssYPGPs-mNRRGGYNDFSGGGGG- 72  Mediterranean fruit...
P19339     1 MYGnnnpgsNNNNGGYPPYGYNN-KSSGGRGFGMSHSLPSGMSRYAFSPQDTEFS--FPSS---SSRRGYNDFPGCGGSg 74  fruit fly
CAA04179   1 ------------------------------MWGMSHSLPSGM--------DTDFSs-YPSTigrQHSQQSQRYYQNNN-- 39  Megaselia scalaris

O61374    73 ----GGGTMGS--MNNMVNAASTNSLN-----CGGGGGRDG--HGGGSNGTNLIVNYLPQDMTDRELYALFRTIGPINTC 139 Mediterranean fruit...
P19339    75 gnggSANNLGGgnMCHLPPMASNNSLNnlcglSLGSGGSDDlmNDPRASNTNLIVNYLPQDMTDRELYALFRAIGPINTC 154 fruit fly
CAA04179  40 ------CGLGS--VGNMAN--STNSLN--------SG--------TNNSGTNLIVNYLPQDMQDRELYSLFRTIGPINTC 93  Megaselia scalaris

O61374   140 RIMRDYKTGYSFGYAFVDFAAETDSQRAIKSLNGITVRNKRLKVSYARPGGESIKDTNLYVTNLPRTITDDQLDTIFGKY 219 Mediterranean fruit...
P19339   155 RIMRDYKTGYSFGYAFVDFTSEMDSQRAIKVLNGITVRNKRLKVSYARPGGESIKDTNLYVTNLPRTITDDQLDTIFGKY 234 fruit fly
CAA04179  94 RIMRDYKTGYSYGYGFVDFGSEADALRAINNLNGITVRNKRIKVSFARPGGEQLRDTNLYVTNLSRSITDEQLETIFGKY 173 Megaselia scalaris

O61374   220 GMIVQKNILRDKLTGKPRGVAFVRFNKREEAQEAISALNNVIPEGASQPLTVRLAEEHGKAKAQHYMS-------QLGli 292 Mediterranean fruit...
P19339   235 GSIVQKNILRDKLTGRPRGVAFVRYNKREEAQEAISALNNVIPEGGSQPLSVRLAEEHGKAKAAHFMS-------QMG-- 305 fruit fly
CAA04179 174 GQIVQKNILRDKHTGTPRGVAFIRFNKREEAQEAISALNNVIPEGGTQPLTVRVAEEHGKSKGHVYMApnqpphgNMGhg 253 Megaselia scalaris

O61374   293 ggggggggggGGGGGGMGGPPPPPMNMGYN-NMVHRGRQNK--SRFQK-MHPYHNAQKFI 348 Mediterranean fruit fly
P19339   306 ----------VVPANVPPPPPQPPAHMAAAfNMMHRGRSIKsqQRFQN-SHPYFDAKKFI 354 fruit fly
CAA04179 254 nmgnmghgnmGMAGGSGMNLNNMNAFNGMN-QMVHRGRQKH---SYQRkIHPYN--PNFL 307 Megaselia scalaris
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